Huifang Zhang
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View article: Biofilm-based continuous secretion of human lysozyme through cell-surface display of FimH on Saccharomyces cerevisiae
Biofilm-based continuous secretion of human lysozyme through cell-surface display of FimH on Saccharomyces cerevisiae Open
View article: Targeted metabolomic and transcriptomic analyses provide insights into flavonoid biosynthesis in the grain of Foxtail millet
Targeted metabolomic and transcriptomic analyses provide insights into flavonoid biosynthesis in the grain of Foxtail millet Open
Background Foxtail millet (Setaria italica L.), a traditional Chinese crop, is valued for its rich abundance of health-beneficial compounds (e.g., flavonoids). Despite the nutritional significance of flavonoids, their biosynthetic pathways…
View article: Targeted metabolomic and transcriptomic analyses provide insights into flavonoid biosynthesis in the grain of foxtail millet
Targeted metabolomic and transcriptomic analyses provide insights into flavonoid biosynthesis in the grain of foxtail millet Open
Background Foxtail millet (Setaria italica L.), a traditional Chinese crop, is valued for its considerable abundance of compounds with health benefits (e.g., flavonoids). Despite the nutritional significance of flavonoids, their biosynthet…
View article: Sub-terahertz transmissive reconfigurable intelligent surface for integrated beam steering and self-OOK-modulation
Sub-terahertz transmissive reconfigurable intelligent surface for integrated beam steering and self-OOK-modulation Open
Boasting superior flexibility in beam manipulation and a simpler framework than traditional phased arrays, terahertz metasurface-based phased arrays show great promise for 5G-A/6G communication networks. Compared with the reflective reconf…
View article: Efficient production of cordycepin in engineered Saccharomyces cerevisiae
Efficient production of cordycepin in engineered Saccharomyces cerevisiae Open
View article: Dynamically logical modulation for THz wave within a dual gate–controlled 2DEG metasurface
Dynamically logical modulation for THz wave within a dual gate–controlled 2DEG metasurface Open
High-speed logic modulation of terahertz (THz) waves is crucial for future communications, yet a technology gap persists. Here, we report a dual gate–controlled two-dimensional electronic gas logic modulation metasurface that enables symme…
View article: IL-2–inducible T cell kinase deficiency sustains chimeric antigen receptor T cell therapy against tumor cells
IL-2–inducible T cell kinase deficiency sustains chimeric antigen receptor T cell therapy against tumor cells Open
Despite the revolutionary achievements of chimeric antigen receptor (CAR) T cell therapy in treating cancers, especially leukemia, several key challenges still limit its therapeutic efficacy. Of particular relevance is the relapse of cance…
View article: Production of 1,4-butanediol through <i>Clostridia</i> C4 pathways
Production of 1,4-butanediol through <i>Clostridia</i> C4 pathways Open
1,4-butanediol (1,4-BDO) is an important building block in the chemical industry that has been mainly produced from fossil fuels, but now biosynthesis of 1,4-BDO has received more and more attention due to environmental issues. The Clostri…
View article: A novel prognostic model based on pyroptosis signature in AML
A novel prognostic model based on pyroptosis signature in AML Open
Acute myeloid leukemia (AML), a highly heterogeneous myeloid malignancy, remains a challenge in terms of proper risk stratification. In this study, we developed a novel pyroptosis prognostic model based on pyroptosis-related gene pairs, wh…
View article: Central nervous system anomalies in 41 Chinese children incontinentia pigmenti
Central nervous system anomalies in 41 Chinese children incontinentia pigmenti Open
View article: Production of 1,4-butanediol through Clostridia C4 pathways
Production of 1,4-butanediol through Clostridia C4 pathways Open
1,4-butanediol (1,4-BDO) is an important building block in the chemical industry that has been mainly produced from fossil fuels, but now biosynthesis of 1,4-BDO has received more and more attention due to environmental issues. The Clostri…
View article: High-speed independent polarization modulation based on dual channel 2DEG anisotropic terahertz metasurfaces
High-speed independent polarization modulation based on dual channel 2DEG anisotropic terahertz metasurfaces Open
In communication and imaging systems, anisotropic metasurfaces bring new degrees of freedom for the independent control of electromagnetic waves with different polarizations. This paper proposes a dual-polarization modulation metasurface (…
View article: Basic magnesium sulfate@TiO2 composite for efficient adsorption and photocatalytic degradation of 4-dodecylmorpholine in brine
Basic magnesium sulfate@TiO2 composite for efficient adsorption and photocatalytic degradation of 4-dodecylmorpholine in brine Open
More than 70% of the potash fertilizer globally is produced by the froth flotation process, in which 4-dodecylmorpholine (DMP) serves as a reverse flotation agent. As the potash fertilizer production rapidly rises, the increased DMP levels…
View article: Self-Supporting np-AlFeNiO Bifunctional Electrode Material for Electrochemical Water Splitting Prepared by Electrooxidation
Self-Supporting np-AlFeNiO Bifunctional Electrode Material for Electrochemical Water Splitting Prepared by Electrooxidation Open
Hydrogen production through water splitting is a promising path to develop renewable green energy. Effective, stable, and low-cost catalysts are the key to water splitting. In the present work, a series of self-supporting nanoporous alloys…
View article: Second-Order Sidebands and Group Delays in Coupled Optomechanical Cavity System with a Cubic Nonlinear Harmonic Oscillator
Second-Order Sidebands and Group Delays in Coupled Optomechanical Cavity System with a Cubic Nonlinear Harmonic Oscillator Open
The generation of second-order sidebands and its associated group delay is an important subject in optical storage and switch. In this work, the efficiency of second-order sideband generation in a coupled optomechanical cavity system with …
View article: Unveiling quality of clinical trial in China: from concern to confirmation
Unveiling quality of clinical trial in China: from concern to confirmation Open
The cornerstone of scientifically valid and ethically sound clinical trials is in compliance with established global quality requirements. Although China has made significant progress over the past 20 years in terms of the clinical trial q…
View article: Improvement of Winter Wheat Aboveground Biomass Estimation Using Digital Surface Model Information Extracted from Unmanned-Aerial-Vehicle-Based Multispectral Images
Improvement of Winter Wheat Aboveground Biomass Estimation Using Digital Surface Model Information Extracted from Unmanned-Aerial-Vehicle-Based Multispectral Images Open
Aboveground biomass (AGB) is an important indicator for characterizing crop growth conditions. A rapid and accurate estimation of AGB is critical for guiding the management of farmland and achieving production potential, and it can also pr…
View article: Basic magnesium sulfate@TiO2 composite for efficient adsorption and photocatalytic degradation of 4-dodecylmorpholine in brine
Basic magnesium sulfate@TiO2 composite for efficient adsorption and photocatalytic degradation of 4-dodecylmorpholine in brine Open
More than 70% of the potash fertilizer globally is produced by the froth flotation process, in which 4-dodecylmorpholine (DMP) serves as a reverse flotation agent. As the potash fertilizer production rapidly rises, the increased DMP levels…
View article: The molecular mechanism of miRNA-195-5p regulating ERK involvement in abnormal phosphorylation of Tau protein by aluminum maltol in PC12 cells
The molecular mechanism of miRNA-195-5p regulating ERK involvement in abnormal phosphorylation of Tau protein by aluminum maltol in PC12 cells Open
Although aluminum is ubiquitously present on Earth, it is not necessary for life. Aluminum is a metal element that can induce neurotoxicity. The neurotoxicity of aluminum is mainly caused by the aggregation of abnormally phosphorylated tau…
View article: SUMOylation is enriched in the nuclear matrix and required for chromosome segregation
SUMOylation is enriched in the nuclear matrix and required for chromosome segregation Open
As an important posttranslational modification, SUMOylation plays critical roles in almost all biological processes. Although it has been well-documented that SUMOylated proteins are mainly localized in the nucleus and have roles in chroma…
View article: Identification and validation of pyroptosis patterns in AML via comprehensive bioinformatics analysis
Identification and validation of pyroptosis patterns in AML via comprehensive bioinformatics analysis Open
Background Pyroptosis, a new type of programmed cell death, was associated with inflammation, immunity, and the development of tumor. However, the prognostic roles of pyroptosis-related genes and the correlation between pyroptosis and immu…
View article: Identification and validation of 5-methylcytosine-associated genes in diffuse large B-cell lymphoma
Identification and validation of 5-methylcytosine-associated genes in diffuse large B-cell lymphoma Open
View article: Microscopic Pore Structure Characteristics and Fluid Mobility in Tight Reservoirs: A Case Study of the Chang 7 Member in the Western Xin’anbian Area of the Ordos Basin, China
Microscopic Pore Structure Characteristics and Fluid Mobility in Tight Reservoirs: A Case Study of the Chang 7 Member in the Western Xin’anbian Area of the Ordos Basin, China Open
This research addresses the limited understanding of movable fluid occurrence characteristics in the Chang 7 reservoir by employing mercury injection capillary pressure, constant-rate mercury injections, and nuclear magnetic resonance meth…
View article: Engineering Saccharomyces cerevisiae for improved biofilm formation and ethanol production in continuous fermentation
Engineering Saccharomyces cerevisiae for improved biofilm formation and ethanol production in continuous fermentation Open
View article: Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex
Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex Open
Elucidating the cellular organization of the cerebral cortex is critical for understanding brain structure and function. Using large-scale single-nucleus RNA sequencing and spatial transcriptomic analysis of 143 macaque cortical regions, w…
View article: Design and research of environmentally friendly field sewage purification mechanical device
Design and research of environmentally friendly field sewage purification mechanical device Open
The shortage of water resources has become a serious constraint to the sustainable development of the country’s economy and society. The environmentally friendly field sewage purification device is one of the effective ways to reduce water…
View article: Downregulation of Peroxidase Activity of Platinum Cube Enables Minute–Time Scale Colorimetric Signaling of Hypoxanthine for Fish Freshness Monitoring
Downregulation of Peroxidase Activity of Platinum Cube Enables Minute–Time Scale Colorimetric Signaling of Hypoxanthine for Fish Freshness Monitoring Open
Due to its unique biological composition, aquatic products, especially fish, are extremely perishable compared to other muscle products. Herein, we proposed an artificial nanozyme-based colorimetric detection of hypoxanthine (Hx), the indi…
View article: Exosomal miRNAs contribute to coal dust particle-induced pulmonary fibrosis in rats
Exosomal miRNAs contribute to coal dust particle-induced pulmonary fibrosis in rats Open
Coal workers’ pneumoconiosis (CWP) is a fatal occupational disease caused by inhalation of coal dust particles, which leads to progressive pulmonary fibrosis. Recently, as new signal carriers for intercellular communication, exosomal miRNA…
View article: Relationship between microbiota classification and working conditions of sequencing biofilm batch reactor process in Tibetan habitat
Relationship between microbiota classification and working conditions of sequencing biofilm batch reactor process in Tibetan habitat Open
View article: Downregulation of peroxidase activity of platinum cube enables minute-time scale colorimetric signaling of hypoxanthine for fish freshness monitoring
Downregulation of peroxidase activity of platinum cube enables minute-time scale colorimetric signaling of hypoxanthine for fish freshness monitoring Open
Due to the unique biological composition of aquatic products especially fish, it is extremely perishable than other muscle products. Herein, we proposed a polyvinylpyrrolidone-modified platinum cubic nanomaterials (PVP-PtNC) with peroxidas…