Hong Dai
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View article: Five autoantibodies identified from immune complexes as breast cancer biomarkers
Five autoantibodies identified from immune complexes as breast cancer biomarkers Open
Objective Comprehensive identification and profiling of antigens in serum immune complexes (ICs) is crucial for developing early diagnostic biomarkers for cancer. We therefore undertook this study to identify novel IC-derived autoantigens …
View article: Identification of interferon-stimulated response elements (ISREs) in canines
Identification of interferon-stimulated response elements (ISREs) in canines Open
Interferon (IFN) responses are vital for antiviral defense, with interferon-stimulated response elements (ISREs) crucial for regulating IFN signaling. While ISREs are well-studied in humans and mice, research on canine ISREs is limited. Th…
View article: Remimazolam for the prevention of emergence agitation in adults following nasal surgery under general anesthesia: a prospective randomized clinical controlled trial
Remimazolam for the prevention of emergence agitation in adults following nasal surgery under general anesthesia: a prospective randomized clinical controlled trial Open
The trial was registered, before patient enrollment, in the Chinese Clinical Trial Registry ( www.chictr.org.cn ) (clinical trial number: ChiCTR2300075300; Principal Investigator: Gongchen Duan; date of registration: 31 August 2023; https:…
View article: Clinical efficacy of Chinese herbal medicine formula for Graves’ hyperthyroidism: A multicentre, randomized, double-blind, placebo-controlled clinical trial
Clinical efficacy of Chinese herbal medicine formula for Graves’ hyperthyroidism: A multicentre, randomized, double-blind, placebo-controlled clinical trial Open
Pingkang granules significantly reduced serum FT3, FT4 and STA-PSV levels, improved ThyPRO39 scores, and lowered serum TRAb levels when combined with MMI in patients with Grave's hyperthyroidism.
View article: The Effect of Low-Dose Dexmedetomidine on Perioperative Neurocognitive Dysfunction in Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP): A Randomized, Controlled, Double-Blind Trial
The Effect of Low-Dose Dexmedetomidine on Perioperative Neurocognitive Dysfunction in Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP): A Randomized, Controlled, Double-Blind Trial Open
Perioperative low-dose dexmedetomidine infusion with propofol in elderly ERCP patients ensures safe and effective monitored anesthesia care (MAC), reducing PND incidence by mitigating peripheral inflammation and stress responses. Long-term…
View article: Design, Synthesis and Bioactivities of Novel Pyridyl Containing Pyrazole Oxime Ether Derivatives
Design, Synthesis and Bioactivities of Novel Pyridyl Containing Pyrazole Oxime Ether Derivatives Open
In this research, with an aim to develop novel pyrazole oxime ether derivatives possessing potential biological activity, thirty-two pyrazole oxime ethers, including a substituted pyridine ring, have been synthesized and structurally ident…
View article: Remimazolam for the prevention of emergence agitation in adult following nasal surgery under general anesthesia: A randomized controlled study
Remimazolam for the prevention of emergence agitation in adult following nasal surgery under general anesthesia: A randomized controlled study Open
The purpose of this study was to evaluate the effectiveness of postoperative use of remimazolam in preventing emergence agitation (EA) in adult following nasal surgery. In total, 86 patients underwent nasal surgery were randomly divided in…
View article: Application of an autotransfusion pressure control system in blood salvage
Application of an autotransfusion pressure control system in blood salvage Open
Objective This study was performed to evaluate the effect of a homemade autotransfusion pressure-control system on the regulation of negative pressure and to clarify the influence of different negative pressures on the recovered erythrocyt…
View article: Real-world EGFR testing practices for non-small-cell lung cancer by thoracic pathology laboratories across Europe
Real-world EGFR testing practices for non-small-cell lung cancer by thoracic pathology laboratories across Europe Open
These results highlight the strong heterogeneity of EGFR testing that still occurs within thoracic pathology and molecular biology laboratories across Europe. Even among expert testing facilities there is variability in testing capabilitie…
View article: Application of PCA Numalgorithm in Remote Sensing Image Processing
Application of PCA Numalgorithm in Remote Sensing Image Processing Open
A numerical algorithm of principal component analysis (PCA) is proposed and its application in remote sensing image processing is introduced:(1) Multispectral image compression; (2) Multi-spectral image noise cancellation; (3) Information …
View article: Response Evaluation after Neoadjuvant Chemotherapy for Resectable Gastric Cancer
Response Evaluation after Neoadjuvant Chemotherapy for Resectable Gastric Cancer Open
Background: The method of response evaluation following neoadjuvant chemotherapy (NAC) in resectable gastric cancer has been widely debated. An essential prerequisite is the ability to stratify patients into subsets of different long-term …
View article: Design, Synthesis, and Biological Activities of Novel 2-Cyanoacrylate Compounds Containing Substituted Pyrazolyl or 1,2,3-Triazolyl Moiety
Design, Synthesis, and Biological Activities of Novel 2-Cyanoacrylate Compounds Containing Substituted Pyrazolyl or 1,2,3-Triazolyl Moiety Open
To develop novel 2-cyanoacrylate derivatives with potential bioactivity, a number of 2-cyanoacrylate compounds, including substituted pyrazole or 1,2,3-triazole ring, were designed, prepared, and structurally detected by 1H NMR, 13C NMR, a…
View article: Additional file 1 of Associations between detectable circulating tumor DNA and tumor glucose uptake measured by 18F-FDG PET/CT in early-stage non-small cell lung cancer
Additional file 1 of Associations between detectable circulating tumor DNA and tumor glucose uptake measured by 18F-FDG PET/CT in early-stage non-small cell lung cancer Open
Supplementary Material 1
View article: Synthesis and Bioactivities of Novel Pyrazole Oxime Derivatives Containing 1,3,4-Oxadiazole Group
Synthesis and Bioactivities of Novel Pyrazole Oxime Derivatives Containing 1,3,4-Oxadiazole Group Open
In order to explore new pyrazole oxime compounds possessing satisfactory bioactivities, sixteen pyrazole oxime derivatives containing 1,3,4-oxadiazole group were prepared with fenpyroximate selected as lead structure.Their insecticidal act…
View article: Assessment of Two Commercial Comprehensive Gene Panels for Personalized Cancer Treatment
Assessment of Two Commercial Comprehensive Gene Panels for Personalized Cancer Treatment Open
(1) Background: Analysis of tumor DNA by next-generation sequencing (NGS) plays various roles in the classification and management of cancer. This study aimed to assess the performance of two similar and large, comprehensive gene panels wi…
View article: Fragmentation assessment of FFPE DNA helps in evaluating NGS library complexity and interpretation of NGS results
Fragmentation assessment of FFPE DNA helps in evaluating NGS library complexity and interpretation of NGS results Open
Formalin-fixed paraffin-embedded (FFPE) tissue remains the most common source for DNA extraction from human tissue both in research and routine clinical practice. FFPE DNA can be considerably fragmented, and the amount of DNA measured in n…
View article: The Prognostic Effect of KRAS Mutations in Non-Small Cell Lung Carcinoma Revisited: A Norwegian Multicentre Study
The Prognostic Effect of KRAS Mutations in Non-Small Cell Lung Carcinoma Revisited: A Norwegian Multicentre Study Open
Background: due to emerging therapeutics targeting KRAS G12C and previous reports with conflicting results regarding the prognostic impact of KRAS and KRAS G12C in non-small cell lung cancer (NSCLC), we aimed to investigate the frequency o…
View article: Probing into the In-Situ Exsolution Mechanism of Metal Nanoparticles from Doped Ceria Host
Probing into the In-Situ Exsolution Mechanism of Metal Nanoparticles from Doped Ceria Host Open
Exsolved nanoparticle catalysts have recently attracted broad research interest as they simultaneously combine the features of catalytic activity and chemical stability in various applications of energy conversion and storage. As the inter…
View article: Efficacy of Low-Dose Rituximab on Neuromyelitis Optica-Associated Optic Neuritis
Efficacy of Low-Dose Rituximab on Neuromyelitis Optica-Associated Optic Neuritis Open
Purpose: To prospectively investigate the efficacy and tolerance of low-dose rituximab (RTX) for the treatment of neuromyelitis optica-associated optic neuritis (NMO-ON). Methods: Optic Neuritis patients with seropositive aquaporin 4-antib…
View article: Prognostic value of absolute quantification of mutated <scp><i>KRAS</i></scp> in circulating tumour <scp>DNA</scp> in lung adenocarcinoma patients prior to therapy
Prognostic value of absolute quantification of mutated <span><i>KRAS</i></span> in circulating tumour <span>DNA</span> in lung adenocarcinoma patients prior to therapy Open
Droplet digital polymerase chain reaction (ddPCR) is a highly sensitive and accurate method for quantification of nucleic acid sequences. We used absolute quantification of mutated v‐Ki‐ras2 Kirsten rat sarcoma viral oncogene homology gene…