Hugh Rickards
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View article: Data-driven Huntington’s disease progression modelling and estimation of societal cost in the UK
Data-driven Huntington’s disease progression modelling and estimation of societal cost in the UK Open
We develop a Huntington’s disease (HD) progression model and integrate this with a novel economic model, accounting for the major factors of the HD’s societal cost. Data from the Enroll-HD observational study were used to fit a continuous-…
View article: Health screening clinic to reduce absenteeism and presenteeism among NHS Staff: eTHOS a pilot RCT
Health screening clinic to reduce absenteeism and presenteeism among NHS Staff: eTHOS a pilot RCT Open
Background Staff sickness absenteeism and presenteeism (attending work while unwell) incur high costs to the NHS, are associated with adverse patient outcomes and have been exacerbated by the COVID-19 pandemic. The main causes are mental a…
View article: Health state utility estimates for value assessments of novel treatments in Huntington’s disease: a systematic literature review
Health state utility estimates for value assessments of novel treatments in Huntington’s disease: a systematic literature review Open
Background Huntington’s disease (HD) is a progressive neurodegenerative disease with a devastating impact on patients and their families. Quantifying how treatments affect patient outcomes is critical for informing reimbursement decisions.…
View article: Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study
Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study Open
View article: An Overview of Specialist Services for Huntington’s Disease in the United Kingdom
An Overview of Specialist Services for Huntington’s Disease in the United Kingdom Open
Background: Huntington’s disease (HD) is a rare inherited neurodegenerative disorder characterized by complex evolving needs that change as the condition progresses. There is limited understanding about the organization of HD clinical serv…
View article: An Overview of Specialist Services for Huntington’s Disease in the United Kingdom
An Overview of Specialist Services for Huntington’s Disease in the United Kingdom Open
Background: Huntington’s disease (HD) is a rare inherited neurodegenerative disorder characterized by complex evolving needs that change as the condition progresses. There is limited understanding about the organization of HD clinical serv…
View article: What does social cognition look like in everyday social functioning in Huntington’s disease? A protocol for a scoping review to explore and synthesise knowledge about social cognition alongside day-to-day social functioning of people with Huntington’s disease
What does social cognition look like in everyday social functioning in Huntington’s disease? A protocol for a scoping review to explore and synthesise knowledge about social cognition alongside day-to-day social functioning of people with Huntington’s disease Open
Introduction Social cognition is problematic in Huntington’s disease (HD). Despite the observations of clinicians and families, there is minimal empirical literature about how it presents in daily life and the impact on social functioning.…
View article: Social cognition and quality of life in Huntington's disease
Social cognition and quality of life in Huntington's disease Open
Individuals with Huntington's disease (HD) and their close others report difficulties with social interaction, and previous studies have shown that the areas of quality of life detrimentally impacted by HD include social and emotional doma…
View article: Enhancing the health of NHS staff: eTHOS — protocol for a randomised controlled pilot trial of an employee health screening clinic for NHS staff to reduce absenteeism and presenteeism, compared with usual care
Enhancing the health of NHS staff: eTHOS — protocol for a randomised controlled pilot trial of an employee health screening clinic for NHS staff to reduce absenteeism and presenteeism, compared with usual care Open
Background Staff absenteeism and presenteeism incur high costs to the NHS and are associated with adverse health outcomes. The main causes are musculoskeletal complaints and mental ill-health, which are potentially modifiable, and cardiova…
View article: Mutation‐related magnetization‐transfer, not axon density, drives white matter differences in premanifest Huntington disease: Evidence from in vivo ultra‐strong gradient <scp>MRI</scp>
Mutation‐related magnetization‐transfer, not axon density, drives white matter differences in premanifest Huntington disease: Evidence from in vivo ultra‐strong gradient <span>MRI</span> Open
White matter (WM) alterations have been observed in Huntington disease (HD) but their role in the disease‐pathophysiology remains unknown. We assessed WM changes in premanifest HD by exploiting ultra‐strong‐gradient magnetic resonance imag…
View article: Mutation-related apparent myelin, not axon density, drives white matter differences in premanifest Huntington’s disease: Evidence from <i>in vivo</i> ultra-strong gradient MRI
Mutation-related apparent myelin, not axon density, drives white matter differences in premanifest Huntington’s disease: Evidence from <i>in vivo</i> ultra-strong gradient MRI Open
White matter (WM) alterations have been observed early in Huntington’s disease (HD) progression but their role in the disease-pathophysiology remains unknown. We exploited ultra-strong-gradient MRI to tease apart contributions of myelin (w…
View article: E05 Mutation-related apparent myelin, not axon density, drives white matter pathology in premanifest huntington’s disease: evidence from in vivo ultra-strong gradient MRI
E05 Mutation-related apparent myelin, not axon density, drives white matter pathology in premanifest huntington’s disease: evidence from in vivo ultra-strong gradient MRI Open
Background White matter (WM) impairments precede striatal atrophy and motor symptoms in Huntington's disease (HD) but their aetiology remains unknown. Aims We exploited ultra-strong gradient MRI to disentangle the contribution of changes i…
View article: Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington’s disease
Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington’s disease Open
White matter (WM) alterations have been identified as a relevant pathological feature of Huntington’s disease (HD). Increasing evidence suggests that WM changes in this disorder are due to alterations in myelin-associated biological proces…
View article: Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease
Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease Open
White matter (WM) alterations have been identified as a relevant pathological feature of Huntington's disease (HD). Increasing evidence suggests that WM changes in this disorder are due to alterations in myelin-associated biological proces…
View article: Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington’s Disease
Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington’s Disease Open
Polygenic risk scores for psychiatric disorders, particularly depression and schizophrenia, are associated with increased risk of the corresponding psychiatric symptoms in HD, suggesting a common genetic liability. However, the genetic lia…
View article: Genetic risk underlying psychiatric and cognitive symptoms in Huntington’s Disease
Genetic risk underlying psychiatric and cognitive symptoms in Huntington’s Disease Open
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expanded CAG repeat in the HTT gene. It is diagnosed following a standardized exam of motor control and often presents with cognitive decline and psychiatric…
View article: F37 Is social cognition in huntington’s disease more than just a marker for disease progression? – an exploration of social functioning in the day to day experiences of people with hd, their companions and friends
F37 Is social cognition in huntington’s disease more than just a marker for disease progression? – an exploration of social functioning in the day to day experiences of people with hd, their companions and friends Open
Background In HD, deducing what another person means through their facial emotions is thought to erode as the illness progresses. Emotional recognition data is now being collected in longitudinal studies (Henley, Novak et al. 2012). Aims S…
View article: Does arterial hypertension influence the onset of Huntington's disease?
Does arterial hypertension influence the onset of Huntington's disease? Open
Huntington's disease (HD) age of onset (AO) is mainly determined by the length of the CAG repeat expansion in the huntingtin gene. The remaining AO variability has been attributed to other little-known factors. A factor that has been assoc…
View article: Through your eyes or mine? The neural correlates of mental state recognition in <scp>H</scp>untington's disease
Through your eyes or mine? The neural correlates of mental state recognition in <span>H</span>untington's disease Open
Huntington's disease (HD) can impair social cognition. This study investigated whether patients with HD exhibit neural differences to healthy controls when they are considering mental and physical states relating to the static expressions …
View article: Transcranial direct current stimulation can enhance working memory in Huntington's disease
Transcranial direct current stimulation can enhance working memory in Huntington's disease Open
View article: Misdiagnosis of Huntington's disease – Authors' reply
Misdiagnosis of Huntington's disease – Authors' reply Open
View article: Temporo-parietal dysfunction in Tourette syndrome: Insights from an fMRI study of Theory of Mind
Temporo-parietal dysfunction in Tourette syndrome: Insights from an fMRI study of Theory of Mind Open
View article: A randomized, controlled trial of a multi-modal exercise intervention in Huntington’s disease
A randomized, controlled trial of a multi-modal exercise intervention in Huntington’s disease Open
View article: Practitioner Review: Treatments for Tourette syndrome in children and young people – a systematic review
Practitioner Review: Treatments for Tourette syndrome in children and young people – a systematic review Open
Background Tourette syndrome ( TS ) and chronic tic disorder ( CTD ) affect 1–2% of children and young people, but the most effective treatment is unclear. To establish the current evidence base, we conducted a systematic review of interve…
View article: The Prevalence of Tic Disorder in Primary School Children in an Electoral District of Mauritius
The Prevalence of Tic Disorder in Primary School Children in an Electoral District of Mauritius Open
Most tic disorder studies have been conducted in countries in the northern hemisphere.So far, there are only 3 studies that have been done in the southern hemisphere countries and they were directed at Tourette syndrome explicitly.This stu…
View article: Exploring the Structural Relationship Between Interviewer and Self-Rated Affective Symptoms in Huntington’s Disease
Exploring the Structural Relationship Between Interviewer and Self-Rated Affective Symptoms in Huntington’s Disease Open
This study explores the structural relationship between self-report and interview measures of affect in Huntington's disease. The findings suggest continued use of both to recognize the multidimensionality within a single common considerat…
View article: Clinical effectiveness and patient perspectives of different treatment strategies for tics in children and adolescents with Tourette syndrome: a systematic review and qualitative analysis
Clinical effectiveness and patient perspectives of different treatment strategies for tics in children and adolescents with Tourette syndrome: a systematic review and qualitative analysis Open
Background Tourette syndrome (TS) is a neurodevelopmental condition characterised by chronic motor and vocal tics affecting up to 1% of school-age children and young people and is associated with significant distress and psychosocial impai…
View article: Provision of neuropsychiatry services: variability and unmet need
Provision of neuropsychiatry services: variability and unmet need Open
Aims and method Neuropsychiatry services remain underdeveloped and underprovided. Previous studies have shown variability in service provision in the UK. In this survey we approached all mental health and neuropsychiatric service providers…
View article: Commissioning neuropsychiatry services: barriers and lessons
Commissioning neuropsychiatry services: barriers and lessons Open
Aims and method Previous studies have shown variations in commissioning of neuropsychiatry services and this makes access to neuropsychiatric services a postcode lottery. In this survey, we approached all mental health and neuropsychiatric…
View article: Disease stage, but not sex, predicts depression and psychological distress in Huntington's disease: A European population study
Disease stage, but not sex, predicts depression and psychological distress in Huntington's disease: A European population study Open