Huiping Yuan
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View article: CLMOAS: collaborative large-scale multi-objective optimization algorithms with adaptive strategies
CLMOAS: collaborative large-scale multi-objective optimization algorithms with adaptive strategies Open
In the field of multi-objective evolutionary optimization, prior studies have largely concentrated on the scalability of objective functions, with relatively less emphasis on the scalability of decision variables. However, in practical app…
View article: Microglia Drive Peripapillary Vascular Density Reduction in Normal Tension Glaucoma by Regulating the Rpl17/Stat5b/Apoa1 Axis
Microglia Drive Peripapillary Vascular Density Reduction in Normal Tension Glaucoma by Regulating the Rpl17/Stat5b/Apoa1 Axis Open
Normal tension glaucoma (NTG) is a predominant subset of glaucoma in Asia and is characterized by glaucomatous optic neuropathy in the absence of elevated intraocular pressure. Alterations in retinal blood vessels are reported to be import…
View article: CLMOAS:Collaborative Large-scale Multi-objective Optimization Algorithms with Adaptive Strategies
CLMOAS:Collaborative Large-scale Multi-objective Optimization Algorithms with Adaptive Strategies Open
In the field of multi-objective evolutionary optimization, existing research has mostly focused on the scalability of the objective dimension, while insufficient attention has been paid to the scalability of the decision variable dimension…
View article: Single‐Cell <scp>RNA</scp>‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury
Single‐Cell <span>RNA</span>‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury Open
Aging is associated with increased retinal cell apoptosis, which contributes to decreases in retinal function. Apoptotic retinal cell clearance relies on microglial efferocytosis, but the impact of aging on this process has not been fully …
View article: Exploring the Plasma Proteome: Identifying Hub Proteins linking Aging, Homeostasis, and Organ Function
Exploring the Plasma Proteome: Identifying Hub Proteins linking Aging, Homeostasis, and Organ Function Open
As effectors of interactions between genes and the environment, plasma proteins can monitor homeostasis and reflect the aging state of an organism. However, biomarkers of aging that are associated with homeostasis are still unclear. This s…
View article: Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation
Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation Open
Excessive fibrosis is the primary factor for the failure of glaucoma drainage device (GDD) implantation. Thus, strategies to suppress scar formation in GDD implantation are crucial. Although it is known that in implanted medical devices, m…
View article: Inhibiting NLRP3 Inflammasome Activation to Alleviate Retinal Inflammation and Protect the Optic Nerve of OPTN(E50K)Mice
Inhibiting NLRP3 Inflammasome Activation to Alleviate Retinal Inflammation and Protect the Optic Nerve of OPTN(E50K)Mice Open
View article: Chitosan-Rapamycin Carbon Dots Alleviate Glaucomatous Retinal Injury by Inducing Autophagy to Promote M2 Microglial Polarization
Chitosan-Rapamycin Carbon Dots Alleviate Glaucomatous Retinal Injury by Inducing Autophagy to Promote M2 Microglial Polarization Open
CRCD could serve as a potential novel treatment strategy for glaucoma, via incorporating RAPA into CDs, in turn not only mitigating its toxic side effects but also enhancing its therapeutic efficacy.
View article: Phacogoniotomy versus phacotrabeculectomy for advanced primary angle-closure glaucoma with cataract: A randomized non-inferiority trial
Phacogoniotomy versus phacotrabeculectomy for advanced primary angle-closure glaucoma with cataract: A randomized non-inferiority trial Open
Phacogoniotomy was non-inferior to phacotrabeculectomy in terms of IOP reduction for advanced PACG and cataracts. Additionally, phacogoniotomy provided a shorter surgical time, lower postoperative complication rate, fewer postoperative int…
View article: Efficacy and Safety of Biosimilar QL1207 vs. the Reference Aflibercept for Patients with Neovascular Age-Related Macular Degeneration: A Randomized Phase 3 Trial
Efficacy and Safety of Biosimilar QL1207 vs. the Reference Aflibercept for Patients with Neovascular Age-Related Macular Degeneration: A Randomized Phase 3 Trial Open
View article: Correction to: Young Sca-1 + bone marrow stem cell-derived exosomes preserve visual function via the miR-150-5p/MEKK3/JNK/c-Jun pathway to reduce M1 microglial polarization
Correction to: Young Sca-1 + bone marrow stem cell-derived exosomes preserve visual function via the miR-150-5p/MEKK3/JNK/c-Jun pathway to reduce M1 microglial polarization Open
View article: Young Sca-1+ bone marrow stem cell-derived exosomes preserve visual function via the miR-150-5p/MEKK3/JNK/c-Jun pathway to reduce M1 microglial polarization
Young Sca-1+ bone marrow stem cell-derived exosomes preserve visual function via the miR-150-5p/MEKK3/JNK/c-Jun pathway to reduce M1 microglial polarization Open
View article: Experimental and Computational Study on the C15 Phase Structure Stability Of Yzni2-Ymny System
Experimental and Computational Study on the C15 Phase Structure Stability Of Yzni2-Ymny System Open
View article: One-Year Results of a Multicenter Study: Intraocular Pressure–Lowering Effect of Combined Phacoemulsification, Goniosynechialysis, and Goniotomy for Cases of Advanced Primary Angle-Closure Glaucoma With Cataract
One-Year Results of a Multicenter Study: Intraocular Pressure–Lowering Effect of Combined Phacoemulsification, Goniosynechialysis, and Goniotomy for Cases of Advanced Primary Angle-Closure Glaucoma With Cataract Open
The 1-year results of combination of PEI+GSL+GT in treating advanced PACG cases with cataract appear to be safe and effective. Further large-scale multination and multicenter studies are warranted.
View article: Multimodal Primary Open Angle Glaucoma Early Diagnosing Program Based on Clinical Process
Multimodal Primary Open Angle Glaucoma Early Diagnosing Program Based on Clinical Process Open
Background: Glaucoma is one of the leading causes of blinding disease. Early detection can improve patients’ quality of vision. Effectively identifying primary open angle glaucoma (POAG) using structural and functional examination is criti…
View article: Effectiveness and safety of tafluprost in primary open-angle glaucoma and ocular hypertension: a post-marketing phase IV study in China
Effectiveness and safety of tafluprost in primary open-angle glaucoma and ocular hypertension: a post-marketing phase IV study in China Open
Background Prostaglandin analogs (PGAs) are the first-line treatment for primary open-angle glaucoma (POAG) and ocular hypertension (OH). This study aimed to confirm the effectiveness and safety of Tapros® (0.0015% tafluprost eye drops) in…
View article: Efficacy and safety of trabeculectomy versus peripheral iridectomy plus goniotomy in advanced primary angle-closure glaucoma: study protocol for a multicentre, non-inferiority, randomised controlled trial (the TVG study)
Efficacy and safety of trabeculectomy versus peripheral iridectomy plus goniotomy in advanced primary angle-closure glaucoma: study protocol for a multicentre, non-inferiority, randomised controlled trial (the TVG study) Open
Introduction Primary angle-closure glaucoma (PACG) is a major subtype of glaucoma that accounts for most bilateral glaucoma-related blindness globally. Filtering surgery is a conventional strategy for PACG, yet it has a long learning curve…
View article: Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation
Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation Open
Retinal ganglion cells (RGCs) axons are the signal carriers of visual information between retina and brain. Therefore, they play one of the important roles affected in many optic neurodegenerative diseases like glaucoma. Among the genetic …
View article: Efficacy and safety of phacotrabeculectomy versus phacogoniotomy in advanced primary angle-closure glaucoma: study protocol for a multicentre non-inferiority randomised controlled trial (PVP Study)
Efficacy and safety of phacotrabeculectomy versus phacogoniotomy in advanced primary angle-closure glaucoma: study protocol for a multicentre non-inferiority randomised controlled trial (PVP Study) Open
Introduction Primary angle-closure glaucoma (PACG) has a high prevalence and blinding rate across Asia. The first-line treatment of PACG is surgery, and phacotrabeculectomy remains the mainstream surgery for advanced PACG. However, it may …
View article: Neuroprotective effects of bone marrow Sca-1+ cells against age-related retinal degeneration in OPTN E50K mice
Neuroprotective effects of bone marrow Sca-1+ cells against age-related retinal degeneration in OPTN E50K mice Open
View article: Multimodal Primary Open Angle Glaucoma Early Diagnosing Program Based on Clinical Process
Multimodal Primary Open Angle Glaucoma Early Diagnosing Program Based on Clinical Process Open
Background: Glaucoma is one of the leading causes of blinding disease. Early detection can improve patients’ quality of vision. Effectively identifying primary open angle glaucoma (POAG) using structural and functional examination is criti…
View article: Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma
Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma Open
Progressive degeneration of retinal ganglion cells (RGCs) is a major characteristic of glaucoma, whose underlying mechanisms are still largely unknown. An E50K mutation in the Optineurin (OPTN) gene is a leading cause of normal tension gla…
View article: The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro
The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro Open
View article: Proteomic Comparison of Aged and OPTN E50K Retina in The Development of Normal Tension Glaucoma
Proteomic Comparison of Aged and OPTN E50K Retina in The Development of Normal Tension Glaucoma Open
Background: Progressive degeneration of retinal ganglion cells (RGCs) is a major characteristic of glaucoma, whose underlying mechanisms are still largely unknown. An E50K mutation in the Optineurin (OPTN) gene is a leading cause of normal…
View article: Proteomic Comparison of Aged and OPTN E50K Retina in the Development of Normal Tension Glaucoma
Proteomic Comparison of Aged and OPTN E50K Retina in the Development of Normal Tension Glaucoma Open
Background: Progressive degeneration of retinal ganglion cells (RGCs) is a major characteristic of glaucoma, whose underlying mechanisms are still largely unknown. An E50K mutation in the Optineurin (OPTN) gene is a leading cause of normal…
View article: Copy number variation of ubiquitin- specific proteases genes in blood leukocytes and colorectal cancer
Copy number variation of ubiquitin- specific proteases genes in blood leukocytes and colorectal cancer Open
Ubiquitin-specific proteases (USPs) play important roles in the regulation of many cancer-related biological processes. USPs copy number variation (CNVs) may affect the risk and prognosis of colorectal cancer (CRC). We detected CNVs of USP…
View article: Glaucoma Drainage Device Coated with Mitomycin C Loaded Opal Shale Microparticles to Inhibit Bleb Fibrosis
Glaucoma Drainage Device Coated with Mitomycin C Loaded Opal Shale Microparticles to Inhibit Bleb Fibrosis Open
View article: Young bone marrow Sca‐1 cells protect aged retina from ischaemia‐reperfusion injury through activation of <scp>FGF</scp>2
Young bone marrow Sca‐1 cells protect aged retina from ischaemia‐reperfusion injury through activation of <span>FGF</span>2 Open
Retinal ganglion cell apoptosis and optic nerve degeneration are prevalent in aged patients, which may be related to the decrease in bone marrow ( BM ) stem cell number/function because of the possible cross‐talk between the two organs. Th…
View article: Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway
Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway Open
Retinal ischemia-reperfusion (RIR) injury causes neuronal degeneration and initiates various optic nerve diseases. This study aimed to investigate the synergistic neuroprotective effect of rasagiline and idebenone against RIR injury. A com…
View article: Co-expression network analysis of lncRNAs and mRNAs in OPTN-silenced cells
Co-expression network analysis of lncRNAs and mRNAs in OPTN-silenced cells Open
The aim of the present study was to reveal the role of long noncoding RNAs (lncRNAs) in the regulation of the pathogenesis of optineurin (OPTN)-silenced cells. The microarray data set GSE12452 was re-annotated using the non-coding RNA func…