Hongsheng Gui
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View article: Genetic Propensities for Psychiatric Disorders Reveal Distinct Pathways Linking Substance Use and Suicidality
Genetic Propensities for Psychiatric Disorders Reveal Distinct Pathways Linking Substance Use and Suicidality Open
This study investigates how genetic propensity for psychiatric disorders contributes to suicidal ideation or attempts via cannabis or opioid use—the two most commonly used federally controlled substances in the U.S. Using data from over 32…
View article: Developmental expression of risk genes implicates the age of onset for neuropsychiatric disorders
Developmental expression of risk genes implicates the age of onset for neuropsychiatric disorders Open
The functional effects of genetic variants associated with complex diseases exhibit pronounced spatiotemporal specificity. Although spatially resolved studies have advanced, their temporal dynamics remain poorly characterized. Here, we pre…
View article: Uncovering genetic diversity and admixture of British Africans with HLA alleles inferred from whole genome sequencing
Uncovering genetic diversity and admixture of British Africans with HLA alleles inferred from whole genome sequencing Open
View article: Differentiating the impact of non-optimum temperature and temperature variability on cause-specific cerebrovascular mortality: An individual-level, case-crossover study in Shanghai, China
Differentiating the impact of non-optimum temperature and temperature variability on cause-specific cerebrovascular mortality: An individual-level, case-crossover study in Shanghai, China Open
View article: Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes
Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes Open
View article: Inherited causes of clonal haematopoiesis in 97,691 whole genomes
Inherited causes of clonal haematopoiesis in 97,691 whole genomes Open
View article: Impact of post-traumatic stress disorder symptoms, childhood adversities and stressful life events on depressive and anxiety symptoms: insights from the UK Biobank
Impact of post-traumatic stress disorder symptoms, childhood adversities and stressful life events on depressive and anxiety symptoms: insights from the UK Biobank Open
Background Childhood adversities (CAs) and stressful life events (SLEs) are linked to depressive, anxiety, and PTSD symptoms. However, their interrelationships are not well studied. We aimed to examine the potential role of PTSD symptoms a…
View article: Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes Open
View article: Editorial: Integrative genetics and multi-omics of complex human disorders
Editorial: Integrative genetics and multi-omics of complex human disorders Open
View article: JotlasNet: Joint tensor low-rank and attention-based sparse unrolling network for accelerating dynamic MRI
JotlasNet: Joint tensor low-rank and attention-based sparse unrolling network for accelerating dynamic MRI Open
View article: Mycosphere Notes 521–571: A special edition of fungal biodiversity to celebrate Kevin D. Hyde's 70th birthday and his exceptional contributions to Mycology
Mycosphere Notes 521–571: A special edition of fungal biodiversity to celebrate Kevin D. Hyde's 70th birthday and his exceptional contributions to Mycology Open
This special edition of Mycosphere Notes commemorates the 70th birthday of Kevin D. Hyde, a seminal figure in fungal taxonomy whose work has profoundly influenced the study of fungal diversity and classification. In this paper, we provide …
View article: Integrated Transcriptome Analysis Reveals Novel Molecular Signatures for Schizophrenia Characterization
Integrated Transcriptome Analysis Reveals Novel Molecular Signatures for Schizophrenia Characterization Open
Schizophrenia (SCZ) is a complex psychiatric disorder presenting challenges for characterization. The current study aimed to identify and evaluate disease‐responsive essential genes (DREGs) to enhance the molecular characterization of SCZ.…
View article: Exploring Cuproptosis-Related Genes and Diagnostic Models in Renal Ischemia-Reperfusion Injury Using Bioinformatics, Machine Learning, and Experimental Validation
Exploring Cuproptosis-Related Genes and Diagnostic Models in Renal Ischemia-Reperfusion Injury Using Bioinformatics, Machine Learning, and Experimental Validation Open
Our study reveals that cuproptosis-related genes are significantly involved in RIRI, particularly influencing mitochondrial dysfunction and immune responses. The diagnostic models developed showed promising predictive performance across in…
View article: Genetic drivers of human plasma metabolites that determine mortality in heart failure patients with reduced ejection fraction
Genetic drivers of human plasma metabolites that determine mortality in heart failure patients with reduced ejection fraction Open
Background Heart failure with reduced ejection fraction (HFrEF) remains a significant public health issue, with the disease advancing despite neurohormonal antagonism. Energetic dysfunction is a likely contributor to residual disease progr…
View article: Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function Open
Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in …
View article: Differentiating the Impact of Non-Optimum Temperature and Temperature Variability on Cause-Specific Cerebrovascular Mortality: An Individual-Level, Case-Crossover Study in Shanghai, China
Differentiating the Impact of Non-Optimum Temperature and Temperature Variability on Cause-Specific Cerebrovascular Mortality: An Individual-Level, Case-Crossover Study in Shanghai, China Open
View article: Saprobic ascomycetes associated with woody litter from the Greater Mekong Subregion (Southwestern China and Northern Thailand)
Saprobic ascomycetes associated with woody litter from the Greater Mekong Subregion (Southwestern China and Northern Thailand) Open
View article: Current Research in Applied and Environmental Mycology Fungal Profiles 1-30
Current Research in Applied and Environmental Mycology Fungal Profiles 1-30 Open
This manuscript represents the first contribution to the CREAM notes series, including detailed descriptions and illustrations of 30 taxa distributed across two phyla (Ascomycota and Basidiomycota), including three classes (Agaricomycetes,…
View article: Correction: Cross-phenotype relationship between opioid use disorder and suicide attempts: new evidence from polygenic association and Mendelian randomization analyses
Correction: Cross-phenotype relationship between opioid use disorder and suicide attempts: new evidence from polygenic association and Mendelian randomization analyses Open
View article: Genome-Wide Association Study of Beta-Blocker Survival Benefit in Black and White Patients with Heart Failure with Reduced Ejection Fraction
Genome-Wide Association Study of Beta-Blocker Survival Benefit in Black and White Patients with Heart Failure with Reduced Ejection Fraction Open
In patients with heart failure with reduced ejection fraction (HFrEF), individual responses to beta-blockers vary. Candidate gene pharmacogenetic studies yielded significant but inconsistent results, and they may have missed important asso…
View article: Mapping the aetiological foundations of the heart failure spectrum using human genetics
Mapping the aetiological foundations of the heart failure spectrum using human genetics Open
Summary paragraph Heart failure (HF), a syndrome of symptomatic fluid overload due to cardiac dysfunction, is the most rapidly growing cardiovascular disorder. Despite recent advances, mortality and morbidity remain high and treatment inno…
View article: Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program
Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program Open
Background The All of Us Research Program enrolls diverse US participants which provide a unique opportunity to better understand the problem of opioid use. This study aims to estimate the prevalence of opioid use and its association with …
View article: The interactions between host genome and gut microbiome increase the risk of psychiatric disorders: Mendelian randomization and biological annotation
The interactions between host genome and gut microbiome increase the risk of psychiatric disorders: Mendelian randomization and biological annotation Open
View article: MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity
MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity Open
View article: Common Variants on <i>FGD5</i> Increase Hazard of Mortality or Rehospitalization in Patients With Heart Failure From the ASCEND-HF Trial
Common Variants on <i>FGD5</i> Increase Hazard of Mortality or Rehospitalization in Patients With Heart Failure From the ASCEND-HF Trial Open
BACKGROUND: Heart failure remains a global health burden, and patients hospitalized are particularly at risk, but genetic associates for subsequent death or rehospitalization are still lacking. METHODS: The genetic substudy of the ASCEND-H…
View article: Evaluation of a New Aptamer-Based Array for Soluble Suppressor of Tumorgenicity (ST2) and N-terminal Pro-B-Type Natriuretic Peptide (NTproBNP) in Heart Failure Patients
Evaluation of a New Aptamer-Based Array for Soluble Suppressor of Tumorgenicity (ST2) and N-terminal Pro-B-Type Natriuretic Peptide (NTproBNP) in Heart Failure Patients Open
View article: The genetic determinants of recurrent somatic mutations in 43,693 blood genomes
The genetic determinants of recurrent somatic mutations in 43,693 blood genomes Open
Nononcogenic somatic mutations are thought to be uncommon and inconsequential. To test this, we analyzed 43,693 National Heart, Lung and Blood Institute Trans-Omics for Precision Medicine blood whole genomes from 37 cohorts and identified …
View article: GBC: a parallel toolkit based on highly addressable byte-encoding blocks for extremely large-scale genotypes of species
GBC: a parallel toolkit based on highly addressable byte-encoding blocks for extremely large-scale genotypes of species Open
View article: Shifting as an Executive Function Separated from Updating and Inhibition in Old Age: Behavioral and Genetic Evidence
Shifting as an Executive Function Separated from Updating and Inhibition in Old Age: Behavioral and Genetic Evidence Open
View article: Additional file 1 of GBC: a parallel toolkit based on highly addressable byte-encoding blocks for extremely large-scale genotypes of species
Additional file 1 of GBC: a parallel toolkit based on highly addressable byte-encoding blocks for extremely large-scale genotypes of species Open
Additional file 1: Table S1. The basic compression performance comparison between GBC and alternative tools. Table S2. The comparison of GBC’s compression and decompression speed under multiple threads in the 1000GP3 dataset. Table S3. The…