Huji Xu
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View article: Advancing precision medicine in axial spondyloarthritis: insights from multi-omics approaches
Advancing precision medicine in axial spondyloarthritis: insights from multi-omics approaches Open
Axial Spondyloarthritis (axSpA) is a chronic inflammatory disease influenced by genetic, immune, metabolic, and environmental factors, significantly impacting patients’ quality of life. Recent advancements in multi-omics technologies—such …
View article: Multi-omic insights from a multi-ancestry genome-wide meta-analysis of ankylosing spondylitis reveal novel pathways of disease susceptibility
Multi-omic insights from a multi-ancestry genome-wide meta-analysis of ankylosing spondylitis reveal novel pathways of disease susceptibility Open
View article: POS0788 BIMEKIZUMAB DEMONSTRATED SUSTAINED EFFICACY AND SAFETY ACROSS THE FULL SPECTRUM OF AXIAL SPONDYLOARTHRITIS: 3-YEAR RESULTS FROM TWO PHASE 3 STUDIES AND THEIR OPEN-LABEL EXTENSION
POS0788 BIMEKIZUMAB DEMONSTRATED SUSTAINED EFFICACY AND SAFETY ACROSS THE FULL SPECTRUM OF AXIAL SPONDYLOARTHRITIS: 3-YEAR RESULTS FROM TWO PHASE 3 STUDIES AND THEIR OPEN-LABEL EXTENSION Open
View article: Structural basis of stepwise proton sensing-mediated GPCR activation
Structural basis of stepwise proton sensing-mediated GPCR activation Open
The regulation of pH homeostasis is crucial in many biological processes vital for survival, growth, and function of life. The pH-sensing G protein-coupled receptors (GPCRs), including GPR4, GPR65 and GPR68, play a pivotal role in detectin…
View article: Harnessing allogeneic CAR-T cell therapy for autoimmune conditions
Harnessing allogeneic CAR-T cell therapy for autoimmune conditions Open
View article: Long-term safety and efficacy of bimekizumab in axial spondyloarthritis: 2-year results from two phase 3 studies
Long-term safety and efficacy of bimekizumab in axial spondyloarthritis: 2-year results from two phase 3 studies Open
Objectives Bimekizumab, a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A, previously demonstrated efficacy and was well tolerated to 1 year in patients with non-radiographic (nr-) and radiographic (r-) axia…
View article: Corilagin Regulates Antigen Processing and Presentation by Directly Binding to Inhibit Erap1
Corilagin Regulates Antigen Processing and Presentation by Directly Binding to Inhibit Erap1 Open
View article: DTDES-KGE: Dual-Teacher Knowledge Distillation with Distinct Embedding Spaces for Knowledge Graph Embeddings
DTDES-KGE: Dual-Teacher Knowledge Distillation with Distinct Embedding Spaces for Knowledge Graph Embeddings Open
View article: Chinese guidelines for the diagnosis and treatment of rheumatoid arthritis: 2024 update
Chinese guidelines for the diagnosis and treatment of rheumatoid arthritis: 2024 update Open
Rheumatoid arthritis (RA) is an autoimmune disease with destructive arthritis as its main clinical manifestation, which is a major cause of disability. It is very important to formulate and update a guideline for the diagnosis and treatmen…
View article: Single‐cell <scp>RNA</scp> sequencing reveals the <scp>CRTAC1</scp><sup>+</sup> population actively contributes to the pathogenesis of spinal ligament degeneration by <scp>SPP1</scp><sup>+</sup> macrophage
Single‐cell <span>RNA</span> sequencing reveals the <span>CRTAC1</span><sup>+</sup> population actively contributes to the pathogenesis of spinal ligament degeneration by <span>SPP1</span><sup>+</sup> macrophage Open
Degenerative spinal stenosis is a chronic disease that affects the spinal ligaments and associated bones, resulting in back pain and disorders of the limbs among the elderly population. There are few preventive strategies for such ligament…
View article: Graphisches Inhaltsverzeichnis: Angew. Chem. 15/2024
Graphisches Inhaltsverzeichnis: Angew. Chem. 15/2024 Open
Article (e202319162).Within such coordination polymers on the close-packed silver surface, thermally activated switches from trans to cis indigo are triggered and result in isomeric indigo-Fe coordination polymers.Analytical Chemistry Dire…
View article: Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program
Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program Open
The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome arrays, resulting in over 100 associated variants. We extended this work with high-coverage whole genome sequencing analyses …
View article: NFAT5 and SLC4A10 loci associate with plasma osmolality
NFAT5 and SLC4A10 loci associate with plasma osmolality Open
Disorders of water balance, an excess or deficit of total body water relative to body electrolyte content, are common and ascertained by plasma hypo- or hypernatremia, respectively. We performed a two-stage genome-wide association study me…
View article: West meets East in genetics of ankylosing spondylitis
West meets East in genetics of ankylosing spondylitis Open
Ankylosing spondylitis (AS), a subtype of seronegative spondyloarthropathy, is a common inflammatory disease that affects the spine and sacroiliac joints of the pelvis, resulting in pain, stiffness, and eventually, joint fusion. A recent w…
View article: Bimekizumab treatment in patients with active axial spondyloarthritis: 52-week efficacy and safety from the randomised parallel phase 3 BE MOBILE 1 and BE MOBILE 2 studies
Bimekizumab treatment in patients with active axial spondyloarthritis: 52-week efficacy and safety from the randomised parallel phase 3 BE MOBILE 1 and BE MOBILE 2 studies Open
NCT03928704; NCT03928743.
View article: Improve quality of patient care for systemic lupus erythematosus in China by enhancing the construction of Centers of Excellence
Improve quality of patient care for systemic lupus erythematosus in China by enhancing the construction of Centers of Excellence Open
View article: Correction: A multi-center, open-label, randomized study to explore efficacy and safety of baricitinib in active primary Sjogren’s syndrome patients
Correction: A multi-center, open-label, randomized study to explore efficacy and safety of baricitinib in active primary Sjogren’s syndrome patients Open
View article: Autoimmune diseases exhibit shared alterations in the gut microbiota
Autoimmune diseases exhibit shared alterations in the gut microbiota Open
Objective Accumulating evidence from microbial studies have highlighted the modulatory roles of intestinal microbes in numerous human diseases, however, the shared microbial signatures across different diseases remain relatively unclear. M…
View article: Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation
Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation Open
As highly organized consortia of bacteria, biofilms have long been implicated in aggravating inflammation. However, our understanding regarding in vivo host-biofilm interactions in the complex tissue environments remains limited. Here, we …
View article: Issue Information
Issue Information Open
View article: The correlations between C-reactive protein and MRI-detected inflammation in patients with axial spondyloarthritis: a systematic review and meta-analysis
The correlations between C-reactive protein and MRI-detected inflammation in patients with axial spondyloarthritis: a systematic review and meta-analysis Open
View article: Identification of potent target and its mechanism of action of <i>Tripterygium wilfordii</i> Hook F in the treatment of lupus nephritis
Identification of potent target and its mechanism of action of <i>Tripterygium wilfordii</i> Hook F in the treatment of lupus nephritis Open
Aim The Chinese anti‐rheumatic herbal remedy Tripterygium wilfordii Hook F (TWHF) has been widely shown to be effective in treating lupus nephritis (LN), but the therapeutic targets and mechanisms of action are still unclear. In this study…
View article: Engineered protein and Jakinib nanoplatform with extraordinary rheumatoid arthritis treatment
Engineered protein and Jakinib nanoplatform with extraordinary rheumatoid arthritis treatment Open
Supplementary material (further details of DLS analysis, biocompatibility of PCP-UPA, CIA models construction, etc.) is available in the online version of this article at 10.1007/s12274-023-5838-0.
View article: Consensus on targeted drug therapy for spondyloarthritis
Consensus on targeted drug therapy for spondyloarthritis Open
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases that predominantly involve the spine and/or peripheral joints. The clinical manifestations of SpA are highly heterogenous and complicated with various comorbidities. SpA i…
View article: POS1103 BIMEKIZUMAB MAINTAINED IMPROVEMENTS IN EFFICACY ENDPOINTS AND HAD A CONSISTENT SAFETY PROFILE THROUGH 52 WEEKS IN PATIENTS WITH NON-RADIOGRAPHIC AND RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS: RESULTS FROM TWO PARALLEL PHASE 3 STUDIES
POS1103 BIMEKIZUMAB MAINTAINED IMPROVEMENTS IN EFFICACY ENDPOINTS AND HAD A CONSISTENT SAFETY PROFILE THROUGH 52 WEEKS IN PATIENTS WITH NON-RADIOGRAPHIC AND RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS: RESULTS FROM TWO PARALLEL PHASE 3 STUDIES Open
View article: Pericytes may facilitate SARS-CoV-2 entry into the nervous system
Pericytes may facilitate SARS-CoV-2 entry into the nervous system Open
Objective: Although the neurological and olfactory symptoms of coronavirus disease 2019 have been identified, the neurotropic properties of the causative virus, severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2), remai…
View article: MYC promotes fibroblast osteogenesis by regulating ALP and BMP2 to participate in ectopic ossification of ankylosing spondylitis
MYC promotes fibroblast osteogenesis by regulating ALP and BMP2 to participate in ectopic ossification of ankylosing spondylitis Open
Background Ectopic ossification is an important cause of disability in patients with ankylosing spondylitis (AS). Whether fibroblasts can transdifferentiate into osteoblasts and contribute to ossification remains unknown. This study aims t…
View article: A multi-center, open-label, randomized study to explore efficacy and safety of baricitinib in active primary Sjogren’s syndrome patients
A multi-center, open-label, randomized study to explore efficacy and safety of baricitinib in active primary Sjogren’s syndrome patients Open
View article: Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections
Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections Open
View article: Genome-Wide Association Study in Acute Tubulointerstitial Nephritis
Genome-Wide Association Study in Acute Tubulointerstitial Nephritis Open
Significance Statement Polymorphisms of HLA genes may confer susceptibility to acute tubulointerstitial nephritis (ATIN), but small sample sizes and candidate gene design have hindered their investigation. The first genome-wide association…