Yunhong Zhang
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View article: Somatostatin Ameliorates Corneal Nerve Abnormalities and Inflammation Through Regulation of Macrophage Activities in Dry Eye Disease
Somatostatin Ameliorates Corneal Nerve Abnormalities and Inflammation Through Regulation of Macrophage Activities in Dry Eye Disease Open
SOM230 alleviates nerve abnormalities in DED by suppressing inflammatory pathways (TNF-α, NF-κB) and promoting a shift in macrophage polarization from the pro-inflammatory M1 phenotype to the reparative M2 phenotype. These findings suggest…
View article: Mechanistic insights into nitric acid-enhanced iodic acid particle nucleation in the upper troposphere and lower stratosphere
Mechanistic insights into nitric acid-enhanced iodic acid particle nucleation in the upper troposphere and lower stratosphere Open
In the upper troposphere and lower stratosphere (UTLS), new particles frequently form to seed cloud condensation nuclei (CCN), thereby affecting radiative forcing and global climate. Iodic acid (IA) particles have been widely detected in t…
View article: Investigation of Transdermal Drug Delivery and In Vivo Pharmacokinetics of Choline Ketoprofen Ionic Liquid
Investigation of Transdermal Drug Delivery and In Vivo Pharmacokinetics of Choline Ketoprofen Ionic Liquid Open
View article: Establishment of a medial arterial calcification model in C57BL/6J mice via arterial intimal injury
Establishment of a medial arterial calcification model in C57BL/6J mice via arterial intimal injury Open
This study not only establishes a MAC animal model by inducing injury to the CCA combined with a VD3 diet but also introduces a corresponding pathological scoring system. Together, this model, coupled with this associated gradin…
View article: Back Cover: D‐Mannose Alleviates Type 2 Diabetes and Rescues Multi‐Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles (EXP2 5/2025)
Back Cover: D‐Mannose Alleviates Type 2 Diabetes and Rescues Multi‐Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles (EXP2 5/2025) Open
View article: Multi-objective optimization of spatial morphology for highrise residential buildings in cold-climate regions of China
Multi-objective optimization of spatial morphology for highrise residential buildings in cold-climate regions of China Open
View article: The Remodeling of Mitochondrial-Endoplasmic Reticulum Contacts by Omega-3 Fatty Acids Mitigates Dietary Advanced Glycation End Product-Driven Sertoli Cell Senescence and Oligoasthenozoospermia
The Remodeling of Mitochondrial-Endoplasmic Reticulum Contacts by Omega-3 Fatty Acids Mitigates Dietary Advanced Glycation End Product-Driven Sertoli Cell Senescence and Oligoasthenozoospermia Open
Dietary components or patterns have been shown to affect male fertility. The increasing intake of processed foods rich in advanced glycation end products (AGEs) may threaten spermatogenesis. However, the key cell type affected by AGEs in s…
View article: D‐Mannose Alleviates Type 2 Diabetes and Rescues Multi‐Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles
D‐Mannose Alleviates Type 2 Diabetes and Rescues Multi‐Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles Open
Type 2 diabetes (T2D) is a prevalent metabolic disease inducing alterations of multiple organ systems with currently no cure. Extracellular vesicles (EVs) have been increasingly noticed as one critical paracrine communicator inducing insul…
View article: Hydrate formation and agglomeration in Pickering emulsions stabilized by hydrophilic and hydrophobic nano-CaCO3 particles
Hydrate formation and agglomeration in Pickering emulsions stabilized by hydrophilic and hydrophobic nano-CaCO3 particles Open
View article: Systematic Review of Assessment Tools for Factors Influencing Missed Nursing Care Among Nurses Based on COSMIN Guidelines
Systematic Review of Assessment Tools for Factors Influencing Missed Nursing Care Among Nurses Based on COSMIN Guidelines Open
View article: Subsoil tillage and straw mulching are synergistic for long-term improvement of soil carbon and structural characteristics
Subsoil tillage and straw mulching are synergistic for long-term improvement of soil carbon and structural characteristics Open
Subsoil tillage (S) improves the stability and quality of soil organic carbon (SOC) and soil structure. Combining straw mulching with subsoil tillage (SS) may further improve soil physical and biogeochemical properties, whilst enabling abu…
View article: The Effects of Landmark Salience on Drivers' Spatial Cognition and Takeover Performance in Autonomous Driving Scenarios.
The Effects of Landmark Salience on Drivers' Spatial Cognition and Takeover Performance in Autonomous Driving Scenarios. Open
With the increasing prevalence of autonomous vehicles (AVs), drivers' spatial cognition and takeover performance have become critical to traffic safety. This study investigates the effects of landmark salience-specifically visual and struc…
View article: Microfluidic Biochip‐Based Multiplexed Profiling of Small Extracellular Vesicles Proteins Integrated with Machine Learning for Early Disease Diagnosis
Microfluidic Biochip‐Based Multiplexed Profiling of Small Extracellular Vesicles Proteins Integrated with Machine Learning for Early Disease Diagnosis Open
Accurate early diagnosis is essential for preventing diseases and improving cure and survival rates. There are no reliable early‐diagnosis biomarkers for most major diseases. Here, esophageal squamous cell carcinoma (ESCC) is used as a dis…
View article: Composite Effect of Nanoparticles and Conventional Additives on Hydrate Formation in Seawater-Based Drilling Fluids
Composite Effect of Nanoparticles and Conventional Additives on Hydrate Formation in Seawater-Based Drilling Fluids Open
The design of high-performance drilling fluid systems is of vital importance for the safe and efficient exploitation of natural gas hydrates. Incorporating appropriate nanoparticles into drilling fluids can significantly enhance drilling f…
View article: Mechanistic Insights into the Atomic-Level Synergy of NiRu Single-Atom Alloy on ZrO2 for Efficient Photocatalytic CO2 Methanation and Biogas Upgrading
Mechanistic Insights into the Atomic-Level Synergy of NiRu Single-Atom Alloy on ZrO2 for Efficient Photocatalytic CO2 Methanation and Biogas Upgrading Open
Atomic-level modulation of transition metal nanoparticles through single-atom hetero-doping provides a promising strategy for optimizing catalytic reaction. However, a fundamental understanding of the underlying reaction mechanism remains …
View article: Dynamic Study on Synergy Mechanism and Characteristics of Particle Removal in Electrostatic Atomization
Dynamic Study on Synergy Mechanism and Characteristics of Particle Removal in Electrostatic Atomization Open
A laboratory-scale wire plate wet electrostatic precipitator was designed and constructed to investigate the particle enhancement and capture characteristics of electrostatically charged droplets in continuous atomization mode. A compariso…
View article: The effect and mechanism of Germacrone in ameliorating alcoholic fatty liver by inhibiting Nrf2/Rbp4
The effect and mechanism of Germacrone in ameliorating alcoholic fatty liver by inhibiting Nrf2/Rbp4 Open
View article: Executive summary for the China Kidney Disease Network (CK-NET) 2017–2018 Annual Data Report
Executive summary for the China Kidney Disease Network (CK-NET) 2017–2018 Annual Data Report Open
View article: miR-126-5p protects from URSA via inhibiting Caspase-1-dependent pyroptosis of trophoblast cells
miR-126-5p protects from URSA via inhibiting Caspase-1-dependent pyroptosis of trophoblast cells Open
View article: Exploring Adult Underweight Through Cluster Analysis: A Study of Socioeconomic and Health Factors in the NHANES 2011-2020 population
Exploring Adult Underweight Through Cluster Analysis: A Study of Socioeconomic and Health Factors in the NHANES 2011-2020 population Open
Background: The underweight population, defined by a body mass index (BMI) of less than 18.5, is often overlooked in clinical practice despite facing unique health risks. This study aimed to explore the distinct demographic, clinical, and …
View article: Universal Amplification-Free RNA Detection by Integrating CRISPR-Cas10 with Aptameric Graphene Field-Effect Transistor
Universal Amplification-Free RNA Detection by Integrating CRISPR-Cas10 with Aptameric Graphene Field-Effect Transistor Open
View article: Structural Characterization and Bioactivity Analysis of Ultrasound‐Assisted Polysaccharides From <i>Codonopsis pilosula</i>: Insights Into Antioxidant and Hypoglycemic Potentials
Structural Characterization and Bioactivity Analysis of Ultrasound‐Assisted Polysaccharides From <i>Codonopsis pilosula</i>: Insights Into Antioxidant and Hypoglycemic Potentials Open
Codonopsis pilosula is a genuine medicinal material and edible plant. However, the structure and activity of its polysaccharides have been infrequently studied. In this study, crude polysaccharides were extracted using ultrasound‐assisted …
View article: Correlations of Levels of Peripheral Blood Inflammatory Cytokines and Serum Lipoprotein-Associated Phospholipase-A<sub>2</sub> with Acute Ischemic Stroke and Their Early Prognostic Value
Correlations of Levels of Peripheral Blood Inflammatory Cytokines and Serum Lipoprotein-Associated Phospholipase-A<sub>2</sub> with Acute Ischemic Stroke and Their Early Prognostic Value Open
Respecting the significant role of inflammation in acute ischemic stroke (AIS) development, we explored the correlations of inflammatory cytokines and lipoprotein-associated phospholipase-A2 (Lp-PLA2) with AIS and the…
View article: Supplementary material to "Mechanistic insights into nitric acid-enhanced iodic acid particle nucleation in the upper troposphere and lower stratosphere"
Supplementary material to "Mechanistic insights into nitric acid-enhanced iodic acid particle nucleation in the upper troposphere and lower stratosphere" Open
View article: Mechanistic insights into nitric acid-enhanced iodic acid particle nucleation in the upper troposphere and lower stratosphere
Mechanistic insights into nitric acid-enhanced iodic acid particle nucleation in the upper troposphere and lower stratosphere Open
In the upper troposphere and lower stratosphere (UTLS), new particles frequently form to seed cloud condensation nuclei (CCN), thereby affecting radiative forcing and global climate. Iodic acid (IA) particles have been widely detected in t…
View article: Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis
Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis Open
We developed a non-invasive high-throughput microfluidic platform for EOC sEV-derived biomarker detection. It significantly reduced false positives and sample volume. Given its convenience and low cost, this platform could advance OC early…
View article: Sulfate formation through copper-catalyzed SO2 oxidation by NO2 at aerosol surfaces
Sulfate formation through copper-catalyzed SO2 oxidation by NO2 at aerosol surfaces Open
Severe urban air pollution in China is driven by a synergistic conversion of SO 2 , NOx, and NH 3 into fine particulate matter (PM 2.5 ). Field studies indicated NO 2 as an important oxidizer to SO 2 in polluted atmospheres with low photoc…
View article: Specific molecular imaging of BALB/c model mice with Graves’ ophthalmopathy based on high expression of insulin-like growth factor 1 receptor
Specific molecular imaging of BALB/c model mice with Graves’ ophthalmopathy based on high expression of insulin-like growth factor 1 receptor Open
View article: Dynamic development of gut microbiota and metabolism during and after weaning of kittens
Dynamic development of gut microbiota and metabolism during and after weaning of kittens Open
View article: Population Shrinkage and Spatio-Temporal Changes in Cultivated Land Use Efficiency in China’s Agro-Pastoral Ecotone
Population Shrinkage and Spatio-Temporal Changes in Cultivated Land Use Efficiency in China’s Agro-Pastoral Ecotone Open
Revealing the level of cultivated land use efficiency and its influencing factors in the northern agro-pastoral ecotone from the perspective of population contraction can provide a decision-making reference for ensuring national food secur…