Wei Chua
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View article: Documentation of Advance Care Planning in Early Phase Cancer Clinical Trials: An Australian Single-Centre Experience
Documentation of Advance Care Planning in Early Phase Cancer Clinical Trials: An Australian Single-Centre Experience Open
Background/Objectives: Patients with incurable cancers enrolled in early phase clinical trials often face uncertainty about prognosis, yet advance care planning (ACP) is frequently delayed. The objective of this study was to assess the doc…
View article: Novel Resting Energy Expenditure Prediction Equations for Multi-Ethnic Asian Older Adults with Multimorbidity
Novel Resting Energy Expenditure Prediction Equations for Multi-Ethnic Asian Older Adults with Multimorbidity Open
Background/Objectives: Malnutrition is prevalent among hospitalized older adults with multimorbidity, leading to adverse health outcomes and increased healthcare costs. An accurate assessment of resting energy expenditure (REE) is crucial …
View article: Longitudinal Measurements of Inflammatory Indices During Treatment for Locally Advanced Rectal Cancer and Associations with Smoking, Ethnicity and Pathological Response
Longitudinal Measurements of Inflammatory Indices During Treatment for Locally Advanced Rectal Cancer and Associations with Smoking, Ethnicity and Pathological Response Open
This study explores the change in inflammatory markers over the course of neoadjuvant chemoradiation and adjuvant chemotherapy for LARC and assesses the association with clinicopathological factors at pre-specified time-points. We examined…
View article: Evaluating patient diversity in early phase clinical trials in Australia through a prospective multicenter nonrandomized cohort study
Evaluating patient diversity in early phase clinical trials in Australia through a prospective multicenter nonrandomized cohort study Open
Background Early phase clinical trials continue to have difficulty with enrolling real-world populations with many minorities being underrepresented. Reasons for this include patient or clinician perception as well as cultural, linguistic,…
View article: Differentiated Thyroid Cancer after Thyroidectomy
Differentiated Thyroid Cancer after Thyroidectomy Open
The widespread use of neck US and other imaging modalities has contributed to a phenomenon of increased detection of differentiated thyroid cancer (DTC). Most of these cancers remain indolent, without requiring surgical intervention. Nonet…
View article: Microsatellite Instability Testing and Prognostic Implications in Colorectal Cancer
Microsatellite Instability Testing and Prognostic Implications in Colorectal Cancer Open
Given the crucial predictive implications of microsatellite instability (MSI) in colorectal cancer (CRC), MSI screening is commonly performed in those with and at risk for CRC. Here, we compared results from immunohistochemistry (IHC) and …
View article: Outcomes of intravesical Bacillus Calmette-Guerin in patients with non-muscle invasive bladder cancer: a retrospective study in Australia
Outcomes of intravesical Bacillus Calmette-Guerin in patients with non-muscle invasive bladder cancer: a retrospective study in Australia Open
Introduction Induction intravesical Bacillus Calmette-Guerin (BCG) followed by maintenance after transurethral resection of bladder tumor, is the standard adjuvant therapy for high-risk non-muscle invasive bladder cancer (NMIBC). There is …
View article: p21 as a Predictor and Prognostic Indicator of Clinical Outcome in Rectal Cancer Patients
p21 as a Predictor and Prognostic Indicator of Clinical Outcome in Rectal Cancer Patients Open
The cell cycle plays a key and complex role in the development of human cancers. p21 is a potent cyclin-dependent kinase inhibitor (CDKI) involved in the promotion of cell cycle arrest and the regulation of cellular senescence. Altered p21…
View article: KRAS and BRAF Mutation Rates and Survival Outcomes in Colorectal Cancer in an Ethnically Diverse Patient Cohort
KRAS and BRAF Mutation Rates and Survival Outcomes in Colorectal Cancer in an Ethnically Diverse Patient Cohort Open
KRAS and BRAF mutation rates in colorectal cancer (CRC) reported from various mono-ethnic studies vary amongst different ethnic groups. However, these differences in mutation rates may not be statistically significant or may be due to diff…
View article: Novel treatments for novel side effects: a case report and review of baricitinib use in the treatment of chronic inflammatory demyelinating polyneuropathy caused by immune checkpoint inhibitor use
Novel treatments for novel side effects: a case report and review of baricitinib use in the treatment of chronic inflammatory demyelinating polyneuropathy caused by immune checkpoint inhibitor use Open
Immune checkpoint inhibitors (ICIs) have transformed the landscape of solid cancer management. These drugs carry a risk of novel side effects, which have become known as immune-related adverse events (irAEs). Traditionally, irAEs have been…
View article: Multigene panel next generation sequencing in metastatic colorectal cancer in an Australian population
Multigene panel next generation sequencing in metastatic colorectal cancer in an Australian population Open
Background Next generation sequencing (NGS) is increasingly used in standard clinical practice to identify patients with potentially actionable mutations. Stratification of NGS mutation tiers is currently based on the European Society of M…
View article: Circulating Tumour Cell Associated MicroRNA Profiles Change during Chemoradiation and Are Predictive of Response in Locally Advanced Rectal Cancer
Circulating Tumour Cell Associated MicroRNA Profiles Change during Chemoradiation and Are Predictive of Response in Locally Advanced Rectal Cancer Open
Locally advanced rectal cancer (LARC) has traditionally been treated with trimodality therapy consisting of neoadjuvant radiation +/− chemotherapy, surgery, and adjuvant chemotherapy. There is currently a clinical need for biomarkers to pr…
View article: Circulating Tumour Cell Associated MicroRNA Profiles Change during Chemoradiation and are Predictive of Response in Locally Advanced Rectal Cancer
Circulating Tumour Cell Associated MicroRNA Profiles Change during Chemoradiation and are Predictive of Response in Locally Advanced Rectal Cancer Open
Locally advanced rectal cancer (LARC) has traditionally been treated with trimodality therapy consisting of neoadjuvant radiation +/- chemotherapy, surgery and adjuvant chemotherapy. There is currently a clinical need for biomarkers to pre…
View article: Ipsilateral Upper-Limb Lymphedema After COVID-19 Vaccine Booster: Reply
Ipsilateral Upper-Limb Lymphedema After COVID-19 Vaccine Booster: Reply Open
Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore [email protected] Conflicts of interest and sources of funding: none declared.
View article: Real‐world tolerance and outcomes of oxaliplatin‐based adjuvant chemotherapy for stage III colon cancer—Does dose intensity matter?
Real‐world tolerance and outcomes of oxaliplatin‐based adjuvant chemotherapy for stage III colon cancer—Does dose intensity matter? Open
Introduction Fluoropyrimidine and oxaliplatin‐based adjuvant chemotherapy delivered as 5‐fluorouracil, leucovorin and oxaliplatin (FOLFOX), or capecitabine and oxaliplatin (CAPOX) is the standard of care for resected stage III colon cancer…
View article: Prognostic Significance of MRE11 Overexpression in Colorectal Cancer Patients
Prognostic Significance of MRE11 Overexpression in Colorectal Cancer Patients Open
Meiotic recombination 11 (MRE11) plays a critical role in the DNA damage response and maintenance of genome stability and is associated with the prognosis for numerous malignancies. Here, we explored the clinicopathological significance an…
View article: Ipsilateral Upper-Limb Lymphedema After COVID-19 Vaccine Booster
Ipsilateral Upper-Limb Lymphedema After COVID-19 Vaccine Booster Open
Recent data suggest that protective immunity from COVID-19 vaccine may wane after a period, with booster doses becoming increasingly deployed in many countries. An 84-year-old woman presents with a 6-month history of left upper-limb swelli…
View article: Prognostic Impact of TP53 Mutations and Tumor Mutational Load in Colorectal Cancer
Prognostic Impact of TP53 Mutations and Tumor Mutational Load in Colorectal Cancer Open
The DNA damage response (DDR) is critical for maintaining genome stability, and abnormal DDR—resulting from mutations in DNA damage-sensing and repair proteins—is a hallmark of cancer. Here, we aimed to investigate the predictive power of …
View article: Single-Circulating Tumor Cell Whole Genome Amplification to Unravel Cancer Heterogeneity and Actionable Biomarkers
Single-Circulating Tumor Cell Whole Genome Amplification to Unravel Cancer Heterogeneity and Actionable Biomarkers Open
The field of single-cell analysis has advanced rapidly in the last decade and is providing new insights into the characterization of intercellular genetic heterogeneity and complexity, especially in human cancer. In this regard, analyzing …
View article: Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells
Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells Open
Background Androgen receptor variant 7 (AR-V7) is an important biomarker to guide treatment options for castration-resistant prostate cancer (CRPC) patients. Its detectability in circulating tumour cells (CTCs) opens non-invasive diagnosti…
View article: Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells
Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells Open
Background: Androgen receptor variant 7 (AR-V7) is an important biomarker to guide treatment options for castration-resistant prostate cancer (CRPC) patients. Its detectability in circulating tumour cells (CTCs) opens non-invasive diagnost…
View article: Prognostic and Predictive Value of Liquid Biopsy-Derived Androgen Receptor Variant 7 (AR-V7) in Prostate Cancer: A Systematic Review and Meta-Analysis
Prognostic and Predictive Value of Liquid Biopsy-Derived Androgen Receptor Variant 7 (AR-V7) in Prostate Cancer: A Systematic Review and Meta-Analysis Open
In advanced prostate cancer, access to recent diagnostic tissue samples is restricted and this affects the analysis of the association of evolving biomarkers such as AR-V7 with metastatic castrate resistance. Liquid biopsies are emerging a…
View article: Biomarkers of Castrate Resistance in Prostate Cancer: Androgen Receptor Amplification and T877A Mutation Detection by Multiplex Droplet Digital PCR
Biomarkers of Castrate Resistance in Prostate Cancer: Androgen Receptor Amplification and T877A Mutation Detection by Multiplex Droplet Digital PCR Open
Androgen Receptor (AR) alterations (amplification, point mutations, and splice variants) are master players in metastatic castration resistant prostate cancer (CRPC) progression and central therapeutic targets for patient management. Here,…
View article: Peripheral Cytokine Levels as a Prognostic Indicator in Gastric Cancer: A Review of Existing Literature
Peripheral Cytokine Levels as a Prognostic Indicator in Gastric Cancer: A Review of Existing Literature Open
Although strong connections exist between the carcinogenesis of gastric cancer and chronic inflammation, gastric cancer is unique in that the chronic gastritis which frequently precedes carcinogenesis is strongly associated with H. pylori …
View article: Rectal cancer treatment and outcomes in elderly patients treated with curative intent
Rectal cancer treatment and outcomes in elderly patients treated with curative intent Open
The elderly population comprises a significant proportion of patients diagnosed with rectal cancer. However, there is a lack of evidence to guide treatment decisions in this group. Thus, this multicentre study compares the histopathology, …
View article: Development of Walking Robot Using Compliance Mechanism
Development of Walking Robot Using Compliance Mechanism Open
Walking robot is a trend in this 21st century as Industrial Revolution 4.0 which involved automation has become a hot topic. Unlike ordinary moving robots, walking robots that take humans and animals as references can move on unpaved surfa…
View article: <sup>18</sup>F-FDG PET/CT Manifestations of IgG4-related Disease
<sup>18</sup>F-FDG PET/CT Manifestations of IgG4-related Disease Open
Immunoglobulin G4-related disease (IgG4-RD) was not recognised as a systemic condition until 2003, when extra pancreatic manifestations were identified in patients with autoimmune pancreatitis. Since then, IgG4-RD has been described to inv…