Huiling Sun
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View article: [Expression of Concern] Gene therapy for human colorectal cancer cell lines with recombinant adenovirus 5 based on loss of the insulin‑like growth factor 2 imprinting
[Expression of Concern] Gene therapy for human colorectal cancer cell lines with recombinant adenovirus 5 based on loss of the insulin‑like growth factor 2 imprinting Open
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, for the immunohistochemical data shown in Fig. 2B and C, the PBS/TUNEL panel in Fig. 2B appeared to be strikingly similar to t…
View article: Magnetic Resonance-Based Hemodynamic Model in Symptomatic Intracranial Atherosclerotic Disease
Magnetic Resonance-Based Hemodynamic Model in Symptomatic Intracranial Atherosclerotic Disease Open
For patients with transient ischemic attack or ischemic stroke caused by sICAS, the hemodynamic indexes of the simple CFD model based on MRI are not feasible to predict the recurrence of ischemic cerebrovascular events. However, the collat…
View article: Pretreatment collateral circulation status modifies the effect of blood pressure trajectory on outcome after endovascular therapy
Pretreatment collateral circulation status modifies the effect of blood pressure trajectory on outcome after endovascular therapy Open
Background and purpose: Blood pressure (BP) management in the acute phage of stroke is associated with clinical outcomes among patients with after endovascular therapy (EVT). This study was to explore whether collateral circulation status …
View article: Pleiotropic Effects of PCSK9 Inhibitors on Cardio-Cerebrovascular Diseases
Pleiotropic Effects of PCSK9 Inhibitors on Cardio-Cerebrovascular Diseases Open
Cardiovascular disease (CVD) and ischemic stroke (IS) are the primary causes of mortality worldwide. Hypercholesterolemia has been recognized as an independent risk factor for CVD and IS. Numerous clinical trials have unequivocally demonst…
View article: A hypoxia–glycolysis–lactate-related gene signature for prognosis prediction in hepatocellular carcinoma
A hypoxia–glycolysis–lactate-related gene signature for prognosis prediction in hepatocellular carcinoma Open
Background Liver cancer ranks sixth in incidence and third in mortality globally and hepatocellular carcinoma (HCC) accounts for 90% of it. Hypoxia, glycolysis, and lactate metabolism have been found to regulate the progression of HCC sepa…
View article: Effect of stability of PTEN on hepatocellular carcinoma
Effect of stability of PTEN on hepatocellular carcinoma Open
Background: As an antioncogene gene, phosphataseandtensinhomolog (PTEN) is closely related to tumorigenesis. However, after mutation, PTEN will lose its function and no longer exert a tumor suppression effect. Through this research, we exp…
View article: Non-coding RNAs in acute ischemic stroke: from brain to periphery
Non-coding RNAs in acute ischemic stroke: from brain to periphery Open
Acute ischemic stroke is a clinical emergency and a condition with high morbidity, mortality, and disability. Accurate predictive, diagnostic, and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain und…
View article: Hsa_circ_0007990 promotes breast cancer growth via inhibiting YBX1 protein degradation to activate E2F1 transcription
Hsa_circ_0007990 promotes breast cancer growth via inhibiting YBX1 protein degradation to activate E2F1 transcription Open
Breast cancer (BC) is the most commonly diagnosed malignant tumour in females worldwide. Although remarkable advances in early detection and treatment strategies have led to decreased mortality, recurrence and metastasis remain the major c…
View article: Phenotype and genotype analysis for <i>Helicobacter pylori</i> antibiotic resistance in outpatients: a retrospective study
Phenotype and genotype analysis for <i>Helicobacter pylori</i> antibiotic resistance in outpatients: a retrospective study Open
To investigate the antibiotic resistance of Helicobacter pylori ( H. pylori ) in outpatients and to explore the consistency between genotype and phenotype of H. pylori antibiotic resistance. A retrospective study on outpatients screened wi…
View article: ANGPTL2+cancer-associated fibroblasts and SPP1+macrophages are metastasis accelerators of colorectal cancer
ANGPTL2+cancer-associated fibroblasts and SPP1+macrophages are metastasis accelerators of colorectal cancer Open
Background Liver metastasis (LM) is a leading cause of cancer-related deaths in CRC patients, whereas the associated mechanisms have not yet been fully elucidated. Therefore, it is urgently needed to deeply explore novel metastasis acceler…
View article: Percutaneous angioplasty and/or stenting versus aggressive medical therapy in patients with symptomatic intracranial atherosclerotic stenosis: a 1-year follow-up study
Percutaneous angioplasty and/or stenting versus aggressive medical therapy in patients with symptomatic intracranial atherosclerotic stenosis: a 1-year follow-up study Open
Background Symptomatic intracranial atherosclerotic stenosis (sICAS) is one of the common causes of ischemic stroke. However, the treatment of sICAS remains a challenge in the past with unfavorable findings. The purpose of this study was t…
View article: Integrating single-cell and bulk RNA sequencing to identify TXNRD1 as effective target for prognostic and therapeutic strategy in Hepatocellular Carcinoma
Integrating single-cell and bulk RNA sequencing to identify TXNRD1 as effective target for prognostic and therapeutic strategy in Hepatocellular Carcinoma Open
Thioredoxin reductase (TXNRD1) acts as part of a major enforcer of redox homeostasis in the intracellular environment. However, its prognostic value and the relationship between TXNRD1 and core ferroptosis-related genes in hepatocellular c…
View article: Circular <scp>RNA</scp> circ0104103 inhibits colorectal cancer progression through interactions with <scp>HuR</scp> and <scp>miR</scp>‐373‐5p
Circular <span>RNA</span> circ0104103 inhibits colorectal cancer progression through interactions with <span>HuR</span> and <span>miR</span>‐373‐5p Open
Emerging evidence has suggested that circular RNAs (circRNAs) have vital functions during the initiation and progression of various diseases. However, circRNA potential mechanisms in colorectal cancer (CRC) are largely unknown. Here, we so…
View article: Reclassifying TNM stage I/II colorectal cancer into two subgroups with different overall survival, tumor microenvironment, and response to immune checkpoint blockade treatment
Reclassifying TNM stage I/II colorectal cancer into two subgroups with different overall survival, tumor microenvironment, and response to immune checkpoint blockade treatment Open
Background: The traditional TNM staging system is often insufficient to differentiate the survival discrepancies of colorectal cancer (CRC) patients at TNM stage I/II. Our study aimed to reclassify stage I/II CRC patients into several subg…
View article: Dual Antiplatelet Therapy in Patients With Minor Stroke Receiving Intravenous Thrombolysis
Dual Antiplatelet Therapy in Patients With Minor Stroke Receiving Intravenous Thrombolysis Open
Introduction Concern over the potential severe bleeding risk of dual antiplatelet therapy for patients with minor stroke after intravenous thrombolysis (IVT) leads to different antiplatelet strategies in the secondary prevention of stroke.…
View article: Upregulated LINC01088 Facilitates Malignant Phenotypes and Immune Escape of Colorectal Cancer by Regulating microRNAs/G3BP1/PD-L1 axis
Upregulated LINC01088 Facilitates Malignant Phenotypes and Immune Escape of Colorectal Cancer by Regulating microRNAs/G3BP1/PD-L1 axis Open
Purpose: Long intergenic non-coding RNA LINC01088 is a newly discovered long non-coding RNA. Its biological function in colorectal cancer (CRC) remains unknown. Methods: Here, 36 paired CRC and para-cancerous tissues were collected. In vit…
View article: Inflammatory Factors as Potential Markers of Early Neurological Deterioration in Acute Ischemic Stroke Patients Receiving Endovascular Therapy – The AISRNA Study
Inflammatory Factors as Potential Markers of Early Neurological Deterioration in Acute Ischemic Stroke Patients Receiving Endovascular Therapy – The AISRNA Study Open
ClinicalTrials.gov NCT04175691. Registered November 21, 2019, https://www.clinicaltrials.gov/ct2/show/NCT04175691.
View article: Laboratory Testing Implications of Risk-Stratification and Management of COVID-19 Patients
Laboratory Testing Implications of Risk-Stratification and Management of COVID-19 Patients Open
Objective: To distinguish COVID-19 patients and non-COVID-19 viral pneumonia patients and classify COVID-19 patients into low-risk and high-risk at admission by laboratory indicators. Materials and methods: In this retrospective cohort, a …
View article: MiR-92a-3p promote s invasion and migration of hepatocellular carcinoma cells by targeting PTEN
MiR-92a-3p promote s invasion and migration of hepatocellular carcinoma cells by targeting PTEN Open
Background MiR-92a-3p has been reported to play a part in hepatocellular carcinoma (HCC), a leading type of lethal cancer around the world. In this study, we explored the function and mechanism of miR-92a-3p in HCC. Methods Firstly, the ex…
View article: Long intergenic non-coding RNA LINC00485 exerts tumor-suppressive activity by regulating miR-581/EDEM1 axis in colorectal cancer
Long intergenic non-coding RNA LINC00485 exerts tumor-suppressive activity by regulating miR-581/EDEM1 axis in colorectal cancer Open
Long non-coding RNAs (lncRNA) play a vital role in colorectal cancer (CRC) progression. To investigate the role of long intergenic non-coding RNA LINC00485 in CRC, we performed in vitro functional experiments. LoVo tumor-bearing and liver …
View article: Analysis of METTL3 and METTL14 in hepatocellular carcinoma
Analysis of METTL3 and METTL14 in hepatocellular carcinoma Open
N6-methyladenosine (m6A) RNA methylation is the most prevalent modification of messenger RNAs (mRNAs) and catalyzed by a multicomponent methyltransferase complex (MTC), among which methyltransferase-like 3 (METTL3) and METTL14 are two core…
View article: <p>Susceptibility of <em>PON1</em>/<em>PON2</em> Genetic Variations to Ischemic Stroke Risk in a Chinese Han Population</p>
Susceptibility of <em>PON1</em>/<em>PON2</em> Genetic Variations to Ischemic Stroke Risk in a Chinese Han Population Open
This study suggested that PON1 rs662 presented a potential risk of IS, especially for males, and this association was more obvious for large-artery atherosclerosis.