Huijie Zhang
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View article: Effect of graded nursing based on the Glasgow-Blatchford score in liver cirrhosis patients complicated with acute upper gastrointestinal bleeding
Effect of graded nursing based on the Glasgow-Blatchford score in liver cirrhosis patients complicated with acute upper gastrointestinal bleeding Open
Aim To study the effect of graded nursing based on the Glasgow-Blatchford score in liver cirrhosis patients complicated with acute upper gastrointestinal bleeding (AUGIB). Methods From January 2022 to December 2024, eighty patients with li…
View article: Stress induces corticosterone-mediated CD8+ T cell exhaustion to promote non-small cell lung cancer
Stress induces corticosterone-mediated CD8+ T cell exhaustion to promote non-small cell lung cancer Open
View article: Mobile App–Based Intervention and Cardiovascular Risk Factors in Patients With Uncontrolled Type 2 Diabetes
Mobile App–Based Intervention and Cardiovascular Risk Factors in Patients With Uncontrolled Type 2 Diabetes Open
Importance Controlling modifiable cardiovascular risk factors is important but underused for patients with type 2 diabetes (T2D). Mobile message–based intervention strategies could address this gap but lack evidence of benefit on multiple …
View article: A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium
A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium Open
Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue …
View article: A Trade-Off between Body Mass and Cancer Resistance in Cetaceans Is Mediated by Cell Cycle-Related Gene Evolution
A Trade-Off between Body Mass and Cancer Resistance in Cetaceans Is Mediated by Cell Cycle-Related Gene Evolution Open
Cetaceans, well-known for their exceptionally long lifespans and substantial body masses, demonstrate a lower risk of cancer mortality compared to other mammals, consistent with Peto's paradox. Yet, the underlying mechanisms of cancer resi…
View article: Shexiang Tongxin Dripping Pills regulates SOD/TNF-α/IL-6 pathway to inhibit inflammation and oxidative stress to improve myocardial ischemia-reperfusion injury in mice
Shexiang Tongxin Dripping Pills regulates SOD/TNF-α/IL-6 pathway to inhibit inflammation and oxidative stress to improve myocardial ischemia-reperfusion injury in mice Open
Introduction Shexiang Tongxin Dropping Pills (STDP), a traditional Chinese medicine (TCM), is clinically used for cardiovascular diseases like myocardial ischemia. Myocardial ischemia-reperfusion injury (MIRI), worsened by oxidative stress…
View article: Effect of dapagliflozin on metabolic dysfunction-associated steatohepatitis: multicentre, double blind, randomised, placebo controlled trial
Effect of dapagliflozin on metabolic dysfunction-associated steatohepatitis: multicentre, double blind, randomised, placebo controlled trial Open
Objective To assess the efficacy and safety of the sodium-glucose cotransporter 2 inhibitor dapagliflozin in participants with metabolic dysfunction-associated steatohepatitis (MASH). Design Multicentre, double blind, randomised, placebo c…
View article: Baseline type 2 biomarker levels and clinical remission predictors in children with asthma
Baseline type 2 biomarker levels and clinical remission predictors in children with asthma Open
Background Few studies have investigated the relationship between baseline type 2 biomarker levels and clinical features in pediatric asthma, particularly in different asthma stages, which may inform prognosis and remission. Objective To e…
View article: Targeting M2 Macrophage Polarization: Icaii Regulates Sirt1/Nlrp3 and Tgf-Β/Smad3 Signaling to Alleviate Chronic Asthma
Targeting M2 Macrophage Polarization: Icaii Regulates Sirt1/Nlrp3 and Tgf-Β/Smad3 Signaling to Alleviate Chronic Asthma Open
View article: Burden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021
Burden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021 Open
[This corrects the article DOI: 10.1016/j.eclinm.2024.102848.].
View article: Chinese expert consensus on the management of hypertension in adults with type 2 diabetes
Chinese expert consensus on the management of hypertension in adults with type 2 diabetes Open
Both hypertension and type 2 diabetes are attributable to premature death, cardiovascular and kidney diseases with largely overlapping population. Followed the GRADE approach, this expert consensus aimed to reduce the cardiovascular and ki…
View article: Prospectively predicting 6-month risk for non-suicidal self-injury among adolescents after psychiatric hospitalization based on a predictive model
Prospectively predicting 6-month risk for non-suicidal self-injury among adolescents after psychiatric hospitalization based on a predictive model Open
Background It is challenging to predict the occurrence of non-suicidal self-injury (NSSI) among adolescents over short periods. Moreover, the predictive value of indices for NSSI remains elusive. Thus, this study aimed to identify predicto…
View article: Burden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021
Burden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021 Open
View article: Sodium Houttuybonate Promotes the Browning of White Adipose Tissue by Inhibiting Ferroptosis via the AMPK-NRF2-HO1 Pathway
Sodium Houttuybonate Promotes the Browning of White Adipose Tissue by Inhibiting Ferroptosis via the AMPK-NRF2-HO1 Pathway Open
The rising prevalence of obesity has resulted in an increased demand for innovative and effective treatment strategies. Houttuynia cordata Thunb. (H. cordata) has demonstrated promising potential in preventing obesity. However, the mechani…
View article: A multidimensional strategy for uncovering comprehensive quality markers of Scutellariae Radix based on UPLC-Q-TOF-MS analysis, artificial neural network, network pharmacology analysis, and molecular simulation
A multidimensional strategy for uncovering comprehensive quality markers of Scutellariae Radix based on UPLC-Q-TOF-MS analysis, artificial neural network, network pharmacology analysis, and molecular simulation Open
Introduction Scutellariae Radix (SR), derived from the root of Scutellaria baicalensis Georgi, is a traditional Chinese medicine (TCM) for clearing heat and cooling blood. It has been used as a traditional herbal medicine and is popular as…
View article: A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease Open
View article: A novel method of swin transformer with time-frequency characteristics for ECG-based arrhythmia detection
A novel method of swin transformer with time-frequency characteristics for ECG-based arrhythmia detection Open
Introduction Arrhythmia is an important indication of underlying cardiovascular diseases (CVD) and is prevalent worldwide. Accurate diagnosis of arrhythmia is crucial for timely and effective treatment. Electrocardiogram (ECG) plays a key …
View article: Effect of time-restricted eating regimen on weight loss is mediated by gut microbiome
Effect of time-restricted eating regimen on weight loss is mediated by gut microbiome Open
View article: Identifying molecular subgroups of patients with preeclampsia through bioinformatics
Identifying molecular subgroups of patients with preeclampsia through bioinformatics Open
Preeclampsia (PE) is a pregnancy-related disorder associated with serious complications. Its molecular mechanisms remain undefined; hence, we aimed to identify molecular subgroups of patients with PE using bioinformatics to aid treatment s…
View article: The Role of Exerkines in Obesity-Induced Disruption of Mitochondrial Homeostasis in Thermogenic Fat
The Role of Exerkines in Obesity-Induced Disruption of Mitochondrial Homeostasis in Thermogenic Fat Open
There is a notable correlation between mitochondrial homeostasis and metabolic disruption. In this review, we report that obesity-induced disruption of mitochondrial homeostasis adversely affects lipid metabolism, adipocyte differentiation…
View article: Baseline Type 2 Biomarker Levels and Clinical Remission Predictors in Children with Asthma
Baseline Type 2 Biomarker Levels and Clinical Remission Predictors in Children with Asthma Open
Background Little study investigates the association between baseline type 2 biomarker levels and clinical features in children diagnosed with asthma. Characterizing clinical remission in Th2-high asthma could offer valuable insights into …
View article: Alternate day fasting aggravates atherosclerosis through the suppression of hepatic ATF3 in <i>Apoe−/−</i> mice
Alternate day fasting aggravates atherosclerosis through the suppression of hepatic ATF3 in <i>Apoe−/−</i> mice Open
Atherosclerosis is the major contributor to cardiovascular mortality worldwide. Alternate day fasting (ADF) has gained growing attention due to its metabolic benefits. However, the effects of ADF on atherosclerotic plaque formation remain …
View article: Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation
Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation Open
Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized…
View article: Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation
Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation Open
Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized…
View article: Whole-orbit radiomics: machine learning-based multi- and fused- region radiomics signatures for intravenous glucocorticoid response prediction in thyroid eye disease
Whole-orbit radiomics: machine learning-based multi- and fused- region radiomics signatures for intravenous glucocorticoid response prediction in thyroid eye disease Open
Background Radiomics analysis of orbital magnetic resonance imaging (MRI) shows preliminary potential for intravenous glucocorticoid (IVGC) response prediction of thyroid eye disease (TED). The current region of interest segmentation conta…
View article: CLCF1 inhibits energy expenditure via suppressing brown fat thermogenesis
CLCF1 inhibits energy expenditure via suppressing brown fat thermogenesis Open
Brown adipose tissue (BAT) is the main site of nonshivering thermogenesis which plays an important role in thermogenesis and energy metabolism. However, the regulatory factors that inhibit BAT activity remain largely unknown. Here, cardiot…
View article: Study on Professor Diangui Li's Medication Experience in Treating Atrophic Gastritis Concomitant with Helicobacter Pylori Infection Based on Data Mining
Study on Professor Diangui Li's Medication Experience in Treating Atrophic Gastritis Concomitant with Helicobacter Pylori Infection Based on Data Mining Open
Objective Our objective was to explore the national traditional Chinese medicine by studying master Diangui Li's medication experience in treating atrophic gastritis (AG) concomitant with Helicobacter pylori (Hp) infection based on data mi…
View article: Associations of Oral Contraceptive Use With Cardiovascular Disease and All‐Cause Death: Evidence From the UK Biobank Cohort Study
Associations of Oral Contraceptive Use With Cardiovascular Disease and All‐Cause Death: Evidence From the UK Biobank Cohort Study Open
Background The associations of oral contraceptive (OC) use with cardiovascular disease (CVD) and all‐cause death remains unclear. We aimed to determine the associations of OC use with incident CVD and all‐cause death. Methods and Results T…
View article: Associations of Serum testosterone and sex hormone-binding globulin with incident Arrhythmias in men from UK Biobank
Associations of Serum testosterone and sex hormone-binding globulin with incident Arrhythmias in men from UK Biobank Open
Supplementary material belonging to the paper "Associations of Serum testosterone and sex hormone-binding globulin with incident Arrhythmias in men from UK Biobank".
View article: Construction of gene subgroups of Crohn disease based on transcriptome data
Construction of gene subgroups of Crohn disease based on transcriptome data Open
Background: The global prevalence of Crohn disease (CD), a chronic inflammatory disease of the intestine, has been increasing; however, the etiology and pathogenesis of this disease have not been fully elucidated. Therefore, in the present…