Hui Ying Yeoh
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View article: ABC-transporter CFTR folds with high fidelity through a modular, stepwise pathway
ABC-transporter CFTR folds with high fidelity through a modular, stepwise pathway Open
The question how proteins fold is especially pointed for large multidomain, multispanning membrane proteins with complex topologies. We have uncovered the sequence of events that encompass proper folding of the ABC transporter CFTR in live…
View article: Clinical and molecular characterization of the R751L-CFTR mutation
Clinical and molecular characterization of the R751L-CFTR mutation Open
Cystic fibrosis (CF) arises from mutations in the CF transmembrane conductance regulator ( CFTR) gene, resulting in progressive and life-limiting respiratory disease. R751L is a rare CFTR mutation that is poorly characterized. Our aims wer…
View article: Folding–function relationship of the most common cystic fibrosis–causing CFTR conductance mutants
Folding–function relationship of the most common cystic fibrosis–causing CFTR conductance mutants Open
Cystic fibrosis is caused by mutations in the CFTR gene, which are subdivided into six classes. Mutants of classes III and IV reach the cell surface but have limited function. Most class-III and class-IV mutants respond well to the recentl…