Huangshu Lei
YOU?
Author Swipe
View article: Prediction of prognostic biomarkers for hepatocellular carcinoma and immune microenvironment infiltration based on single-cell sequencing and RNA-Seq integration
Prediction of prognostic biomarkers for hepatocellular carcinoma and immune microenvironment infiltration based on single-cell sequencing and RNA-Seq integration Open
This study identified and validated prognostic biomarkers in HCC that effectively predict patient survival rates and immune infiltration characteristics. These findings provide a potential foundation for precision medicine strategies in HC…
View article: Unraveling Traditional Chinese Medicine with single-cell RNA sequencing: Current applications and future frontiers
Unraveling Traditional Chinese Medicine with single-cell RNA sequencing: Current applications and future frontiers Open
This review summarizes cutting-edge studies and future directions, emphasizing scRNA-seq's role as a critical bridge in integrating TCM's systemic principles with molecular insights, thereby accelerating TCM and its integration into precis…
View article: A Case of Acne Fulminans Treated with 5-Aminolevulinic Acid Photodynamic Therapy
A Case of Acne Fulminans Treated with 5-Aminolevulinic Acid Photodynamic Therapy Open
View article: A Case of Cosmetic-Induced Acne Fulminans Treated with 5-Aminolevulinic Acid Photodynamic Therapy
A Case of Cosmetic-Induced Acne Fulminans Treated with 5-Aminolevulinic Acid Photodynamic Therapy Open
View article: Co-administration of berberine and evodiamine: Mitigating evodiamine-induced hepatotoxicity and potentiating colitis treatment
Co-administration of berberine and evodiamine: Mitigating evodiamine-induced hepatotoxicity and potentiating colitis treatment Open
ACSL3 was identified as the critical therapeutic target through underlying the amelioration of fatty acid metabolism-mediated inflammatory injury in colitis by the combined administration of EVO and BBR, thereby offering a scientific found…
View article: Inhaled pH-Responsive polymyxin B-loaded albumin nanoparticles against pneumonia caused by carbapenem resistant Klebsiella pneumoniae
Inhaled pH-Responsive polymyxin B-loaded albumin nanoparticles against pneumonia caused by carbapenem resistant Klebsiella pneumoniae Open
The pneumonia induced by carbapenem resistant Klebsiella pneumoniae (CRKP) has high morbidity and mortality. Among the antibiotics currently available, polymyxin B (PMB) is considered to be the last line of defense. Routine intraven…
View article: Unraveling Traditional Chinese Medicine with Single-cell RNA Sequencing: Current Applications and Future Frontiers
Unraveling Traditional Chinese Medicine with Single-cell RNA Sequencing: Current Applications and Future Frontiers Open
View article: Baricitinib in the management of persistent actinic granuloma: An innovative therapeutic approach
Baricitinib in the management of persistent actinic granuloma: An innovative therapeutic approach Open
View article: Cobdock: an accurate and practical machine learning-based consensus blind docking method
Cobdock: an accurate and practical machine learning-based consensus blind docking method Open
Probing the surface of proteins to predict the binding site and binding affinity for a given small molecule is a critical but challenging task in drug discovery. Blind docking addresses this issue by performing docking on binding regions r…
View article: FLONE: fully Lorentz network embedding for inferring novel drug targets
FLONE: fully Lorentz network embedding for inferring novel drug targets Open
Motivation: To predict novel drug targets, graph-based machine learning methods have been widely used to capture the relationships between drug, target, and disease entities in heterogeneous biological networks. However, most of the existi…
View article: FLONE: fully Lorentz network embedding for inferring novel drug targets
FLONE: fully Lorentz network embedding for inferring novel drug targets Open
Motivation To predict drug targets, graph-based machine-learning methods have been widely used to capture the relationships between drug, target and disease entities in drug–disease–target (DDT) networks. However, many methods cannot expli…
View article: Improving therapeutic synergy score predictions with adverse effects using multi-task heterogeneous network learning
Improving therapeutic synergy score predictions with adverse effects using multi-task heterogeneous network learning Open
Drug combinations could trigger pharmacological therapeutic effects (TEs) and adverse effects (AEs). Many computational methods have been developed to predict TEs, e.g. the therapeutic synergy scores of anti-cancer drug combinations, or AE…
View article: α-Tocopherol Pharmacokinetics in Adults with Cystic Fibrosis: Benefits of Supplemental Vitamin C Administration
α-Tocopherol Pharmacokinetics in Adults with Cystic Fibrosis: Benefits of Supplemental Vitamin C Administration Open
Background: Numerous abnormalities in cystic fibrosis (CF) could influence tocopherol absorption, transportation, storage, metabolism and excretion. We hypothesized that the oxidative distress due to inflammation in CF increases vitamin E …