Huixi Chen
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View article: Characterization of DNA Methylation Episignatures for Radon-Induced Lung Cancer.
Characterization of DNA Methylation Episignatures for Radon-Induced Lung Cancer. Open
Radon (Rn) exposure has a strong association with lung cancer risk and is influenced by epigenetic modifications. To investigate the characterization of DNA methylation (DNAm) episignatures for radon-induced lung cancer, we detected the sp…
View article: Comprehensive high-throughput sequencing analysis and verification of miRNAs isolated from bronchial epithelial cells undergoing radiation-induced epithelial-mesenchymal transition
Comprehensive high-throughput sequencing analysis and verification of miRNAs isolated from bronchial epithelial cells undergoing radiation-induced epithelial-mesenchymal transition Open
Radiation-induced pulmonary fibrosis (RIPF) constitutes a significant complication in radiotherapy for various cancers, often severely limiting its efficacy. Recent studies suggest that epithelial-mesenchymal transition (EMT) plays a vital …
View article: Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance
Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance Open
Our study provides additional evidence of the abnormal behavioral phenotypes of APA offspring and reveals potential epigenetic inheritance signatures and targeted genes for future research.
View article: TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation
TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation Open
Background Although recent studies provide mechanistic understanding to the pathogenesis of radiation induced lung injury (RILI), rare therapeutics show definitive promise for treating this disease. Type II alveolar epithelial cells (AECII…
View article: Low‐dose ionizing radiation‐induced RET/PTC1 rearrangement via the non‐homologous end joining pathway to drive thyroid cancer
Low‐dose ionizing radiation‐induced RET/PTC1 rearrangement via the non‐homologous end joining pathway to drive thyroid cancer Open
Thyroid cancer incidence increases worldwide annually, primarily due to factors such as ionizing radiation (IR), iodine intake, and genetics. Papillary carcinoma of the thyroid (PTC) accounts for about 80% of thyroid cancer cases. RET/PTC1…
View article: Effects of exposure to multiple metallic elements in the first trimester of pregnancy on the risk of preterm birth
Effects of exposure to multiple metallic elements in the first trimester of pregnancy on the risk of preterm birth Open
Exposure to certain heavy metals has been demonstrated to be associated with a higher risk of preterm birth (PTB). However, studies focused on the effects of other metal mixtures were limited. A nested case‒control study enrolling 94 PTB c…
View article: DNA‐PKcs/AKT1 inhibits epithelial–mesenchymal transition during radiation‐induced pulmonary fibrosis by inducing ubiquitination and degradation of Twist1
DNA‐PKcs/AKT1 inhibits epithelial–mesenchymal transition during radiation‐induced pulmonary fibrosis by inducing ubiquitination and degradation of Twist1 Open
Introduction Radiation‐induced pulmonary fibrosis (RIPF) is a chronic, progressive, irreversible lung interstitial disease that develops after radiotherapy. Although several previous studies have focused on the mechanism of epithelial–mese…
View article: The stability of lower genital tract (LGT) microbiota correlates with reproductive system function and in vitro fertilization and frozen embryo transfer outcomes in women with polycystic ovarian syndrome
The stability of lower genital tract (LGT) microbiota correlates with reproductive system function and in vitro fertilization and frozen embryo transfer outcomes in women with polycystic ovarian syndrome Open
We previously found that the lower genital tract (LGT) microbiota of polycystic ovarian syndrome (PCOS) women has altered when compared to healthy reproductive-aged women, however whether this alternation will have an impact on the reprodu…
View article: Effect of transvaginal Lactobacillus supplementation on reversing lower genital tract dysbiosis and improving perinatal outcomes in PCOS patients after IVF-FET: a study protocol for a multicenter randomized controlled trial
Effect of transvaginal Lactobacillus supplementation on reversing lower genital tract dysbiosis and improving perinatal outcomes in PCOS patients after IVF-FET: a study protocol for a multicenter randomized controlled trial Open
Background Significant lower genital tract (LGT) dysbiosis and an associated lower rate of clinical pregnancy after in vitro fertilization–frozen embryo transfer (IVF-FET) among polycystic ovary syndrome (PCOS) patients have been previousl…
View article: Spatiotemporal transcriptome atlas of human embryos after gastrulation
Spatiotemporal transcriptome atlas of human embryos after gastrulation Open
The spatial and temporal atlas of gene expression in the human embryo at early gestation is critical in understanding embryo development, organogenesis, and disease origins. We obtained the spatiotemporal transcriptome from 90 sagittal sec…
View article: Content analysis of breast milk substitutes marketing on Chinese e‐commerce platforms
Content analysis of breast milk substitutes marketing on Chinese e‐commerce platforms Open
China has the largest and fastest‐growing breast milk substitutes (BMSs) market and a disproportionately low exclusive breastfeeding rate. Many BMS manufacturers have established Chinese e‐commerce stores. This marketing is of concern as i…
View article: Comorbidities and Quality of Life in Women Undergoing First Surgery for Endometriosis: Differences Between Chinese and Italian Population
Comorbidities and Quality of Life in Women Undergoing First Surgery for Endometriosis: Differences Between Chinese and Italian Population Open