Hong Yang
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View article: RNF168 dephosphorylation ameliorates cognitive decline in Aβ-based mouse models of Alzheimer’s disease
RNF168 dephosphorylation ameliorates cognitive decline in Aβ-based mouse models of Alzheimer’s disease Open
View article: Schwann cell-derived extracellular vesicles inhibit osteoclastogenesis through the PTEN/AKT axis in peripheral nerve-bone crosstalk
Schwann cell-derived extracellular vesicles inhibit osteoclastogenesis through the PTEN/AKT axis in peripheral nerve-bone crosstalk Open
Osteoclasts, the sole bone-resorbing cells, play a central part in bone homeostasis, and their overactivation is implicated in bone diseases such as osteoporosis. Schwann cells (SCs), the primary glial cells of the peripheral nervous syste…
View article: Integrating CEUS Imaging Features and LI-RADS Classification for Postoperative Early Recurrence Prediction in Solitary Hepatocellular Carcinoma: A Machine Learning-Based Prognostic Approach
Integrating CEUS Imaging Features and LI-RADS Classification for Postoperative Early Recurrence Prediction in Solitary Hepatocellular Carcinoma: A Machine Learning-Based Prognostic Approach Open
The GBM-based ML model integrating CEUS imaging features and LI-RADS classification demonstrates potential for predicting early postoperative recurrence of HCC, which may assist in guiding follow-up strategies.
View article: Transformer model based on Sonazoid contrast‐enhanced ultrasound for microvascular invasion prediction in hepatocellular carcinoma
Transformer model based on Sonazoid contrast‐enhanced ultrasound for microvascular invasion prediction in hepatocellular carcinoma Open
Background Microvascular invasion (MVI) is strongly associated with the prognosis of patients with hepatocellular carcinoma (HCC). Purpose To evaluate the value of Transformer models with Sonazoid contrast‐enhanced ultrasound (CEUS) in the…
View article: A rare case of potentially malignant tumor: Epithelioid angiomyolipoma of the liver
A rare case of potentially malignant tumor: Epithelioid angiomyolipoma of the liver Open
View article: Malignant risk prediction of cystic-solid thyroid nodules using a comprehensive model integrating clinical and ultrasound features, ultrasound radiomics, and deep transfer learning
Malignant risk prediction of cystic-solid thyroid nodules using a comprehensive model integrating clinical and ultrasound features, ultrasound radiomics, and deep transfer learning Open
The novel comprehensive model based on ultrasound demonstrates excellent performance in predicting the malignancy risk of CSTN, providing clinicians with a preoperative non-invasive screening method to predict the malignancy risk of CSTN.
View article: Integrating single-cell and bulk RNA sequencing data to characterize the heterogeneity of glycan-lipid metabolism polarization in hepatocellular carcinoma
Integrating single-cell and bulk RNA sequencing data to characterize the heterogeneity of glycan-lipid metabolism polarization in hepatocellular carcinoma Open
Collectively, our analysis demonstrated the metabolic heterogeneity of HCCs and enabled the development of clinical translation strategies, thus promoting understanding and clinical applications about HCC metabolism heterogeneity.
View article: Development of modified multi-parametric CT algorithms for diagnosing clear-cell renal cell carcinoma in small solid renal masses
Development of modified multi-parametric CT algorithms for diagnosing clear-cell renal cell carcinoma in small solid renal masses Open
Objective To refine the existing CT algorithm to enhance inter-reader agreement and improve the diagnostic performance for clear-cell renal cell carcinoma (ccRCC) in solid renal masses less than 4 cm. Methods A retrospective collection of …
View article: Author response: Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats
Author response: Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats Open
View article: Profiling Exosomal Metabolomics as a Means for Diagnosis and Researching Early-Stage Hypertensive Nephropathy
Profiling Exosomal Metabolomics as a Means for Diagnosis and Researching Early-Stage Hypertensive Nephropathy Open
Aims/Background Hypertension (HT) is a prevalent medical condition showing an increasing incidence rate in various populations over recent years. Long-term hypertension increases the risk of the occurrence of hypertensive nephropathy (HTN)…
View article: Preoperative prediction of lymph node metastasis in intrahepatic cholangiocarcinoma: an integrative approach combining ultrasound-based radiomics and inflammation-related markers
Preoperative prediction of lymph node metastasis in intrahepatic cholangiocarcinoma: an integrative approach combining ultrasound-based radiomics and inflammation-related markers Open
View article: Tibial Biomechanics and Adaptive Response to Mechanical Stimuli in the Green Iguana
Tibial Biomechanics and Adaptive Response to Mechanical Stimuli in the Green Iguana Open
Synopsis Mechanical loading models are used to study adaptive skeletal mechanobiology mechanisms. However, most studies have used mammal models, leaving a knowledge gap regarding how these mechanisms differ among vertebrate groups. To addr…
View article: Schwann Cell-Derived Extracellular Vesicles Inhibit Osteoclastogenesis Through the Pten/Akt Axis in Peripheral Nerve-Bone Crosstalk
Schwann Cell-Derived Extracellular Vesicles Inhibit Osteoclastogenesis Through the Pten/Akt Axis in Peripheral Nerve-Bone Crosstalk Open
View article: Melanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB
Melanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB Open
Melanin-like nanoparticles (MNPs) have recently emerged as valuable agents in antioxidant therapy due to their excellent biocompatibility and potent capacity to scavenge various reactive oxygen species (ROS). However, previous studies have…
View article: The value of multiple diffusion metrics based on whole-lesion histogram analysis in evaluating the subtypes and proliferation status of non-small cell lung cancer
The value of multiple diffusion metrics based on whole-lesion histogram analysis in evaluating the subtypes and proliferation status of non-small cell lung cancer Open
Objective Limited studies have explored the utility of whole-lesion histogram analysis in discerning the subtypes and proliferation status of non-small cell lung cancer (NSCLC), despite its potential to provide comprehensive tissue assessm…
View article: Correction to: Melatonin attenuates detrimental effects of diabetes on the niche of mouse spermatogonial stem cells by maintaining Leydig cells
Correction to: Melatonin attenuates detrimental effects of diabetes on the niche of mouse spermatogonial stem cells by maintaining Leydig cells Open
View article: Incomplete Thermal Ablation-Induced FOXP4-Mediated Promotion of Malignant Progression in Liver Cancer via NDST2
Incomplete Thermal Ablation-Induced FOXP4-Mediated Promotion of Malignant Progression in Liver Cancer via NDST2 Open
FOXP4 and NDST2 are crucial in the incomplete thermal ablation of residual cancer. FOXP4 might regulate the biological progression of residual HCC after incomplete thermal ablation through NDST2.
View article: Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats
Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats Open
Excessive consumption of sucrose, in the form of sugar-sweetened beverages, has been implicated in the pathogenesis of metabolic dysfunction‐associated fatty liver disease (MAFLD) and other related metabolic syndromes. The c-Jun N-terminal…
View article: A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in ovariectomized rats
A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in ovariectomized rats Open
Many women have sought alternative therapies to address menopause. Recently, a multi-ingredient supplement (MIS) containing L-histidine, L-carnosine, L-serine, and L-cysteine has been shown to be effective at ameliorating hepatic steatosis…
View article: Ultrasound features as predictive markers of BRAFV600E mutation in thyroid cancer: a systematic review and meta-analysis
Ultrasound features as predictive markers of BRAFV600E mutation in thyroid cancer: a systematic review and meta-analysis Open
The expression status of the BRAFV600E gene in thyroid cancer correlates with nodules exhibiting hypoechogenicity, absence of halo, irregular borders, and taller-than-wide shape. Notably, the absence of a halo and hypoechogenicity w…
View article: Deep Learning-Enabled Ultrasound Radiomics for Accurate Prediction of Breast Cancer Lymph Node Metastasis
Deep Learning-Enabled Ultrasound Radiomics for Accurate Prediction of Breast Cancer Lymph Node Metastasis Open
Background: Lymph node metastasis serves as a pivotal prognostic marker in breast cancer progression. The present study endeavors to devise a deep learning-driven ultrasound radiomics model for precise forecasting of lymph node metastasis …
View article: Overexpression of PLK1 Molecule Following Incomplete Thermal Ablation Promotes the Proliferation and Invasion of Residual Hepatocellular Carcinoma
Overexpression of PLK1 Molecule Following Incomplete Thermal Ablation Promotes the Proliferation and Invasion of Residual Hepatocellular Carcinoma Open
TAT, a widely used treatment for HCC, can exacerbate the progression of residual HCC. The present study investigated the mechanism of action of PLK1 following ITA of HCC. The PLK1 levels in HCC were determined using qRT-PCR from clinical p…
View article: Identification of clear cell renal cell carcinoma subtypes by integrating radiomics and transcriptomics
Identification of clear cell renal cell carcinoma subtypes by integrating radiomics and transcriptomics Open
Unsupervised clustering based on radiotranscriptomics can identify the intrinsic subtypes of ccRCC, and radiotranscriptomic subtypes can characterize the prognosis and molecular features of tumors, enabling noninvasive tumor risk stratific…
View article: Exploring the impact of insufficient thermal ablation on hepatocellular carcinoma: NDST2 overexpression mechanism and its role in facilitating growth and invasion of residual cancer cells
Exploring the impact of insufficient thermal ablation on hepatocellular carcinoma: NDST2 overexpression mechanism and its role in facilitating growth and invasion of residual cancer cells Open
The upregulation of NDST2 can accelerate the progression of residual HCC after ITA, suggesting a potential role for NDST2 in the therapeutic efficacy and prognosis of residual HCC.
View article: MiR-18 regulates lipid metabolism of non-alcoholic fatty liver disease via IGF1
MiR-18 regulates lipid metabolism of non-alcoholic fatty liver disease via IGF1 Open
We aimed to illustrate the regulatory effect of miR-18 on the onset of non-alcoholic fatty liver disease (NAFLD). MiR-18 level in liver tissues collected from NAFLD patients and mice was detected. In vivo and in vitro influences of miR-18 …
View article: A comparison between different human hepatocyte models reveals profound differences in net glucose production, lipid composition and metabolism in vitro
A comparison between different human hepatocyte models reveals profound differences in net glucose production, lipid composition and metabolism in vitro Open
View article: Exploring non-invasive precision treatment in non-small cell lung cancer patients through deep learning radiomics across imaging features and molecular phenotypes
Exploring non-invasive precision treatment in non-small cell lung cancer patients through deep learning radiomics across imaging features and molecular phenotypes Open
Background Accurate prediction of tumor molecular alterations is vital for optimizing cancer treatment. Traditional tissue-based approaches encounter limitations due to invasiveness, heterogeneity, and molecular dynamic changes. We aim to …
View article: Effectiveness of Glutamine Oral Care in Reducing Oral Mucositis and Improving Oral Health After Neurosurgery: A Randomized Controlled Trial with Microbiome Analysis
Effectiveness of Glutamine Oral Care in Reducing Oral Mucositis and Improving Oral Health After Neurosurgery: A Randomized Controlled Trial with Microbiome Analysis Open
BACKGROUND Hospital-acquired infections negatively impact the health of inpatients and are highly costly to treat. Oral care reduces the microorganism number in the mouth and lungs and is essential in preventing postoperative oral inflamma…
View article: Phillygenin rescues impaired autophagy flux by modulating the PI3K/Akt/mToR signaling pathway in a rat model of severe acute pancreatitis
Phillygenin rescues impaired autophagy flux by modulating the PI3K/Akt/mToR signaling pathway in a rat model of severe acute pancreatitis Open
To investigate the mechanism of pancreatic alveolar cell autophagy in rats with severe acute pancreatitis (SAP) by phillygenin (PHI) based on the PI3K/Akt/mToR pathway. Rats were randomly divided into control group (CON group), SAP model g…
View article: 1070P Patterns of adverse reactions for immune checkpoint inhibitors in cancer patients with central nervous system metastases
1070P Patterns of adverse reactions for immune checkpoint inhibitors in cancer patients with central nervous system metastases Open