Hugo J. Albers
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View article: Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19
Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19 Open
COVID-19 plasma induces endothelial activation and thromboinflammation in a Vessel-on-Chip model, highlighting the causative role of systemic factors and offering a platform for studying severe COVID-19 pathophysiology and therapeutic inte…
View article: Embedded macrophages induce intravascular coagulation in 3D blood vessel-on-chip
Embedded macrophages induce intravascular coagulation in 3D blood vessel-on-chip Open
Macrophages are innate immune cells that prevent infections and help in wound healing and vascular inflammation. While these cells are natural helper cells, they also contribute to chronic diseases, e.g., by infiltrating the endothelial la…
View article: Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions
Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions Open
Objective: platelets possess not only haemostatic but also inflammatory properties, which combined are thought to play a detrimental role in thromboinflammatory diseases such as acute coronary syndromes and stroke. Phosphodiesterase (PDE) …
View article: Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation <i>in vitro</i>
Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation <i>in vitro</i> Open
Intraluminal thrombus formation precipitates conditions such as acute myocardial infarction and disturbs local blood flow resulting in areas of rapidly changing blood flow velocities and steep gradients of blood shear rate. Shear rate grad…
View article: In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time Open
The formation of blood clots involves complex interactions between endothelial cells, their underlying matrix, various blood cells, and proteins. The endothelium is the primary source of many of the major hemostatic molecules that control …
View article: In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time Open
The formation of blood clots involves complex interactions between endothelial cells, their underlying matrix, various blood cells, and proteins. The endothelium is the primary source of many of the major hemostatic molecules that control …
View article: Automated Analysis of Platelet Aggregation on Cultured Endothelium in a Microfluidic Chip Perfused with Human Whole Blood
Automated Analysis of Platelet Aggregation on Cultured Endothelium in a Microfluidic Chip Perfused with Human Whole Blood Open
Organ-on-a-chip models with incorporated vasculature are becoming more popular to study platelet biology. A large variety of image analysis techniques are currently used to determine platelet coverage, ranging from manually setting thresho…
View article: Human induced pluripotent stem cell-derived endothelial cells in thrombosis-on-a-chip devices
Human induced pluripotent stem cell-derived endothelial cells in thrombosis-on-a-chip devices Open
A microfluidic thrombosis-on-a-chip platform was developed to compare the pro-thrombotic response of healthy and inflamed monolayers of human umbilical vein endothelial cells (HUVECs) and human induced pluripotent stem cell-derived endothe…
View article: Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology
Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology Open
The vascular system is one of the first to develop during embryogenesis and is essential for all organs and tissues in our body to develop and function. It has many essential roles including controlling the absorption, distribution and exc…
View article: A gut-on-a-chip study: Enabling on-demand manipulation of the outer cell microenvironment in a multicompartmental 3D culture array
A gut-on-a-chip study: Enabling on-demand manipulation of the outer cell microenvironment in a multicompartmental 3D culture array Open
This paper reports a novel approach to build large arrays of cell-laden hydrogel microcompartments with well-controlled fluid flow to mimic the gut environment. Human intestinal epithelial cells (Caco-2) that were cultured in ~500 disconti…
View article: Compartmentalized 3D Tissue Culture Arrays under Controlled Microfluidic Delivery
Compartmentalized 3D Tissue Culture Arrays under Controlled Microfluidic Delivery Open
View article: Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data
Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data Open
Studying blood clotting in stereolithography 3D-printed microfluidic chips with endothelialised vascular structures.