Huixing Wu YOU? Author Swipe

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PD-L1 antibody-modified plant-derived nanovesicles carrying a STING agonist for the combinational immunotherapy of melanoma Open

Zhanxue Xu, Xinrui Yang, Xingyu Lu, Dandan Su, Yidan Wang , et al. · 2025

Combination therapies for melanoma face challenges due to asynchronous drug delivery and associated toxicity, underscoring the need for advanced delivery systems. While immune checkpoint inhibitors (ICIs) enhance T cell activity, optimal c…

9308 GPNMB Promotes Tumor Growth and is a Biomarker for Lymphangioleiomyomatosis (LAM) Open

Erin Gibbons, Manisha Taya, Huixing Wu, Samia Lopa, Joel Moss , et al. · 2024

Disclosure: E. Gibbons: None. M. Taya: None. H. Wu: None. S. Lopa: None. J. Moss: None. E.P. Henske: None. F.X. McCormack: None. S.R. Hammes: None. Lymphangioleiomyomatosis (LAM) is a rare, progressive cystic lung disease affecting almost …

7908 GPNMB Promotes Tumor Growth And Is A Biomarker For Lymphangioleiomyomatosis (LAM) Open

Erin Gibbons, Manisha Taya, Huixing Wu, Samia Lopa, Joel Moss , et al. · 2024

Disclosure: E. Gibbons: None. M. Taya: None. H. Wu: None. S. Lopa: None. J. Moss: None. E.P. Henske: None. F.X. McCormack: None. S.R. Hammes: None. Lymphangioleiomyomatosis (LAM) is a rare, progressive cystic lung disease affecting almost …

9308 GPNMB Promotes Tumor Growth And Is A Biomarker For Lymphangioleiomyomatosis (LAM) Open

Erin Gibbons, Manisha Taya, Huixing Wu, Samia Lopa, Joel Moss , et al. · 2024

Disclosure: E. Gibbons: None. M. Taya: None. H. Wu: None. S. Lopa: None. J. Moss: None. E.P. Henske: None. F.X. McCormack: None. S.R. Hammes: None. Lymphangioleiomyomatosis (LAM) is a rare, progressive cystic lung disease affecting almost …

7908 GPNMB Promotes Tumor Growth and is a Biomarker for Lymphangioleiomyomatosis (LAM) Open

Erin Gibbons, Manisha Taya, Huixing Wu, Samia Lopa, Joel Moss , et al. · 2024

Disclosure: E. Gibbons: None. M. Taya: None. H. Wu: None. S. Lopa: None. J. Moss: None. E.P. Henske: None. F.X. McCormack: None. S.R. Hammes: None. Lymphangioleiomyomatosis (LAM) is a rare, progressive cystic lung disease affecting almost …

Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis Open

Yoshihiro Hasegawa, Jennifer M. Franks, Yusuke Tanaka, Yasuaki Uehara, David F. Read , et al. · 2024

The pathophysiology of silicosis is poorly understood, limiting development of therapies for those who have been exposed to the respirable particle. We explored mechanisms of silica-induced pulmonary fibrosis in human lung samples collecte…

Glycoprotein non-metastatic melanoma protein B promotes tumor growth and is a biomarker for lymphangioleiomyomatosis Open

Erin Gibbons, Manisha Taya, Huixing Wu, Samia Lopa, Joel Moss , et al. · 2024

Lymphangioleiomyomatosis (LAM) is a rare, progressive cystic lung disease affecting almost exclusively female-sexed individuals. The cysts represent regions of lung destruction caused by smooth muscle tumors containing mutations in one of …

Simultaneous Quantification of Venetoclax, Busulfan and Voriconazole in Plasma by Lc-Ms/Ms: Clinical Applications in Patients with Acute Myeloid Leukemia Open

Zhenhua Zhang, Bingchen Ge, Yanyu Wang, Changrui Long, Huixing Wu , et al. · 2024

THU551 Glycoprotein-NMB (GPNMB) Is A Potential Lymphangioleiomyomatosis (LAM) Therapeutic Target And Biomarker Open

Erin Gibbons, Manisha Taya, Huixing Wu, Francis X. McCormack, Stephen R. Hammes · 2023

Disclosure: E. Gibbons: None. S.R. Hammes: None. Lymphangioleiomyomatosis (LAM) is a rare, progressive, destructive cystic lung disease affecting almost exclusively female-sexed individuals. Mutations in the tuberous sclerosis (TSC1 or TSC…

Isoliquiritigenin attenuates non-alcoholic fatty liver disease via the amelioration of hepatic inflammation and autophagy in mice Open

Lina Jian, Huixing Wu, Haiyan Zeng, Ting Quan, Fan Xia , et al. · 2023

The therapeutic and pharmacological potential of isoliquiritigenin has been reported in relieving inflammation and lipid metabolism disorders, particularly in the context of non-alcoholic fatty liver disease (NAFLD). The aim of this study …

Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis Open

Yasuaki Uehara, Yusuke Tanaka, Shuyang Zhao, Nikolaos M. Nikolaidis, Lori B. Pitstick , et al. · 2023

Pulmonary alveolar microlithiasis is an autosomal recessive lung disease caused by a deficiency in the pulmonary epithelial Npt2b sodium-phosphate co-transporter that results in accumulation of phosphate and formation of hydroxyapatite mic…

Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis Open

Yoshihiro Hasegawa, Jennifer M. Franks, Yusuke Tanaka, Yasuaki Uehara, David F. Read , et al. · 2023

The pathophysiology of silicosis is poorly understood, limiting development of therapies for those who have been exposed to the respirable particle. We explored the mechanisms of silica-induced pulmonary fibrosis in a mouse model using mul…

Novel insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis Open

Yasuaki Uehara, Nikolaos M. Nikolaidis, Lori B. Pitstick, Huixing Wu, Jane Yu , et al. · 2021

Pulmonary alveolar microlithiasis (PAM) is an autosomal recessive lung disease caused by a deficiency in the pulmonary epithelial Npt2b sodium-phosphate co-transporter that results in accumulation of phosphate and formation of hydroxyapati…

A Novel Long Noncoding RNA, Lnc‐OAD, Is Required for Bone Morphogenetic Protein 2‐ (BMP‐2‐) Induced Osteoblast Differentiation Open

Zonggui Wang, Yanfang Zhou, Zhong Dai, Xiuju Chen, Chuyu Li , et al. · 2021

Long noncoding RNAs (lncRNAs) play very important roles in cell differentiation. Our recent study has demonstrated that a novel lncRNA named lnc‐OAD modulated 3T3‐L1 adipocyte differentiation. In the present study, we examined the roles of…

Serum Vascular Endothelial Growth Factor C as a Marker of Therapeutic Response to Sirolimus in Lymphangioleiomyomatosis Open

Nishant Gupta, Miles Hagner, Huixing Wu, Lisa R. Young, Anushka Palipana , et al. · 2020

Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection Open

Nikolaos M. Nikolaidis, John G. Noel, Lori B. Pitstick, Jason C. Gardner, Yasuaki Uehara , et al. · 2017

Significance Influenza is a recurring global health threat that preferentially targets vulnerable groups such as the very young, the pregnant, the elderly, and the infirm. The spread of influenza A virus (IAV) from the epithelium of the co…

Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations Open

Boon Chong Goh, Huixing Wu, Michael J. Rynkiewicz, Klaus Schulten, Barbara A. Seaton , et al. · 2016

Surfactant protein A (SP-A) is a collagenous C-type lectin (collectin) that is critical for pulmonary defense against inhaled microorganisms. Bifunctional avidity of SP-A for pathogen-associated molecular patterns (PAMPs) such as lipid A a…

Keratinocyte growth factor supports pulmonary innate immune defense through maintenance of alveolar antimicrobial protein levels and macrophage function Open

Jason C. Gardner, Huixing Wu, John G. Noel, Benjamin Ramser, Lori B. Pitstick , et al. · 2016

Keratinocyte growth factor (KGF) is an epithelial mitogen that has been reported to protect the lungs from a variety of toxic and infectious insults. In prior studies we found that recombinant human KGF accelerates clearance of bacteria fr…

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