Explanipedia

Development of a Ghrelin Deacylase to Attenuate Drug Reward and Associated Effects of Methamphetamine Open

Madeline J. Stewart, Huimei Wei, Nellore Bhanu Chandar, Fang Zheng, Chang‐Guo Zhan · 2025

All addictive substances directly or indirectly interact with the dopamine reward system to alter the brain's dopamine receptor activities. It is essential for a truly effective addiction medication to attenuate substance reward and normal…

Effects of Fentanyl-Laced Cocaine on Circulating Ghrelin, Insulin, and Glucose Levels in Rats Open

Huimei Wei, Elise C. Maul, Annet Kyomuhangi, Shawn Park, Maddilynn L. Mutchler , et al. · 2025

Opioid mixed with cocaine has been increasingly implicated in overdose deaths, including both intentional co-use of opioid and cocaine and fentanyl-adulterated drug supply. As ghrelin plays an important role in drug reward and can also inf…

Enhanced Vehicle Recognition and Collision Alert System Using Yolo+DeepSORT Algorithm Open

Xinchi Wang, Huimei Wei, Lijuan Wang, Chenrui Zhao, Shan Wu · 2024

This paper sets out to develop and deploy a deep learning-driven vehicle collision avoidance warning system. Initially, it delves into the foundational principles of traditional collision avoidance warning systems, alongside key safety dri…

In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase Open

Linyue Shang, Huimei Wei, Jing Deng, Madeline J. Stewart, Johnathan E LeSaint , et al. · 2024

Long-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats Open

Huimei Wei, Johnathan E LeSaint, Zhenyu Jin, Chang‐Guo Zhan, Fang Zheng · 2024

Cocaine dependence is a serious world-wide public health problem without an FDA-approved pharmacotherapy. We recently designed and discovered a highly efficient long-acting cocaine hydrolase CocH5-Fc(M6). The present study examined the eff…

Intelligent Medical Knowledge Robot Based on Knowledge Graph Open

Jingyu Li, Mingxu Han, Guangyu Dong, Huimei Wei, Li Yao · 2023

Artificial intelligence has been gradually integrated into life, and knowledge graph is also particularly important, and its application is gradually maturing. In recent years researchers have used the rich entity and relationship informat…

Catalytic activities of a highly efficient cocaine hydrolase for hydrolysis of biologically active cocaine metabolites norcocaine and benzoylecgonine Open

Linyue Shang, Zhenyu Jin, Huimei Wei, Shawn Park, Chang‐Guo Zhan , et al. · 2023

Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy specific for cocaine addiction or overdose. It is recognized as a promising therapeutic strategy to accelerate cocaine metabolism which can convert cocain…

Catalytic activities of a highly efficient cocaine hydrolase for hydrolysis of biologically active cocaine metabolites norcocaine and benzoylecgonine Open

Linyue Shang, Zhenyu Jin, Huimei Wei, Shawn Park, Chang‐Guo Zhan , et al. · 2022

Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy specific for cocaine addiction or overdose. It is recognized as a promising therapeutic strategy to accelerate cocaine metabolism which can convert cocain…

Generation, Transmission, and Amplification of OAM Modes in the PbSe-Doped Ring-Core Fiber Carrying 3D Printed Spiral Phase Plate Open

Yana Shang, Huimei Wei, Hengfei Guo, Na Chen, Zhenyi Chen , et al. · 2022

Vortex beams carrying orbital angular momentum (OAM) have increasingly attracted attention in the field of optical communication. However, transmission is still an issue due to transmission loss, especially in optical fibers. In this work,…

Table of Contents Open

Jianguo Wang, Dangjuan Li, Xi Xi, Xiaoyu Dong, Cailin Zhang , et al. · 2022

Image Segmentation Algorithm of Colorimetric Sensor Array Based on Fuzzy C-Means Clustering Open

Bo Yu, Peng Shi, Can Wang, Qin Fang, Huimei Wei · 2022

In the real world, the boundaries between many objective things are often fuzzy. When classifying things, they are accompanied by ambiguity, which leads to fuzzy cluster analysis. The most typical in fuzzy clustering analysis is the fuzzy …

Research on Sentiment Analysis in Network Public Opinion – A Case Study of Song Plagiarism Open

Yao Li, Sihui Li, Jingjing Jiang, Huimei Wei · 2022

In the Internet age, the online music platform is not only a platform for people to listen to music, but also a platform for comments, exchanges, and sentiments.In addition to reflecting users' opinions, song online review can also be used…

Clinical potential of a rationally engineered enzyme for treatment of cocaine dependence: Long-lasting blocking of the psychostimulant, discriminative stimulus, and reinforcing effects of cocaine Open

Ting Zhang, Huimei Wei, Jing Deng, Fang Zheng, Chang‐Guo Zhan · 2020

Effects of Cebranopadol on Cocaine-induced Hyperactivity and Cocaine Pharmacokinetics in Rats Open

Huimei Wei, Linyue Shang, Chang‐Guo Zhan, Fang Zheng · 2020

Cebranopadol reduces cocaine self-administration in male rats: Dose, treatment and safety consideration Open

Huimei Wei, Ting Zhang, Chang‐Guo Zhan, Fang Zheng · 2020

Reengineering of Albumin-Fused Cocaine Hydrolase CocH1 (TV-1380) to Prolong Its Biological Half-Life Open

Yingting Cai, Shuo Zhou, Zhenyu Jin, Huimei Wei, Linyue Shang , et al. · 2019

Development of a long-acting Fc-fused cocaine hydrolase with improved yield of protein expression Open

Xiabin Chen, Jing Deng, Xirong Zheng, Jinling Zhang, Ziyuan Zhou , et al. · 2019

Development of Fc-Fused Cocaine Hydrolase for Cocaine Addiction Treatment: Catalytic and Pharmacokinetic Properties Open

Xiabin Chen, Jing Deng, Wenpeng Cui, Shurong Hou, Jinling Zhang , et al. · 2018

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