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View article: Targeting hepatocellular carcinoma: Molecular mechanisms and clinical studies
Targeting hepatocellular carcinoma: Molecular mechanisms and clinical studies Open
Hepatocellular carcinoma (HCC), a highly vascularized solid tumor, is the second leading cause of cancer-related death worldwide. Its high morbidity, recurrence and mortality rates place an extremely heavy economic burden on global public …
View article: Living Donor Liver Transplantation Versus Deceased Donor Liver Transplantation for Hepatocellular Carcinoma and HCV Patients: An Initial Umbrella Review
Living Donor Liver Transplantation Versus Deceased Donor Liver Transplantation for Hepatocellular Carcinoma and HCV Patients: An Initial Umbrella Review Open
Background: Living donor liver transplantation (LDLT) has become a widely accepted alternative to deceased donor liver transplantation (DDLT). Nevertheless, the available meta-analyses shed light on a perplexing issue regarding which trans…
View article: Crucial functions of gut microbiota on gut–liver repair
Crucial functions of gut microbiota on gut–liver repair Open
The gut microbiota exert a critical influence on the gut–liver axis by facilitating intestinal and hepatic repair via intricate bidirectional mechanisms. Inflammatory bowel disease (IBD), metabolic-associated steatohepatitis (MASH), and th…
View article: Study on Small-Scale Forest Fire Risk Zoning Based on Random Forest and the Fuzzy Analytic Network Process
Study on Small-Scale Forest Fire Risk Zoning Based on Random Forest and the Fuzzy Analytic Network Process Open
Forest fire risk mapping is an essential measure for forest fire management. Quickly and precisely assessing forest fire risks, rationally planning fire risk zones, and scientifically allocating firefighting resources are of great signific…
View article: Exploring the Potential Link Between Autoimmune Diseases and Pan‐Cancer: A Multidatabase Mendelian Randomization Analysis
Exploring the Potential Link Between Autoimmune Diseases and Pan‐Cancer: A Multidatabase Mendelian Randomization Analysis Open
Background: The relationship between autoimmune diseases (AIDs) and cancer is unclear and this study aimed to investigate the relationship between AIDs and cancer at the genetic level using Mendelian randomization (MR). Methods: The study …
View article: Treating radiation‑related nasopharyngeal necrosis with endostar in patient with nasopharyngeal carcinoma: A report of two cases and a literature review
Treating radiation‑related nasopharyngeal necrosis with endostar in patient with nasopharyngeal carcinoma: A report of two cases and a literature review Open
Radiation-related nasopharyngeal necrosis (RRNN) is a rare and often fatal complication in patients with nasopharyngeal carcinoma (NPC). Currently, no standard treatments are recommended for RRNN. The effects of traditional conservative tr…
View article: Alveolar–arterial oxygen gradient nonlinearly impacts the 28‐day mortality of patients with sepsis: Secondary data mining based on the MIMIC‐IV database
Alveolar–arterial oxygen gradient nonlinearly impacts the 28‐day mortality of patients with sepsis: Secondary data mining based on the MIMIC‐IV database Open
Objective Lung is often implicated in sepsis, resulting in acute respiratory distress syndrome (ARDS). The alveolar–arterial oxygen gradient [D(A‐a)O 2 ] reflects lung diffusing capacity, which is usually compromised in ARDS. But whether D…
View article: Microglial/macrophage activation in the cerebrospinal fluid of neuromyelitis optica spectrum disorders
Microglial/macrophage activation in the cerebrospinal fluid of neuromyelitis optica spectrum disorders Open
Aim The aims of this pilot study were to investigate the levels of biomarkers of microglial/macrophage activation—YKL‐40, sCD163, and sCD14—in patients with neuromyelitis optica spectrum disorder (NMOSD) and determine the possible associat…
View article: Comparison of Second-Line Treatments for Patients with Platinum-Resistant Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Systematic Review and Bayesian Network Meta-Analysis
Comparison of Second-Line Treatments for Patients with Platinum-Resistant Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Systematic Review and Bayesian Network Meta-Analysis Open
Several new drugs and combination strategies can be used to treat patients with recurrent or metastatic head and neck squamous cell carcinoma in the second-line treatment. Questions regarding the relative efficacy and safety of any two of …
View article: Cancer‐specific survival after diagnosis in men versus women: A pan‐cancer analysis
Cancer‐specific survival after diagnosis in men versus women: A pan‐cancer analysis Open
Comprehensive understanding of cancer‐specific survival differences in gender is critical for cancer prevention and treatment. Based on the Surveillance Epidemiology and End Results database, we included data from the most prevalent cancer…
View article: Establishment of prediction models for COVID-19 patients in different age groups based on Random Forest algorithm
Establishment of prediction models for COVID-19 patients in different age groups based on Random Forest algorithm Open
Summary Background Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic. Age is an independent factor in death from the disease, and predictive models to stratify patients according to their mortality risk are needed. A…
View article: Association between fish oil supplementation and cancer risk according to fatty fish consumption: A large prospective population‐based cohort study using <scp>UK</scp> Biobank
Association between fish oil supplementation and cancer risk according to fatty fish consumption: A large prospective population‐based cohort study using <span>UK</span> Biobank Open
Whether regular fish oil supplementation is associated with cancer risk is controversial. We aimed to evaluate the association of fish oil supplementation on cancer risk according to fatty fish consumption patterns. From the UK Biobank coh…
View article: Prognostic Impact of Autophagy and Immunity Related Biomarker for Uveal Melanoma
Prognostic Impact of Autophagy and Immunity Related Biomarker for Uveal Melanoma Open
Background: Autophagy and immunity related genes serve crucial roles in carcinogenesis, but little is known about the prognostic impact for uveal melanoma (UM).Methods: Autophagy related and immunity related genes (AIRGs) expression data o…
View article: Development and validation of nomograms for predicting survival and recurrence in patients with parotid gland cancer
Development and validation of nomograms for predicting survival and recurrence in patients with parotid gland cancer Open
The nomogram showed good performance in predicting both OS and DFS in patients with PGC. It might be useful for selecting patients for postoperative treatments.
View article: Cancer or Tuberculosis: A Comprehensive Review of the Clinical and Imaging Features in Diagnosis of the Confusing Mass
Cancer or Tuberculosis: A Comprehensive Review of the Clinical and Imaging Features in Diagnosis of the Confusing Mass Open
Confusing masses constitute a challenging clinical problem for differentiating between cancer and tuberculosis diagnoses. This review summarizes the major theories designed to identify factors associated with misdiagnosis, such as imaging …
View article: Comparative efficacy and safety of immunotherapy in the first-line treatment of metastatic renal cell carcinoma: a systematic review and network meta-analysis
Comparative efficacy and safety of immunotherapy in the first-line treatment of metastatic renal cell carcinoma: a systematic review and network meta-analysis Open
Through a meta-analysis of the latest available first-line immunotherapy progression-free survival and overall survival data for mRCC, this study found that pembrolizumab plus axitinib might be the best immunotherapy option for first-line …
View article: Primary pulmonary diffuse large B-cell lymphoma with multiple ground-glass nodules as the primary manifestation
Primary pulmonary diffuse large B-cell lymphoma with multiple ground-glass nodules as the primary manifestation Open
Introduction: Primary pulmonary lymphoma (PPL) is a rare extranodal lymphoma. Only 5% to 20% of patients suffering from PPL have diffuse large β-cell lymphoma (DLBCL), and their chest computed tomography (CT) findings show single- or doubl…
View article: Burnout in emergency medicine physicians
Burnout in emergency medicine physicians Open
Background: Physician burnout has been a global problem that affects severely the mental status among doctors, especially in emergency medicine (EM). However, few studies have focused on emergency medicine physicians, and the published dat…