Huimin Jiang
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View article: Identification of novel pathogenic mutations in <i>ATP6V0A4</i> associated with distal renal tubular acidosis and analysis of wild-type expression in glomerular disease
Identification of novel pathogenic mutations in <i>ATP6V0A4</i> associated with distal renal tubular acidosis and analysis of wild-type expression in glomerular disease Open
Distal renal tubular acidosis (dRTA) is a rare renal disorder caused by genetic mutations or secondary factors. If untreated, it can result in a significant electrolyte imbalance and progressive chronic kidney disease (CKD). This study inv…
View article: Molecular mechanisms of endothelial–mesenchymal transition and its pathophysiological feature in cerebrovascular disease
Molecular mechanisms of endothelial–mesenchymal transition and its pathophysiological feature in cerebrovascular disease Open
View article: Emerging Targets, Novel Directions, and Innovative Approaches in Thrombosis Therapy
Emerging Targets, Novel Directions, and Innovative Approaches in Thrombosis Therapy Open
In clinical practice, antiplatelet, anticoagulant and fibrinolytic drugs are the mainstay of thrombosis treatment, but their potential bleeding side effects limit their widespread use. Therefore, modifying these existing drugs or developin…
View article: Hexagonal CEO 2 Nanoplates Loaded with Nife Alloy: A Synergistic Boost for Stable Oxygen Evolution Reaction
Hexagonal CEO 2 Nanoplates Loaded with Nife Alloy: A Synergistic Boost for Stable Oxygen Evolution Reaction Open
View article: Microfluidic platforms for CRISPR-based biosensing advancing molecular diagnostics from benchtop to point-of-care
Microfluidic platforms for CRISPR-based biosensing advancing molecular diagnostics from benchtop to point-of-care Open
This review highlights recent advances in microfluidics-integrated CRISPR–Cas systems for rapid, sensitive, and portable detection of diverse biomarkers, emphasizing their potential to enable sample-to-answer point-of-care diagnostics.
View article: Constructing Interconnected Cofe 2 O 4 /Cofe Alloyed Nanosheets for Efficient Oxygen Evolution Reaction
Constructing Interconnected Cofe 2 O 4 /Cofe Alloyed Nanosheets for Efficient Oxygen Evolution Reaction Open
View article: Revisiting Virchow’s triad: exploring the cellular and molecular alterations in cerebral venous congestion
Revisiting Virchow’s triad: exploring the cellular and molecular alterations in cerebral venous congestion Open
View article: Progress and recognition of idiopathic intracranial hypertension: A narrative review
Progress and recognition of idiopathic intracranial hypertension: A narrative review Open
Background Idiopathic intracranial hypertension (IIH) mainly affects obese young women, causing elevated intracranial pressure, headaches, and papilledema, risking vision loss and severe headaches. Despite weight loss as the primary treatm…
View article: Effect of sequential nursing care combined with communication intervention on visual recovery and pain after cataract ultrasound emulsification
Effect of sequential nursing care combined with communication intervention on visual recovery and pain after cataract ultrasound emulsification Open
BACKGROUND Cataracts are a common ophthalmic disease and postoperative vision recovery is crucial to patient quality of life. Rational and efficient care models play an important role in promoting vision recovery. AIM To evaluate the clini…
View article: The impact of industrialization on the distribution of heavy metals in surrounding soil: Evidence from the Chang-Zhu-Tan urban agglomeration, central China
The impact of industrialization on the distribution of heavy metals in surrounding soil: Evidence from the Chang-Zhu-Tan urban agglomeration, central China Open
Rapid industrial development has resulted in serious pollutants to the urban transitional areas. But less is known on the spatial distribution and ecological risk of heavy metals (HMs) caused by regional industrialization. In present study…
View article: Cerebral venous congestion alters CNS homeostatic plasticity, evoking tinnitus-like behavior
Cerebral venous congestion alters CNS homeostatic plasticity, evoking tinnitus-like behavior Open
View article: Microbial communities outperform extracellular polymeric substances in the reduction of hexavalent chromium by anaerobic granular sludge
Microbial communities outperform extracellular polymeric substances in the reduction of hexavalent chromium by anaerobic granular sludge Open
The reduction of hexavalent chromium [Cr(VI)] by microbiota agents is a potential method for ecological remediation in heavily contaminated soil. This study investigated the contribution of microbial community and extracellular polymeric s…
View article: Redox regulation of platelet function and thrombosis
Redox regulation of platelet function and thrombosis Open
View article: Analytical Validation of a Telomerase Reverse Transcriptase (<i>TERT</i>) Promoter Mutation Assay
Analytical Validation of a Telomerase Reverse Transcriptase (<i>TERT</i>) Promoter Mutation Assay Open
Context Telomerase reverse transcriptase (TERT) promoter-mutated thyroid cancers are associated with a decreased rate of disease-free and disease-specific survival. High-quality analytical validation of a diagnostic test promotes confidenc…
View article: Evidence for ethnicity and location as regulators of the newborn blood metabolome: a monozygous twin study
Evidence for ethnicity and location as regulators of the newborn blood metabolome: a monozygous twin study Open
Introduction Monochorionic, diamniotic (MCDA) monozygotic twins share nearly all genetic variation and a common placenta in utero . Despite this, MCDA twins are often discordant for a range of common phenotypes, including early growth and …
View article: C-Doped Amorphous Nife Alloy Nanoparticle Via Simple Room Temperature Fermentation for Efficient Oxygen Evolution Reaction
C-Doped Amorphous Nife Alloy Nanoparticle Via Simple Room Temperature Fermentation for Efficient Oxygen Evolution Reaction Open
View article: Behavioral Adaptations of Cruise-Feeding Copepods to Harmful Algal Blooms: Insights from the East China Sea
Behavioral Adaptations of Cruise-Feeding Copepods to Harmful Algal Blooms: Insights from the East China Sea Open
View article: C-Doped Amorphous Nife Alloy Nanoparticle Via Simple Room Temperature Fermentation for Efficient Oxygen Evolution Reaction
C-Doped Amorphous Nife Alloy Nanoparticle Via Simple Room Temperature Fermentation for Efficient Oxygen Evolution Reaction Open
View article: Metabolic Dysfunction in Idiopathic Intracranial Hypertension: Current Theories and Updates
Metabolic Dysfunction in Idiopathic Intracranial Hypertension: Current Theories and Updates Open
Idiopathic intracranial hypertension (IIH) is a disease characterized by increased intracranial pressure (ICP) without identifiable secondary causes. While the increased ICP is a critical diagnostic feature, the underlying pathophysiologic…
View article: Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke
Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke Open
The Coronavirus disease 2019 (COVID-19) epidemic has triggered a huge impact on healthcare, socioeconomics, and other aspects of the world over the past three years. An increasing number of studies have identified a complex relationship be…
View article: Expression and metabolism profiles of <scp>CVT</scp> associated with inflammatory responses and oxygen carrier ability in the brain
Expression and metabolism profiles of <span>CVT</span> associated with inflammatory responses and oxygen carrier ability in the brain Open
Aim As the main type of stroke, the incidence of cerebral venous thrombosis (CVT) has been rising. However, the comprehensive mechanisms behind it remain unclear. Thus, the multi‐omics study is required to investigate the mechanism after C…
View article: Molecular characteristics of circulating B cells and kidney cells at the single-cell level in special types of primary membranous nephropathy
Molecular characteristics of circulating B cells and kidney cells at the single-cell level in special types of primary membranous nephropathy Open
Background Although primary membranous nephropathy (pMN) associated with podocyte autoantibodies (POS) is becoming well-known, the molecular characteristics of the specific type of pMN that is negative for podocyte autoantibodies (NEG) is …
View article: Cell-type-specific molecular characterization of cells from circulation and kidney in IgA nephropathy with nephrotic syndrome
Cell-type-specific molecular characterization of cells from circulation and kidney in IgA nephropathy with nephrotic syndrome Open
Nephrotic syndrome (NS) is a relatively rare and serious presentation of IgA nephropathy (IgAN) (NS-IgAN). Previous research has suggested that the pathogenesis of NS-IgAN may involve circulating immune imbalance and kidney injury; however…
View article: A genomic association study revealing subphenotypes of childhood steroid-sensitive nephrotic syndrome in a larger genomic sequencing cohort
A genomic association study revealing subphenotypes of childhood steroid-sensitive nephrotic syndrome in a larger genomic sequencing cohort Open
View article: Factors associated with exclusive breastfeeding during postpartum in Lanzhou city, China: a cross-sectional study
Factors associated with exclusive breastfeeding during postpartum in Lanzhou city, China: a cross-sectional study Open
Aim Breastfeeding generates short-term and long-term benefits for both mother and child. Exclusive breastfeeding (EBF) is promoted in China for years, but its practice still lags far behind the international average, even among low- and mi…
View article: Analysis of lactate metabolism-related genes and their association with immune infiltration in septic shock via bioinformatics method
Analysis of lactate metabolism-related genes and their association with immune infiltration in septic shock via bioinformatics method Open
Background: Lactate, as an essential clinical evaluation index of septic shock, is crucial in the incidence and progression of septic shock. This study aims to investigate the differential expression, regulatory relationship, clinical diag…
View article: Cortical vein involvement and its influence in a cohort of adolescents with cerebral venous thrombosis
Cortical vein involvement and its influence in a cohort of adolescents with cerebral venous thrombosis Open
View article: Cerebral venous thrombosis in patients with autoimmune disease, hematonosis or coronavirus disease 2019: Many familiar faces and some strangers
Cerebral venous thrombosis in patients with autoimmune disease, hematonosis or coronavirus disease 2019: Many familiar faces and some strangers Open
Background Cerebral venous thrombosis, a rare stroke, is characterized by neurological dysfunction caused by bleeding and/or infarction resulting from venous sinus thrombosis, the so‐called venous stroke. Current guidelines recommend antic…
View article: Cerebral venous congestion alters brain metabolite profiles, impairing cognitive function
Cerebral venous congestion alters brain metabolite profiles, impairing cognitive function Open
Vascular cognitive impairment (VCI) represents the second most common cause of dementia after Alzheimer's disease, and pathological changes in cerebral vascular structure and function are pivotal causes of VCI. Cognitive impairment caused …
View article: #4970 SINGLE-CELL RNA SEQUENCING REVEALS THE MOLECULAR CHARACTERISTIC OF IGA-MCD
#4970 SINGLE-CELL RNA SEQUENCING REVEALS THE MOLECULAR CHARACTERISTIC OF IGA-MCD Open
Background and Aims IgA nephropathy (IgAN) is the most common primary glomerular disease in children and adolescents worldwide, and is one of the major causes of end-stage renal disease in China. Minimal change disease(MCD) is the most com…