Hui Y. Lan
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View article: Association of cumulative changes in atherogenic index of plasma and its obesity-related derivatives with cardiovascular disease: emphasis on incremental risk of diabetes status
Association of cumulative changes in atherogenic index of plasma and its obesity-related derivatives with cardiovascular disease: emphasis on incremental risk of diabetes status Open
AIP and its obesity-related derivatives (particularly AIP-CVAI) exhibited significant positive associations with incident CVD risk. The strength of these associations dynamically influenced with cumulative changes in these metrics and sign…
View article: Decoding the heterogeneity of liver-resident macrophages in chronic liver diseases: therapeutic responses to immunomodulatory strategies
Decoding the heterogeneity of liver-resident macrophages in chronic liver diseases: therapeutic responses to immunomodulatory strategies Open
Chronic liver diseases (CLDs), encompassing a spectrum of etiologies including metabolic dysfunction, alcohol abuse, and viral infections, represent a significant global health burden. The progression of these diseases to fibrosis, cirrhos…
View article: Independent and joint associations of glucose modified by high-density lipoprotein cholesterol with mortality in heart failure patients: evidence from the Jiangxi, China cohort
Independent and joint associations of glucose modified by high-density lipoprotein cholesterol with mortality in heart failure patients: evidence from the Jiangxi, China cohort Open
Introduction Metabolic disorders characterized by dysregulation of glucose and lipid homeostasis are significant drivers of heart failure progression. This study proposes using high-density lipoprotein cholesterol (HDL-C) to modify fasting…
View article: Impact of serum uric acid to high-density lipoprotein cholesterol ratio on short-term outcomes in acute decompensated heart failure: a cohort study in Jiangxi Province, China
Impact of serum uric acid to high-density lipoprotein cholesterol ratio on short-term outcomes in acute decompensated heart failure: a cohort study in Jiangxi Province, China Open
Introduction Accumulating evidence suggests that both serum uric acid (UA) and high-density lipoprotein cholesterol(HDL-C) play critical roles in the pathogenesis of heart failure. This study aimed to investigate the association between th…
View article: Smad3 Mediates Renal Fibrosis via GPX4-Dependent Ferroptosis
Smad3 Mediates Renal Fibrosis via GPX4-Dependent Ferroptosis Open
TGF-β/Smad3 signaling is a key pathway leading to the cell death and renal fibrosis. Here we report a new mechanism through which Smad3 mediates renal fibrosis by downregulating the glutathione peroxidase 4 (GPX4), a central inhibitor for …
View article: Relaxed DNA substrate specificity of transposases involved in programmed genome rearrangement
Relaxed DNA substrate specificity of transposases involved in programmed genome rearrangement Open
During post-zygotic development, the ciliate Oxytricha trifallax undergoes massive programmed genome rearrangement that involves over 225 000 DNA cleavage and joining events. An Oxytricha family of Tc1/mariner transposons, known as telomer…
View article: Manganese toxicity suppressing nitrogen-fixing bacteria growth and impairing nitrogen uptake and utilization in sugarcane
Manganese toxicity suppressing nitrogen-fixing bacteria growth and impairing nitrogen uptake and utilization in sugarcane Open
Introduction Sugarcane ( Saccharum spp.) is a crucial crop for sugar and bioethanol production. However, sugarcane grown in the acidic soils of southern China often suffers from severe leaf chlorosis due to excessive soil manganese (Mn). T…
View article: Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis
Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis Open
Recipients’ age has emerged as a key factor that impacts on acute renal allograft rejection and graft survival. Age-related functional and structural changes in the immune system have been observed, yet the precise influence of aged immuni…
View article: A cross‐sectional review of policies on conflicts of interest and funding in the development manuals of practice guidelines
A cross‐sectional review of policies on conflicts of interest and funding in the development manuals of practice guidelines Open
Importance Policies on conflicts of interest (COI) and funding are essential to reduce the risk of bias in the guideline development process. Objective To collate and review the content related to COI and funding policies from guideline de…
View article: Relaxed DNA substrate specificity of transposases involved in programmed genome rearrangement
Relaxed DNA substrate specificity of transposases involved in programmed genome rearrangement Open
During post-zygotic development, the ciliate Oxytricha trifallax undergoes massive programmed genome rearrangement that involves over 225,000 DNA cleavage and joining events. An Oxytricha family of Tc 1/mariner transposons, known as Telome…
View article: Differential analysis of microRNAs in plasma exosomes in patients with cerebral ischemic stroke
Differential analysis of microRNAs in plasma exosomes in patients with cerebral ischemic stroke Open
The high incidence, disability, mortality, and recurrence rates of cerebral infarction impose a heavy burden on both the Chinese and global populations. It is essential for the early diagnosis, prevention, and protection against brain cell…
View article: [E<sub>2</sub> signaling in myofibers promots macrophage efferocytosis in mouse skeletal muscles with cardiotoxin-induced acute injury].
[E<sub>2</sub> signaling in myofibers promots macrophage efferocytosis in mouse skeletal muscles with cardiotoxin-induced acute injury]. Open
In injured mouse skeletal muscles, myofiber E2 signaling promotes M1 to M2 transition to increase macrophage efferocytosis, thereby relieving inflammation and promoting muscle regeneration and repair.
View article: Identification of a Novel ECM Remodeling Macrophage Subset in AKI to CKD Transition by Integrative Spatial and Single‐Cell Analysis (Adv. Sci. 38/2024)
Identification of a Novel ECM Remodeling Macrophage Subset in AKI to CKD Transition by Integrative Spatial and Single‐Cell Analysis (Adv. Sci. 38/2024) Open
Spatial Transcriptomic The cover depicts a Chinese Taoist concept: Yang promotes tissue repair through dynamic equilibrium, while imbalance of Yin disrupts tissue's ability to regenerate, leading to fibrosis. In article number 2309752, Yi‐…
View article: Identification of a Novel ECM Remodeling Macrophage Subset in AKI to CKD Transition by Integrative Spatial and Single‐Cell Analysis
Identification of a Novel ECM Remodeling Macrophage Subset in AKI to CKD Transition by Integrative Spatial and Single‐Cell Analysis Open
The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) is a critical clinical issue. Although previous studies have suggested macrophages as a key player in promoting inflammation and fibrosis during this transition,…
View article: Disrupting Smad3 potentiates immunostimulatory function of NK cells against lung carcinoma by promoting GM-CSF production
Disrupting Smad3 potentiates immunostimulatory function of NK cells against lung carcinoma by promoting GM-CSF production Open
Through Smad3-dependent signalings, transforming growth factor-β (TGF-β) suppresses the development, maturation, cytokine productions and cytolytic functions of NK cells in cancer. Silencing Smad3 remarkably restores the cytotoxicity of NK…
View article: CircPAPPA2 plays a role in preeclampsia pathogenesis via regulation of the miR-942/miR-5006-3p
CircPAPPA2 plays a role in preeclampsia pathogenesis via regulation of the miR-942/miR-5006-3p Open
C ircRNAs are a class of endogenous non-coding RNAs implicated in the pathogenesis of many pregnancy related diseases, one of which is pre-eclampsia (PE). This study aims to investigate the role of CircPAPPA2 (circbase ID: hsa_circ_0015382…
View article: Macrophage-derived macrophage migration inhibitory factor mediates renal injury in anti-glomerular basement membrane glomerulonephritis
Macrophage-derived macrophage migration inhibitory factor mediates renal injury in anti-glomerular basement membrane glomerulonephritis Open
Macrophages are a rich source of macrophage migration inhibitory factor (MIF). It is well established that macrophages and MIF play a pathogenic role in anti-glomerular basement membrane crescentic glomerulonephritis (anti-GBM CGN). Howeve…
View article: #1771 ANXA13 protects against acute kidney injury by inhibiting TGF-β/Smad3 pathway
#1771 ANXA13 protects against acute kidney injury by inhibiting TGF-β/Smad3 pathway Open
Background and Aims Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid loss of kidney function but with limited diagnostic and treatment options. Annexins (ANXA) are a superfamily of calcium-dependent and lipid-…
View article: Long Non-coding RNA NEAT1, NOD-Like Receptor Family Protein 3 Inflammasome, and Acute Kidney Injury
Long Non-coding RNA NEAT1, NOD-Like Receptor Family Protein 3 Inflammasome, and Acute Kidney Injury Open
Key Points Long non-coding RNA (lncRNA) nuclear-enriched abundant transcript 1 ( NEAT1 ) was upregulated in human and murine AKI. It returned to baseline after recovery in humans. Its knockdown preserved kidney function in animals. In vitr…
View article: Circulating metabolomic markers linking diabetic kidney disease and incident cardiovascular disease in type 2 diabetes: analyses from the Hong Kong Diabetes Biobank
Circulating metabolomic markers linking diabetic kidney disease and incident cardiovascular disease in type 2 diabetes: analyses from the Hong Kong Diabetes Biobank Open
Aims/hypothesis The aim of this study was to describe the metabolome in diabetic kidney disease (DKD) and its association with incident CVD in type 2 diabetes, and identify prognostic biomarkers. Methods From a prospective cohort of indivi…
View article: Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury: Erratum
Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury: Erratum Open
[This corrects the article DOI: 10.7150/thno.54550.].
View article: Hematopoietic Transcription Factor RUNX1 is Essential for Promoting Macrophage–Myofibroblast Transition in Non‐Small‐Cell Lung Carcinoma (Adv. Sci. 1/2024)
Hematopoietic Transcription Factor RUNX1 is Essential for Promoting Macrophage–Myofibroblast Transition in Non‐Small‐Cell Lung Carcinoma (Adv. Sci. 1/2024) Open
Macrophage–Myofibroblast Transition In article number 2302203, Philip Chiu‐Tsun Tang, Max Kam‐Kwan Chan, Patrick Ming‐Kuen Tang, and co‐workers, elucidated dynamics of cancer‐associated fibroblast (CAF) with integrative bioinformatics at s…