Huimin Zhou
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View article: Longitudinal <i>in vivo</i> ( <i>R</i> )-[ <sup>18</sup> F]FBFP PET imaging for preclinical evaluation of cerebral sigma-1 receptor after ischemic stroke
Longitudinal <i>in vivo</i> ( <i>R</i> )-[ <sup>18</sup> F]FBFP PET imaging for preclinical evaluation of cerebral sigma-1 receptor after ischemic stroke Open
View article: Soil multifunctionality in the face of climate change and human impact in China’s drylands
Soil multifunctionality in the face of climate change and human impact in China’s drylands Open
The United Nations has designated 2021–2030 as the “Decade on Ecosystem Restoration” to combat ecosystem degradation. Climate change and human activities are the primary drivers of this degradation, which has significantly impacted soil mu…
View article: Morphology– and adhesion–dual biomimetic nanovaccine boosts antigen cross-presentation through subcellular transport regulation
Morphology– and adhesion–dual biomimetic nanovaccine boosts antigen cross-presentation through subcellular transport regulation Open
In situ tumor vaccines have immense potential for immunotherapy because they generate whole tumor–derived antigens (TDAs) to activate antitumor immune responses. However, the rapid degradation and clearance of the released TDAs severely hi…
View article: VaEIN3.1‐VaERF057‐VaFBA1 Module Positively Regulates Cold Tolerance by Accumulating Soluble Sugar in Grapevine
VaEIN3.1‐VaERF057‐VaFBA1 Module Positively Regulates Cold Tolerance by Accumulating Soluble Sugar in Grapevine Open
Ethylene‐responsive transcription factors (ERFs) were widely found to participate in cold response in plants. But the underlying regulatory mechanism of each cold‐induced ERFs remains to be elucidated. Previously, we identified VaERF057 as…
View article: Network pharmacology combined with untargeted metabolomics reveals the intervention mechanism and compatibility of chenpi-rougui herb pair in nonalcoholic fatty liver disease
Network pharmacology combined with untargeted metabolomics reveals the intervention mechanism and compatibility of chenpi-rougui herb pair in nonalcoholic fatty liver disease Open
Background Chenpi (the dried mature peel of Citrus reticulata Blanco) and Rougui (the dried bark of Cinnamomum cassia Presl) are both edible and medicinal plants, which have therapeutic effects on nonalcoholic fatty liver disease (NAFLD). …
View article: <i>VaWRKY65</i> contributes to cold tolerance through dual regulation of soluble sugar accumulation and reactive oxygen species scavenging in <i>Vitis amurensis</i>
<i>VaWRKY65</i> contributes to cold tolerance through dual regulation of soluble sugar accumulation and reactive oxygen species scavenging in <i>Vitis amurensis</i> Open
Although the significance of some plant WRKYs in response to cold stress have been identified, the molecular mechanisms of most WRKYs remain unclear in grapevine. In this study, we demonstrate that cold-induced expression of VaBAM3 in Viti…
View article: Molecular mechanism of follicular development in laying hens based on the regulation of water metabolism
Molecular mechanism of follicular development in laying hens based on the regulation of water metabolism Open
Water metabolism is fundamental to sustaining physiological functions in living organisms and plays a particularly vital role in poultry, especially laying hens. It directly influences their health status and production performance. Follic…
View article: The Physiological Response of Salix matsudana for Water Pollution by 2,4-Dinitrophenol
The Physiological Response of Salix matsudana for Water Pollution by 2,4-Dinitrophenol Open
In this study, the effects of different concentrations of 2,4-dinitrophenol (2,4-DNP) stress on physiological parameters, as well as the uptake and removal of 2,4-DNP in Salix matsudana, were investigated using hydroponic simulation experi…
View article: Eradication of Large Tumors by Nanoscale Drug Self‐Assembly
Eradication of Large Tumors by Nanoscale Drug Self‐Assembly Open
Most patients with cancer are first diagnosed at an advanced disease stage, when tumors are already large and/or metastases are present. This circumstance has a negative impact on the prognosis and therapeutic effect of anticancer drugs. I…
View article: Experimental investigation and numerical prediction on heat transfer performance of a high speed radially rotating heat pipe
Experimental investigation and numerical prediction on heat transfer performance of a high speed radially rotating heat pipe Open
A CFD model considering the saturation pressure difference inside radially rotating heat pipes (RRHP) was proposed to reveal the heat transfer characteristics. To validate the model, copper-water RRHPs were designed and experimented. These…
View article: The Natural Product Secoemestrin C Inhibits Colorectal Cancer Stem Cells via p38–S100A8 Feed-Forward Regulatory Loop
The Natural Product Secoemestrin C Inhibits Colorectal Cancer Stem Cells via p38–S100A8 Feed-Forward Regulatory Loop Open
Cancer stem cells (CSCs) are closely associated with tumor initiation, metastasis, chemoresistance, and recurrence, which represent some of the primary obstacles to cancer treatment. Targeting CSCs has become an important therapeutic appro…
View article: Study on the Spatiotemporal Evolution of Urban Land Use Efficiency in the Beijing–Tianjin–Hebei Region
Study on the Spatiotemporal Evolution of Urban Land Use Efficiency in the Beijing–Tianjin–Hebei Region Open
The Beijing–Tianjin–Hebei region (BTH) is one of the crucial areas for economic development in China. However, rapid urban expansion and industrial development in this region have severely impacted the surrounding ecological environment. T…
View article: Regulation mechanism and bioactivity characteristic of surfactin homologues with C14 and C15 fatty acid chains
Regulation mechanism and bioactivity characteristic of surfactin homologues with C14 and C15 fatty acid chains Open
View article: The <i>Cissus quadrangularis</i> genome reveals its adaptive features in an arid habitat
The <i>Cissus quadrangularis</i> genome reveals its adaptive features in an arid habitat Open
Cissus quadrangularis is a tetraploid species belonging to the Vitaceae family and is known for the Crassulacean acid metabolism (CAM) pathway in the succulent stem, while the leaves perform C3 photosynthesis. Here, we report a high-qualit…
View article: An AND Logic Gate for Magnetic‐Resonance‐Imaging‐Guided Ferroptosis Therapy of Tumors
An AND Logic Gate for Magnetic‐Resonance‐Imaging‐Guided Ferroptosis Therapy of Tumors Open
To improve the magnetic resonance imaging (MRI) efficiency and ferroptosis therapy efficacy of exceedingly small magnetic iron oxide nanoparticles (IO, <5 nm) for tumors via enhancing the sensitivity of tumor microenvironment (TME) respons…
View article: The functions and regulatory pathways of S100A8/A9 and its receptors in cancers
The functions and regulatory pathways of S100A8/A9 and its receptors in cancers Open
Inflammation primarily influences the initiation, progression, and deterioration of many human diseases, and immune cells are the principal forces that modulate the balance of inflammation by generating cytokines and chemokines to maintain…
View article: Intermittent mixing facilitates energy recovery and low carbon emissions from high-solids anaerobic co-digestion of food waste and sewage sludge
Intermittent mixing facilitates energy recovery and low carbon emissions from high-solids anaerobic co-digestion of food waste and sewage sludge Open
Mixing inside high-solids anaerobic co-digestion (HS-AcoD) is essential for process feasibility and economic sustainability. This study developed a proper energy assessment for a high solids anaerobic digestion-combined heat and power (AD-…
View article: Climate warming interacts with other global change drivers to influence plant phenology: A meta‐analysis of experimental studies
Climate warming interacts with other global change drivers to influence plant phenology: A meta‐analysis of experimental studies Open
Shifts in plant phenology influence ecosystem structures and functions, yet how multiple global change drivers interact to affect phenology remains elusive. We conducted a meta‐analysis of 242 published articles to assess interactions betw…
View article: Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4–MAPK pathway in T2DM mice
Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4–MAPK pathway in T2DM mice Open
Diabetic kidney disease (DKD) is a severe complication of type 2 diabetes mellitus (T2DM). However, the pathogenesis of DKD remains unclear, and effective treatment strategies are still lacking. Ginsenoside Rg1 (Rg1) has been reported to i…
View article: Activation of Adenosine A2b Receptor Alleviated Myocardial Ischemia Reperfusion Injury Via Inhibiting Endoplasmic Reticulum Stress and Restoring Autophagy Flux
Activation of Adenosine A2b Receptor Alleviated Myocardial Ischemia Reperfusion Injury Via Inhibiting Endoplasmic Reticulum Stress and Restoring Autophagy Flux Open
View article: Ginsenoside Rg1 alleviates learning and memory impairments and Aβ disposition through inhibiting NLRP1 inflammasome and autophagy dysfunction in APP/PS1 mice
Ginsenoside Rg1 alleviates learning and memory impairments and Aβ disposition through inhibiting NLRP1 inflammasome and autophagy dysfunction in APP/PS1 mice Open
Alzheimer's disease (AD) is a common neurodegenerative disorder. Amyloid β (Aβ) deposition is considered an important pathological feature of AD. Growing evidence has linked neuroinflammation and autophagy to Aβ deposition in the progressi…
View article: Effect of Storage Temperature and Time on Biogenic Amines in Canned Seafood
Effect of Storage Temperature and Time on Biogenic Amines in Canned Seafood Open
Biogenic amines in canned seafood are associated with food quality and human health. In this study, a total of nine biogenic amines (histamine (HIS), phenylethylamine (PHE), tyramine (TYM), putrescine (PUT), cadaverine (CAD), tryptamine (T…
View article: Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance
Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance Open
Receptor for activated C kinase 1 (RACK1) is a versatile protein involved in multiple biological processes. In a previous study by Zhao et al. , hepatic RACK1 deletion in mice led to an inhibition of autophagy, blocked autophagy-dependent …
View article: Adenosine A2a Receptor Regulates Autophagy Flux and Apoptosis to Alleviate Ischemia-Reperfusion Injury via the cAMP/PKA Signaling Pathway
Adenosine A2a Receptor Regulates Autophagy Flux and Apoptosis to Alleviate Ischemia-Reperfusion Injury via the cAMP/PKA Signaling Pathway Open
Exploring effective methods to lessen myocardial ischemia-reperfusion injury still has positive significance. The adenosine A2a receptor (A2aR) has played a crucial part in cardiac ischemia-reperfusion injury. Previous studies revealed tha…
View article: Ginsenoside Rg1 attenuates LPS-induced chronic renal injury by inhibiting NOX4-NLRP3 signaling in mice
Ginsenoside Rg1 attenuates LPS-induced chronic renal injury by inhibiting NOX4-NLRP3 signaling in mice Open
View article: ER-phagy in the Occurrence and Development of Cancer
ER-phagy in the Occurrence and Development of Cancer Open
As an organelle, the endoplasmic reticulum (ER) is closely related to protein synthesis and modification. When physiological or pathological stimuli induce disorders of ER function, misfolded proteins trigger ER-phagy, which is beneficial …
View article: Information communication technology and manufacturing decentralisation in China
Information communication technology and manufacturing decentralisation in China Open
The advent of the "information age" ushered in renewed expectations of systematic urban spatial structure transformation. However, few studies have quantitatively assessed these changes, especially the decentralisation of manufacturing emp…
View article: Methane Production, Substrates Transformation and Microbial Community in High-Solid Anaerobic Digestion: Insight into C/N Ratio and Biodegradability
Methane Production, Substrates Transformation and Microbial Community in High-Solid Anaerobic Digestion: Insight into C/N Ratio and Biodegradability Open
View article: Formation, Analytical Methods, Change Tendency, and Control Strategies of Biogenic Amines in Canned Aquatic Products: A Systematic Review
Formation, Analytical Methods, Change Tendency, and Control Strategies of Biogenic Amines in Canned Aquatic Products: A Systematic Review Open
Biogenic amines (BAs) are organic compounds with low molecular weight and can be used as indicators of the quality and safety of canned aquatic products during processing and storage. However, excess of these amines can cause foodborne poi…
View article: Eriocalyxin B Inhibits Adipogenesis in 3T3-L1 Adipocytes by Cell Cycle Arrest
Eriocalyxin B Inhibits Adipogenesis in 3T3-L1 Adipocytes by Cell Cycle Arrest Open