Hui Li
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View article: A more selective risk-stratified, machine learning based, lung cancer thromboprophylaxis protocol following vats segmentectomy: a prospective cohort study
A more selective risk-stratified, machine learning based, lung cancer thromboprophylaxis protocol following vats segmentectomy: a prospective cohort study Open
Background: Venous thromboembolism (VTE) represents a potentially fatal but preventable postoperative complication. We sought to establish and validate an explainable prediction model based on the machine learning (ML) approach for VTE, an…
View article: Nitidine chloride inhibits colorectal cancer by targeting BUB1: mechanistic insights from molecular dynamics simulation, spatial transcriptomics, and single-cell RNA sequencing
Nitidine chloride inhibits colorectal cancer by targeting BUB1: mechanistic insights from molecular dynamics simulation, spatial transcriptomics, and single-cell RNA sequencing Open
NC exerts anti-CRC effects by downregulating BUB1, disrupting the RAD21-BUB1 axis, and alleviating BUB1-mediated immune suppression.
View article: Transanal intersphincteric approach combined with Kangfuxin enema for treating anastomotic leakage after low anterior resection: Three case reports
Transanal intersphincteric approach combined with Kangfuxin enema for treating anastomotic leakage after low anterior resection: Three case reports Open
BACKGROUND Anastomotic leakage (AL) is a serious and challenging complication following low anterior resection (LAR) for low rectal cancer. This case series presents the successful management of AL in three patients using a combined approa…
View article: A novel mucosa-associated lymphoid tissue translocation gene 1-related immune prognostic signature and targeted drug screening for glioblastoma
A novel mucosa-associated lymphoid tissue translocation gene 1-related immune prognostic signature and targeted drug screening for glioblastoma Open
BACKGROUND: Glioblastoma (GBM) is the most common intracranial malignancy in adults, and traditional treatments such as surgery, chemotherapy, and radiotherapy have shown limited improvements in patient prognosis. While immunotherapy has t…
View article: Association of unhealthy lifestyle and the risk of type 2 diabetes mellitus with arthritis in middle-aged and elderly Chinese individuals: evidence from the CHARLS
Association of unhealthy lifestyle and the risk of type 2 diabetes mellitus with arthritis in middle-aged and elderly Chinese individuals: evidence from the CHARLS Open
An unhealthy lifestyle was significantly associated with diabetes-arthritis comorbidity among participants ≥ 45 years of age in China, which suggesting that promoting healthy lifestyle may be important for reducing the burden of chronic di…
View article: HSF-HSP-GST coordinated network underlies ginger's adaptation to combined high-temperature and strong-light stress: Insights from multi-omics integration
HSF-HSP-GST coordinated network underlies ginger's adaptation to combined high-temperature and strong-light stress: Insights from multi-omics integration Open
High-temperature and strong-light (HTSL) stress constituting a major environmental constraint that limits crop growth and development. Ginger productivity is significantly compromised by HTSL exposure during critical growth phases, adverse…
View article: ISG20: The multifaceted ‘molecular star’ in cancer research (Review)
ISG20: The multifaceted ‘molecular star’ in cancer research (Review) Open
IFN‑stimulated gene (ISG)20 is a key member of the ISG family, serving a central role in antiviral defense, immune regulation and cell metabolism through its exonuclease activity. ISG20 is markedly dysregulated in various malignancies, inc…
View article: Metagenomic Next-Generation Sequencing Reveals Porphyromonas gingivalis in Geriatric Severe Pneumonia Complicated by Empyema: Case Report
Metagenomic Next-Generation Sequencing Reveals Porphyromonas gingivalis in Geriatric Severe Pneumonia Complicated by Empyema: Case Report Open
This case highlights the clinical utility of mNGS in diagnosing culture-negative pulmonary infections. Porphyromonas gingivalis should be considered a potential pathogen in patients with severe pneumonia and empyema, particularly in…
View article: Global, regional, and national trends in the incidence of pneumoconiosis among populations aged 20 and above from 1990 to 2021
Global, regional, and national trends in the incidence of pneumoconiosis among populations aged 20 and above from 1990 to 2021 Open
Background Pneumoconiosis remains one of the most critical occupational health hazards globally. Utilizing data from the Global Burden of Disease (GBD) 2021, we have updated the epidemiological trends of pneumoconiosis. Methods We conducte…
View article: Correlation risk analysis of serum inflammatory factors and 25-hydroxyvitamin D in vascular lesions in type 2 diabetes patients
Correlation risk analysis of serum inflammatory factors and 25-hydroxyvitamin D in vascular lesions in type 2 diabetes patients Open
Objective: To explore the relationships between the levels of serum inflammatory factors and 25-hydroxyvitamin D and diabetic vascular lesions in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 362 adult (aged ≥18 years)…
View article: OTUD3-mediated stabilization of SLC7A11 drives sunitinib resistance by suppressing ferroptosis in clear cell renal cell carcinoma
OTUD3-mediated stabilization of SLC7A11 drives sunitinib resistance by suppressing ferroptosis in clear cell renal cell carcinoma Open
Clear cell renal cell carcinoma (ccRCC), as the main type of RCC was treated with tyrosine kinase inhibitor (TKI) at the late stage. While drug resistance is the main challenge for TKIs like sunitinib, and the underline mechanisms remain u…
View article: WISP1 drives esophageal squamous cell carcinoma progression via modulation of cancer-associated fibroblasts and immune microenvironment
WISP1 drives esophageal squamous cell carcinoma progression via modulation of cancer-associated fibroblasts and immune microenvironment Open
Background Previous studies have reported abnormal expression of WNT1-inducible signaling pathway protein 1 (WISP1)/Cellular Communication Network Factor 4 (CCN4) in esophageal squamous cell carcinoma (ESCC). However, its specific signific…
View article: Integrative Transcriptomic and Metabolomics Reveal Dynamic Differences in Pathogen Resistance Between Resistant and Susceptible Cultivars of Myrica rubra
Integrative Transcriptomic and Metabolomics Reveal Dynamic Differences in Pathogen Resistance Between Resistant and Susceptible Cultivars of Myrica rubra Open
Background: Twig blight (TB), caused by Pestalotiopsis -like species, induces twig dieback in Myrica rubra, leading to substantial economic losses in its production across China and posing a significant threat to M. rubra cultivation. To d…
View article: PANoptosis-driven molecular stratification in esophageal squamous cell carcinoma: A multi-omics prognostic model and FGFR-Targeted therapeutic validation
PANoptosis-driven molecular stratification in esophageal squamous cell carcinoma: A multi-omics prognostic model and FGFR-Targeted therapeutic validation Open
This study developed and validated the first prognostic model for ESCC based on PANoptosis, highlighting FGFR inhibitors as potential therapeutic strategies for targeting specific subtypes through the suppression of EMT and modulation of t…
View article: Embryonic stem cell-derived small extracellular vesicles alleviate lead-induced cochlear spiral ganglion neurons injury by activating PI3 K/AKT signaling pathway
Embryonic stem cell-derived small extracellular vesicles alleviate lead-induced cochlear spiral ganglion neurons injury by activating PI3 K/AKT signaling pathway Open
Objective Embryonic stem cell (ESC)-derived small extracellular vesicles (sEVs) exhibit considerable potential as an innovative therapeutic approach in the fields of regenerative medicine and disease management. This in vitro study aimed t…
View article: Predicting response to patients with gastric cancer via a dynamic-aware model with longitudinal liquid biopsy data
Predicting response to patients with gastric cancer via a dynamic-aware model with longitudinal liquid biopsy data Open
Background Gastric cancer (GC) presents challenges in predicting treatment responses due to its patient-specific heterogeneity. Recently, liquid biopsies have emerged as a valuable data modality, offering essential cellular and molecular i…
View article: Effects of Different Types of Medications on Olfactory Dysfunction in <scp>CRSwNP</scp> : A Systematic Review and Network Meta‐Analysis
Effects of Different Types of Medications on Olfactory Dysfunction in <span>CRSwNP</span> : A Systematic Review and Network Meta‐Analysis Open
Objective To evaluate the efficacy of various pharmacological treatments for olfactory disorders in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Data Sources PubMed, Embase, Cochrane Library, and Web of Science. Methods…
View article: Potential drug targets for peripheral artery disease identified through Mendelian randomization analysis
Potential drug targets for peripheral artery disease identified through Mendelian randomization analysis Open
This study integrates genetic and proteomic data to identify therapeutic targets for PAD and evaluate their potential for drug development. The prioritization of MMP1 and ISG15 as key targets shows promise for PAD treatment, but further va…
View article: QuEChERS and UPLC-MS/MS-Based Quantification of Human Plasma of Eight Nucleoside Reverse Transcriptase Inhibitors and Platinum Anticancer Drugs for Hepatocellular Carcinoma
QuEChERS and UPLC-MS/MS-Based Quantification of Human Plasma of Eight Nucleoside Reverse Transcriptase Inhibitors and Platinum Anticancer Drugs for Hepatocellular Carcinoma Open
Nucleoside reverse transcriptase inhibitors (NRTIs) and platinum-based chemotherapeutics are widely utilized in cancer treatment. Evidence suggests that drug plasma concentrations are closely linked to both therapeutic efficacy and the ris…
View article: Key amino acids in RNA polymerase and helicase proteins regulate RNA synthesis efficiency in porcine reproductive and respiratory syndrome virus
Key amino acids in RNA polymerase and helicase proteins regulate RNA synthesis efficiency in porcine reproductive and respiratory syndrome virus Open
Porcine reproductive and respiratory syndrome virus (PRRSV) exhibits rapid evolution due to its high mutation rate and frequent recombination, posing significant challenges for disease control. In this study, we investigated the molecular …
View article: Composite dietary antioxidant index of antioxidant vitamins and sarcopenia risk: insights from the UK biobank and NHANES cohorts
Composite dietary antioxidant index of antioxidant vitamins and sarcopenia risk: insights from the UK biobank and NHANES cohorts Open
View article: Revealing gene expression links between milk fat globules and mammary glands in rodents via transcriptomics
Revealing gene expression links between milk fat globules and mammary glands in rodents via transcriptomics Open
Currently, most studies on lactation-related traits and gene expression rely on invasive techniques to obtain mammary tissue. These methods are not only difficult to perform but also limit the availability of samples. Therefore, this study…
View article: Clinicopathological characteristics of progressive gastrointestinal stromal tumors and heterogeneity analyses of secondary mutations
Clinicopathological characteristics of progressive gastrointestinal stromal tumors and heterogeneity analyses of secondary mutations Open
Background Although there have been multiple lines of drugs for gastrointestinal stromal tumors (GISTs), the drug response depends on the progressive tumors’ biological behaviors and secondary mutations. Methods We investigated the primary…
View article: Younger-onset type 2 diabetes associated with increased long-term cancer risk in Chinese adults: A 30-year follow-up of the Da Qing Diabetes Study
Younger-onset type 2 diabetes associated with increased long-term cancer risk in Chinese adults: A 30-year follow-up of the Da Qing Diabetes Study Open
Younger-onset type 2 diabetes was significantly associated with an increased risk of cancer beyond the influence of diabetes duration.
View article: Tumor associated chromosomal instability drives colorectal adenoma to adenocarcinoma progression based on 17 year follow up evidence
Tumor associated chromosomal instability drives colorectal adenoma to adenocarcinoma progression based on 17 year follow up evidence Open
View article: Modulation of Intestinal Barrier Function and Wnt/β- Catenin Pathway by Sanzi Formula in Colorectal Adenoma Development
Modulation of Intestinal Barrier Function and Wnt/β- Catenin Pathway by Sanzi Formula in Colorectal Adenoma Development Open
Sanzi formula interfered with the progression of colorectal adenoma in Apcmin/+ mice by repairing the intestinal barrier function and blocking the Wnt/β-catenin signaling pathway, which provided a new idea and scientific basis for clinical…
View article: No differences in IVF pregnancy outcomes following hysteroscopic polypectomy using a manual hysteroscopic tissue removal device versus conventional resection
No differences in IVF pregnancy outcomes following hysteroscopic polypectomy using a manual hysteroscopic tissue removal device versus conventional resection Open
View article: Malignant ascites enhance γδ T cell cytotoxicity towards ovarian cancer via modulating chemokines secretion from the cancer cells that recruits γδ T cells
Malignant ascites enhance γδ T cell cytotoxicity towards ovarian cancer via modulating chemokines secretion from the cancer cells that recruits γδ T cells Open
Ovarian cancer patients usually develops peritoneal metastasis and malignant ascites in the advanced stages, which form immuno-suppressive tumor microenvironments that limit the efficacy of immuno-therapies. However, during our previous re…
View article: Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor
Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor Open
Overdose intake of acetaminophen (APAP) causes liver injury involving hepatic drug metabolism and activation of oxidative stress pathways, and forsythiaside A (FA) has hepatoprotective pharmacological activity, but knowledge of the mechani…
View article: Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma
Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma Open