Hugo Alexandre Oliveira Rocha
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View article: Gallic Acid Functionalization Improves the Pharmacological Profile of Fucoidan B: A Polysaccharide with Antioxidant Properties
Gallic Acid Functionalization Improves the Pharmacological Profile of Fucoidan B: A Polysaccharide with Antioxidant Properties Open
Fucoidan B (FucB) is a sulfated polysaccharide with recognized biological activity. In this study, FucB was chemically modified through redox conjugation with gallic acid (GA) to obtain FucB-GA, aiming to enhance its antioxidant properties…
View article: Cenostigma bracteosum Hydroethanolic Extract: Chemical Profile, Antibacterial Activity, Cytotoxicity, and Gel Formulation Development
Cenostigma bracteosum Hydroethanolic Extract: Chemical Profile, Antibacterial Activity, Cytotoxicity, and Gel Formulation Development Open
Background:Cenostigma bracteosum (Tul.) Gagnon & G.P. Lewis (Fabaceae), popularly known as “catingueira”, is a plant widely distributed in the Caatinga biome, which comprises 11% of the Brazilian territory. While this species is of interes…
View article: Apoptosis and G2/M Phase Cell Cycle Arrest Induced by Alkaloid Erythraline Isolated from Erythrina velutina in SiHa Cervical Cancer Cell
Apoptosis and G2/M Phase Cell Cycle Arrest Induced by Alkaloid Erythraline Isolated from Erythrina velutina in SiHa Cervical Cancer Cell Open
Cervical cancer remains a significant global health concern, causing more than 300,000 deaths annually. Erythrina velutina, a tree native to north-eastern Brazil, contains bioactive alkaloids with potential anticancer properties. This stud…
View article: Bioavailability for the Improved Therapeutic Profile of trans-Dehydrocrotonin Incorporated into a Copaiba Oil Self-Nanoemulsifying Drug Delivery System: Formulation, Physicochemical Characterizations, and Antioxidant In Vitro Effect
Bioavailability for the Improved Therapeutic Profile of trans-Dehydrocrotonin Incorporated into a Copaiba Oil Self-Nanoemulsifying Drug Delivery System: Formulation, Physicochemical Characterizations, and Antioxidant In Vitro Effect Open
Croton cajucara Benth and Copaifera reticulata Ducke are prominent species in the traditional medicine of the Amazon region of Brazil. Copaifera species produce oil resin rich in bioactive diterpenes, and C. cajucara is a prolific producer…
View article: Effect of trypsin inhibitor isolated from tamarind seed (TTI) on caenorhabditis elegans survival under bacterial infection
Effect of trypsin inhibitor isolated from tamarind seed (TTI) on caenorhabditis elegans survival under bacterial infection Open
The study aimed to evaluate the effect of a trypsin inhibitor isolated from tamarind seeds (TTI) on Caenorhabditis elegans as an anti-infective agent. No statistical difference was found in the toxicity test to TTI for locomotion, oviposit…
View article: Evaluation of the Pharmacological Activities of a Xylan from Corn Cobs
Evaluation of the Pharmacological Activities of a Xylan from Corn Cobs Open
Xylans, polysaccharides abundantly derived from agricultural byproducts, have shown potential pharmacological properties, making them a subject of increasing research interest. This study aimed to expand the understanding of xylans’ pharma…
View article: Batis maritima Linnaeus: Wound healing in vivo, chemical characterization and antioxidant activity of leaf extracts incorporated into hydrophilic cream
Batis maritima Linnaeus: Wound healing in vivo, chemical characterization and antioxidant activity of leaf extracts incorporated into hydrophilic cream Open
View article: Evaluation of the Antioxidant and Osteoinductive Potential of the Leaf Extract from Dysphania ambrosioides L.
Evaluation of the Antioxidant and Osteoinductive Potential of the Leaf Extract from Dysphania ambrosioides L. Open
Objective: To analyze the antioxidant activity of an alcoholic extract from the leaves of Dysphania ambrosioides L. and investigate its influence on in vitro differentiation of MC3T3-E1 pre-osteoblastic cells. Material and Methods: The con…
View article: Exploring the Pharmacological Potential of Carrageenan Disaccharides as Antitumor Agents: An In Silico Approach
Exploring the Pharmacological Potential of Carrageenan Disaccharides as Antitumor Agents: An In Silico Approach Open
Carrageenans have demonstrated enhanced antitumor activity upon depolymerization into disaccharides. However, the pharmacological viability of these disaccharides and their mechanisms of antitumor action remains to be fully elucidated. Thi…
View article: Protective Effects of Annona Atemoya Extracts on Inflammation, Oxidative Stress, and Renal Function in Cadmium-Induced Nephrotoxicity in Wistar Rats
Protective Effects of Annona Atemoya Extracts on Inflammation, Oxidative Stress, and Renal Function in Cadmium-Induced Nephrotoxicity in Wistar Rats Open
Background: Cadmium (Cd), a highly toxic heavy metal from agricultural activities, and its exposure can lead to impaired renal function by increasing reactive oxygen species. The atemoya fruit is known for its high phenolic and antioxidant…
View article: Algal polysaccharides: new perspectives for the treatment of basal ganglia neurodegenerative diseases
Algal polysaccharides: new perspectives for the treatment of basal ganglia neurodegenerative diseases Open
The objective of this review was to verify the therapeutic effect of polysaccharides derived from algae in neurodegenerative disease models involving the basal ganglia. To achieve this goal, a literature search was conducted in PubMed, Sci…
View article: Novel Synthesis of Zinc Oxide on Cotton Fabric by Cathodic Cage Plasma Deposition for Photocatalytic and Antibacterial Performance
Novel Synthesis of Zinc Oxide on Cotton Fabric by Cathodic Cage Plasma Deposition for Photocatalytic and Antibacterial Performance Open
Cotton fabrics with zinc oxide (ZnO) coating are of significant interest due to their excellent antibacterial performance. Thus, they are widely in demand in the textile industry due to their medical and hygienic properties. However, conve…
View article: Optimizing Antioxidant Potential: Factorial Design-Based Formulation of Fucoidan and Gallic Acid-Conjugated Dextran Blends
Optimizing Antioxidant Potential: Factorial Design-Based Formulation of Fucoidan and Gallic Acid-Conjugated Dextran Blends Open
The role of oxidative stress in health and homeostasis has generated interest in the scientific community due to its association with cardiovascular and neurodegenerative diseases, cancer, and other diseases. Therefore, extensive research …
View article: Prospecting of the Antioxidant Activity from Extracts Obtained from Chañar (Geoffroea decorticans) Seeds Evaluated In Vitro and In Vivo Using the Tenebrio molitor Model
Prospecting of the Antioxidant Activity from Extracts Obtained from Chañar (Geoffroea decorticans) Seeds Evaluated In Vitro and In Vivo Using the Tenebrio molitor Model Open
Geoffroea decorticans, commonly known as Chañar, is a native Chilean plant widely used in folk medicine for its expectorant, pain relief, and antinociceptive properties. This study explored the antioxidant, cytotoxic, and protective effect…
View article: Mechanism of action and synergistic effect of Eugenia uniflora extract in Candida spp.
Mechanism of action and synergistic effect of Eugenia uniflora extract in Candida spp. Open
The limited arsenal of antifungal drugs have prompted the search for novel molecules with biological activity. This study aimed to characterize the antifungal mechanism of action of Eugenia uniflora extract and its synergistic activity wit…
View article: Unlocking the power of Libidibia ferrea extracts: antimicrobial, antioxidant, and protective properties for potential use in poultry production
Unlocking the power of Libidibia ferrea extracts: antimicrobial, antioxidant, and protective properties for potential use in poultry production Open
Plant extracts are increasingly recognized as potential prophylactic agents in poultry production due to their diverse bioactive properties. This study investigated the phytochemical and biological properties of Libidibia ferrea (L. ferrea…
View article: Toward Enhanced Antioxidant and Protective Potential: Conjugation of Corn Cob Xylan with Gallic Acid as a Novel Approach
Toward Enhanced Antioxidant and Protective Potential: Conjugation of Corn Cob Xylan with Gallic Acid as a Novel Approach Open
Maize ranks as the second most widely produced crop globally, yielding approximately 1.2 billion tons, with corn cob being its primary byproduct, constituting 18 kg per 100 kg of corn. Agricultural corn production generates bioactive polys…
View article: Protein fraction from Sesbania virgata (Cav.) Pers. seeds exhibit antioxidant and antifungal activities
Protein fraction from Sesbania virgata (Cav.) Pers. seeds exhibit antioxidant and antifungal activities Open
Sesbania virgata (Cav.) Pers. seeds are protein sources with health and environmental benefits. In this research, proteins with lectin activity were identified in a protein fraction from S. virgata seeds (PFLA), as well its antioxidant and…
View article: <i>Lippia origanoides</i> essential oil increases longevity and ameliorates β-amyloid peptide-induced toxicity in <i>Caenorhabditis elegans</i>
<i>Lippia origanoides</i> essential oil increases longevity and ameliorates β-amyloid peptide-induced toxicity in <i>Caenorhabditis elegans</i> Open
Lippia origanoides essential oil (LOEO) is extensively utilised as food preservative due to its antioxidant and antibacterial activities. In this study, the antioxidant and anti-ageing effects of LOEO was investigated in vivo…
View article: The Antioxidant and Immunomodulatory Potential of Coccoloba alnifolia Leaf Extracts
The Antioxidant and Immunomodulatory Potential of Coccoloba alnifolia Leaf Extracts Open
Oxidative stress has been associated with different diseases, and different medicinal plants have been used to treat or prevent this condition. The leaf ethanolic extract (EE) and aqueous extract (AE) from Coccoloba alnifolia have previous…
View article: Anti-Inflammatory Activity of Fucan from Spatoglossum schröederi in a Murine Model of Generalized Inflammation Induced by Zymosan
Anti-Inflammatory Activity of Fucan from Spatoglossum schröederi in a Murine Model of Generalized Inflammation Induced by Zymosan Open
Fucans from marine algae have been the object of many studies that demonstrated a broad spectrum of biological activities, including anti-inflammatory effects. The aim of this study was to verify the protective effects of a fucan extracted…
View article: THERMORESPONSIVE CELLULOSE NANOCRYSTALS PROTECTING MACROPHAGE CELLS FROM OXIDATIVE STRESS
THERMORESPONSIVE CELLULOSE NANOCRYSTALS PROTECTING MACROPHAGE CELLS FROM OXIDATIVE STRESS Open
Cellulose nanocrystals (CNCs) were grafted with poly(N-isopropylacrylamide) (PNIPAM) chains, by means of the grafting from route, using the TEMED/KPS redox pair as free-radical initiators. The confirmation of grafting was revealed by 13C N…
View article: Exploring the Antioxidant Potential of Talisia esculenta Using In Vitro and In Vivo Approaches
Exploring the Antioxidant Potential of Talisia esculenta Using In Vitro and In Vivo Approaches Open
Medicinal plants, such as Talisia esculenta, are rich in antioxidant biomolecules, which are used in the treatment and prevention of many diseases. The antioxidant potential of T. esculenta extracts obtained from leaves and fruit peels was…
View article: Unlocking the Antioxidant and Antimicrobial Potential of Flavone and Amide-rich Fractions from Conchocarpus macrocarpus (Rutaceae) Leaves
Unlocking the Antioxidant and Antimicrobial Potential of Flavone and Amide-rich Fractions from Conchocarpus macrocarpus (Rutaceae) Leaves Open
Conchocarpus macrocarpus (Rutaceae) is an endemic species in Brazil, whose chemical and biological properties are poorly understood. This study aimed to evaluate the antioxidant and antimicrobial potential of the butanolic partition phase …
View article: A Blend Consisting of Agaran from Seaweed Gracilaria birdiae and Chromium Picolinate Is a Better Antioxidant Agent than These Two Compounds Alone
A Blend Consisting of Agaran from Seaweed Gracilaria birdiae and Chromium Picolinate Is a Better Antioxidant Agent than These Two Compounds Alone Open
A blend refers to the combination of two or more components to achieve properties that are superior to those found in the individual products used for their production. Gracilaria birdiae agaran (SPGb) and chromium picolinate (ChrPic) are …
View article: Chondroitin Sulfate from Oreochromis niloticus Waste Reduces Leukocyte Influx in an Acute Peritonitis Model
Chondroitin Sulfate from Oreochromis niloticus Waste Reduces Leukocyte Influx in an Acute Peritonitis Model Open
Oreochromis niloticus (tilapia) is one of the most cultivated fish species worldwide. Tilapia farming generates organic waste from fish removal processes in nurseries. Visceral waste can damage natural ecosystems. Therefore, the use of thi…
View article: Tephrosia toxicaria (Sw.) Pers. extracts: Screening by examining aedicidal action under laboratory and field conditions along with its antioxidant, antileishmanial, and antimicrobial activities
Tephrosia toxicaria (Sw.) Pers. extracts: Screening by examining aedicidal action under laboratory and field conditions along with its antioxidant, antileishmanial, and antimicrobial activities Open
An increase in the incidence of arboviral, microbial and parasitic infections, and to disorders related to oxidative stress has encouraged the development of adjuvant therapies based on natural formulations, such as those involving plant e…
View article: Copaiba Oil-Loaded Polymeric Nanocapsules: Production and In Vitro Biosafety Evaluation on Lung Cells as a Pre-Formulation Step to Produce Phytotherapeutic Medicine
Copaiba Oil-Loaded Polymeric Nanocapsules: Production and In Vitro Biosafety Evaluation on Lung Cells as a Pre-Formulation Step to Produce Phytotherapeutic Medicine Open
Copaiba oil has been largely used due to its therapeutic properties. Nanocapsules were revealed to be a great nanosystem to carry natural oils due to their ability to improve the bioaccessibility and the bioavailability of lipophilic compo…
View article: Comparative analysis of the biocompatibility of endothelial cells on surfaces treated by thermal plasma and cold atmospheric plasma
Comparative analysis of the biocompatibility of endothelial cells on surfaces treated by thermal plasma and cold atmospheric plasma Open
In recent years, cold atmospheric plasma (CAP) is used for surface disinfection. However, little is known about its ability to improve biocompatibility of metallic surfaces when compared to thermal plasma methods. In this context, the stud…
View article: Isolation of Indole Alkaloids and a New Norneolignan of Hydroethanol Extract from the Trunk Barks of Aspidosperma Nitidum Benth: Preclinical Evaluation of Safety and Anti-Inflammatory and Healing Properties
Isolation of Indole Alkaloids and a New Norneolignan of Hydroethanol Extract from the Trunk Barks of Aspidosperma Nitidum Benth: Preclinical Evaluation of Safety and Anti-Inflammatory and Healing Properties Open