Hui Zheng
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View article: Euglycaemic diabetic ketoacidosis and its risk factors in patients undergoing coronary artery bypass grafting surgery: a single-centre nested case-control study in China
Euglycaemic diabetic ketoacidosis and its risk factors in patients undergoing coronary artery bypass grafting surgery: a single-centre nested case-control study in China Open
Objectives This study examines the incidence and risk factors of euglycaemic diabetic ketoacidosis (euDKA) in patients undergoing coronary artery bypass grafting (CABG) and evaluates their postoperative outcomes over a 6-month follow-up pe…
View article: Changes in choriocapillaris blood flow density and associated factors affecting axial elongation in Chinese children and adolescents with mild to moderate myopia: a cross-sectional study
Changes in choriocapillaris blood flow density and associated factors affecting axial elongation in Chinese children and adolescents with mild to moderate myopia: a cross-sectional study Open
Choriocapillaris blood flow density in the macular region changes in the early stages of myopia, showing decreases in the perifoveal region. Both SE and CFD-peri may serve as potential biomarkers for predicting axial length elongation in t…
View article: Clinical features of hereditary transthyretin amyloidosis-polyneuropathy with transthyretin Ala97Ser(p.Ala117Ser) mutation in South Mainland China
Clinical features of hereditary transthyretin amyloidosis-polyneuropathy with transthyretin Ala97Ser(p.Ala117Ser) mutation in South Mainland China Open
Objective Our study aimed to report the clinical features and epidemiological characteristics of hereditary transthyretin amyloidosis-polyneuropathy(ATTRv-PN) with TTR Ala97Ser(p.Ala117Ser) mutation from South Mainland China. Methods We id…
View article: Clinical features of familial amyloidotic polyneuropathy with transthyretin p.Ala117Ser mutation in South Mainland China
Clinical features of familial amyloidotic polyneuropathy with transthyretin p.Ala117Ser mutation in South Mainland China Open
Objective Our study aimed to report the clinical features and epidemiological characteristics of hereditary transthyretin amyloidosis-polyneuropathy(ATTRv-PN) with TTR Ala97Ser(p.Ala117Ser) mutation from South Mainland China. Methods We id…
View article: ToxiLab: How Well Do Open-Source LLMs Generate Synthetic Toxicity Data?
ToxiLab: How Well Do Open-Source LLMs Generate Synthetic Toxicity Data? Open
Effective toxic content detection relies heavily on high-quality and diverse data, which serve as the foundation for robust content moderation models. Synthetic data has become a common approach for training models across various NLP tasks…
View article: Combined assessment of Caprini score, D-dimer, and thromboelastography for predicting deep venous thrombosis in lung cancer patients
Combined assessment of Caprini score, D-dimer, and thromboelastography for predicting deep venous thrombosis in lung cancer patients Open
Caprini score, D-dimer levels, α angle, and MA are independently associated with DVT occurrence and severity in lung cancer patients. Combined assessment enhances predictive accuracy, providing valuable guidance for early identification an…
View article: Risk factors for pulmonary embolism in malignant tumors patients with lower limb deep vein thrombosis: a retrospective study
Risk factors for pulmonary embolism in malignant tumors patients with lower limb deep vein thrombosis: a retrospective study Open
LLDVT density ratio, Hcy, and cTNI are independent predictors of PE in malignant tumor patients with LLDVT. These markers are closely associated with PE severity, which could assist in optimizing clinical management for these patients.
View article: [Neuronal plasticity changes in the central amygdala and prelimbic cortex network in mice with chronic unpredictable mild stress-induced depression].
[Neuronal plasticity changes in the central amygdala and prelimbic cortex network in mice with chronic unpredictable mild stress-induced depression]. Open
CUMS-induced depression may lead to plastic changes in the excitatory and inhibitory neuronal networks within the CeA and PrL to cause impairment of spatial learning and memory abilities in mice.
View article: ToxiLab: How Well Do Open-Source LLMs Generate Synthetic Toxicity Data?
ToxiLab: How Well Do Open-Source LLMs Generate Synthetic Toxicity Data? Open
Effective toxic content detection relies heavily on high-quality and diverse data, which serve as the foundation for robust content moderation models. Synthetic data has become a common approach for training models across various NLP tasks…
View article: Du-IN-v2: Unleashing the Power of Vector Quantization for Decoding Cognitive States from Intracranial Neural Signals
Du-IN-v2: Unleashing the Power of Vector Quantization for Decoding Cognitive States from Intracranial Neural Signals Open
While invasive brain-computer interfaces have shown promise for high-performance speech decoding under medical use, the potential of intracranial stereoElectroEncephaloGraphy (sEEG), which causes less damage to patients, remains underexplo…
View article: Du-IN: Discrete units-guided mask modeling for decoding speech from Intracranial Neural signals
Du-IN: Discrete units-guided mask modeling for decoding speech from Intracranial Neural signals Open
Invasive brain-computer interfaces with Electrocorticography (ECoG) have shown promise for high-performance speech decoding in medical applications, but less damaging methods like intracranial stereo-electroencephalography (sEEG) remain un…
View article: A rare germline BMP15 missense mutation causes hereditary ovarian immature teratoma in human
A rare germline BMP15 missense mutation causes hereditary ovarian immature teratoma in human Open
Ovarian immature teratomas (OITs) are malignant tumors originating from the ovarian germ cells that mainly occur during the first 30 y of a female’s life. Early age of onset strongly suggests the presence of susceptibility gene mutations f…
View article: miR-590-3p Overexpression Improves the Efficacy of hiPSC-CMs for Myocardial Repair
miR-590-3p Overexpression Improves the Efficacy of hiPSC-CMs for Myocardial Repair Open
View article: Outcome prediction comparison of ischaemic areas’ radiomics in acute anterior circulation non-lacunar infarction
Outcome prediction comparison of ischaemic areas’ radiomics in acute anterior circulation non-lacunar infarction Open
The outcome prediction of acute anterior circulation non-lacunar infarction (AACNLI) is important for the precise clinical treatment of this disease. However, the accuracy of prognosis prediction is still limited. This study aims to develo…
View article: The decipherment of tissue-based proteome signatures revealed predictive biomarkers of diseases for primary Sjogren's syndrome with peripheral neuropathy system
The decipherment of tissue-based proteome signatures revealed predictive biomarkers of diseases for primary Sjogren's syndrome with peripheral neuropathy system Open
Background and objectives The peripheral neuropathy system in Primary Sjogren's syndrome (pSS-PNS) is often disregarded as a significant neuropathy, and there is limited research on the underlying pathological mechanisms. This study aimed …
View article: Multi-functional fibrous dressings for infectious injury treatment with anti-adhesion wound healing
Multi-functional fibrous dressings for infectious injury treatment with anti-adhesion wound healing Open
Skin regeneration is hindered by poor vascularization, bacterial infection, prolonged inflammation, and oxidative wound microenvironment, which necessitate the fabrication of alternative wound dressings with anti-adhesion, anti-infection, …
View article: Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment
Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment Open
The poor efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumors is due to insufficient CAR T cell tumor infiltration, in vivo expansion, persistence, and effector function, as well as exhaustion, intrinsic target ant…
View article: Serum metabolic signatures for acute pulmonary embolism identified by untargeted metabolomics
Serum metabolic signatures for acute pulmonary embolism identified by untargeted metabolomics Open
Background and aims The important metabolic features of acute pulmonary embolism (APE) risk stratification and their underlying biological basis remain elusive. Our study aims to develop early diagnostic models and classification models by…
View article: Novel risk prediction models, involving coagulation, thromboelastography, stress response, and immune function indicators, for deep vein thrombosis after radical resection of cervical cancer and ovarian cancer
Novel risk prediction models, involving coagulation, thromboelastography, stress response, and immune function indicators, for deep vein thrombosis after radical resection of cervical cancer and ovarian cancer Open
This study aimed to investigate the predictive value of coagulation, thromboelastography, stress response, and immune function indicators for the occurrence of deep venous thrombosis (DVT) following radical resection of cervical cancer and…
View article: Elevated ENO2 Disrupts VSMCs Homeostasis Facilitating the Development of Aortic Dissection
Elevated ENO2 Disrupts VSMCs Homeostasis Facilitating the Development of Aortic Dissection Open
OBJECTIVE Aortic dissection (AD) is a dangerous cardiovascular disease. However, its regulatory mechanism remains poorly understood. Autophagy is an important pathway for maintaining cellular homeostasis. Recent studies have shown that gly…
View article: Prediction of the Activity of Early Ankylosing Spondylitis using Radiomics Texture Analysis on STIR
Prediction of the Activity of Early Ankylosing Spondylitis using Radiomics Texture Analysis on STIR Open
Purpose To evaluate the early activity of ankylosing spondylitis(AS)is very important for clinical decision. Owing to lacking of uniform standard and some other limitations, the methods for it are still difficult to practice by clinicians.…
View article: Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and tumor microenvironment, overcoming multiple obstacles of CAR T therapy for solid tumors
Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and tumor microenvironment, overcoming multiple obstacles of CAR T therapy for solid tumors Open
The poor efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumor is due to insufficient CAR T cell tumor infiltration, in vivo expansion, persistence, and effector function, as well as exhaustion, intrinsic target anti…
View article: Netrin-1 Monoclonal Antibody-Functionalized Nanoparticle Loaded with Metformin Prevents the Progression of Abdominal Aortic Aneurysms
Netrin-1 Monoclonal Antibody-Functionalized Nanoparticle Loaded with Metformin Prevents the Progression of Abdominal Aortic Aneurysms Open
Our findings identify metformin as a functional suppressor for macrophage-mediated phenotypic transformation of VSMCs and Tgt-NP-Met as an efficient therapeutic strategy for AAA management.
View article: Novel risk prediction models, involving coagulation, thromboelastography, stress response, and immune function indicators, for deep vein thrombosis after radical resection of cervical cancer and ovarian cancer
Novel risk prediction models, involving coagulation, thromboelastography, stress response, and immune function indicators, for deep vein thrombosis after radical resection of cervical cancer and ovarian cancer Open
This study aimed to investigate the predictive value of coagulation, thromboelastography, stress response, and immune function indicators for the occurrence of deep venous thrombosis (DVT) following radical resection of cervical cancer and…
View article: Association between serum uric acid/HDL-cholesterol ratio and chronic kidney disease: a cross-sectional study based on a health check-up population
Association between serum uric acid/HDL-cholesterol ratio and chronic kidney disease: a cross-sectional study based on a health check-up population Open
Objective Evidence suggests that both serum uric acid (SUA) and high-density lipoprotein cholesterol (HDL-C) are risk factors for chronic kidney disease (CKD). The SUA-to-HDL-C ratio (UHR) has recently attracted attention as a new biomarke…
View article: Upregulation of miR-222-3p alleviates the symptom of aortic dissection through targeting STAT3
Upregulation of miR-222-3p alleviates the symptom of aortic dissection through targeting STAT3 Open
The upregulation of miR-222-3p attenuates the progression of AD. Our study provides a theoretical basis for exploring new strategies against AD.
View article: Development of a Three-Dimensional Multi-Modal Perfusion-Thermal Electrode System for Complete Tumor Eradication
Development of a Three-Dimensional Multi-Modal Perfusion-Thermal Electrode System for Complete Tumor Eradication Open
Background: Residual viable tumor cells after ablation at the tumor periphery serve as the source for tumor recurrence, leading to treatment failure. Purpose: To develop a novel three-dimensional (3D) multi-modal perfusion-thermal electrod…
View article: Improving the Therapeutic Efficacy of Sorafenib for Hepatocellular Carcinoma by Repurposing Disulfiram
Improving the Therapeutic Efficacy of Sorafenib for Hepatocellular Carcinoma by Repurposing Disulfiram Open
Background Sorafenib, a kinase inhibitor, is a standard treatment for advanced hepatocellular carcinoma (HCC) but provides only a limited survival benefit. Disulfiram (DSF), a drug for treating alcoholism and a chelator of copper (Cu), for…
View article: Single Cell RNA Sequencing Reveals the Pathogenesis of Aortic Dissection Caused by Hypertension and Marfan Syndrome
Single Cell RNA Sequencing Reveals the Pathogenesis of Aortic Dissection Caused by Hypertension and Marfan Syndrome Open
Aortic dissection (AD) is mainly caused by hypertension and Marfan syndrome. However, it is unclear whether the cellular components and functions are different between the two causes. A total of 11 aortic samples were collected for single-…
View article: Secreted Phosphoprotein 1 (SPP1) Promotes Angiogenesis of Glioblastoma Through Up-regulating PSMA Expression Via Transcription Factor HIF-1α
Secreted Phosphoprotein 1 (SPP1) Promotes Angiogenesis of Glioblastoma Through Up-regulating PSMA Expression Via Transcription Factor HIF-1α Open
Background: Glioblastoma multiforme (GBM) is a highly vascular-rich and devastatingly aggressive type of malignant brain tumors, thus anti-angiogenesis therapy plays an essential role in the treatment of GBM. Our previous study had showed …