Jiahui Chen
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View article: Preclinical development of [18F]TAAR1-2203 as a PET radioligand for imaging TAAR1 expression and receptor occupancy
Preclinical development of [18F]TAAR1-2203 as a PET radioligand for imaging TAAR1 expression and receptor occupancy Open
Purpose Trace amine-associated receptor 1 (TAAR1) is an emerging therapeutic target with various implications in neuropsychiatric and metabolic disorders. However, the absence of a suitable positron emission tomography (PET) radioligand ha…
View article: Development of Novel <sup>18</sup> F-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission Tomography
Development of Novel <sup>18</sup> F-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission Tomography Open
View article: MTIL: Encoding Full History With Mamba for Temporal Imitation Learning
MTIL: Encoding Full History With Mamba for Temporal Imitation Learning Open
Standard imitation learning (IL) methods have achieved considerable success in robotics, yet often rely on the Markov assumption, limiting their applicability to tasks where historical context is crucial for disambiguating current observat…
View article: Immune checkpoint inhibitors combined with chemotherapy in conversion therapy for stage IV gastric cancer: a multicenter retrospective cohort study
Immune checkpoint inhibitors combined with chemotherapy in conversion therapy for stage IV gastric cancer: a multicenter retrospective cohort study Open
The combination of PD-1 inhibitors with chemotherapy in conversion therapy is feasible for patients with stage IV gastric cancer. Individuals who exhibit improved responses to chemoimmunotherapy potentially experience survival benefits, pa…
View article: Radiosynthesis and Preclinical Evaluation of a Carbon-11 Labeled Phosphodiesterase 7 Inhibitor for PET Neuroimaging
Radiosynthesis and Preclinical Evaluation of a Carbon-11 Labeled Phosphodiesterase 7 Inhibitor for PET Neuroimaging Open
Dysfunction of cyclic nucleotide phosphodiesterase 7 (PDE7) has been associated with excess intracellular cAMP concentrations, fueling pathogenic processes that are implicated in neurodegenerative disorders. This study aimed to develop a s…
View article: Development and Preclinical Characterization of [<sup>18</sup>F]H3-2406 and [<sup>18</sup>F]H3-2407 for Positron Emission Tomography Imaging of the Histamine Subtype-3 Receptor
Development and Preclinical Characterization of [<sup>18</sup>F]H3-2406 and [<sup>18</sup>F]H3-2407 for Positron Emission Tomography Imaging of the Histamine Subtype-3 Receptor Open
The histamine subtype 3 receptor (H3R) is a G protein-coupled receptor involved in various central nervous system (CNS) disorders. We herein describe the identification and preclinical evaluation of two H3R antagonist…
View article: Dimerization and substrate recognition of human taurine transporter
Dimerization and substrate recognition of human taurine transporter Open
Taurine is a conditionally essential nutrient and one of the most abundant amino acids in humans, with diverse physiological functions. The cellular uptake of taurine is primarily mediated by the taurine transporter (TauT), and its dysfunc…
View article: Orexin-A and motion sickness: a systematic review of animal model studies
Orexin-A and motion sickness: a systematic review of animal model studies Open
Background Sensory input mismatches among the vestibular system, autonomic control, and visual perception cause motion sickness. Anticholinergics and antihistamines are commonly used but have limited efficacy and cause significant side eff…
View article: Fine structural design of 3βHSD1 inhibitors for prostate cancer therapy
Fine structural design of 3βHSD1 inhibitors for prostate cancer therapy Open
Prostate cancer is a global health challenge, particularly for patients resistant to the second-generation anti-androgen receptor pathway inhibitors. The steroidogenic enzyme 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) has emerged as a…
View article: Radiosynthesis and Evaluation of <sup>11</sup>C-Labeled Imidazolyl Pyrimidine Derivatives for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3
Radiosynthesis and Evaluation of <sup>11</sup>C-Labeled Imidazolyl Pyrimidine Derivatives for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3 Open
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that regulates various biological processes by phosphorylating protein substrates. Dysregulation of GSK-3 is linked to a variety of diseases, including malignancies, diabetes,…
View article: Regulating Photocarrier Dynamics via Constructing 1D CdS/2D Semi‐Metallic MoReS₃ Schottky Junction Boosts Solar‐Driven CO₂ Conversion
Regulating Photocarrier Dynamics via Constructing 1D CdS/2D Semi‐Metallic MoReS₃ Schottky Junction Boosts Solar‐Driven CO₂ Conversion Open
Heterostructure strategy is promising to overcome the dynamic bottleneck for fast photocarrier recombination competing with sluggish surface redox in photocatalytic CO 2 conversion but remains limitations for sacrificing stronger redox abi…
View article: Development of a novel 18F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography
Development of a novel 18F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography Open
View article: Imaging poly(ADP-ribose) polymerase-1 (PARP1) in vivo with 18F-labeled brain penetrant positron emission tomography (PET) ligand
Imaging poly(ADP-ribose) polymerase-1 (PARP1) in vivo with 18F-labeled brain penetrant positron emission tomography (PET) ligand Open
Poly(ADP-ribose) polymerase 1 (PARP1) is a multifunctional protein involved in diverse cellular functions, notably DNA damage repair. Pharmacological inhibition of PARP1 has therapeutic benefits for various pathologies. Despite the increas…
View article: Signs of Alzheimer’s Disease: Tied to Aging
Signs of Alzheimer’s Disease: Tied to Aging Open
: Alzheimer’s disease (AD) is a neurodegenerative disorder closely associated with aging, and its pathogenesis involves the interaction of multidimensional pathophysiologic processes. This review outlines the core mechanisms linking aging …
View article: Transport and inhibition mechanisms of human creatine transporter
Transport and inhibition mechanisms of human creatine transporter Open
View article: Brain-derived extracellular vesicles: A promising avenue for Parkinson’s disease pathogenesis, diagnosis, and treatment
Brain-derived extracellular vesicles: A promising avenue for Parkinson’s disease pathogenesis, diagnosis, and treatment Open
The misfolding, aggregation, and deposition of alpha-synuclein into Lewy bodies are pivotal events that trigger pathological changes in Parkinson’s disease. Extracellular vesicles are nanosized lipidbilayer vesicles secreted by cells that …
View article: GPX4 knockdown suppresses M2 macrophage polarization in gastric cancer by modulating kynurenine metabolism
GPX4 knockdown suppresses M2 macrophage polarization in gastric cancer by modulating kynurenine metabolism Open
Background: Glutathione peroxidase 4 (GPX4), an important factor regulating redox homeostasis, plays an important role in tumor microenvironment and progression. However, the role of GPX4 in gastric cancer (GC) is unclear. Method…
View article: Highly dynamic and sensitive NEMOer calcium indicators for imaging ER calcium signals in excitable cells
Highly dynamic and sensitive NEMOer calcium indicators for imaging ER calcium signals in excitable cells Open
View article: Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation
Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation Open
SUMMARY While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occurs with both randomly integrate…
View article: Programmable Piezoelectricity of 2D Hexagonal Boron Nitride via Defect Engineering
Programmable Piezoelectricity of 2D Hexagonal Boron Nitride via Defect Engineering Open
Piezoelectricity in 2D hexagonal boron nitride (hBN) plays a crucial role in its applications in various advanced functional devices. Therefore, appropriately adjusting intrinsic piezoelectric properties of 2D hBN becomes desirable for dif…
View article: Development of a Novel <sup>18</sup>F-Labeled Radioligand for Imaging Cholesterol 24-Hydroxylase with Positron Emission Tomography
Development of a Novel <sup>18</sup>F-Labeled Radioligand for Imaging Cholesterol 24-Hydroxylase with Positron Emission Tomography Open
Cholesterol 24-hydroxylase (CYP46A1), also known as CH24H, is a brain-specific monooxygenase responsible for the elimination of cholesterol from the central nervous system (CNS). It catalyzes the conversion of cholesterol to 24(S)-h…
View article: Development of a Novel <sup>18</sup>F-Labeled Radioligand for Imaging Phosphodiesterase 7 with Positron Emission Tomography
Development of a Novel <sup>18</sup>F-Labeled Radioligand for Imaging Phosphodiesterase 7 with Positron Emission Tomography Open
Phosphodiesterases (PDEs) are phosphohydrolytic enzymes responsible for degrading cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), two key second messengers involved in regulating cellular functions. The PDE…
View article: Serum amino acid alterations in hyperuricemia: potential targets for renal disease prevention
Serum amino acid alterations in hyperuricemia: potential targets for renal disease prevention Open
View article: Drug Resistance Predictions Based on a Directed Flag Transformer.
Drug Resistance Predictions Based on a Directed Flag Transformer. Open
The continuous evolution of the SARS-CoV-2 virus poses a significant challenge to global public health. Of particular concern is the potential resistance to the widely prescribed drug PAXLOVID, of which the main ingredient nirmatrelvir inh…
View article: Preclinical Evaluation of [<sup>18</sup>F]P4B-2412 as Phosphodiesterase 4B Radioligand for Positron Emission Tomography Imaging
Preclinical Evaluation of [<sup>18</sup>F]P4B-2412 as Phosphodiesterase 4B Radioligand for Positron Emission Tomography Imaging Open
Phosphodiesterase 4B (PDE4B) plays a critical role in cAMP hydrolysis and is highly expressed in brain regions associated with neuroinflammation and central nervous system (CNS) disorders. Selective PDE4B radioligands hold significant pote…
View article: Serum Amino Acid Alterations in Hyperuricemia: Potential Targets for Renal Disease Prevention
Serum Amino Acid Alterations in Hyperuricemia: Potential Targets for Renal Disease Prevention Open
Background Observational studies have linked uric acid (UA) levels and kidney disease to amino acid homeostasis, but the causal relationship is unclear. This study aims to determine if elevated UA affects amino acid levels and whether amin…
View article: The effect of the Hippocampus erectus decoction on improving osteoporosis in zebrafish
The effect of the Hippocampus erectus decoction on improving osteoporosis in zebrafish Open
The seahorse is a traditional Chinese herbal medicine that has been utilized for the treatment of conditions such as osteoporosis, nonunion fractures, knee osteoarthritis, and herniated lumbar disks.Zebrafish is an excellent animal model t…
View article: PD-1 agonist: A novel therapeutic approach to resolve atherosclerosis
PD-1 agonist: A novel therapeutic approach to resolve atherosclerosis Open
Atherosclerosis, which is the primary cause of several leading fatal diseases worldwide, has long been a challenge, and thus the need for effective treatments is urgent. The discovery of the immune checkpoint proteins programmed cell death…
View article: Development of a Candidate <sup>11</sup>C-Labeled Selective Phosphodiesterase 1 Radioligand for Positron Emission Tomography
Development of a Candidate <sup>11</sup>C-Labeled Selective Phosphodiesterase 1 Radioligand for Positron Emission Tomography Open
Phosphodiesterases (PDEs) constitute a superfamily of phosphohydrolytic enzymes that regulate intracellular second messenger signaling by hydrolyzing cyclic adenosine monophosphate and cyclic guanosine monophosphate. Among the 11 subfamili…
View article: Human Memory‐Inspired MoS<sub>2</sub>/BST Ferroelectric Phototransistor with Synchronous Sensory, Short‐Term and Long‐Term Memories
Human Memory‐Inspired MoS<sub>2</sub>/BST Ferroelectric Phototransistor with Synchronous Sensory, Short‐Term and Long‐Term Memories Open
The collaborative working mode of different memory patterns–sensory, short‐term, and long‐term memories–in the human brain is significantly efficient and economical. This work reproduces the three memory patterns synchronously with the ret…