Explanipedia

Multi-omics analysis revealed coordinated responses of rumen microbiota and epithelium of goats to dietary supplementation of glucosamine selenium Open

Tianwei Liu, Shuang Li, Yan Huang, Shijie Chu, Xiang Huang , et al. · 2025

ELF5 modulates casein synthesis in goat mammary epithelial cells via JAK2/STAT5 signaling pathway Open

Yuzhu Guo, Cunxia Ma, Tao Meng, Tao Tu, Shuangshuang Cui , et al. · 2025

ELF5 upregulates casein synthesis by activating JAK2/STAT5 signaling pathway, which provides the strategy for manipulating ELF5 to increase casein content and improve goat milk protein quality.

Preparation of two kinds of immunocastration vaccines and their immune effects on male goats Open

Fuqiang Pan, Yumeng Guo, Panpan Chen, Wei Qian, Mingzhe Han , et al. · 2025

Objective: Post-pubertal male goats exhibit undesirable behaviors (fighting, mounting) and reduced growth due to high testosterone, while traditional castration causes stress. Immunocastration offers a humane alternative. This study aimed …

Transcriptome and DNA methylation analysis of the goat pineal gland during puberty Open

Bochao Zhang, Genbao Zhu, Jianling Wu, Huihui Xie, Jiankun Cui , et al. · 2025

Previous studies have confirmed that methylation regulates gene transcription in the hypothalamus-pituitary-gonadal axis during puberty initiation, but little is known about the regulation of DNA methylation on gene expression in the pinea…

Transcriptome analysis revealed the mechanism of skeletal muscle growth and development in different hybrid sheep Open

Mengyu Lou, Sihuan Zhang, Wen‐Horng Yang, Shuang Li, Hongguo Cao , et al. · 2024

Objective: This study aimed to analyze the molecular mechanism of heterosis in East Friesian sheep×Hu sheep (EH) hybrid sheep and Suffolk×EH (SHE) hybrid sheep (Ovis aries).Methods: In this research, the growth performance data of Hu sheep…

Transcriptome and DNA Methylation Analysis of the Goat Pineal Gland During Puberty Open

Bochao Zhang, Huihui Xie, Wei Qian, Jianling Wu, Jiankun Cui , et al. · 2024

Epigenetic regulation of gene transcription may play a critical role in the onset of puberty. Previous studies have confirmed that methylation regulates gene transcription in the hypothalamus-pituitary-gonadal axis during puberty initiatio…

Transcriptome analysis revealed differences in gene expression in sheep muscle tissue at different developmental stages Open

Sailuo Wan, Mengyu Lou, Sihuan Zhang, Shuang Li, Yinghui Ling · 2024

The regulatory mechanism of garlic skin improving the growth performance of fattening sheep through metabolism and immunity Open

Yongjie Xu, Mingliang Yi, Shixin Sun, Lei Wang, Zijun Zhang , et al. · 2024

Objective Garlic skin (GAS) has been proven to improve the growth performance of fattening sheep. However, the mechanism by which GAS affects fattening sheep is not yet clear. The aim of this study is to investigate the effects of adding G…

Identifying differentially expressed genes in goat mammary epithelial cells induced by overexpression of SOCS3 gene using RNA sequencing Open

Ning Song, Cunxia Ma, Yuzhu Guo, Shuangshuang Cui, Shihao Chen , et al. · 2024

The suppressor of cytokine signaling 3 (SOCS3) is a key signaling molecule that regulates milk synthesis in dairy livestock. However, the molecular mechanism by which SOCS3 regulates lipid synthesis in goat milk remains unclear. This study…

Positive In Vitro Effect of ROCK Pathway Inhibitor Y-27632 on Qualitative Characteristics of Goat Sperm Stored at Low Temperatures Open

Yongjie Xu, Shixin Sun, Yu Fu, Lei Wang, Chunhuan Ren , et al. · 2024

Y-27632, as a cytoskeleton protector, is commonly used for low-temperature preservation of cells. Goat sperm are prone to damage to the cytoskeleton under low-temperature conditions, leading to a loss of sperm vitality. However, the Y-2763…

Multi-Omics Analysis Reveals the Regulatory Mechanism of Probiotics on the Growth Performance of Fattening Sheep Open

Mingyue Wang, Mingliang Yi, Lei Wang, Shixin Sun, Yinghui Ling , et al. · 2024

Probiotics have been proven to improve the growth performance of livestock and poultry. The aim of this experiment was to investigate the effects of probiotic supplementation on the growth performance; rumen and intestinal microbiota; rume…

Preservative Effects of Curcumin on Semen of Hu Sheep Open

Kaiyuan Ji, Jinbo Wei, Zhiwei Fan, Mengkang Zhu, Xin Yuan , et al. · 2024

Reactive oxygen species (ROS) are important factors that lead to a decline in sperm quality during semen preservation. Excessive ROS accumulation disrupts the balance of the antioxidant system in sperm and causes lipid oxidative damage, de…

circKIF27 inhibits melanogenesis and proliferation by targeting miR-129-5p/TGIF2 pathway in goat melanocytes Open

Kaiyuan Ji, Yi-wei ZHAO, Xin Yuan, Chune E Liang, X. R. Zhang , et al. · 2024

Skin and hair pigmentation in animals involve intricate regulatory processes. Circular RNA-microRNA (circRNA-miRNA) networks play vital roles in various biological processes, although their involvement in pigmentation has been underexplore…

Multi-omics analysis on the mechanism of the effect of Isatis leaf on the growth performance of fattening sheep Open

Zhikun Cao, Mingliang Yi, J. F. Zhou, Zhe Zhang, Zibo Liu , et al. · 2024

Introduction This study evaluated the effects of Isatis Leaf (ISL) on the growth performance, gastrointestinal tissue morphology, rumen and intestinal microbiota, rumen, serum and urine metabolites, and rumen epithelial tissue transcriptom…

Ezrin Thr567 phosphorylation participates in mouse oocyte maturation, fertilization, and early embryonic development Open

Huihui Xie, Tiandong Xia, Bochao Zhang, Jiankun Cui, Fuqiang Pan , et al. · 2024

Background Ezrin is a membrane-cytoskeleton linker, involved in cell polarization, cell migration, cell division, signal transduction and some other cellular activities that play an important role in oocyte maturation, fertilization and ea…

Antioxidant activity and metabolic regulation of sodium salicylate on goat sperm at low temperature Open

Wenzheng Shen, Yu Fu, Haiyu Bai, Zhiyu Zhang, Zhikun Cao , et al. · 2024

Objective: The purpose of this study was to explore the effect of sodium salicylate (SS) on semen preservation and metabolic regulation in goats.Methods: Under the condition of low temperature, SS was added to goat semen diluent to detect …

<i>Grid1</i> regulates the onset of puberty in female rats Open

Jing Ye, Xiaoqian Li, Zhihao Pan, Zhuoya WU, Yanyun Zhu , et al. · 2024

The study aimed to investigate the effect of Grid1, encoding the glutamate ionotropic receptor delta type subunit 1 (GluD1), on puberty onset in female rats. Grid1 mRNA and protein expression was detected in the hypothalamus of female rats…

Comprehensive analyses of 435 goat transcriptomes provides insight into male reproduction Open

Xu Han, Sihuan Zhang, Qin Duan, Mengyu Lou, Yinghui Ling · 2023

A systematic analysis of genes related to reproduction is crucial for obtaining a comprehensive understanding of the molecular mechanisms that underlie male reproductive traits in mammals. Here, we utilized 435 goat transcriptome datasets …

Multi-Omics Analysis of the Mechanism of Mentha Haplocalyx Briq on the Growth and Metabolic Regulation of Fattening Sheep Open

Mingliang Yi, Zhikun Cao, J. F. Zhou, Yinghui Ling, Zijun Zhang , et al. · 2023

Mentha haplocalyx Briq (MHB) and its components have been proven to improve the growth performance of livestock and poultry. The aim of this experiment was to investigate the effects of MHB addition on growth performance, rumen and fecal m…

Integrative proteomic and phosphoproteomic analysis in the female goat hypothalamus to study the onset of puberty Open

Jing Ye, Xu Yan, Wei Zhang, Juntai Lu, Shuangshuang Xu , et al. · 2023

Background Puberty marks the end of childhood and achieve sexual maturation and fertility. The role of hypothalamic proteins in regulating puberty onset is unclear. We performed a comprehensive differential proteomics and phosphoproteomics…

Identification of transition factors in myotube formation from proteome and transcriptome analyses Open

Qi Zheng, Rong-cui HU, Cuiyun Zhu, Jing Jing, Mengyu Lou , et al. · 2023

Muscle fibers are the main component of skeletal muscle and undergo maturation through the formation of myotubes. During early development, a population of skeletal muscle satellite cells (SSCs) proliferate into myoblasts. The myoblasts th…

CRISPR-based m6A modification and its potential applications in telomerase regulation Open

Mingliang Yi, Mingyue Wang, Yongjie Xu, Zhikun Cao, Yinghui Ling , et al. · 2023

Telomerase determines cell lifespan by controlling chromosome stability and cell viability, m 6 A epigenetic modification plays an important role in the regulation of telomerase activity. Using CRISPR epigenome editing to analyze specific …

MiR-188-5p regulates the proliferation and differentiation of goat skeletal muscle satellite cells by targeting calcium/calmodulin dependent protein kinase II beta Open

Jing Jing, Sihuan Zhang, Jinbo Wei, Yuhang Yang, Qi Zheng , et al. · 2023

Objective: The aim of this study was to reveal the role and regulatory mechanism of miR-188-5p in the proliferation and differentiation of goat muscle satellite cells.Methods: Goat skeletal muscle satellite cells isolated in the pre-labora…

Analysis of serum reproductive hormones and ovarian genes in pubertal female goats Open