Hugo M. Santos
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View article: Targeted identification of cyanide and fluoride ions utilizing dansyl-derived fluorescent probes: a deprotonation-driven sensing mechanism
Targeted identification of cyanide and fluoride ions utilizing dansyl-derived fluorescent probes: a deprotonation-driven sensing mechanism Open
Funding Information: This work was financed by national funds from FCT - Fundação para a Ciência e a Tecnologia, I.P., under the scope of the project UID/50006/2023 of the Associate Laboratory for Green Chemistry - LAQV REQUIMTE, as well a…
View article: A dual-responsive Dansyl–Naphthalimide system for Hg(II) CHEF detection and ligand-mediated Cu(II) reduction with catalytic relevance
A dual-responsive Dansyl–Naphthalimide system for Hg(II) CHEF detection and ligand-mediated Cu(II) reduction with catalytic relevance Open
PM003/2016. This work is also developed and acknowledged by A.K. as part of contract №: BG-RRP-2.004-0002-C01, Laboratory of Organic Functional Materials (Project BiOrgaMCT), Procedure BG-RRP-2.004 „Establishing of a network of research hi…
View article: How microsampling is impacting pharmacokinetic and toxicokinetic studies: volumetric absorptive microsampling (VAMS)
How microsampling is impacting pharmacokinetic and toxicokinetic studies: volumetric absorptive microsampling (VAMS) Open
Microsampling, using minute amounts of biological specimen, is uniquely suited for carrying out human and animal pharmacokinetic and toxicokinetic studies. Indeed, it provides important advantages over common blood-drawing procedures (e.g.…
View article: Novel tissue markers in renal neoplasms using molar-scale quantitative proteomics via the total protein approach normalised with protein deglycase DJ-1 (PARK7)
Novel tissue markers in renal neoplasms using molar-scale quantitative proteomics via the total protein approach normalised with protein deglycase DJ-1 (PARK7) Open
Mass spectrometry-based proteomics enables large-scale protein quantification but is hindered by inter- and intra-laboratory variability, complicating data integration and biomarker discovery. This study aims to develop an optimised normal…
View article: Exploring Plant Agro‐Industrial By‐Products as a Source of Fibrous Food Ingredients: A Review of Extraction Methods and Technological Properties
Exploring Plant Agro‐Industrial By‐Products as a Source of Fibrous Food Ingredients: A Review of Extraction Methods and Technological Properties Open
The agro‐industrial sector generates a large amount of by‐products, and researchers have been seeking new ways to use them, especially those of plant origin. The concept of biorefinery and circular bioeconomy aims to enhance and maximize t…
View article: Dyadic vs. triadic taxonomy of body representation: A scoping review of brain mapping studies
Dyadic vs. triadic taxonomy of body representation: A scoping review of brain mapping studies Open
Introduction: Body representation refers to how the brain processes information about the body, traditionally categorised by the dyadic taxonomy into body schema and body image. However, the triadic taxonomy proposes the inclusion of the b…
View article: Differential Urinary Proteomics and Absolute Protein Quantification Reveal Biomarkers of Muscle-Invasive and Non-Muscle-Invasive Bladder Cancer
Differential Urinary Proteomics and Absolute Protein Quantification Reveal Biomarkers of Muscle-Invasive and Non-Muscle-Invasive Bladder Cancer Open
A comparative urinary proteomic analysis using the Total Protein Approach (TPA) revealed distinct protein abundance profiles between patients with muscle-invasive (MIBC) and non-muscle-invasive bladder cancer (NMIBC), suggesting potential …
View article: Design and evaluation of dansyl-derived chemosensors for disulfide-cleavage-triggered detection: photophysical, metal sensing, and thermometric applications
Design and evaluation of dansyl-derived chemosensors for disulfide-cleavage-triggered detection: photophysical, metal sensing, and thermometric applications Open
In this work, two new dansyl-derived chemosensors have been designed with the aim of developing a disulfide-cleavage-triggered probe.
View article: Tailor-made strategies through different weight simulation of factor-based investing
Tailor-made strategies through different weight simulation of factor-based investing Open
This study explores the implementation and factor integration of diverse factor-based investment strategies in the European market. Specifically, we investigate a contrarian strategy, two value strategies, and a momentum strategy from 2015…
View article: AI-driven Classification of Heart Failure Preserved and Reduced Ejection Fraction Patients Using the Total Protein Approach
AI-driven Classification of Heart Failure Preserved and Reduced Ejection Fraction Patients Using the Total Protein Approach Open
Heart failure (HF) presents two major subtypes: HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF), each one with distinct metabolic characteristics. This study utilized artificial intelligence, high-…
View article: Design and Evaluation of Dansyl-Derived Chemosensors for Disulfide-Cleavage-Triggered Detection: Photophysical, Metal Sensing, and Thermometric Applications
Design and Evaluation of Dansyl-Derived Chemosensors for Disulfide-Cleavage-Triggered Detection: Photophysical, Metal Sensing, and Thermometric Applications Open
In this work, two new dansyl-derived chemosensors have been designed with the aim of developing a disulfide-cleavage-triggered probe. These stable new ligands, containing a thioether (L1) and a disulfide bridge (L2), have been synthesized …
View article: Fluorescent polymers for environmental monitoring: Targeting pathogens and metal contaminants with naphthalimide derivatives
Fluorescent polymers for environmental monitoring: Targeting pathogens and metal contaminants with naphthalimide derivatives Open
Monitoring Hg2+ levels in aqueous environments is crucial to assess the potential methylmercury contamination via bacterial conversion, however, existing methods often require extensive sample treatment and expensive equipment. To mitigate…
View article: Dithiothreitol-based protein equalisation in the context of multiple myeloma: Enhancing proteomic analysis and therapeutic insights
Dithiothreitol-based protein equalisation in the context of multiple myeloma: Enhancing proteomic analysis and therapeutic insights Open
In this study, we employed the dithiothreitol-based protein equalisation technique and analytical proteomics to better understand myeloma diseases by comparing the proteomes of pellets and supernatants formed upon application of DTT on ser…
View article: Antimicrobial profile and Turn-On sensing of cyanide and water traces using a dual chromophoric Dansyl-Acridine conjugate as multifunctional system
Antimicrobial profile and Turn-On sensing of cyanide and water traces using a dual chromophoric Dansyl-Acridine conjugate as multifunctional system Open
9-aminocridine derivatives bearing a dimethylmethanimidamide, L1, and the dyad conjugate dansyl-acridine, L2, were synthesized and their ability to be used as multifunctional materials using different polymer matrixes was investigated. L1 …
View article: Precision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensor
Precision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensor Open
A new chemosensor based on Seleno-BODIPY (4) was designed and synthesized for the rapid and sensitive detection of CN–, F−, and OH– ions in THF, exhibiting ultra-low detection limits of 26.26 nM, 43.05 nM, and 8.64 nM, respectively, throug…
View article: Fluorescent Polymers for Environmental Monitoring: Targeting Pathogens and Metal Contaminants with Naphthalimide Derivatives
Fluorescent Polymers for Environmental Monitoring: Targeting Pathogens and Metal Contaminants with Naphthalimide Derivatives Open
The continuous monitoring of Hg2+ levels in aqueous environments is crucial to assess a potential indication of methylmercury contamination via bacterial conversion, yet existing methods often require extensive sample treatment, expensive …
View article: Comparative studies on enhancing pea protein extraction recovery rates and structural integrity using ultrasonic and hydrodynamic cavitation technologies
Comparative studies on enhancing pea protein extraction recovery rates and structural integrity using ultrasonic and hydrodynamic cavitation technologies Open
This study explored the efficacy of various cavitation technologies, including ultrasonic bath (USB), ultrasonic plate (US-plate), ultrasonic probe (US-probe), and hydrodynamic cavitation (HDC), in extracting proteins from peas. US-probe s…
View article: Exploring the Hypocholesterolemic Potential of a Fucus vesiculosus Extract: Omic Insights into Molecular Mechanisms at the Intestinal Level
Exploring the Hypocholesterolemic Potential of a Fucus vesiculosus Extract: Omic Insights into Molecular Mechanisms at the Intestinal Level Open
High blood cholesterol levels are a major risk factor for cardiovascular diseases. A purified aqueous extract of Fucus vesiculosus, rich in phlorotannins and peptides, has been described for its potential to inhibit cholesterol biosynthesi…
View article: DTT protein equalization and Tryptophan protein quantification as a powerful tool in analytical proteomics.
DTT protein equalization and Tryptophan protein quantification as a powerful tool in analytical proteomics. Open
Assessing total protein levels in biological samples is a common procedure in biochemistry and molecular biology. In this study, we compare tryptophan fluorescence (WF) with Bradford and BCA assays to determine total protein in serum sampl…