Hui Deng
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View article: Author Correction: Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants
Author Correction: Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants Open
View article: High-throughput Treg cell receptor sequencing reveals the relationship between disease activity and immunosenescence in patients with rheumatoid arthritis
High-throughput Treg cell receptor sequencing reveals the relationship between disease activity and immunosenescence in patients with rheumatoid arthritis Open
Treg cells play an important role in the induction of autoimmune tolerance, and their ability of antigen recognition and regulation is determined by the receptor (TCR). TCR diversity determines the autoimmune responses in RA and is closely…
View article: M2 Macrophage‐Derived Migrasomes Mediate Ischaemia‐Induced Retinal Neovascularization by Targeting TREM2
M2 Macrophage‐Derived Migrasomes Mediate Ischaemia‐Induced Retinal Neovascularization by Targeting TREM2 Open
Retinal neovascular diseases are leading causes of global blindness. Migrasomes, organelles released during cell migration, play a role in intercellular communication and are present in M2 macrophages, which are critical to the pathology o…
View article: Continuing immune checkpoint inhibitors after pseudoprogression improves survival in lung cancer patients: a systematic review and meta-analysis
Continuing immune checkpoint inhibitors after pseudoprogression improves survival in lung cancer patients: a systematic review and meta-analysis Open
Continuing ICIs post-PsP improves outcomes in lung cancer patients. iRECIST facilitates the accurate diagnosis of PsP, while chest CT pattern diagrams and a diagnostic-therapeutic framework contribute to optimizing the management of immuno…
View article: Gamma-Calibrated 33 MHz Ultrasound Imaging Strategy Unlocks High-Resolution Identification of Dermatology-Invisible High-Risk Acne: From Inclusive Superficial Ultrasound Imaging to Graded Risk Assessment
Gamma-Calibrated 33 MHz Ultrasound Imaging Strategy Unlocks High-Resolution Identification of Dermatology-Invisible High-Risk Acne: From Inclusive Superficial Ultrasound Imaging to Graded Risk Assessment Open
The Gamma-calibrated 33 MHz ultrasound imaging strategy was an accurate mode in risk stratification for various pseudopodia patterns. Macro-pseudopodia were associated with poor prognosis, underscoring their indispensable role in the strat…
View article: White blood cells, monocytes and thrombin time in predicting symptomatic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage
White blood cells, monocytes and thrombin time in predicting symptomatic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage Open
Objective To investigate the value of admission blood routine and coagulation function parameters in predicting acute symptomatic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods This retrospective study in…
View article: Case Report: Guselkumab treatment for sintilimab-exacerbated psoriasis in a cancer patient
Case Report: Guselkumab treatment for sintilimab-exacerbated psoriasis in a cancer patient Open
Psoriasis is a chronic inflammatory skin disease associated with multisystem comorbidities and impaired mental health. The lesions are typically characterized by sharply demarcated, erythematous plaques covered with silvery scales. Treatme…
View article: Deubiquitinase USP18 mediates cell migration, apoptosis and ferroptosis in lung adenocarcinoma by depending on POU4F1/PRKAA2 axis
Deubiquitinase USP18 mediates cell migration, apoptosis and ferroptosis in lung adenocarcinoma by depending on POU4F1/PRKAA2 axis Open
View article: Combined inhibition of S100A4 and TIGIT suppresses late-stage breast cancer metastasis
Combined inhibition of S100A4 and TIGIT suppresses late-stage breast cancer metastasis Open
View article: Comprehensive Analysis of Effectiveness and Cost‐Effectiveness of Treatments for Psoriasis Integrating Clinician‐ and Patient‐Reported Outcomes: A Cohort Study From SPEECH
Comprehensive Analysis of Effectiveness and Cost‐Effectiveness of Treatments for Psoriasis Integrating Clinician‐ and Patient‐Reported Outcomes: A Cohort Study From SPEECH Open
Effective and cost‐effective management strategies for psoriasis are crucial for clinical decision‐making. In the management of psoriasis, evidence concerning the effectiveness and cost‐effectiveness of therapies from both clinicians’ and …
View article: Neutrophil extracellular traps promote tumor chemoresistance to anthracyclines
Neutrophil extracellular traps promote tumor chemoresistance to anthracyclines Open
The microenvironment plays an important role in promoting tumor cell chemoresistance, but the mechanisms responsible for this effect are not clear. Here, using models of multiple myeloma (MM) and solid cancers, we demonstrate a novel mecha…
View article: Transcriptome-based analysis of key functional genes in the triterpenoid saponin synthesis pathway of Platycodon grandiflorum
Transcriptome-based analysis of key functional genes in the triterpenoid saponin synthesis pathway of Platycodon grandiflorum Open
View article: Blocking Oncostatin M receptor abrogates STAT3 mediated integrin signaling and overcomes chemoresistance in ovarian cancer
Blocking Oncostatin M receptor abrogates STAT3 mediated integrin signaling and overcomes chemoresistance in ovarian cancer Open
View article: Ribosomal protein S3 mediates drug resistance of proteasome inhibitor: potential therapeutic application in multiple myeloma
Ribosomal protein S3 mediates drug resistance of proteasome inhibitor: potential therapeutic application in multiple myeloma Open
Multiple myeloma (MM) remains incurable due to drug resistance. Ribosomal protein S3 (RPS3) has been identified as a non-Rel subunit of NF-κB. However, the detailed biological roles of RPS3 remain unclear. Here, we report for the first tim…
View article: A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer
A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer Open
Background Immune exclusion (IE) where tumors deter the infiltration of immune cells into the tumor microenvironment has emerged as a key mechanism underlying immunotherapy resistance. We recently reported a novel role of discoidin domain-…
View article: SIRT3 alleviates imiquimod-induced psoriatic dermatitis through deacetylation of XBP1s and modulation of TLR7/8 inducing IL-23 production in macrophages
SIRT3 alleviates imiquimod-induced psoriatic dermatitis through deacetylation of XBP1s and modulation of TLR7/8 inducing IL-23 production in macrophages Open
Current evidence suggests that IL-23, IL-6, and TNF-α play pivotal roles in the pathogenesis of psoriasis. Although it has been established that Sirtuin 3 (SIRT3) mediates the inflammatory process, the underlying mechanisms remain largely …
View article: Overcoming adaptive resistance to anti-VEGF therapy by targeting CD5L
Overcoming adaptive resistance to anti-VEGF therapy by targeting CD5L Open
View article: Data from A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma
Data from A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma Open
Multiple myeloma is a plasma cell malignancy, which grows in the bone marrow (BM). The major population of cells in the BM is represented by neutrophils and they can form neutrophil extracellular traps (NET). Here, we investigated whether …
View article: Data from A Novel Therapeutic Strategy to Rescue the Immune Effector Function of Proteolytically Inactivated Cancer Therapeutic Antibodies
Data from A Novel Therapeutic Strategy to Rescue the Immune Effector Function of Proteolytically Inactivated Cancer Therapeutic Antibodies Open
Primary and acquired resistance to anticancer antibody immunotherapies presents significant clinical challenges. Here, we demonstrate that proteolytic inactivation of cancer-targeting antibodies is an unappreciated contributor to cancer im…
View article: Supplementary Table S1 from A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma
Supplementary Table S1 from A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma Open
Table S1 shows biochemical potency and selectivity of BMS-P5 for PAD4
View article: Supplementary Figure Legends and Supplementary Figures 1 through 4 from A Novel Therapeutic Strategy to Rescue the Immune Effector Function of Proteolytically Inactivated Cancer Therapeutic Antibodies
Supplementary Figure Legends and Supplementary Figures 1 through 4 from A Novel Therapeutic Strategy to Rescue the Immune Effector Function of Proteolytically Inactivated Cancer Therapeutic Antibodies Open
Figure S1: IdeS expression in BT474 breast cancer cells Figure S2: Detection of MMPs in cancer cell lysates and culture supernatant Figure S3: scIgG-T was not in the SKBR-3 cell culture medium Figure S4: Detection of immune cells infiltrat…
View article: Supplementary Figure Legends and Supplementary Figures 1 through 4 from A Novel Therapeutic Strategy to Rescue the Immune Effector Function of Proteolytically Inactivated Cancer Therapeutic Antibodies
Supplementary Figure Legends and Supplementary Figures 1 through 4 from A Novel Therapeutic Strategy to Rescue the Immune Effector Function of Proteolytically Inactivated Cancer Therapeutic Antibodies Open
Figure S1: IdeS expression in BT474 breast cancer cells Figure S2: Detection of MMPs in cancer cell lysates and culture supernatant Figure S3: scIgG-T was not in the SKBR-3 cell culture medium Figure S4: Detection of immune cells infiltrat…
View article: Supplementary Figure S1 from A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma
Supplementary Figure S1 from A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma Open
Figure S1 shows that pharmacological inhibition of PAD4 prevents MM1.S cell-induced NETosis.
View article: Data from A Novel Therapeutic Strategy to Rescue the Immune Effector Function of Proteolytically Inactivated Cancer Therapeutic Antibodies
Data from A Novel Therapeutic Strategy to Rescue the Immune Effector Function of Proteolytically Inactivated Cancer Therapeutic Antibodies Open
Primary and acquired resistance to anticancer antibody immunotherapies presents significant clinical challenges. Here, we demonstrate that proteolytic inactivation of cancer-targeting antibodies is an unappreciated contributor to cancer im…
View article: Data from A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma
Data from A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma Open
Multiple myeloma is a plasma cell malignancy, which grows in the bone marrow (BM). The major population of cells in the BM is represented by neutrophils and they can form neutrophil extracellular traps (NET). Here, we investigated whether …
View article: Supplementary Table S1 from A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma
Supplementary Table S1 from A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma Open
Table S1 shows biochemical potency and selectivity of BMS-P5 for PAD4
View article: Supplementary Figure S1 from A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma
Supplementary Figure S1 from A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma Open
Figure S1 shows that pharmacological inhibition of PAD4 prevents MM1.S cell-induced NETosis.
View article: Supplementary Data from Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth
Supplementary Data from Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth Open
Supplementary Material-1. Heatmap shows all the known ligand-receptor interactions between different cell types identified by CellPhoneDB in the OvD5-SS2 dataset.
View article: Data from Dysfunctional Antibodies in the Tumor Microenvironment Associate with Impaired Anticancer Immunity
Data from Dysfunctional Antibodies in the Tumor Microenvironment Associate with Impaired Anticancer Immunity Open
Purpose: Studies have demonstrated that cancer-associated matrix metalloproteinases (MMP) can generate single peptide bond cleavages in the hinge region of immunoglobulin G1 (IgG1). This study investigated the cleavage of…
View article: Supplementary Tables 1-2, Supplementary Figures 1-6 from Dysfunctional Antibodies in the Tumor Microenvironment Associate with Impaired Anticancer Immunity
Supplementary Tables 1-2, Supplementary Figures 1-6 from Dysfunctional Antibodies in the Tumor Microenvironment Associate with Impaired Anticancer Immunity Open
Supplementary Tables 1-2, Supplementary Figures 1-6. Supplemental table 1. Patient clinical information; Supplemental table 2 Patient clinical information; Supplemental Figure 1. Standard curves developed for calculation of IgG subclasses;…