Wen Hui Lim
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View article: Waitlist and Post‐Transplant Outcomes in Liver Transplantation for Alcohol‐Associated Liver Disease: An Individual Patient Data Meta‐Analysis
Waitlist and Post‐Transplant Outcomes in Liver Transplantation for Alcohol‐Associated Liver Disease: An Individual Patient Data Meta‐Analysis Open
Background and Aims Alcohol‐associated liver disease (ALD) is a rapidly rising indication for liver transplantation. Early studies showed comparable post‐transplant outcomes but emerging data suggest long‐term survival benefits in ALD, thu…
View article: Sex-based Disparities in Liver Transplantation for Hepatocellular Carcinoma and the Impact of the Growing Burden of NASH
Sex-based Disparities in Liver Transplantation for Hepatocellular Carcinoma and the Impact of the Growing Burden of NASH Open
Background. The cause of liver disease is changing, but its impact on liver transplantation (LT) for hepatocellular carcinoma (HCC) in women and men is unclear. We performed a nationwide study to assess the prevalence and posttransplant su…
View article: Meta‐analysis: Prevalence and impact of alcohol abstinence in alcohol‐associated cirrhosis
Meta‐analysis: Prevalence and impact of alcohol abstinence in alcohol‐associated cirrhosis Open
Summary Background Although alcohol abstinence may be an effective intervention for alcohol‐associated cirrhosis, its association with prognosis has not been systematically assessed or quantified. Aims To determine the prevalence of alcoho…
View article: Clinical Course, Immunogenicity, and Efficacy of BNT162b2 mRNA Vaccination Against SARS-CoV-2 Infection in Liver Transplant Recipients
Clinical Course, Immunogenicity, and Efficacy of BNT162b2 mRNA Vaccination Against SARS-CoV-2 Infection in Liver Transplant Recipients Open
Background. Immunocompromised individuals have been excluded from landmark studies of messenger RNA vaccinations for severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). In such patients, the response to vaccination may be bl…
View article: The silent burden of non‐alcoholic fatty liver disease in the elderly: A global burden of disease analysis
The silent burden of non‐alcoholic fatty liver disease in the elderly: A global burden of disease analysis Open
Summary Background Non‐alcoholic fatty liver disease (NAFLD) represents a significant health threat worldwide. The growing trend towards an aging population, along with an alarming rise in obesity and diabetes, may have significant implica…
View article: Patterns in Cancer Incidence Among People Younger Than 50 Years in the US, 2010 to 2019
Patterns in Cancer Incidence Among People Younger Than 50 Years in the US, 2010 to 2019 Open
Importance Emerging data suggest that the incidence of early-onset cancers, defined as cancers diagnosed in people younger than 50 years, is increasing, but updated data are limited. Objective To characterize the patterns in the incidence …
View article: Trial watch: immunotherapeutic strategies on the horizon for hepatocellular carcinoma
Trial watch: immunotherapeutic strategies on the horizon for hepatocellular carcinoma Open
The use of immune checkpoint inhibitors (ICIs) targeting PD-L1/PD-1 and CTLA-4 has transformed the oncology practice of hepatocellular carcinoma. However, only 25-30% of the patients with advanced HCC treated with atezolizumab-bevacizumab …
View article: Meta‐analysis: Prevalence of significant or advanced fibrosis in adults with alpha‐1‐antitrypsin deficiency
Meta‐analysis: Prevalence of significant or advanced fibrosis in adults with alpha‐1‐antitrypsin deficiency Open
Summary Background The prevalence of liver fibrosis detected by non‐invasive imaging in alpha‐1‐antitrypsin (AAT) deficiency has not been systematically assessed. Aims We conducted a systematic review and meta‐analysis to determine the pre…
View article: The prognostic value of including non‐alcoholic fatty liver disease in the definition of metabolic syndrome
The prognostic value of including non‐alcoholic fatty liver disease in the definition of metabolic syndrome Open
Summary Background/Aims Metabolic syndrome (MetS) affects over one third of the US adult population. Despite its close association with non‐alcoholic fatty liver disease (NAFLD), the traditional definition of MetS does not account for the …
View article: Meta‐analysis: Chemoprevention of hepatocellular carcinoma with statins, aspirin and metformin
Meta‐analysis: Chemoprevention of hepatocellular carcinoma with statins, aspirin and metformin Open
Summary Background Emerging data suggest that statins, aspirin and metformin may protect against hepatocellular carcinoma (HCC) development. However, prior meta‐analyses were limited by heterogeneity and inclusion of studies without adequa…
View article: Global Epidemiology of Cirrhosis: Changing Etiological Basis and Comparable Burden of Nonalcoholic Steatohepatitis between Males and Females
Global Epidemiology of Cirrhosis: Changing Etiological Basis and Comparable Burden of Nonalcoholic Steatohepatitis between Males and Females Open
Introduction: The etiology of liver diseases has changed significantly, but its impact on the comparative burden of cirrhosis between males and females is unclear. We estimated sex differences in the burden of cirrhosis across 204 countrie…
View article: Survival Trends in Sorafenib for Advanced Hepatocellular Carcinoma: A Reconstructed Individual Patient Data Meta-Analysis of Randomized Trials
Survival Trends in Sorafenib for Advanced Hepatocellular Carcinoma: A Reconstructed Individual Patient Data Meta-Analysis of Randomized Trials Open
Background: Emerging data suggest that outcomes for advanced hepatocellular carcinoma (HCC) treated with sorafenib may have improved over time. We aimed to provide robust, time-to-event estimates of survival outcomes for sorafenib in advan…
View article: Quality Assessment of Ultrasound and Magnetic Resonance Imaging for Hepatocellular Carcinoma Surveillance: A Systematic Review and Meta-Analysis
Quality Assessment of Ultrasound and Magnetic Resonance Imaging for Hepatocellular Carcinoma Surveillance: A Systematic Review and Meta-Analysis Open
Introduction: To achieve early detection and curative treatment options, surveillance imaging for hepatocellular carcinoma (HCC) must remain of quality and without substantial limitations in liver visualization. However, the prevalence of …
View article: A qualitative systematic review of anonymous/unspecified living kidney and liver donors’ perspectives
A qualitative systematic review of anonymous/unspecified living kidney and liver donors’ perspectives Open
Objectives & background Anonymous live organ donors or unspecified donors are individuals willing to be organ donors for any transplant recipient with whom they have no biological or antecedent emotional relationship. Despite excellent rec…
View article: Global incidence and prevalence of nonalcoholic fatty liver disease
Global incidence and prevalence of nonalcoholic fatty liver disease Open
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver disease worldwide. The estimated global incidence of NAFLD is 47 cases per 1,000 population and is higher among males than females. The estimated global prevalence of NAF…
View article: DEXA Scan Body Fat Mass Distribution in Obese and Non-Obese Individuals and Risk of NAFLD—Analysis of 10,865 Individuals
DEXA Scan Body Fat Mass Distribution in Obese and Non-Obese Individuals and Risk of NAFLD—Analysis of 10,865 Individuals Open
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide yet predicting non-obese NAFLD is challenging. Thus, this study investigates the potential of regional fat percentages obtained by dual-energy X-r…
View article: Depression in non-alcoholic fatty liver disease is associated with an increased risk of complications and mortality
Depression in non-alcoholic fatty liver disease is associated with an increased risk of complications and mortality Open
Background and aims The global prevalence of non-alcoholic fatty liver disease (NAFLD) is expected to rise continuously. Furthermore, emerging evidence has also shown the potential for concomitant depression in NAFLD. This study aims to ex…
View article: Metabolic associated fatty liver disease increases risk of adverse events after acute coronary syndrome
Metabolic associated fatty liver disease increases risk of adverse events after acute coronary syndrome Open
Metabolic Associated Fatty Liver Disease (MAFLD) was recently introduced as an alternative definition for fatty liver, that has been linked to an increased risk of systemic end-organ damage. However, current studies have not examined the i…
View article: Reconstructed meta-analysis of percutaneous coronary intervention versus coronary artery bypass grafting for left main disease
Reconstructed meta-analysis of percutaneous coronary intervention versus coronary artery bypass grafting for left main disease Open
Background Randomized controlled trials (RCTs) comparing percutaneous coronary intervention (PCI) with drug-eluting stents and coronary artery bypass grafting (CABG) for patients with left main coronary artery disease (LMCAD) have reported…
View article: Placebo Adverse Events in Non-alcoholic Steatohepatitis Clinical Trials: A Pooled Analysis of 2,944 Participants
Placebo Adverse Events in Non-alcoholic Steatohepatitis Clinical Trials: A Pooled Analysis of 2,944 Participants Open
INTRODUCTION: In the absence of an effective treatment for non-alcoholic steatohepatitis (NASH), a randomized, placebo-controlled trial (RCT) remains the current gold standard study design in NASH. As NASH is a largely asymptomatic disease…
View article: Type 2 diabetes mellitus in metabolic-associated fatty liver disease vs. type 2 diabetes mellitus non-alcoholic fatty liver disease: a longitudinal cohort analysis
Type 2 diabetes mellitus in metabolic-associated fatty liver disease vs. type 2 diabetes mellitus non-alcoholic fatty liver disease: a longitudinal cohort analysis Open
The identification and treatment of NAFLD in patients with T2DM is a major concern and the premature change to MAFLD results in an over-diagnosis of fatty liver, exaggerated mortality, and morbidity in patients with T2DM. The definition of…
View article: A poor perspective of self weight significantly increases adverse outcomes in non-alcoholic fatty liver disease (NAFLD)
A poor perspective of self weight significantly increases adverse outcomes in non-alcoholic fatty liver disease (NAFLD) Open
Background Non-alcoholic fatty liver disease (NAFLD) is prevalent amongst overweight and obese individuals, and weight loss remains the main mode of treatment for NAFLD patients. Weight perception plays a key role in the efficacy of such t…
View article: Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation
Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation Open
The guidelines recommend radiofrequency ablation (RFA) for early hepatocellular carcinomas that are less than 3 cm and trans-arterial chemoembolization (TACE) for intermediate-stage tumors. Real-world patient and tumor factors commonly lim…