Huiliang Li
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View article: Hypomyelination in autism-associated neuroligin-3 mutant mice impairs parvalbumin interneuron excitability, gamma oscillations, and sensory discrimination
Hypomyelination in autism-associated neuroligin-3 mutant mice impairs parvalbumin interneuron excitability, gamma oscillations, and sensory discrimination Open
Whether and how myelin plasticity, an emerging new form of brain plasticity, is involved in autism spectrum disorder (ASD) remains unknown. Here, we identify deficits in oligodendrocyte (OL) generation and myelination in the barrel cortex …
View article: Oligodendrogenesis in Evolution, Development and Adulthood
Oligodendrogenesis in Evolution, Development and Adulthood Open
Oligodendrogenesis and myelin formation are important processes in the central nervous system (CNS) of jawed vertebrates, underpinning the highly efficient neural computation within the compact CNS architecture. Myelin, the dense lipid she…
View article: The <scp>INO80</scp> Chromatin Remodeling Complex Regulates Histone <scp>H2A</scp> .Z Mobility and the <scp>G1</scp> ‐S Transition in Oligodendrocyte Precursors
The <span>INO80</span> Chromatin Remodeling Complex Regulates Histone <span>H2A</span> .Z Mobility and the <span>G1</span> ‐S Transition in Oligodendrocyte Precursors Open
Chromatin remodeling complexes (CRCs) participate in oligodendrocyte (OL) differentiation, survival, and maintenance. We asked whether CRCs also control the proliferation of OL precursors (OPs)—focusing on the INO80 complex, which is known…
View article: Gut microbial GABA imbalance emerges as a metabolic signature in mild autism spectrum disorder linked to overrepresented Escherichia
Gut microbial GABA imbalance emerges as a metabolic signature in mild autism spectrum disorder linked to overrepresented Escherichia Open
Gut microbiota (GM) alterations have been implicated in autism spectrum disorder (ASD), yet the specific functional architecture remains elusive. Here, employing multi-omics approaches, we investigate stool samples from two distinct cohort…
View article: GPR158 in pyramidal neurons mediates social novelty behavior via modulating synaptic transmission in male mice
GPR158 in pyramidal neurons mediates social novelty behavior via modulating synaptic transmission in male mice Open
Impairment in social communication skills is a hallmark feature of autism spectrum disorder (ASD). The role of G-protein-coupled receptor 158 (GPR158) in ASD remains largely unexplored. In this study, we observed that both constitutive and…
View article: The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model
The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model Open
View article: Microbiota profiling reveals alteration of gut microbial neurotransmitters in a mouse model of autism-associated 16p11.2 microduplication
Microbiota profiling reveals alteration of gut microbial neurotransmitters in a mouse model of autism-associated 16p11.2 microduplication Open
The gut-brain axis is evident in modulating neuropsychiatric diseases including autism spectrum disorder (ASD). Chromosomal 16p11.2 microduplication 16p11.2 dp/+ is among the most prevalent genetic copy number variations (CNV) linked with …
View article: Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy
Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy Open
View article: The INO80 chromatin remodeling complex regulates histone H2A.Z mobility and the G1-S transition in oligodendrocyte precursors
The INO80 chromatin remodeling complex regulates histone H2A.Z mobility and the G1-S transition in oligodendrocyte precursors Open
SUMMARY Chromatin remodelling complexes (CRCs) participate in oligodendrocyte (OL) differentiation, survival and maintenance. We asked whether CRCs also control proliferation of OL precursors (OPs) – focusing on the INO80 complex, which is…
View article: Expression mapping of GREM1 and functional contribution of its secreting cells in the brain using transgenic mouse models
Expression mapping of GREM1 and functional contribution of its secreting cells in the brain using transgenic mouse models Open
GREMLIN1 (GREM1) is a secreted protein that antagonizes bone morphogenetic proteins (BMPs). While abnormal GREM1 expression has been reported to cause behavioral defects in postpartum mice, the spatial and cellular distribution of GREM1 in…
View article: Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice
Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice Open
Previous work has shown that motor skill learning stimulates and requires generation of myelinating oligodendrocytes (OLs) from their precursor cells (OLPs) in the brains of adult mice. In the present study we ask whether OL production is …
View article: PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia
PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia Open
Isocitrate dehydrogenase (IDH) mutation, a known pathologic classifier, initiates metabolic reprogramming in glioma cells and has been linked to the reaction status of glioma‐associated microglia/macrophages (GAMs). However, it remains unc…
View article: GPR158 in pyramidal neurons mediates social novelty behavior via modulating synaptic transmission in mice
GPR158 in pyramidal neurons mediates social novelty behavior via modulating synaptic transmission in mice Open
Social novelty impairment is a hallmark feature of autism spectrum disorder associated with synaptic dysfunction. While G-protein coupled receptor 158 (GPR158) has been shown to be essential for synaptic neurotransmission, its role in modu…
View article: The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model
The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model Open
Background Microdeletion of the 16p11.2 region of the human chromosome is a prevalent genetic factor for autism spectrum disorder (ASD) and other neurodevelopmental disorders, but its pathogenic mechanism remains unclear, and effective tre…
View article: Oligodendrocyte dynamics dictate individual performance outcomes of working memory training in mice
Oligodendrocyte dynamics dictate individual performance outcomes of working memory training in mice Open
Summary Motor skill learning stimulates and requires generation of myelinating oligodendrocytes (OLs) from their precursors (OLPs). We asked whether OL production is also required for non-motor learning and cognition, using T-maze and radi…
View article: Editorial: The role of microglia in the pathogenesis of neurodegenerative diseases
Editorial: The role of microglia in the pathogenesis of neurodegenerative diseases Open
EDITORIAL article Front. Aging Neurosci., 06 January 2023Sec. Neuroinflammation and Neuropathy Volume 14 - 2022 | https://doi.org/10.3389/fnagi.2022.1105896
View article: Kinase inhibit region of <scp>SOCS3</scp> attenuates <scp>IL6</scp>‐induced proliferation and astrocytic differentiation of neural stem cells via cross talk between signaling pathways
Kinase inhibit region of <span>SOCS3</span> attenuates <span>IL6</span>‐induced proliferation and astrocytic differentiation of neural stem cells via cross talk between signaling pathways Open
Aims Efficiency of neural stem cells (NSCs) therapy for brain injury is restricted by astrogliosis around the damaged region, in which JAK2/STAT3 signaling plays a key role. The SOCS3 that can directly inhibit JAK/STAT3 pathway. Here, we i…
View article: Author Correction: Structure-based design of a dual-warhead covalent inhibitor of FGFR4
Author Correction: Structure-based design of a dual-warhead covalent inhibitor of FGFR4 Open
View article: Chemical approach to generating long-term self-renewing pMN progenitors from human embryonic stem cells
Chemical approach to generating long-term self-renewing pMN progenitors from human embryonic stem cells Open
Spinal cord impairment involving motor neuron degeneration and demyelination can cause lifelong disabilities, but effective clinical interventions for restoring neurological functions have yet to be developed. In early spinal cord developm…
View article: Neutralization of Hv1/HVCN1 With Antibody Enhances Microglia/Macrophages Myelin Clearance by Promoting Their Migration in the Brain
Neutralization of Hv1/HVCN1 With Antibody Enhances Microglia/Macrophages Myelin Clearance by Promoting Their Migration in the Brain Open
Microglia dynamically monitor the microenvironment of the central nervous system (CNS) by constantly extending and retracting their processes in physiological conditions, and microglia/macrophages rapidly migrate into lesion sites in respo…
View article: G protein‐coupled receptor GPR37‐like 1 regulates adult oligodendrocyte generation
G protein‐coupled receptor GPR37‐like 1 regulates adult oligodendrocyte generation Open
Oligodendrocytes (OLs) continue to be generated from OL precursors (OPs) in the adult mammalian brain. Adult‐born OLs are believed to contribute to neural plasticity, learning and memory through a process of “adaptive myelination,” but how…
View article: Structural and Lipidomic Alterations of Striatal Myelin in 16p11.2 Deletion Mouse Model of Autism Spectrum Disorder
Structural and Lipidomic Alterations of Striatal Myelin in 16p11.2 Deletion Mouse Model of Autism Spectrum Disorder Open
Myelin abnormalities have been observed in autism spectrum disorder (ASD). In this study, we seek to discover myelin-related changes in the striatum, a key brain region responsible for core ASD features, using the 16p11.2 deletion (16p11.2…
View article: Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence
Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence Open
The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the complex homeostatic feedback responses required for the maintenance of energy ba…
View article: Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis
Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis Open
Given the growing evidence of a link between gut microbiota (GM) dysbiosis and multiple sclerosis (MS), fecal microbiota transplantation (FMT), aimed at rebuilding GM, has been proposed as a new therapeutic approach to MS treatment. To eva…
View article: Generation of Chicken IgY against SARS‐COV‐2 Spike Protein and Epitope Mapping
Generation of Chicken IgY against SARS‐COV‐2 Spike Protein and Epitope Mapping Open
This new decade has started with a global pandemic of COVID‐19 caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), precipitating a worldwide health crisis and economic downturn. Scientists and clinicians have been racin…
View article: Bim contributes to the progression of Huntington’s disease-associated phenotypes
Bim contributes to the progression of Huntington’s disease-associated phenotypes Open
Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded polyglutamine tract in the huntingtin (HTT) protein. Mutant HTT (mHTT) toxicity is caused by its aggregation/oligomerization. The striatum is the most vulnerab…
View article: G protein‐coupled receptor 37‐like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia
G protein‐coupled receptor 37‐like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia Open
We show that the G protein‐coupled receptor GPR37‐like 1 (GPR37L1) is expressed in most astrocytes and some oligodendrocyte precursors in the mouse central nervous system. This contrasts with GPR37, which is mainly in mature oligodendrocyt…
View article: Crystal structure of the DNA-binding domain of Myelin-gene Regulatory Factor
Crystal structure of the DNA-binding domain of Myelin-gene Regulatory Factor Open
View article: Faculty Opinions recommendation of lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS.
Faculty Opinions recommendation of lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS. Open
View article: Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning
Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning Open