Huige Li
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View article: M <sup>3</sup> NID: an intrusion detection system based on the dual-mode spatio-temporal feature fusion method
M <sup>3</sup> NID: an intrusion detection system based on the dual-mode spatio-temporal feature fusion method Open
The rapid adoption of cloud computing and big data has led to increasingly sophisticated cyberattacks that exploit weaknesses in conventional network defenses. Although machine learning-based intrusion detection systems (IDS) have made con…
View article: The influence of physical activity on the mental health of high school students: the chain mediating effects of social support and self-esteem
The influence of physical activity on the mental health of high school students: the chain mediating effects of social support and self-esteem Open
Mental health issues among high school students have become increasingly prominent. While physical activity is recognized for its ability to reduce symptoms of anxiety and depression, the underlying psychological mechanisms of this effect …
View article: Vascular effects of perivascular adipose tissue-derived chemerin in obesity-associated cardiovascular disease
Vascular effects of perivascular adipose tissue-derived chemerin in obesity-associated cardiovascular disease Open
Perivascular adipose tissue (PVAT) is a unique and metabolically active adipose tissue that is adjacent to most systemic blood vessels. Healthy PVAT exerts anticontractile and anti-inflammatory effects, contributing to vascular protection.…
View article: Pharmacological targeting of endothelial nitric oxide synthase dysfunction and nitric oxide replacement therapy
Pharmacological targeting of endothelial nitric oxide synthase dysfunction and nitric oxide replacement therapy Open
The Global Burden of Disease Study identified cardiovascular risk factors as leading causes of global deaths and life-years lost. Endothelial dysfunction is a pathomechanism associated with these risk factors and stressors, and is an early…
View article: Interventions by Cardiovascular Drugs Against Aircraft Noise-Induced Cardiovascular Oxidative Stress and Damage
Interventions by Cardiovascular Drugs Against Aircraft Noise-Induced Cardiovascular Oxidative Stress and Damage Open
Noise pollution is a known health risk factor and evidence for cardiovascular diseases associated with traffic noise is growing. At least 20% of the European Union’s population lives in noise-polluted areas with exposure levels exceeding t…
View article: CTMAPPO-Clip: A CTCE-Based Approach to Mitigate Policy Overfitting in Multi-Agent Reinforcement Learning
CTMAPPO-Clip: A CTCE-Based Approach to Mitigate Policy Overfitting in Multi-Agent Reinforcement Learning Open
View article: Exposure to aircraft noise exacerbates cardiovascular and oxidative damage in three mouse models of diabetes
Exposure to aircraft noise exacerbates cardiovascular and oxidative damage in three mouse models of diabetes Open
Aims Epidemiology links noise to increased risk of metabolic diseases like diabetes and obesity. Translational studies in humans and experimental animals showed that noise causes reactive oxygen species (ROS)–mediated cardiovascular damage…
View article: The multifaceted roles of B lymphocytes in metabolic dysfunction–associated steatotic liver disease
The multifaceted roles of B lymphocytes in metabolic dysfunction–associated steatotic liver disease Open
Recent evidence suggests that adaptive immune cells are important contributors to metabolic dysfunction–associated steatotic liver disease (MASLD, formerly non-alcoholic fatty liver disease, NAFLD). In liver biopsies from MASLD patients, t…
View article: MM-Transformer: a Transformer-based Knowledge Graph Link Prediction Model by Fusing Multimodal Features
MM-Transformer: a Transformer-based Knowledge Graph Link Prediction Model by Fusing Multimodal Features Open
Multimodal knowledge graph completion necessitates the integration of information from multiple modalities (such as images and text) into the structural representation of entities to improve link prediction. However, most existing studies …
View article: An intrusion detection system based on convolution neural network
An intrusion detection system based on convolution neural network Open
With the rapid extensive development of the Internet, users not only enjoy great convenience but also face numerous serious security problems. The increasing frequency of data breaches has made it clear that the network security situation …
View article: Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2/ET-1 axis-controlled ERK1/2 pathway
Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2/ET-1 axis-controlled ERK1/2 pathway Open
View article: High-fat diet causes endothelial dysfunction in the mouse ophthalmic artery
High-fat diet causes endothelial dysfunction in the mouse ophthalmic artery Open
Obesity is a significant health concern that leads to impaired vascular function and subsequent abnormalities in various organs. The impact of obesity on ocular blood vessels, however, remains largely unclear. In this study, we examined th…
View article: Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin
Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin Open
Aims Obesity is an epidemic that is a critical contributor to hypertension and other cardiovascular diseases. Current paradigms suggest that endothelial nitric oxide synthase (eNOS/NOS3) in the vessel wall is the primary regulator of vascu…
View article: B-118 Evaluation of Thirteen Commercially Available Clinical Chemistry Assays on the Alinity® <i>c</i> System
B-118 Evaluation of Thirteen Commercially Available Clinical Chemistry Assays on the Alinity® <i>c</i> System Open
Background Expansion of instrument analyte menus is often needed to accommodate country specific needs. To address specific needs in China, thirteen clinical chemistry assays have been modified for evaluation on the Alinity c system. These…
View article: Studies on the Effects of Hypercholesterolemia on Mouse Ophthalmic Artery Reactivity
Studies on the Effects of Hypercholesterolemia on Mouse Ophthalmic Artery Reactivity Open
Atherogenic lipoproteins may impair vascular reactivity, leading to tissue damage in various organs, including the eye. This study aimed to investigate whether ophthalmic artery reactivity is affected in mice lacking the apolipoprotein E g…
View article: Effects of Chronic Apolipoprotein E Deficiency on Mouse Ophthalmic Artery Reactivity
Effects of Chronic Apolipoprotein E Deficiency on Mouse Ophthalmic Artery Reactivity Open
Atherogenic lipoproteins may impair vascular reactivity, leading to tissue damage in various organs, including the eye. This study aimed to investigate whether ophthalmic artery reactivity is affected in mice lacking the apolipoprotein E g…
View article: Perivascular Adipose Tissue Oxidative Stress in Obesity
Perivascular Adipose Tissue Oxidative Stress in Obesity Open
Perivascular adipose tissue (PVAT) adheres to most systemic blood vessels in the body. Healthy PVAT exerts anticontractile effects on blood vessels and further protects against cardiovascular and metabolic diseases. Healthy PVAT regulates …
View article: Effects of aircraft noise cessation on blood pressure, cardio- and cerebrovascular endothelial function, oxidative stress, and inflammation in an experimental animal model
Effects of aircraft noise cessation on blood pressure, cardio- and cerebrovascular endothelial function, oxidative stress, and inflammation in an experimental animal model Open
View article: Research progress on pleiotropic neuroprotective drugs for traumatic brain injury
Research progress on pleiotropic neuroprotective drugs for traumatic brain injury Open
Traumatic brain injury (TBI) has become one of the most important causes of death and disability worldwide. A series of neuroinflammatory responses induced after TBI are key factors for persistent neuronal damage, but at the same time, suc…
View article: Research progress of neuroinflammation-related cells in traumatic brain injury: A review
Research progress of neuroinflammation-related cells in traumatic brain injury: A review Open
Neuroinflammation after traumatic brain injury (TBI) is related to chronic neurodegenerative diseases and is one of the causes of acute secondary injury after TBI. Therefore, it is particularly important to clarify the role of cellular mec…
View article: Models of traumatic brain injury-highlights and drawbacks
Models of traumatic brain injury-highlights and drawbacks Open
Traumatic brain injury (TBI) is the leading cause for high morbidity and mortality rates in young adults, survivors may suffer from long-term physical, cognitive, and/or psychological disorders. Establishing better models of TBI would furt…
View article: Alcohol and the vasculature: a love-hate relationship?
Alcohol and the vasculature: a love-hate relationship? Open
Alcohol consumption is a leading risk factor and increases the risk of liver diseases, cancers, tuberculosis, and injuries. The relationship between alcohol use and cardiovascular risk is complex. While it is well established that heavy al…
View article: Dietary supplements and vascular function in hypertensive disorders of pregnancy
Dietary supplements and vascular function in hypertensive disorders of pregnancy Open
Hypertensive disorders of pregnancy are complications that can lead to maternal and infant mortality and morbidity. Hypertensive disorders of pregnancy are generally defined as hypertension and may be accompanied by other end organ damages…
View article: Effects of Resveratrol on Vascular Function in Retinal Ischemia-Reperfusion Injury
Effects of Resveratrol on Vascular Function in Retinal Ischemia-Reperfusion Injury Open
Ischemia-reperfusion (I/R) events are involved in the development of various ocular pathologies, e.g., retinal artery or vein occlusion. We tested the hypothesis that resveratrol is protective against I/R injury in the murine retina. Intra…
View article: B lymphocyte-deficiency in mice promotes venous thrombosis
B lymphocyte-deficiency in mice promotes venous thrombosis Open
View article: Intraocular Pressure-Induced Endothelial Dysfunction of Retinal Blood Vessels Is Persistent, but Does Not Trigger Retinal Ganglion Cell Loss
Intraocular Pressure-Induced Endothelial Dysfunction of Retinal Blood Vessels Is Persistent, but Does Not Trigger Retinal Ganglion Cell Loss Open
Research has been conducted into vascular abnormalities in the pathogenesis of glaucoma, but conclusions remain controversial. Our aim was to test the hypothesis that retinal endothelial dysfunction induced by elevated intraocular pressure…
View article: Analysis of 16 studies in nine rodent models does not support the hypothesis that diabetic polyuria is a main reason of urinary bladder enlargement
Analysis of 16 studies in nine rodent models does not support the hypothesis that diabetic polyuria is a main reason of urinary bladder enlargement Open
The urinary bladder is markedly enlarged in the type 1 diabetes mellitus model of streptozotocin-injected rats, which may contribute to the frequent diabetic uropathy. Much less data exists for models of type 2 diabetes. Diabetic polyuria …
View article: Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue
Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue Open
Perivascular adipose tissue (PVAT) is a special type of ectopic fat depot that adheres to most vasculatures. PVAT has been shown to exert anticontractile effects on the blood vessels and confers protective effects against metabolic and car…
View article: Cases Abusing Brain Death Definition in Organ Procurement in China
Cases Abusing Brain Death Definition in Organ Procurement in China Open
Organ donation after brain death has been practiced in China since 2003 in the absence of brain death legislation. Similar to international standards, China’s brain death diagnostic criteria include coma, absence of brainstem reflexes, and…
View article: Measurement of Tetrahydrobiopterin in Animal Tissue Samples by HPLC with Electrochemical Detection—Protocol Optimization and Pitfalls
Measurement of Tetrahydrobiopterin in Animal Tissue Samples by HPLC with Electrochemical Detection—Protocol Optimization and Pitfalls Open
Tetrahydrobiopterin (BH4) is an essential cofactor of all nitric oxide synthase isoforms, thus determination of BH4 levels can provide important mechanistic insight into diseases. We established a protocol for high-performance liquid chrom…