Huiling He
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View article: Pythium Insidiosum Biological Characteristics and Treatment: A Strain Cured by Repurposing of Existing Drugs in China
Pythium Insidiosum Biological Characteristics and Treatment: A Strain Cured by Repurposing of Existing Drugs in China Open
Background Pythiosis is an infectious disease caused by P. insidiosum that threatens humans and animals. The number of people being diagnosed with this disease has been increasing worldwide. Pythiosis has a high rate of morbidity and morta…
View article: Presumed Pathogenic Germ Line and Somatic Variants in African American Thyroid Cancer
Presumed Pathogenic Germ Line and Somatic Variants in African American Thyroid Cancer Open
Background: African American (AA) thyroid cancer patients have worse prognoses than European Americans (EA), which has been attributed to both health care disparities and possible genetic differences. We investigated the impa…
View article: Comparison of the effects of contrast-enhanced ultrasound and conventional ultrasound-guided radiofrequency ablation on benign thyroid nodules
Comparison of the effects of contrast-enhanced ultrasound and conventional ultrasound-guided radiofrequency ablation on benign thyroid nodules Open
Objective: To compare the effect of contrast-enhanced ultrasound (CEUS) and conventional ultrasound-guided radiofrequency ablation (RFA) on benign thyroid nodules (BTNs).
Methods: In this retrospective observational study, the data of 72 …
View article: <i>CpxA/R</i>‐Controlled Nitroreductase Expression as Target for Combinatorial Therapy against Uropathogens by Promoting Reactive Oxygen Species Generation
<i>CpxA/R</i>‐Controlled Nitroreductase Expression as Target for Combinatorial Therapy against Uropathogens by Promoting Reactive Oxygen Species Generation Open
The antibiotic resistances emerged in uropathogens lead to accumulative treatment failure and recurrent episodes of urinary tract infection (UTI), necessitating more innovative therapeutics to curb UTI before systematic infection. In the c…
View article: Combined analysis of single-cell and bulk RNA sequencing reveals the expression patterns of circadian rhythm disruption in the immune microenvironment of Alzheimer’s disease
Combined analysis of single-cell and bulk RNA sequencing reveals the expression patterns of circadian rhythm disruption in the immune microenvironment of Alzheimer’s disease Open
Background Circadian rhythm disruption (CRD) represents a critical contributor to the pathogenesis of Alzheimer’s disease (AD). Nonetheless, how CRD functions within the AD immune microenvironment remains to be illustrated. Methods Circadi…
View article: Supplementary Figure 2 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
Supplementary Figure 2 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24 Open
Supplementary Figure 2 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
View article: Supplementary Table 2 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
Supplementary Table 2 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24 Open
Supplementary Table 2 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
View article: Supplementary Table 1 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
Supplementary Table 1 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24 Open
Supplementary Table 1 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
View article: Supplementary Table 3 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
Supplementary Table 3 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24 Open
Supplementary Table 3 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
View article: Supplementary Table 1 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
Supplementary Table 1 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24 Open
Supplementary Table 1 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
View article: Data from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
Data from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24 Open
Papillary thyroid carcinoma (PTC) displays higher heritability than most other cancers. To search for genes predisposing to PTC, we performed a genome-wide linkage analysis in a large family with PTC and melanoma. Among several peaks the h…
View article: Data from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
Data from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24 Open
Papillary thyroid carcinoma (PTC) displays higher heritability than most other cancers. To search for genes predisposing to PTC, we performed a genome-wide linkage analysis in a large family with PTC and melanoma. Among several peaks the h…
View article: Supplementary Figure 2 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
Supplementary Figure 2 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24 Open
Supplementary Figure 2 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
View article: Supplementary Table 2 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
Supplementary Table 2 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24 Open
Supplementary Table 2 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
View article: Supplementary Figure 1 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
Supplementary Figure 1 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24 Open
Supplementary Figure 1 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
View article: Supplementary Figure 1 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
Supplementary Figure 1 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24 Open
Supplementary Figure 1 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
View article: Supplementary Table 3 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
Supplementary Table 3 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24 Open
Supplementary Table 3 from A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24
View article: Diagnostic accuracy of contrast-enhanced ultrasound synchronized with shear wave elastography in the differential diagnosis of benign and malignant breast lesions: a diagnostic test
Diagnostic accuracy of contrast-enhanced ultrasound synchronized with shear wave elastography in the differential diagnosis of benign and malignant breast lesions: a diagnostic test Open
The combination of CEUS and SWE has a better diagnostic value in differentiating benign and malignant breast lesions compared to separate techniques.
View article: The diagnostic value of novel ultrasound attenuation analysis in detecting liver steatosis identified by the controlled attenuation parameter: a diagnostic accuracy study
The diagnostic value of novel ultrasound attenuation analysis in detecting liver steatosis identified by the controlled attenuation parameter: a diagnostic accuracy study Open
USAT had a strong association with CAP and a good diagnostic capability in the detection of hepatic steatosis, which appears to be a promising tool for the non-invasive detection and quantification of hepatic steatosis.
View article: Author Correction: GWAS of thyroid stimulating hormone highlights the pleiotropic effects and inverse association with thyroid cancer
Author Correction: GWAS of thyroid stimulating hormone highlights the pleiotropic effects and inverse association with thyroid cancer Open
View article: Transcriptome analysis discloses dysregulated genes in normal appearing tumor-adjacent thyroid tissues from patients with papillary thyroid carcinoma
Transcriptome analysis discloses dysregulated genes in normal appearing tumor-adjacent thyroid tissues from patients with papillary thyroid carcinoma Open
View article: A novel essential splice site variant in SPTB in a large hereditary spherocytosis family
A novel essential splice site variant in SPTB in a large hereditary spherocytosis family Open
Background We studied a large family with 22 individuals affected with autosomal dominant hereditary spherocytosis (HS). Methods Genome‐wide linkage, whole‐genome sequencing (WGS), Sanger sequencing, RT‐PCR, and ToPO TA cloning analyses we…
View article: Characterizing the function of EPB41L4A in the predisposition to papillary thyroid carcinoma
Characterizing the function of EPB41L4A in the predisposition to papillary thyroid carcinoma Open
Papillary thyroid carcinoma (PTC) is the most common histotype of thyroid carcinoma. The heritability of PTC is high compared to other cancers, but its underlying causes are unknown. A recent genome-wide association study revealed the asso…
View article: GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer Open
View article: Multiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium
Multiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium Open
Incidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. Here, we conducted a genome-wide association study (GWAS) involving 1,554 cases/1,9…
View article: Assessing thyroid cancer risk using polygenic risk scores
Assessing thyroid cancer risk using polygenic risk scores Open
Genome-wide association studies (GWASs) have identified at least 10 single-nucleotide polymorphisms (SNPs) associated with papillary thyroid cancer (PTC) risk. Most of these SNPs are common variants with small to moderate effect sizes. Her…
View article: Variants in <i>LRRC34</i> reveal distinct mechanisms for predisposition to papillary thyroid carcinoma
Variants in <i>LRRC34</i> reveal distinct mechanisms for predisposition to papillary thyroid carcinoma Open
Background Papillary thyroid carcinoma (PTC) demonstrates high heritability and a low somatic mutation burden relative to other cancers. Therefore, the genetic risk predisposing to PTC is likely due to a combination of low penetrance varia…
View article: A Truncating Germline Mutation of <i>TINF2</i> in Individuals with Thyroid Cancer or Melanoma Results in Longer Telomeres
A Truncating Germline Mutation of <i>TINF2</i> in Individuals with Thyroid Cancer or Melanoma Results in Longer Telomeres Open
Background: Our genome sequencing analysis revealed a frameshift mutation in the shelterin gene TINF2 in a large family with individuals affected with papillary thyroid carcinoma (PTC) and melanoma. Here, we further ch…
View article: Differential gene expression profiling of the goose pineal gland
Differential gene expression profiling of the goose pineal gland Open
1. The present study was conducted to obtain a better understanding of the molecular mechanisms underlying broodiness in a commercial breed, Tianfu geese, as little is known about the role of the pineal gland in this period. The aim was to…
View article: The Impact of Primary Treatment on Post-Traumatic Endophthalmitis in Children with Open Globe Injuries: A Study in China
The Impact of Primary Treatment on Post-Traumatic Endophthalmitis in Children with Open Globe Injuries: A Study in China Open
Post-traumatic endophthalmitis (PTE) is considered as one of the most serious complications after open globe injuries (OGIs), especially in children. Poor prognosis of this disease can lead to a variety of socioeconomic problems. This stud…