Hui‐Chun Wang
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View article: Hybrid Molecules of p53 Activators and Protoflavones to Target Multiple Myeloma
Hybrid Molecules of p53 Activators and Protoflavones to Target Multiple Myeloma Open
Multiple myeloma is a rare blood cancer that develops from abnormal plasma cells in the bone marrow. Treatment of multiple myeloma remains an enormous challenge. In this work, hybrid compounds are developed and studied for their potential …
View article: Regulation of Petal Coloration by the Auxin Amide Hydrolase Gene RhILL1 in Rose (Rosa hybrida)
Regulation of Petal Coloration by the Auxin Amide Hydrolase Gene RhILL1 in Rose (Rosa hybrida) Open
Objective: This study aimed to elucidate the regulatory mechanism of an auxin amide hydrolase gene (IAA-Leucine Resistant1-like Hydrolase, RhILL1) in the petal pigmentation of rose (Rosa hybrida), providing theoretical insight into the hor…
View article: Genome‐wide identification of WOX family members in rose and functional analysis of <i>RcWUS1</i> in embryogenic transformation
Genome‐wide identification of WOX family members in rose and functional analysis of <i>RcWUS1</i> in embryogenic transformation Open
WUSCHEL‐related homeobox (WOX) is a class of plant‐specific transcription factors and plays vital roles in plant development and evolution. Here, we analyzed WOX family genes of three Rosa species and explored their potential functions in …
View article: Amphibians rise to flourishing under climate change on the Qinghai-Tibetan Plateau
Amphibians rise to flourishing under climate change on the Qinghai-Tibetan Plateau Open
Amphibian populations are declining globally due to climate change. However, the impacts on the geographic distribution of amphibians on the Qinghai-Tibetan Plateau (QTP), a global biodiversity hotspot with 112 species of amphibians that i…
View article: Preparation of Dearomatized <i>p</i>‐Coumaric Acid Derivatives as DNA Damage Response Inhibitors with Potent <i>In Vitro</i> Antitumor Effect
Preparation of Dearomatized <i>p</i>‐Coumaric Acid Derivatives as DNA Damage Response Inhibitors with Potent <i>In Vitro</i> Antitumor Effect Open
Our research group previously identified graviquinone ( 1 ) as a promising antitumor metabolite that is formed in situ when the antioxidant methyl caffeate scavenges free radicals. Furthermore, it exerted a DNA damaging effect on cancer ce…
View article: Identification and Validation of Reference Genes for qRT-PCR Analysis of Petal-Color-Related Genes in Rosa praelucens
Identification and Validation of Reference Genes for qRT-PCR Analysis of Petal-Color-Related Genes in Rosa praelucens Open
The flower’s color is regarded as one of the most outstanding features of the rose. Rosa praelucens Byhouwer, an endemic and critically endangered decaploid wild rose species, is abundant in phenotypic diversity, especially in flower color…
View article: Indigofera suffruticosa aerial parts extract induce G2/M arrest and ATR/CHK1 pathway in Jurkat cells
Indigofera suffruticosa aerial parts extract induce G2/M arrest and ATR/CHK1 pathway in Jurkat cells Open
View article: Conservation genetics and potential geographic distribution modeling of Corybas taliensis, a small ‘sky Island’ orchid species in China
Conservation genetics and potential geographic distribution modeling of Corybas taliensis, a small ‘sky Island’ orchid species in China Open
Background Corybas taliensis is an endemic species of sky islands in China. Its habitat is fragile and unstable, and it is likely that the species is threatened. However, it is difficult to determine the conservation priority or unit witho…
View article: Target-Guided Isolation and Purification of Antioxidants from Urtica laetevirens Maxim. by HSCCC Combined with Online DPPH-HPLC Analysis
Target-Guided Isolation and Purification of Antioxidants from Urtica laetevirens Maxim. by HSCCC Combined with Online DPPH-HPLC Analysis Open
Urtica laetevirens Maxim. is used extensively in traditional Chinese medicine (TCM) for its potent antioxidative properties. In this study, three antioxidants were purified from U. laetevirens. using HSCCC guided by online DPPH-HPLC analys…
View article: Conservation Genetics and Modeling Potential Geographic Distribution of Corybas taliensis, a Small ‘Sky Island’ Orchid Species in China
Conservation Genetics and Modeling Potential Geographic Distribution of Corybas taliensis, a Small ‘Sky Island’ Orchid Species in China Open
Background Corybas taliensis is an endemic species of sky islands in the Pan-Tibetan Plateau region of China. Its habitat is fragile and volatile, and it is likely that the species is threatened. However, it is difficult to determine the c…
View article: Ethylene controls cambium stem cell activity via promoting local auxin biosynthesis
Ethylene controls cambium stem cell activity via promoting local auxin biosynthesis Open
Summary The vascular cambium is the main secondary meristem in plants that produces secondary phloem (outside) and xylem (inside) on opposing sides of the cambium. The phytohormone ethylene has been implicated in vascular cambium activity,…
View article: Supplementary Methods from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Methods from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i> Open
PDF file, 75KB.
View article: Data from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i>
Data from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i> Open
DNA damage caused during cancer treatment can rapidly activate the ataxia telangiectasia-mutated (ATM) and ATM and Rad3-related (ATR)-dependent phosphorylation of Chk2 and Chk1 kinases, which are hallmarks of the DNA damage response (DDR).…
View article: Supplementary Figures 1 - 8 from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Figures 1 - 8 from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i> Open
PDF file, 984KB.
View article: Supplementary Methods from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Methods from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i> Open
PDF file, 75KB.
View article: Supplementary Figures 1 - 8 from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Figures 1 - 8 from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i> Open
PDF file, 984KB.
View article: Data from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i>
Data from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <i>In Vitro</i> and <i>In Vivo</i> Open
DNA damage caused during cancer treatment can rapidly activate the ataxia telangiectasia-mutated (ATM) and ATM and Rad3-related (ATR)-dependent phosphorylation of Chk2 and Chk1 kinases, which are hallmarks of the DNA damage response (DDR).…
View article: Data from Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining
Data from Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining Open
Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are the two mechanisms responsible for repairing DNA double-strand breaks (DSBs) and act in either a collaborative or competitive manner in mammalian cells. DSB repaired by…
View article: Supplementary Figure 1 from Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining
Supplementary Figure 1 from Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining Open
Supplementary Figure 1 from Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining
View article: Data from Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining
Data from Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining Open
Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are the two mechanisms responsible for repairing DNA double-strand breaks (DSBs) and act in either a collaborative or competitive manner in mammalian cells. DSB repaired by…
View article: Supplementary Figure 1 from Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining
Supplementary Figure 1 from Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining Open
Supplementary Figure 1 from Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining
View article: Effects of Cd treatment on morphology, chlorophyll content and antioxidant enzyme activity of <i>Elymus nutans</i> Griseb., a native plant in Qinghai-Tibet Plateau
Effects of Cd treatment on morphology, chlorophyll content and antioxidant enzyme activity of <i>Elymus nutans</i> Griseb., a native plant in Qinghai-Tibet Plateau Open
Cd pollution is a global environmental problem. However, the response mechanism of the alpine plant Pelagia under Cd stress remains unclear. Therefore, in this study, a native plant(Elymus nutans Griseb.) of the Qinghai-Tibet Platea…
View article: Loss of Rose Fragrance under Chilling Stress Is Associated with Changes in DNA Methylation and Volatile Biosynthesis
Loss of Rose Fragrance under Chilling Stress Is Associated with Changes in DNA Methylation and Volatile Biosynthesis Open
Rose plants are widely cultivated as cut flowers worldwide and have economic value as sources of natural fragrance and flavoring. Rosa ‘Crimson Glory’, whose petals have a pleasant fragrance, is one of the most important cultivars of edibl…
View article: New Verticillene Diterpenoids, Eudesmane Sesquiterpenoids, and Hydroperoxysteroids from the Further Chemical Investigation of a Taiwanese Soft Coral Cespitularia sp.
New Verticillene Diterpenoids, Eudesmane Sesquiterpenoids, and Hydroperoxysteroids from the Further Chemical Investigation of a Taiwanese Soft Coral Cespitularia sp. Open
An investigation of the chemical composition of a Formosan soft coral Cespitularia sp. led to the discovery of one new verticillene-type diterpenoid, cespitulactam M (1); one new eudesmane sesquiterpenoid, cespilamide F (2); and three new …
View article: A draft Diabrotica virgifera virgifera genome: insights into control and host plant adaption by a major maize pest insect
A draft Diabrotica virgifera virgifera genome: insights into control and host plant adaption by a major maize pest insect Open
View article: Effects of cadmium stress on fruits germination and growth of two herbage species
Effects of cadmium stress on fruits germination and growth of two herbage species Open
Cadmium (Cd) pollution is a global environmental problem. It is of great significance to find a kind of pasture that can grow normally in a cadmium environment, especially in the Tibetan Plateau. We studied the fruit germination and fruit …
View article: Hybrid molecules of protoflavones and spirooxindole derivatives with selective cytotoxicity against triple-negative breast cancer cells
Hybrid molecules of protoflavones and spirooxindole derivatives with selective cytotoxicity against triple-negative breast cancer cells Open
New lead compounds were synthesized with selectivity against triple negative breast cancer by the combination of DNA damage response inhibitor protoflavones and p53-MDM2/X protein–protein interaction inhibitor spirooxindoles.
View article: Current Developments on Chemical Compositions, Biosynthesis, Color Properties and Health Benefits of Black Goji Anthocyanins: An Updated Review
Current Developments on Chemical Compositions, Biosynthesis, Color Properties and Health Benefits of Black Goji Anthocyanins: An Updated Review Open
Lycium ruthenicum is a therapeutic plant and its fruits (black goji) are commonly used as a traditional Chinese medicine. This review comprehensively discusses the recent research developments of black goji anthocyanins (BGAs), including c…
View article: Ecological Niche and Interspecific Association of Plant Communities in Alpine Desertification Grasslands: A Case Study of Qinghai Lake Basin
Ecological Niche and Interspecific Association of Plant Communities in Alpine Desertification Grasslands: A Case Study of Qinghai Lake Basin Open
The study of niche and interspecific relationships is one of the classical ecological theories. We set up four desertification gradients. The “Levins” and “Pianka” method were used to calculate the species’ niche breadth and niche overlap.…
View article: Primary adrenal anaplastic large cell lymphoma: a case report and literature review (Preprint)
Primary adrenal anaplastic large cell lymphoma: a case report and literature review (Preprint) Open
UNSTRUCTURED Involvement of the adrenal gland by anaplastic large cell lymphoma (ALCL) is infrequent. We report a 69-year-old male patient who underwent general weakness and anorexia for one year. Positron emission tomography-computed tom…