Huihong Zhang
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View article: Genetic architecture of primary sclerosing cholangitis: shared pathways with inflammatory bowel disease and gut-liver axis mediation
Genetic architecture of primary sclerosing cholangitis: shared pathways with inflammatory bowel disease and gut-liver axis mediation Open
Background: Primary sclerosing cholangitis (PSC) is a chronic liver disease strongly linked to inflammatory bowel disease (IBD), yet its causal genetic drivers and the mechanisms underlying this comorbidity remain poorly understood. This s…
View article: Integration of single-cell and bulk transcriptomics to explore prognostic and immunotherapeutic characteristics of sodium overload-induced cell death in lung adenocarcinoma
Integration of single-cell and bulk transcriptomics to explore prognostic and immunotherapeutic characteristics of sodium overload-induced cell death in lung adenocarcinoma Open
The prognostic model developed from NECSOs enables robust survival prediction for LUAD patients and provides insights into the immune landscape of LUAD. Notably, epithelial cells with higher NECSOs scores displayed a greater propensity for…
View article: Immunoregulatory peptides from <em>Ganoderma sinense</em>: Characterization, isolation, molecular docking and molecular mechanism
Immunoregulatory peptides from <em>Ganoderma sinense</em>: Characterization, isolation, molecular docking and molecular mechanism Open
View article: Transcriptomic and ultrastructural insights into zinc-induced hormesis in wheat seedlings: Glutathione-mediated antioxidant defense in zinc toxicity regulation
Transcriptomic and ultrastructural insights into zinc-induced hormesis in wheat seedlings: Glutathione-mediated antioxidant defense in zinc toxicity regulation Open
View article: Elucidating the interaction and toxicity of cadmium and cerium on the growth of maize seedlings: Insights from morpho-physiological and biochemical analysis
Elucidating the interaction and toxicity of cadmium and cerium on the growth of maize seedlings: Insights from morpho-physiological and biochemical analysis Open
The exploitation of rare earth elements (REEs) is often accompanied by heavy metal contamination. However, our understanding regarding the growth responses of plants to the co-existence of REEs and heavy metals (HMs), remains limited. In t…
View article: A turn-on fluorescent chemical sensor based on imidazole-Schiff base structure for highly selective and accurate detection of Al3+ ions in living cells
A turn-on fluorescent chemical sensor based on imidazole-Schiff base structure for highly selective and accurate detection of Al3+ ions in living cells Open
An imidazole-Schiff base fluorescent probe EBI was designed and synthesized for the sensitive and selective detection of Al3+. The probe EBI exhibits good anti-interference performance against Al3+ in the presence of …
View article: VEGF-A Remissions Brown Adipocyte Function Following Combined Exposure to Bisphenol A and a High-Fat Diet
VEGF-A Remissions Brown Adipocyte Function Following Combined Exposure to Bisphenol A and a High-Fat Diet Open
Obesity has emerged as a global health crisis, with its pathogenesis being closely linked to metabolic dysregulation in brown adipose tissue (BAT). However, the underlying mechanisms by which high-fat diets and environmental endocrine disr…
View article: A Turn-On Fluorescent Chemical Sensor Based on Imidazole-Schiff Base Structure for Highly Selective and Accurate Detection of Al3+ Ion in Living Cells
A Turn-On Fluorescent Chemical Sensor Based on Imidazole-Schiff Base Structure for Highly Selective and Accurate Detection of Al3+ Ion in Living Cells Open
View article: Early‐Life Exposure to Bisphenol A Damaged Pancreas That May Increase Offspring Sensitivity to High‐Fat Diets
Early‐Life Exposure to Bisphenol A Damaged Pancreas That May Increase Offspring Sensitivity to High‐Fat Diets Open
Previous studies have identified early life as a sensitive window for BPA exposure that may increase the risk of metabolic disease in adulthood. However, less attention has been paid to the effects of early‐life BPA exposure on the pancrea…
View article: The clinical and neuropsychological profiles of Alzheimer’s disease with white matter hyperintensity in North China
The clinical and neuropsychological profiles of Alzheimer’s disease with white matter hyperintensity in North China Open
Background Patients with Alzheimer’s disease (AD) often exhibit characteristic clinical manifestations, particularly neuropsychiatric symptoms. Previous studies have shown that white matter hyperintensity (WMH) is strongly associated with …
View article: Biodegradation of phenol-contaminated soil and plant growth promotion by <i>Myroides xuanwuensis</i> H13
Biodegradation of phenol-contaminated soil and plant growth promotion by <i>Myroides xuanwuensis</i> H13 Open
Physicochemical methods for remediating phenol-contaminated soils are costly and inefficient, making biodegradation an environmentally friendly alternative approach. This study aims to screen for potential phenol-degrading bacteria and to …
View article: Elucidating the Interaction and Toxicity of Cadmium and Cerium on the Growth of Maize Seedlings: Insights from Morph-Physiological and Biochemical Analysis
Elucidating the Interaction and Toxicity of Cadmium and Cerium on the Growth of Maize Seedlings: Insights from Morph-Physiological and Biochemical Analysis Open
View article: Deciphering Primary Sclerosing Cholangitis: A Comprehensive Genetic Approach to Unravel the Gut-Liver Axis and Microbiome Influences
Deciphering Primary Sclerosing Cholangitis: A Comprehensive Genetic Approach to Unravel the Gut-Liver Axis and Microbiome Influences Open
View article: Elucidating the Interactive and Toxicological Effects of Maize Seedlings Under Combined Exposure of Cadmium and Cerium: Insights from Morphological, Physiological, and Molecular Docking Analyses
Elucidating the Interactive and Toxicological Effects of Maize Seedlings Under Combined Exposure of Cadmium and Cerium: Insights from Morphological, Physiological, and Molecular Docking Analyses Open
View article: Colorimetric Fluorescence of the 1,10-Phenantholineyl-Imidazole Sensor Probe for the Selective Detection of Zn 2+ And Cd 2+ Ions
Colorimetric Fluorescence of the 1,10-Phenantholineyl-Imidazole Sensor Probe for the Selective Detection of Zn 2+ And Cd 2+ Ions Open
View article: Hardware Design and Implementation of a Lightweight Saber Algorithm Based on DRC Method
Hardware Design and Implementation of a Lightweight Saber Algorithm Based on DRC Method Open
With the development of quantum computers, the security of classical cryptosystems is seriously threatened, and the Saber algorithm has become one of the potential candidates for post-quantum cryptosystems (PQCs). To address the problems o…
View article: Effects of physical exercise intervention on depressive and anxious moods of college students: A meta-analysis of randomized controlled trials
Effects of physical exercise intervention on depressive and anxious moods of college students: A meta-analysis of randomized controlled trials Open
Background: Due to the limitation of drug treatment and other adverse reactions, many psychological treatments always adopt rehabilitation training or non-drug intervention methods, while physical exercise is considered as an auxiliary way…
View article: Convolutional Neural Network-Based Lightweight Hardware Ip Core Design for Eeg Epilepsy Prediction
Convolutional Neural Network-Based Lightweight Hardware Ip Core Design for Eeg Epilepsy Prediction Open
View article: Screening of phosphate-solubilizing bacteria and their abilities of phosphorus solubilization and wheat growth promotion
Screening of phosphate-solubilizing bacteria and their abilities of phosphorus solubilization and wheat growth promotion Open
Background Phosphate-solubilizing bacteria (PSB) can enhance plant growth and phosphorus (P) solubilization, it also has been reported to reduce the negative effects of overused agricultural fertilizer in farmland and protect the soil envi…
View article: Case analysis of early-onset Alzheimer's disease associated with TBK1 p.Tyr235Phe gene mutation
Case analysis of early-onset Alzheimer's disease associated with TBK1 p.Tyr235Phe gene mutation Open
TANK1-binding kinase 1 (TBK1) is mainly involved in the regulation of various cellular pathways through the autophagic lysosomal system, and the loss of function or hypofunction caused by TBK1 gene mutation mainly leads to frontotemporal l…
View article: Early-stage differentiation between Alzheimer’s disease and frontotemporal lobe degeneration: Clinical, neuropsychology, and neuroimaging features
Early-stage differentiation between Alzheimer’s disease and frontotemporal lobe degeneration: Clinical, neuropsychology, and neuroimaging features Open
Background Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) are the two most common forms of neurodegenerative dementia. Although both of them have well-established diagnostic criteria, achieving early diagnosis remain…
View article: Preparation and Characterization of Electrospun PAN-CuCl2 Composite Nanofiber Membranes with a Special Net Structure for High-Performance Air Filters
Preparation and Characterization of Electrospun PAN-CuCl2 Composite Nanofiber Membranes with a Special Net Structure for High-Performance Air Filters Open
The growing issue of particulate matter (PM) air pollution has given rise to extensive research into the development of high-performance air filters recently. As the core of air filters, various types of electrospun nanofiber membranes hav…
View article: Hypophosphatemia and Poor Prognosis in Critically Ill Patients: A Systematic Review and Meta-Analysis
Hypophosphatemia and Poor Prognosis in Critically Ill Patients: A Systematic Review and Meta-Analysis Open
View article: Characteristics of cognitive and neuropsychiatric behavioral features of Alzheimer's disease with white matter lesion
Characteristics of cognitive and neuropsychiatric behavioral features of Alzheimer's disease with white matter lesion Open
Objective To study the characteristics of cognitive and neuropsychiatric behavioral features of Alzheimer's disease (AD) with white matter lesion (WML). Methods A total of 58 cases of AD patients were reruited from January 2010 to December…
View article: Objective Assessment of Hyposmia in Alzheimer's Disease From Image and Behavior by Combining Pleasant Odor With Unpleasant Odor
Objective Assessment of Hyposmia in Alzheimer's Disease From Image and Behavior by Combining Pleasant Odor With Unpleasant Odor Open
Background: Olfactory functional magnetic resonance imaging (fMRI) of responses to a pleasant odor (PO) (lavender) can objectively evaluate olfactory dysfunction in Alzheimer's disease (AD) patients. The brain responses to a PO and unpleas…
View article: Association between maternal thallium exposure and risk of gestational diabetes mellitus: Evidence from a birth cohort study
Association between maternal thallium exposure and risk of gestational diabetes mellitus: Evidence from a birth cohort study Open
View article: Mean Apparent Propagator MRI Is Better Than Conventional Diffusion Tensor Imaging for the Evaluation of Parkinson’s Disease: A Prospective Pilot Study
Mean Apparent Propagator MRI Is Better Than Conventional Diffusion Tensor Imaging for the Evaluation of Parkinson’s Disease: A Prospective Pilot Study Open
MAP MRI outperformed the conventional DTI in the diagnosis of PD and evaluation of the disease severity.
View article: The clinical significance of the SIRT2 expression level in the early stage of sepsis patients
The clinical significance of the SIRT2 expression level in the early stage of sepsis patients Open
The data demonstrate that sepsis and septic shock patients have a decreased expression level of SIRT2 mRNA, and thus SIRT2 may be a potential biomarker for the diagnosis of sepsis, akin to PCT and hs-CRP.
View article: Plasma cholesterol in Alzheimer’s disease and frontotemporal dementia
Plasma cholesterol in Alzheimer’s disease and frontotemporal dementia Open
Background The relationship between the apolipoprotein E ( APOE )- ε4 allele, triglyceride (TG) level, and cholesterol level and an increased risk of developing Alzheimer’s disease (AD) has been well established, but their relationship wit…
Circadian misalignment alters insulin sensitivity during the light phase and shifts glucose tolerance rhythms in female mice Open