Huifen Chen
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View article: Time-updated patterns of hemoglobin and hematocrit and the risk of CKD progression
Time-updated patterns of hemoglobin and hematocrit and the risk of CKD progression Open
Background Early intervention and management of anemia, particularly the commonly used measures of hemoglobin (Hb) and hematocrit (HCT), are important in slowing and preventing the progression of chronic kidney disease (CKD). However, the …
View article: Single-cell profiles delineate immune cell remodeling and enhanced tumor-fibroblast interaction of hepatoblastoma after chemotherapy
Single-cell profiles delineate immune cell remodeling and enhanced tumor-fibroblast interaction of hepatoblastoma after chemotherapy Open
View article: Association between energy intake and prognosis in Chronic Kidney Disease (CKD) stages 3–5: an ambispective cohort study
Association between energy intake and prognosis in Chronic Kidney Disease (CKD) stages 3–5: an ambispective cohort study Open
High and low energy intake are significantly associated with an increased risk of adverse outcomes in non-dialysis CKD 3-5 patients. An energy intake of 24.6-29.5 kcal/kg/day may be optimal to reduce the risk of poor health outcomes.
View article: Research waste among randomized controlled trials in preterm infants: a Cross-sectional study
Research waste among randomized controlled trials in preterm infants: a Cross-sectional study Open
Nearly 70% of RCTs involving preterm infants exhibited features of research waste. However, large-scale RCTs conducted in North America and Europe were less likely to contribute to this issue.
View article: Dietary quality and adherence to dietary recommendations in Chinese patients with chronic kidney disease
Dietary quality and adherence to dietary recommendations in Chinese patients with chronic kidney disease Open
Objectives There is a lack of data regarding the quality of the diet and the adherence to dietary guidelines of patients with non-dialysis-dependent CKD (NDD-CKD) in China. Design and methods Single-center cross-sectional study of 261 pati…
View article: Single-cell sequencing of the vermiform appendix during development identifies transcriptional relationships with appendicitis in preschool children
Single-cell sequencing of the vermiform appendix during development identifies transcriptional relationships with appendicitis in preschool children Open
View article: Author Response: Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2
Author Response: Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2 Open
View article: Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2
Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2 Open
Activation of the extracellular signal-regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Discovery of TRPA1 Antagonist <b>GDC-6599</b>: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease
Discovery of TRPA1 Antagonist <b>GDC-6599</b>: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease Open
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium ion channel highly expressed in the primary sensory neurons, functioning as a polymodal sensor for exogenous and endogenous stimuli, and has been implicated in neurop…
View article: Ultra-processed food consumption and the risk of incident chronic kidney disease: a systematic review and meta-analysis of cohort studies
Ultra-processed food consumption and the risk of incident chronic kidney disease: a systematic review and meta-analysis of cohort studies Open
Recent individual studies have indicated that ultra-processed food (UPF) consumption may be associated with the incidence of chronic kidney disease (CKD). We conducted a systematic review and meta-analysis based on those longitudinal studi…
View article: Progress in Biomarkers Related to Biliary Atresia
Progress in Biomarkers Related to Biliary Atresia Open
Biliary atresia (BA) is a congenital cholestatic disease that can seriously damage children's liver function. It is one of the main reasons for liver transplantation in children. Early diagnosis of BA is crucial to the prognosis of patient…
View article: Lipid parameters, adipose tissue distribution and prognosis prediction in chronic kidney Disease patients
Lipid parameters, adipose tissue distribution and prognosis prediction in chronic kidney Disease patients Open
View article: PROTACs Targeting BRM (SMARCA2) Afford Selective <i>In Vivo</i> Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models
PROTACs Targeting BRM (SMARCA2) Afford Selective <i>In Vivo</i> Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models Open
The identification of VHL-binding proteolysis targeting chimeras (PROTACs) that potently degrade the BRM protein (also known as SMARCA2) in SW1573 cell-based experiments is described. These molecules exhibit between 10- and 100-fold degrad…
View article: Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Author Response: Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Author Response: Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Composite Lipid Parameters are Optimal in Predicting Chronic Kidney Disease Prognosis
Composite Lipid Parameters are Optimal in Predicting Chronic Kidney Disease Prognosis Open
Background Lipid management in clinic is critical to the prevention and treatment of CKD, while the manifestations of fat metabolism vary in type and have flexible correlations with CKD prognosis. Purpose Explore correlations between the w…
View article: Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2
Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2 Open
Activation of the extracellular signal-regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Reviewer #3 (Public Review): Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Reviewer #3 (Public Review): Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Reviewer #2 (Public Review): Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Reviewer #2 (Public Review): Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Reviewer #1 (Public Review): Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Reviewer #1 (Public Review): Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Generation of a whole-brain hemodynamic response function and sex-specific differences in cerebral processing of mechano-sensation in mice detected by BOLD fMRI
Generation of a whole-brain hemodynamic response function and sex-specific differences in cerebral processing of mechano-sensation in mice detected by BOLD fMRI Open
BOLD fMRI has become a prevalent method to study cerebral sensory processing in rodent disease models, including pain and mechanical hypersensitivity. fMRI data analysis is frequently combined with a general-linear-model (GLM) -based analy…
View article: Supplementary Figures 1-7, Methods from ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors
Supplementary Figures 1-7, Methods from ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors Open
PDF file - 451K
View article: Data from ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors
Data from ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors Open
The RAS/RAF/MEK pathway is activated in more than 30% of human cancers, most commonly via mutation in the K-ras oncogene and also via mutations in BRAF. Several allosteric mitogen-activated protein/extracellular signal–regulated kin…
View article: Supplementary Figures 1-7, Methods from ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors
Supplementary Figures 1-7, Methods from ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors Open
PDF file - 451K
View article: Data from ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors
Data from ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors Open
The RAS/RAF/MEK pathway is activated in more than 30% of human cancers, most commonly via mutation in the K-ras oncogene and also via mutations in BRAF. Several allosteric mitogen-activated protein/extracellular signal–regulated kin…
View article: Machine learning algorithms’ accuracy in predicting kidney disease progression: a systematic review and meta-analysis
Machine learning algorithms’ accuracy in predicting kidney disease progression: a systematic review and meta-analysis Open
View article: Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors
Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors Open
VPS34 is a class III phosphoinositide 3-kinase involved in endosomal trafficking and autophagosome formation. Inhibitors of VPS34 were believed to have value as anticancer agents, but genetic and pharmacological data suggest that sustained…
View article: A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists
A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists Open
Transient receptor potential ankyrin 1 (TRPA1) antagonists have generated broad interest in the pharmaceutical industry for the treatment of both pain and asthma. Over the past decade, multiple antagonist classes have been reported in the …