Hua Yang
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View article: A novel micropeptide 9790aa mediates melatonin regulation of granulosa cell proliferation, apoptosis, and estrogen secretion in Hu sheep through the MAPK1/3-Elk1 signaling pathway.
A novel micropeptide 9790aa mediates melatonin regulation of granulosa cell proliferation, apoptosis, and estrogen secretion in Hu sheep through the MAPK1/3-Elk1 signaling pathway. Open
View article: Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy
Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy Open
Cancer cells undergo significant metabolic reprogramming to support rapid growth, survival under stress, and resistance to therapies. As our understanding of tumor metabolism and the tumor microenvironment (TME) deepens, there is growing i…
View article: Toll-like Receptor Expression Patterns in the Female Reproductive Tract of Sheep
Toll-like Receptor Expression Patterns in the Female Reproductive Tract of Sheep Open
Toll-like receptors (TLRs) play crucial roles in innate immunity, but their function in reproduction remains poorly understood. This study investigated the expression patterns and localization of TLR1-9 in the reproductive system of Hu she…
View article: Novel Prognostic Stratification and Therapeutic Implications in T1N0M0 Breast Cancer: Insights from a Multi-Center Chinese Cohort
Novel Prognostic Stratification and Therapeutic Implications in T1N0M0 Breast Cancer: Insights from a Multi-Center Chinese Cohort Open
Background: Early-stage breast cancer (T1N0M0 BC) generally has a favorable prognosis, but relapse risks persist over time. The role of adjuvant systemic treatments (AST) for tumors ≤ 10 mm remains debated. Given the limited availability o…
View article: Polygonum multiflorum Stilbene Glycoside Oligomers induce the ferroptosis of triple negative breast cancer cells
Polygonum multiflorum Stilbene Glycoside Oligomers induce the ferroptosis of triple negative breast cancer cells Open
The quality control testing component and main active ingredient of Polygonum multiflorum Thunb. (P. multiflorum), known as trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-D-glucopyranoside (TSG), exhibits diverse biological activities. In this …
View article: RNA splicing and alternative polyadenylation profile during sheep zygotic genome activation
RNA splicing and alternative polyadenylation profile during sheep zygotic genome activation Open
Zygotic genome activation (ZGA) is a critical biological step in mammalian early embryo development. However, ZGA initiation in sheep and the related sophisticated RNA metabolism remains largely unknown. Here, we observed extensive alterat…
View article: H3K4me3 Genome-Wide Distribution and Transcriptional Regulation of Transposable Elements by RNA Pol2 Deposition
H3K4me3 Genome-Wide Distribution and Transcriptional Regulation of Transposable Elements by RNA Pol2 Deposition Open
Zygotic genome activation (ZGA) is critical for early embryo development and is meticulously regulated by epigenetic modifications. H3K4me3 is a transcription-permissive histone mark preferentially found at promoters, but its distribution …
View article: Enhancing antitumor activity of herceptin in HER2-positive breast cancer cells: a novel DNMT-1 inhibitor approach
Enhancing antitumor activity of herceptin in HER2-positive breast cancer cells: a novel DNMT-1 inhibitor approach Open
HER2 antagonists remain the cornerstone of therapy for patients with HER2-positive breast cancer. This study introduces a novel small-molecule inhibitor of DNA methyltransferase 1 (DNMT-1), referred to as DI-1, designed to synergize with H…
View article: Amino acids promote the rejuvenation of degenerated Metarhizium anisopliae
Amino acids promote the rejuvenation of degenerated Metarhizium anisopliae Open
Metarhizium anisopliae, an entomopathogenic fungus widely employed in agricultural and forestry pest control, faces challenges related to colony growth degradation and sporulation decline during industrial production and germplasm preserva…
View article: Enhancing Antitumor Activity of Herceptin in HER2-Positive Breast Cancer Cells: A Novel DNMT-1 Inhibitor Approach
Enhancing Antitumor Activity of Herceptin in HER2-Positive Breast Cancer Cells: A Novel DNMT-1 Inhibitor Approach Open
HER2 antagonists remain the cornerstone of therapy for patients with HER2-positive breast cancer. This study introduces a novel small-molecule inhibitor of DNA methyltransferase 1 (DNMT-1), referred to as DI-1, designed to synergize with H…
View article: Plasma proteome profiling reveals dynamic of cholesterol marker after dual blocker therapy
Plasma proteome profiling reveals dynamic of cholesterol marker after dual blocker therapy Open
View article: Comprehensive transcriptomic analysis revealing the regulatory dynamics and networks of the pituitary-testis axis in sheep across developmental stages
Comprehensive transcriptomic analysis revealing the regulatory dynamics and networks of the pituitary-testis axis in sheep across developmental stages Open
Spermatogenesis is a complex process intricately regulated by the hypothalamic-pituitary-testis (HPT) axis. However, research on the regulatory factors governing the HPT axis remains limited. This study addresses this gap by conducting a c…
View article: Pattnet：Lightweight Neural Network Models Based on Partial Convolution and Attention Mechanisms
Pattnet：Lightweight Neural Network Models Based on Partial Convolution and Attention Mechanisms Open
View article: Reviewer #1 (Public Review): The 14-3-3/spastin pathway coordinates neurite regeneration and recovery of spinal cord injury by targeting microtubule dynamics
Reviewer #1 (Public Review): The 14-3-3/spastin pathway coordinates neurite regeneration and recovery of spinal cord injury by targeting microtubule dynamics Open
Axon regeneration is abortive in the central nervous system following injury. Orchestrating microtubule dynamics has emerged as a promising approach to improve axonal regeneration. The microtubule severing enzyme spastin is essential for a…
View article: Cullin7 induces docetaxel resistance by regulating the protein level of the antiapoptotic protein Survivin in lung adenocarcinoma cells
Cullin7 induces docetaxel resistance by regulating the protein level of the antiapoptotic protein Survivin in lung adenocarcinoma cells Open
Cul7 and Survivin were both highly expressed in docetaxel-resistant LUAD cells. Our results suggest that Cul7 may inhibit apoptosis and promote the proliferation of LUAD cells by increasing the Survivin protein level, which in turn contrib…
View article: Lysine-Specific Demethylase 4D Is Critical for the Regulation of the Cell Cycle and Antioxidant Capacity in Goat Fibroblast Cells
Lysine-Specific Demethylase 4D Is Critical for the Regulation of the Cell Cycle and Antioxidant Capacity in Goat Fibroblast Cells Open
Oxidative damage to skin fibroblast cells is a causative factor in many skin diseases. Previous studies have reported that lysine-specific demethylase 4D (Kdm4d) is involved in DNA replication, but its role on antioxidant capacity remains …
View article: Graphisches Inhaltsverzeichnis: Angew. Chem. 30/2023
Graphisches Inhaltsverzeichnis: Angew. Chem. 30/2023 Open
… utilize oxygen from the atmosphere as the active material in the positive electrode and have high potential as next-generation energy devices owing to their high energy density.In their Research Article (e202304366), Kenji Miyatake et al…
View article: Graphical Abstract: Angew. Chem. Int. Ed. 30/2023
Graphical Abstract: Angew. Chem. Int. Ed. 30/2023 Open
Supramolecular ChemistryIn their Communication (e202305525), Mark J. Mac-Lachlan use a single PtÀPt bond to glue two cyclometalated hosts together and generate a flytrap-like molecule.This compound traps inorganic ions, assembles and disas…
View article: Key Soil Physicochemical Properties Regulating Microbial Community Structure under Vegetation Restoration in a Karst Region of China
Key Soil Physicochemical Properties Regulating Microbial Community Structure under Vegetation Restoration in a Karst Region of China Open
Background: Vegetation restoration influences soil properties considerably, which in turn interact with microbial community structure and regulate ecosystem stability. However, the influence of soil physical properties on soil microbial co…
View article: Automated Prediction of Complete Pathological Response to Neo-Adjuvant Chemoradiotherapy Using Hybrid Model -Based MRI Radiomics in Locally Advanced Cervical Cancer
Automated Prediction of Complete Pathological Response to Neo-Adjuvant Chemoradiotherapy Using Hybrid Model -Based MRI Radiomics in Locally Advanced Cervical Cancer Open
Background: To develop a model that could automatically predict treatment response (pathologic complete response (pCR or non-pCR) for patients with locally advanced cervical cancer (LACC) based on T2-weighted MR images and clinical paramet…
View article: The Novel Competing Endogenous Long Noncoding RNA SM2 Regulates Gonadotropin Secretion in the Hu Sheep Anterior Pituitary by Targeting the Oar-miR-16b/TGF-β/SMAD2 Signaling Pathway
The Novel Competing Endogenous Long Noncoding RNA SM2 Regulates Gonadotropin Secretion in the Hu Sheep Anterior Pituitary by Targeting the Oar-miR-16b/TGF-β/SMAD2 Signaling Pathway Open
Pituitary gonadotropins play a pivotal role in reproduction. Long noncoding RNAs (lncRNAs) have been identified as important regulators in the hypothalamic–pituitary–ovarian (HPO) axis associated with reproduction. However, the contributio…
View article: Comparative Transcriptomic Analysis of Hu Sheep Pituitary Gland Prolificacy at the Follicular and Luteal Phases
Comparative Transcriptomic Analysis of Hu Sheep Pituitary Gland Prolificacy at the Follicular and Luteal Phases Open
The pituitary gland directly regulates the reproduction of domestic animals. Research has increasingly focused on the potential regulatory mechanism of non-coding RNA in pituitary development. Little is known about the differential express…
View article: Circular RNA circPSAP functions as an efficient miR-331-3p sponge to regulate proliferation, apoptosis and bortezomib sensitivity of human multiple myeloma cells by upregulating HDAC4
Circular RNA circPSAP functions as an efficient miR-331-3p sponge to regulate proliferation, apoptosis and bortezomib sensitivity of human multiple myeloma cells by upregulating HDAC4 Open
Our findings highlight a novel mechanism, in which circPSAP functions as a miR-331-3p sponge to impact MM cell proliferation, apoptosis and BTZ sensitivity by regulating HDAC4 expression.
View article: Overexpression of bmp4, dazl, nanos3 and sycp2 in Hu Sheep Leydig Cells Using CRISPR/dcas9 System Promoted Male Germ Cell Related Gene Expression
Overexpression of bmp4, dazl, nanos3 and sycp2 in Hu Sheep Leydig Cells Using CRISPR/dcas9 System Promoted Male Germ Cell Related Gene Expression Open
Male germ cells directly affect the reproduction of males; however, their accurate isolation and culture in vitro is extremely challenging, hindering the study of germ cell development and function. CRISPR/dcas9, as an efficient gene repro…
View article: Investigating the Responses of Microbial Communities to Banana Fusarium Wilt in Suppressive and Conducive Soils Based on Soil Particle-Size Differentiation
Investigating the Responses of Microbial Communities to Banana Fusarium Wilt in Suppressive and Conducive Soils Based on Soil Particle-Size Differentiation Open
The microbiota plays a primary role in inhibiting plant pathogens in the soils. However, the correlation between soil particles and local microbial communities has not been fully confirmed. In this study, we contrasted the different assemb…
View article: Automated Prediction of Complete Pathological Response to Neo-Adjuvant Chemoradiotherapy Using Hybrid Model-Based MRI Radiomics in Locally Advanced Cervical Cancer
Automated Prediction of Complete Pathological Response to Neo-Adjuvant Chemoradiotherapy Using Hybrid Model-Based MRI Radiomics in Locally Advanced Cervical Cancer Open
View article: RETRACTED ARTICLE: Knockdown of zinc finger protein 267 suppresses diffuse large B-cell lymphoma progression, metastasis, and cancer stem cell properties
RETRACTED ARTICLE: Knockdown of zinc finger protein 267 suppresses diffuse large B-cell lymphoma progression, metastasis, and cancer stem cell properties Open
Zinc finger protein 267 (ZNF267) is a member of the Kruppel-like transcription factor family, which regulates various biological processes such as cell proliferation and differentiation. However, the biological significance of ZNF267 and i…
View article: miR-27-3p Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to the Antitumor Agent Olaparib by Targeting PSEN-1, the Catalytic Subunit of Γ-Secretase
miR-27-3p Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to the Antitumor Agent Olaparib by Targeting PSEN-1, the Catalytic Subunit of Γ-Secretase Open
Olaparib has been used in the treatment of triple-negative breast cancer (TNBC) with BRCA mutations. In the present study, we demonstrated the effect of miR-27-3p on the γ-secretase pathway by regulating the sensitivity of TNBC cells to ol…
View article: Role of Yes-associated Protein-1 in Gastrointestinal Cancers and Hepatocellular Carcinoma
Role of Yes-associated Protein-1 in Gastrointestinal Cancers and Hepatocellular Carcinoma Open
Yes-associated protein-1 (YAP1) is a potent transcriptional co-activator and functions as an important downstream effector of the Hippo signaling pathway, which is key to regulating cell proliferation, apoptosis, and organ growth. YAP1 has…
View article: Graphical Abstract: Angew. Chem. Int. Ed. 23/2021
Graphical Abstract: Angew. Chem. Int. Ed. 23/2021 Open
The recent discoveries of both dicationic and monoanionic ferrocene derivatives throw light on the effect of the substituents on the C 5 ring as well as the choice of redox agents and solvent system in the preparation of previously believe…