Hui‐Chen Hsu
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View article: Aryl hydrocarbon receptor as an intrinsic novel checkpoint that inhibits TLR7-induced B-cell activation in lupus 2500
Aryl hydrocarbon receptor as an intrinsic novel checkpoint that inhibits TLR7-induced B-cell activation in lupus 2500 Open
Description Systemic lupus erythematosus (SLE) is marked by an increase in T-bet+CXCR3+Fcrl5+IgD−CD27− double negative 2 (DN2) B cells, driven by heightened TLR7 signaling. We found that SLE patients have reduced aryl hydrocarbon receptor …
View article: Enhanced mitochondrial biogenesis in B cells from females is required to drive increased T-bet induction by TLR7 in lupus 2317
Enhanced mitochondrial biogenesis in B cells from females is required to drive increased T-bet induction by TLR7 in lupus 2317 Open
Description The development of T-bet+ B cells, driven by aberrant TLR7 and interferon (IFN) signaling, is a key pathogenic feature of systemic lupus erythematosus (SLE), a disease that predominantly affects women. We analyzed the transcrip…
View article: 201 IL-4 acts through aryl hydrocarbon receptor to antagonize TLR7-induced double negative 2 B cells in lupus
201 IL-4 acts through aryl hydrocarbon receptor to antagonize TLR7-induced double negative 2 B cells in lupus Open
Background/Purpose We recently showed that in SLE, IL-4 suppressed the development of interferon-beta (IFNβ) and TLR7-stimulated T-bet+ double negative 2 (DN2) B cells. Here we investigate the potential DN2 B-cell suppressive effects of IL…
View article: 17β-estradiol and B-cell intrinsic type I interferon amplify toll-like receptor 7 signaling loop in B cells of female lupus prone BXD2 mice
17β-estradiol and B-cell intrinsic type I interferon amplify toll-like receptor 7 signaling loop in B cells of female lupus prone BXD2 mice Open
While systemic lupus erythematosus (SLE) disproportionally affects women versus men, elevation in 17β-estradiol (E2) alone is not sufficient to promote the development of autoantibody producing B cells. The objective of the present study i…
View article: 204 IL-4 as a negative regulator of pathogenic extrafollicular DN2 B cells in SLE
204 IL-4 as a negative regulator of pathogenic extrafollicular DN2 B cells in SLE Open
Background Pathogenic extrafollicular double negative 2 (DN2) B cells in SLE have a phenotype of IgD−CD27−Tbet+CD11c+, and are the precursor of ribonuclear protein (RNP) autoantibody producing B cells. This trajectory of development is pro…
View article: IL-4-Induced Quiescence of Resting Naive B Cells Is Disrupted in Systemic Lupus Erythematosus
IL-4-Induced Quiescence of Resting Naive B Cells Is Disrupted in Systemic Lupus Erythematosus Open
Activated naive (aNAV) B cells have been shown to be the precursor of the CD11c+T-bet+ IgD−CD27− double-negative (DN)2 or atypical memory (aMEM) B cells in systemic lupus erythematosus (SLE). To determine factors that maintain resting naiv…
View article: Antibacterial and Anticancer Activities of Pleurocidin-Amide, a Potent Marine Antimicrobial Peptide Derived from Winter Flounder, Pleuronectes americanus
Antibacterial and Anticancer Activities of Pleurocidin-Amide, a Potent Marine Antimicrobial Peptide Derived from Winter Flounder, Pleuronectes americanus Open
The extensive use of conventional antibiotics has led to the growing emergence of many resistant strains of pathogenic bacteria. Evidence suggests that cationic antimicrobial peptides (AMPs) have the greatest potential to serve as traditio…
View article: Lupus nephritis correlates with B cell interferon-β, anti-Smith, and anti-DNA: a retrospective study
Lupus nephritis correlates with B cell interferon-β, anti-Smith, and anti-DNA: a retrospective study Open
Background In systemic lupus erythematosus (SLE), detection of interferon-β (IFNβ) in B cells was found to be most prominent in patients with high anti-Smith (Sm) and renal disease, but a mechanistic connection was not clear. The objective…
View article: Lupus Nephritis Correlates with B-Cell Interferon-β, Anti-Smith, and Anti-DNA: A Retrospective Study
Lupus Nephritis Correlates with B-Cell Interferon-β, Anti-Smith, and Anti-DNA: A Retrospective Study Open
Background: In systemic lupus erythematosus (SLE), detection of interferon-β (IFNβ)in B cells was found to be most prominent in patients with high anti-Smith (Sm) and renal disease, but a mechanistic connection was not clear . The objectiv…
View article: 510 B-cell interferon-β correlates with lupus nephritis in systemic lupus erythematosus
510 B-cell interferon-β correlates with lupus nephritis in systemic lupus erythematosus Open
Background Early diagnosis of lupus nephritis (LN) can be challenging since some patients do not exhibit overt clinical manifestations until advanced stages. B cell interferon-beta (IFNβ) correlates with development of B cell autoreactive …
View article: Host Genetics But Not Commensal Microbiota Determines the Initial Development of Systemic Autoimmune Disease in <scp>BXD2</scp> Mice
Host Genetics But Not Commensal Microbiota Determines the Initial Development of Systemic Autoimmune Disease in <span>BXD2</span> Mice Open
Objective To determine the extent to which the gut microbiome influences systemic autoimmunity in a mouse model of lupus. Methods We generated germ‐free (GF) lupus‐prone BXD2 mice, which under normal conditions develop spontaneous germinal…
View article: Issue Information
Issue Information Open
in At-Risk First-Degree Relatives Cover image: The fi gure on the cover (from Yuba et al, pages 769-778) shows immunofl uorescence staining of popliteal lymph node from an arthritic BALB/c mouse after intravenous injection of DyLight 594-l…
View article: Issue Information
Issue Information Open
The fi gure on the cover (from Zuo et al, pages 2130-2135) illustrates the detection of antineutrophil extracellular trap (NET) antibodies from patients with primary antiphospholipid syndrome, by immunofl uorescence microscopy.When NETs we…
View article: IL-23 Promotes a Coordinated B Cell Germinal Center Program for Class-Switch Recombination to IgG2b in BXD2 Mice
IL-23 Promotes a Coordinated B Cell Germinal Center Program for Class-Switch Recombination to IgG2b in BXD2 Mice Open
IL-23 promotes autoimmune disease, including Th17 CD4 T cell development and autoantibody production. In this study, we show that a deficiency of the p19 component of IL-23 in the autoimmune BXD2 (BXD2-p19−/−) mouse leads to a shift of the…
View article: Bioinformatics Analysis of Single Cell Sequencing Data
Bioinformatics Analysis of Single Cell Sequencing Data Open
A single cell data analysis tutorial for ATTIS 2020 (https://www.uab.edu/medicine/informatics/news-events/attis-2020). See source code at https://gitlab.rc.uab.edu/attis2020/single_cell_attis2020.
View article: Autoreactive B cells in SLE, villains or innocent bystanders?
Autoreactive B cells in SLE, villains or innocent bystanders? Open
The current concepts for development of autoreactive B cells in SLE (systemic lupus erythematosus) focus on extrinsic stimuli and factors that provoke B cells into tolerance loss. Traditionally, major tolerance loss pathways are thought to…