Huixia Zheng
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View article: Hotspots and frontiers of the relationship between hepatocellular carcinoma and cancer-associated fibroblasts: a bibliometric analysis and review
Hotspots and frontiers of the relationship between hepatocellular carcinoma and cancer-associated fibroblasts: a bibliometric analysis and review Open
CAFs research in HCC has transitioned from descriptive studies to precision therapeutic targeting. Future directions involve dissecting CAFs plasticity, leveraging single-cell multiomics, and optimizing combination therapies to overcome TM…
View article: CD4 as a Potential Biomarker for Differentiating Cirrhosis with Dysplastic Nodules from Well-Differentiated Hepatocellular Carcinoma
CD4 as a Potential Biomarker for Differentiating Cirrhosis with Dysplastic Nodules from Well-Differentiated Hepatocellular Carcinoma Open
Distinguishing high-grade dysplastic nodules in cirrhotic livers from well-differentiated hepatocellular carcinoma (HCC) remains difficult due to overlapping histological features and limited biomarker specificity. In this study, 85 liver …
View article: Clofazimine enhances anti-PD-1 immunotherapy in glioblastoma by inhibiting Wnt6 signaling and modulating the tumor immune microenvironment
Clofazimine enhances anti-PD-1 immunotherapy in glioblastoma by inhibiting Wnt6 signaling and modulating the tumor immune microenvironment Open
Glioblastoma multiforme (GBM) is an aggressive and lethal primary brain tumor with limitedtreatment options due to its resistance to conventional therapies and an immunosuppressive tumor microenvironment. In this study, we investigated whe…
View article: Combined oral low-dose cyclophosphamide endocrine therapy may improve clinical response among patients with metastatic breast cancer via Tregs in TLSs
Combined oral low-dose cyclophosphamide endocrine therapy may improve clinical response among patients with metastatic breast cancer via Tregs in TLSs Open
Despite limited research on refractory and/or endocrine therapy failure in elderly metastatic breast cancer (MBC) patients, a prior study showed that low-dose oral cyclophosphamide (CY) can improve the overall survival rate of MBC patients…
View article: Oral low-dose cyclophosphamide with endocrine therapy through effects on Tregs in TLSs may improve clinical response in elderly metastatic breast cancer patients
Oral low-dose cyclophosphamide with endocrine therapy through effects on Tregs in TLSs may improve clinical response in elderly metastatic breast cancer patients Open
Background: Despite limited research on refractory and/or endocrine therapy failure in elderly metastatic breast cancer (MBC) patients, a prior study did show that low-dose oral cyclophosphamide (CY) can improve the overall survival rate o…
View article: Expression and relationship of ECT2 with cell cycle proteins CDK1 and CyclinB1 on the Paclitaxel intervention in three negative breast cancer cells
Expression and relationship of ECT2 with cell cycle proteins CDK1 and CyclinB1 on the Paclitaxel intervention in three negative breast cancer cells Open
Purpose To investigate the relationship of expression of ECT2 and cell cycle-related proteins CDK1 and CyclinB1 in triple-negative breast cancer cells (TNBC) after ECT2 overexpression and interference and after paclitaxel (PTX) therapy,and…
View article: ERBB2D16 Expression in HER2 Positive Gastric Cancer Is Associated With Resistance to Trastuzumab
ERBB2D16 Expression in HER2 Positive Gastric Cancer Is Associated With Resistance to Trastuzumab Open
The human epidermal growth factor receptor-2 (ERBB2; formerly HER2)isoform ERBB2ΔEx16 (ERBB2d16) was oncogenic by mediating epithelial-mesenchymal transition (EMT), immune evasion, and resistance cell death to the anti-HER2 (trastuzumab) t…
View article: <p>Effect of Ect2 Expression on the Growth of Triple-Negative Breast Cancer Cells with Paclitaxel Intervention</p>
Effect of Ect2 Expression on the Growth of Triple-Negative Breast Cancer Cells with Paclitaxel Intervention Open
ECT2, which is a major driving factor in the growth of breast cancer cells, plays an important role in regulating TNBC growth. PTX therapy had significantly improved efficacy after silencing ECT2. This finding indicates that the inhibition…
View article: Comparative analysis between aerial parts and roots (<i>Astragali Radix</i>) of <i>astragalus membranaceus</i> by NMR-based metabolomics
Comparative analysis between aerial parts and roots (<i>Astragali Radix</i>) of <i>astragalus membranaceus</i> by NMR-based metabolomics Open
Aerial parts of Astragalus membranaceus (APAM), which are derived from the overground part of Astragalus membranaceus consist of stems and leaves. The aim of this study was to provide a scientific basis for the comprehensive utilization of…
View article: MAPK and Hippo signaling pathways crosstalk via the RAF-1/MST-2 interaction in malignant melanoma
MAPK and Hippo signaling pathways crosstalk via the RAF-1/MST-2 interaction in malignant melanoma Open
The aim of the present study was to expound on the interactions between the mitogen-activated protein kinase (MAPK) and Hippo pathway members, and to further elucidate the molecular mechanisms of melanoma tumorigenesis. Four melanoma cell …