Huijuan Dou
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View article: IL-18 inhibition enlarges lesions, necrotic cores and thickens fibrous caps in <i>Jak2<sup>V617F</sup></i> clonal hematopoiesis-driven atherosclerosis
IL-18 inhibition enlarges lesions, necrotic cores and thickens fibrous caps in <i>Jak2<sup>V617F</sup></i> clonal hematopoiesis-driven atherosclerosis Open
Background Inflammasome activation promotes atherosclerosis in clonal hematopoiesis (CH). Active inflammasomes secrete both IL-1β and IL-18. Plasma IL-18 levels are elevated in Jak2 VF CH. Genetic deficiency of IL-18 has been shown to redu…
View article: Hematopoietic and eosinophil-specific LNK(SH2B3) deficiency promotes eosinophilia and arterial thrombosis
Hematopoietic and eosinophil-specific LNK(SH2B3) deficiency promotes eosinophilia and arterial thrombosis Open
Increased eosinophil counts are associated with cardiovascular disease and may be an independent predictor of major cardiovascular events. However, the causality and underlying mechanisms are poorly understood. Genome-wide association stud…
View article: Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion
Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion Open
Aims Neutrophil extracellular trap formation (NETosis) increases atherosclerotic plaque vulnerability and athero-thrombosis. However, mechanisms promoting NETosis during atherogenesis are poorly understood. We have shown that cholesterol a…
View article: Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis
Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis Open
Elevated hematocrit is associated with cardiovascular risk; however, the causality and mechanisms are unclear. The JAK2V617F (Jak2VF) mutation increases cardiovascular risk in myeloproliferative disorders and in clonal hematopoiesis. Jak2V…
View article: Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis
Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis Open
Background: Cholesterol loaded macrophage foam cells are a prominent feature of atherosclerotic plaques. Single-cell RNA sequencing has identified foam cells as TREM2 (triggering receptor expressed on myeloid cells 2) positive populations …
View article: Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter
Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter Open
Objective Microvascular brain injury (mVBI) is a common pathological correlate of vascular contributions to cognitive impairment and dementia (VCID) that leads to white matter (WM) injury (WMI). VCID appears to arise from chronic recurrent…
View article: Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction
Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction Open
Objective— A disintegrin and metalloproteinase ADAM17 (tumor necrosis factor-α [TNF]–converting enzyme) regulates soluble TNF levels. We tested the hypothesis that aging-induced activation in adipose tissue (AT)-expressed ADAM17 contribute…
View article: Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes
Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes Open
Significance Growth hormone-releasing hormone (GHRH) antagonist MIA-602 reduces hyperlipidemia in rats with type 1 diabetes (T1D). Elevated triglyceride-rich lipoprotein (TRL) and LDL levels correlate with renal and cardiovascular disease …
View article: Analysis and Research on Distribution of Ticks and SFTSV and HGA Carried by Ticks in Prevalence Area in South of Henan
Analysis and Research on Distribution of Ticks and SFTSV and HGA Carried by Ticks in Prevalence Area in South of Henan Open
Objective: To make a study of the distribution features of ticks in south of Henan and the SFTSV and HGA.Methods: From January to December in 2015in Xinyang region of Henan Province the artificial cloth flag method and surface pick tick me…