Huige Lin
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Taurine Alleviates Pancreatic β‐Cell Senescence by Inhibition of p53 Pathway Open
Background Pancreatic β‐cells function deteriorates during aging, leading to increased risk of type 2 diabetes. We and others previously demonstrated that p53 activation triggers β‐cell senescence and dysfunction in aging, but how its acti…
The mitochondrial enzyme pyruvate carboxylase restricts pancreatic β-cell senescence by blocking p53 activation Open
Defective glucose-stimulated insulin secretion (GSIS) and β-cell senescence are hallmarks in diabetes. The mitochondrial enzyme pyruvate carboxylase (PC) has been shown to promote GSIS and β-cell proliferation in the clonal β-cell lines, y…
Hepatic MDM2 Causes Metabolic Associated Fatty Liver Disease by Blocking Triglyceride‐VLDL Secretion via ApoB Degradation Open
Dysfunctional triglyceride‐very low‐density lipoprotein (TG‐VLDL) metabolism is linked to metabolic‐associated fatty liver disease (MAFLD); however, the underlying cause remains unclear. The study shows that hepatic E3 ubiquitin ligase mur…
The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells Open
Significance Dysregulation of cytoskeletal remodeling could result in defective GSIS and cause type 2 diabetes. Previous studies have reported the role of small GTPases including Rac1 and Cdc42 in the regulation of F-actin remodeling, wher…