Huijie Cui
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View article: Adult Height, Cardiovascular Disease, and the Underlying Mechanism: A Comprehensive Epidemiological and Genetic Analysis
Adult Height, Cardiovascular Disease, and the Underlying Mechanism: A Comprehensive Epidemiological and Genetic Analysis Open
Our study confirms the health effects of height on CAD, atrial fibrillation, and venous thromboembolism and emphasizes forced vital capacity as the primary pathway that links height to CAD. Importantly, it indicates that the CAD risk assoc…
View article: Research on the Judicial Application of the Crime of Sexual Assault by Persons with Care Duties
Research on the Judicial Application of the Crime of Sexual Assault by Persons with Care Duties Open
The Criminal Law Amendment (XI) adds the crime of sexual assault by persons with care duties, and since this crime is a new crime, many controversies and problems have arisen in judicial practice, such as how to identify the legal interest…
View article: The reporting quality and methodological quality of dynamic prediction models for cancer prognosis
The reporting quality and methodological quality of dynamic prediction models for cancer prognosis Open
View article: Genomic correlation, shared loci, and causal association between obesity, periodontitis and tooth loss
Genomic correlation, shared loci, and causal association between obesity, periodontitis and tooth loss Open
Observational studies have reported an association of obesity with periodontitis and tooth loss, yet findings remain inconsistent. We aim to investigate the genetic link underlying obesity-related traits (BMI [body mass index], WHR [waist-…
View article: Integrating Experimental and Computational Analyses for Mechanical Characterization of Titanium Carbide/Aluminum Metal Matrix Composites
Integrating Experimental and Computational Analyses for Mechanical Characterization of Titanium Carbide/Aluminum Metal Matrix Composites Open
This study investigates the mechanical properties of titanium carbide/aluminum metal matrix composites (AMMCs) using both experimental and computational methods. Through accumulative roll bonding (ARB) and cryorolling (CR) processes, AA105…
View article: Risk factors for prostate cancer: An umbrella review of prospective observational studies and mendelian randomization analyses
Risk factors for prostate cancer: An umbrella review of prospective observational studies and mendelian randomization analyses Open
Background The incidence of prostate cancer is increasing in older males globally. Age, ethnicity, and family history are identified as the well-known risk factors for prostate cancer, but few modifiable factors have been firmly establishe…
View article: Independent association of general and central adiposity with risk of gallstone disease: observational and genetic analyses
Independent association of general and central adiposity with risk of gallstone disease: observational and genetic analyses Open
Background General obesity is a well-established risk factor for gallstone disease (GSD), but whether central obesity contributes additional independent risk remains controversial. We aimed to comprehensively clarify the effect of body fat…
View article: Observational and genetic analyses clarify the relationship between type 2 diabetes mellitus and gallstone disease
Observational and genetic analyses clarify the relationship between type 2 diabetes mellitus and gallstone disease Open
Background The relationship between type 2 diabetes mellitus (T2DM) and gallstone disease (GSD) have been incompletely understood. We aimed to investigate their phenotypic and genetic associations and evaluate the biological mechanisms und…
View article: Microstructure and Mechanical Properties of AA1050/AA6061 Laminated Composites Fabricated through Three-Cycle Accumulative Roll Bonding and Subsequent Cryorolling
Microstructure and Mechanical Properties of AA1050/AA6061 Laminated Composites Fabricated through Three-Cycle Accumulative Roll Bonding and Subsequent Cryorolling Open
In this study, AA1050/AA6061 laminated composites were prepared by three-cycle accumulative roll bonding (ARB) and subsequent rolling. The effects of the rolling process on the microstructure evolution and mechanical properties of AA1050/A…
View article: Bidirectional relationship between type 2 diabetes mellitus and coronary artery disease: Prospective cohort study and genetic analyses
Bidirectional relationship between type 2 diabetes mellitus and coronary artery disease: Prospective cohort study and genetic analyses Open
Background: While type 2 diabetes mellitus (T2DM) is considered a putative causal risk factor for coronary artery disease (CAD), the intrinsic link underlying T2DM and CAD is not fully understood. We aimed to highlight the importance of in…
View article: 45P Therapeutic potential of ISM8207: A novel QPCTL inhibitor, in triple-negative breast cancer and B-cell non-Hodgkin lymphoma
45P Therapeutic potential of ISM8207: A novel QPCTL inhibitor, in triple-negative breast cancer and B-cell non-Hodgkin lymphoma Open
View article: Understanding the relationship between circulating lipids and risk of chronic kidney disease: a prospective cohort study and large-scale genetic analyses
Understanding the relationship between circulating lipids and risk of chronic kidney disease: a prospective cohort study and large-scale genetic analyses Open
Background This study aims to comprehensively investigate the phenotypic and genetic relationships between four common lipids (high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; total cholesterol, TC; …
View article: Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses
Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses Open
View article: Genetic Correlation, Shared Loci, and Causal Association Between Sex Hormone-Binding Globulin and Bone Mineral Density: Insights From a Large-Scale Genomewide Cross-Trait Analysis
Genetic Correlation, Shared Loci, and Causal Association Between Sex Hormone-Binding Globulin and Bone Mineral Density: Insights From a Large-Scale Genomewide Cross-Trait Analysis Open
Although the impact of sex hormones on bone metabolism is well-documented, effect of their primary modulator, sex hormone-binding globulin (SHBG), remains inconclusive. This study aims to elucidate the genetic overlap between SHBG and heel…
View article: Additional Evidence for the Relationship between Type 2 Diabetes Mellitus and Stroke through Observational and Genetic Analyses
Additional Evidence for the Relationship between Type 2 Diabetes Mellitus and Stroke through Observational and Genetic Analyses Open
While type 2 diabetes mellitus (T2DM) is commonly considered a putative causal risk factor for stroke, the effect of stroke on T2DM remains unclear. The intrinsic link underlying T2DM and stroke has neither been thoroughly examined. We aim…
View article: The impact of immunoglobulin G N-glycosylation level on COVID-19 outcome: evidence from a Mendelian randomization study
The impact of immunoglobulin G N-glycosylation level on COVID-19 outcome: evidence from a Mendelian randomization study Open
Background The coronavirus disease 2019 (COVID-19) pandemic has exerted a profound influence on humans. Increasing evidence shows that immune response is crucial in influencing the risk of infection and disease severity. Observational stud…
View article: Additional Evidence for the Relationship between Type 2 Diabetes Mellitus and Stroke through Observational and Genetic Analyses
Additional Evidence for the Relationship between Type 2 Diabetes Mellitus and Stroke through Observational and Genetic Analyses Open
While type 2 diabetes mellitus (T2DM) is commonly considered a putative causal risk factor for stroke, the effect of stroke on T2DM remains unclear. The intrinsic link underlying T2DM and stroke has neither been thoroughly examined. We aim…
View article: Additional Evidence for the Relationship between Type 2 Diabetes Mellitus and Stroke through Observational and Genetic Analyses
Additional Evidence for the Relationship between Type 2 Diabetes Mellitus and Stroke through Observational and Genetic Analyses Open
While type 2 diabetes mellitus (T2DM) is commonly considered a putative causal risk factor for stroke, the effect of stroke on T2DM remains unclear. The intrinsic link underlying T2DM and stroke has neither been thoroughly examined. We aim…
View article: Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer
Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer Open
Background and Hypothesis While the phenotypic association between schizophrenia and breast cancer has been observed, the underlying intrinsic link is not adequately understood. We aim to conduct a comprehensive interrogation on both pheno…
View article: Migraine, chronic kidney disease and kidney function: observational and genetic analyses
Migraine, chronic kidney disease and kidney function: observational and genetic analyses Open
View article: Temporal relationship between sleep duration and obesity among Chinese Han people and ethnic minorities
Temporal relationship between sleep duration and obesity among Chinese Han people and ethnic minorities Open
View article: Additional file 1 of Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses
Additional file 1 of Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses Open
Additional file 1: Table S1. Characteristics of genetic instruments of gallstone disease. Table S2. Data sources, sample sizes, number of IVs. Table S3. The detailed search strategy for meta-analysis. Table S4. STROBE-MR checklist of recom…
View article: Addictive behavior and incident gallstone disease: A dose–response meta-analysis and Mendelian randomization study
Addictive behavior and incident gallstone disease: A dose–response meta-analysis and Mendelian randomization study Open
Background Previous studies have suggested associations between addictive behavior and gallstone disease (GSD) risk, yet conflicting results exist. It also remains unclear whether this association is causal or due to confounding or reverse…
View article: Targeting fibrosis: mechanisms and clinical trials
Targeting fibrosis: mechanisms and clinical trials Open
View article: Effects of long-term thermal aging on the microstructure and mechanical behaviors of 16MND5/Alloy 152 dissimilar metal weld
Effects of long-term thermal aging on the microstructure and mechanical behaviors of 16MND5/Alloy 152 dissimilar metal weld Open
The effect of thermal aging on microstructural evolution and mechanical behavior was investigated via advanced instrumental analysis. The scanning electron microscope (SEM) results demonstrated that the microstructure transformed from mart…
View article: Cumulative Evidence for Associations Between Genetic Variants in Interleukin 6 Receptor Gene and Human Diseases and Phenotypes
Cumulative Evidence for Associations Between Genetic Variants in Interleukin 6 Receptor Gene and Human Diseases and Phenotypes Open
Background Genetic studies have linked polymorphisms in the interleukin 6 receptor ( IL6R ) gene to the risk of multiple human diseases and phenotypes, yet have reported inconsistent results. We aimed to synthesize current knowledge of var…
View article: Novel physical performance-based models for activities of daily living disability prediction among Chinese older community population: a nationally representative survey in China
Novel physical performance-based models for activities of daily living disability prediction among Chinese older community population: a nationally representative survey in China Open
Background Physical performances including upper and lower limb functions have predictive roles in activities of daily living (ADL) disability, but they have rarely been incorporated into prediction models. This study primarily aimed to de…
View article: The Causal Relationships Between Extrinsic Exposures and Risk of Prostate Cancer: A Phenome-Wide Mendelian Randomization Study
The Causal Relationships Between Extrinsic Exposures and Risk of Prostate Cancer: A Phenome-Wide Mendelian Randomization Study Open
Background Prostate cancer is the second most common cancer in males worldwide, and multitudes of factors have been reported to be associated with prostate cancer risk. Objectives We aim to conduct the phenome-wide exposed-omics analysis o…
View article: Association between systemic lupus erythematosus and cancer: findings from cohort studies and Mendelian randomization analysis
Association between systemic lupus erythematosus and cancer: findings from cohort studies and Mendelian randomization analysis Open
Background Observational studies suggested that systemic lupus erythematosus (SLE) was associated with an increased risk of cancer, however, the causal effect remains unclear. We aim to determine the causality between SLE and cancer using …
View article: A web-based dynamic Nomogram for predicting instrumental activities of daily living disability in older adults: a nationally representative survey in China
A web-based dynamic Nomogram for predicting instrumental activities of daily living disability in older adults: a nationally representative survey in China Open
Background Instrumental Activities of Daily Living (IADL) disability is a common health burden in aging populations. The identification of high-risk individuals is essential for timely targeted interventions. Although predictors for IADL d…