Huibo Ti
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View article: Primary cilia as mechanosensors in musculoskeletal homeostasis and disease
Primary cilia as mechanosensors in musculoskeletal homeostasis and disease Open
The musculoskeletal system relies on precise mechanical signal transduction to maintain physiological homeostasis, yet the underlying mechanisms remain incompletely characterized. Primary cilia (PC), membrane-bound organelles that protrude…
View article: Emerging regulated cell death mechanisms in bone remodeling: decoding ferroptosis, cuproptosis, disulfidptosis, and PANoptosis as therapeutic targets for skeletal disorders
Emerging regulated cell death mechanisms in bone remodeling: decoding ferroptosis, cuproptosis, disulfidptosis, and PANoptosis as therapeutic targets for skeletal disorders Open
The adult skeleton preserves its structural and functional integrity through continuous bone remodeling, a process tightly regulated by osteoblasts, osteoclasts, and osteocytes. Disruptions to this balance contribute to skeletal pathologie…
View article: Decoding TAGLN2 in cancer: the molecular linchpin bridging actin remodeling, immune dysregulation and therapeutic challenges
Decoding TAGLN2 in cancer: the molecular linchpin bridging actin remodeling, immune dysregulation and therapeutic challenges Open
Cancer development involves complex interactions between tumors and the host microenvironment. Throughout this process, dynamic regulation of the actin cytoskeleton is crucial for tumor invasion, metastasis, and immune evasion. Transgelin …
View article: Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis
Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis Open
Rheumatoid arthritis (RA) is a systemic autoimmune disease in which synovial fibroblasts (SFs) maintain chronic inflammation by secreting proinflammatory mediators, leading to joint destruction. While the role of proinflammatory mediators …
View article: Osteoclast Secretes Stage‐Specific Key Molecules for Modulating Osteoclast–Osteoblast Communication
Osteoclast Secretes Stage‐Specific Key Molecules for Modulating Osteoclast–Osteoblast Communication Open
In most cases of bone metabolic disorders, such as osteoporosis and osteomalacia, these conditions are often attributed to dysfunctional osteoclasts, leading to their common characterization as “destructors.” In addition to the widely docu…