Ping He
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View article: Lack of children in public medical imaging data points to growing age bias in biomedical AI
Lack of children in public medical imaging data points to growing age bias in biomedical AI Open
Background. Artificial intelligence (AI) is transforming healthcare, but its benefits have not been equitably distributed, with children being particularly overlooked. Only 17% of FDA-approved medical AI devices are labeled for pediatric u…
View article: ‘My body isn’t perfect, and I get quite anxious’: a qualitative exploration of body image dissatisfaction among Chinese female undergraduates
‘My body isn’t perfect, and I get quite anxious’: a qualitative exploration of body image dissatisfaction among Chinese female undergraduates Open
Objectives Body image dissatisfaction (BID) is relatively common in Chinese female undergraduates. This study aims to explore the reasons for BID among female undergraduates to develop effective early intervention strategies. Design A qual…
View article: Traditional and New Views on MSI-H/dMMR Endometrial Cancer
Traditional and New Views on MSI-H/dMMR Endometrial Cancer Open
MSI-H/dMMR endometrial cancer (EC) is closely linked to the mismatch repair (MMR) pathway, and its pathogenesis is associated with microsatellite instability (MSI) caused by abnormalities in the core genes of the conventional MMR system. T…
View article: Early plasma cytokines associated with multi-drug resistant ventilator-associated pneumonia after neurosurgery: A retrospective cohort study
Early plasma cytokines associated with multi-drug resistant ventilator-associated pneumonia after neurosurgery: A retrospective cohort study Open
Ventilator-associated pneumonia (VAP) is a major infectious complication in the neurologic intensive care unit (NICU). VAP caused by multi-drug resistant (MDR) pathogens is related to poor clinical outcomes. This study investigates the rel…
View article: Potential role of Fanconi anemia pathway in the pathogenesis of endometrial cancer (Review)
Potential role of Fanconi anemia pathway in the pathogenesis of endometrial cancer (Review) Open
Endometrial cancer (EC) is a common gynecologic malignancy that often exhibits molecular features such as extensive somatic copy number alterations, microsatellite instability and frequent TP53 mutations, which considerably affect the phys…
View article: Dynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium
Dynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium Open
Stromal fibroblasts regulate critical signaling gradients along the intestinal crypt-villus axis 1 and provide a niche that supports adjacent epithelial stem cells. Here we report that Pdgfra -expressing fibroblasts secrete ligands that pr…
View article: Establishment and evaluation of a nomogram prediction model for risk of atrial fibrillation recurrence after the cox-maze IV procedure
Establishment and evaluation of a nomogram prediction model for risk of atrial fibrillation recurrence after the cox-maze IV procedure Open
The Cox-Maze IV (CMIV) procedure is the mainstay in surgical treatment of atrial fibrillation (AF), but the rate of AF recurrence after the CMIV procedure in patients with persistent AF is difficult to accurately evaluate. In this study, w…
View article: Correlation between ultrasound measurements and the expression of Her-2 and CD147 in breast cancer
Correlation between ultrasound measurements and the expression of Her-2 and CD147 in breast cancer Open
The contrast-enhanced ultrasound data of malignant breast tumors significantly differed from those of benign tumors, demonstrating good diagnostic value for breast cancer. In addition, these ultrasound data were significantly correlated wi…
View article: Dynamic change of lymphocytes associated with short-term prognosis in anti-MDA5-positive dermatomyositis with interstitial lung disease: a multicenter retrospective study
Dynamic change of lymphocytes associated with short-term prognosis in anti-MDA5-positive dermatomyositis with interstitial lung disease: a multicenter retrospective study Open
Lymphopenia is a unique manifestation of anti-MDA5 positive dermatomyositis with interstitial lung disease (MDA5 + DM-ILD). This study aimed to investigate the relationship between dynamic changes in peripheral lymphocytes and short-term p…
View article: PerturbAtlas: a comprehensive atlas of public genetic perturbation bulk RNA-seq datasets
PerturbAtlas: a comprehensive atlas of public genetic perturbation bulk RNA-seq datasets Open
Manipulating gene expression is crucial for understanding gene function, with high-throughput sequencing techniques such as RNA-seq elucidating the downstream mechanisms involved. However, the lack of a standardized metadata format for sma…
View article: Ascending Aortic Progression After Isolated Aortic Valve Replacement Among Patients with Bicuspid and Tricuspid Aortic Valves
Ascending Aortic Progression After Isolated Aortic Valve Replacement Among Patients with Bicuspid and Tricuspid Aortic Valves Open
Our study revealed that the long-term survival and the risks of adverse aortic events between BAV and TAV patients were similar after isolated aortic valve replacement. BAV was not a risk factor of adverse aortic events.
View article: Effect of transcatheter aortic valve replacement on ascending aorta dilatation rate in patients with tricuspid and bicuspid aortic stenosis
Effect of transcatheter aortic valve replacement on ascending aorta dilatation rate in patients with tricuspid and bicuspid aortic stenosis Open
Compared with TAV-AS, BAV-AS patients were younger and underwent TAVR more frequently, resulting in a considerable survival advantage. After TAVR, ascending aorta dilatation rates were similar in BAV-AS and TAV-AS patients, suggesting an i…
View article: Early outcome of simplified total arch reconstruction under mild hypothermia (30–32 °C) with distal aortic perfusion
Early outcome of simplified total arch reconstruction under mild hypothermia (30–32 °C) with distal aortic perfusion Open
Objective We designed a simplified total arch reconstruction (s-TAR) technique which could be performed under mild hypothermia (30–32 °C) with distal aortic perfusion. This study aimed to compare its efficacy of organ protection with the c…
View article: Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein driving the genesis of Omicron variants
Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein driving the genesis of Omicron variants Open
Continued evolution of SARS-CoV-2 generates variants to challenge antibody immunity established by infection and vaccination. A connection between population immunity and genesis of virus variants has long been suggested but its molecular …
View article: Early outcome of simplified total arch reconstruction under mild hypothermia (30-32°C) with distal aortic perfusion
Early outcome of simplified total arch reconstruction under mild hypothermia (30-32°C) with distal aortic perfusion Open
Objective We designed a simplified total arch reconstruction (s-TAR) technique which could be performed under mild hypothermia (30–32°C) with distal aortic perfusion. This study aimed to compare its efficacy of organ protection with the co…
View article: Transfemoral transcatheter aortic valve replacement for pure native aortic regurgitation: one-year outcomes of a single-center study
Transfemoral transcatheter aortic valve replacement for pure native aortic regurgitation: one-year outcomes of a single-center study Open
Background Evidence about safety and efficacy of transcatheter aortic valve replacement (TAVR) with the Venus A-Valve system (Venus Medtech, Hangzhou, China) remains limited for patients with pure native aortic regurgitation (PNAR). Object…
View article: Transfemoral Transcatheter Aortic Valve Replacement for Pure Native Aortic Regurgitation: One-Year Outcomes of a Single-center study
Transfemoral Transcatheter Aortic Valve Replacement for Pure Native Aortic Regurgitation: One-Year Outcomes of a Single-center study Open
Background Evidence about safety and efficacy of transcatheter aortic valve replacement (TAVR) with the Venus A-Valve system (Venus Medtech, Hangzhou, China) remains limited for patients with pure native aortic regurgitation (PNAR). Object…
View article: High diversity of clinical Mycobacterium intracellulare in China revealed by whole genome sequencing
High diversity of clinical Mycobacterium intracellulare in China revealed by whole genome sequencing Open
Mycobacterium intracellulare is the most common cause of nontuberculous mycobacterial lung disease, with a rapidly growing prevalence worldwide. In this study, we performed comparative genomic analysis and antimicrobial susceptibility char…
View article: Extracellular vesicles derived from Trichinella Spiralis larvae promote the polarization of macrophages to M2b type and inhibit the activation of fibroblasts
Extracellular vesicles derived from Trichinella Spiralis larvae promote the polarization of macrophages to M2b type and inhibit the activation of fibroblasts Open
Trichinella spiralis ( T. spiralis ) is a globally distributed food-borne parasite that can coexist with the host for a long time after infection. Trichinella -derived secretions can regulate the immune response and fibroblasts of the host…
View article: Application Research of Three-Dimensional Printing Technology and Three-Dimensional Computed Tomography in Segmentectomy
Application Research of Three-Dimensional Printing Technology and Three-Dimensional Computed Tomography in Segmentectomy Open
Background To compare the application of the emerging 3D printing technology and 3D-CT in segmentectomy. And to explore the advantages of 3D printing technology in thoracoscopic segmentectomy. Methods We collected the clinical data of 118 …
View article: Glutamate blunts cell‐killing effects of neutrophils in tumor microenvironment
Glutamate blunts cell‐killing effects of neutrophils in tumor microenvironment Open
Neutrophils are the first defenders of the innate system for injury and infection. They have gradually been recognized as important participants in tumor initiation and development due to their heterogeneity and plasticity. In the tumor mi…
View article: Pluripotency-State-Dependent Role of Dax1 in Embryonic Stem Cells Self-Renewal
Pluripotency-State-Dependent Role of Dax1 in Embryonic Stem Cells Self-Renewal Open
Dax1(also known as Nr0b1) is regarded as an important component of the transcription factor network in mouse embryonic stem cells (ESCs). However, the role and the molecular mechanism of Dax1 in the maintenance of different pluripotency st…
View article: Construction of a five-gene prognostic model based on immune-related genes for the prediction of survival in pancreatic cancer
Construction of a five-gene prognostic model based on immune-related genes for the prediction of survival in pancreatic cancer Open
Purpose: To identify differentially expressed immune-related genes (DEIRGs) and construct a model with survival-related DEIRGs for evaluating the prognosis of patients with pancreatic cancer (PC). Methods: Six microarray gene expression da…
View article: A nomogram prediction model for sternal incision problems
A nomogram prediction model for sternal incision problems Open
Presently, the incidence and mortality rates of sternal incision problems (SIPs) after thoracotomy remain high, and no effective preventive measures are available. The data on 23 182 patients at Xinqiao Hospital, Army Medical University tr…
View article: Peer Review #2 of "GBP2 as a potential prognostic biomarker in pancreatic adenocarcinoma (v0.2)"
Peer Review #2 of "GBP2 as a potential prognostic biomarker in pancreatic adenocarcinoma (v0.2)" Open
Background Pancreatic adenocarcinoma (PAAD) is a disease with atypical symptoms, an unfavorable response to therapy, and a poor outcome.Abnormal guanylate-binding proteins (GBPs) play an important role in the host's defense against viral i…
View article: Peer Review #1 of "GBP2 as a potential prognostic biomarker in pancreatic adenocarcinoma (v0.1)"
Peer Review #1 of "GBP2 as a potential prognostic biomarker in pancreatic adenocarcinoma (v0.1)" Open
Background Pancreatic adenocarcinoma (PAAD) is a disease with atypical symptoms, an unfavorable response to therapy, and a poor outcome.Abnormal guanylate-binding proteins (GBPs) play an important role in the host's defense against viral i…
View article: Peer Review #2 of "GBP2 as a potential prognostic biomarker in pancreatic adenocarcinoma (v0.1)"
Peer Review #2 of "GBP2 as a potential prognostic biomarker in pancreatic adenocarcinoma (v0.1)" Open
Background Pancreatic adenocarcinoma (PAAD) is a disease with atypical symptoms, an unfavorable response to therapy, and a poor outcome.Abnormal guanylate-binding proteins (GBPs) play an important role in the host's defense against viral i…
View article: GABAergic synapses suppress intestinal innate immunity via insulin signaling in <i>Caenorhabditis elegans</i>
GABAergic synapses suppress intestinal innate immunity via insulin signaling in <i>Caenorhabditis elegans</i> Open
Significance GABAergic signaling is crucial for the physiological function and the pathological onset of neuropsychiatric disorder, but its roles in innate immunity remain unknown. Here, we reveal that pathogen Pseudomonas aeruginosa infec…
View article: Effect of High-Flow Nasal Cannula for Hypoxemia Following Sun's Procedure in Acute Aortic Dissection Type a Patients
Effect of High-Flow Nasal Cannula for Hypoxemia Following Sun's Procedure in Acute Aortic Dissection Type a Patients Open
Background: Patients with acute aortic dissection type A (AADA) often have hypoxemia (partial pressure of oxygen [PaO 2 ]/fraction of inspired oxygen [FiO 2 ] <300 mmHg) before weaning in the intensive care unit (ICU). This study compar…