Zubair Khan
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View article: Acute cellular rejection in adult liver transplant recipients in Johannesburg, South Africa
Acute cellular rejection in adult liver transplant recipients in Johannesburg, South Africa Open
Background. Wits Donald Gordon Medical Centre (WDGMC) in Johannesburg, South Africa, established a liver transplant programme in 2004. Acute cellular rejection (ACR) of the transplanted liver is a serious complication because of the potent…
View article: Open‐Label, Prospective Study of a Prebiotic Gel Cream on Its Efficacy of Mild to Moderate Acne Management and Effects on the Functional Skin Microbiome
Open‐Label, Prospective Study of a Prebiotic Gel Cream on Its Efficacy of Mild to Moderate Acne Management and Effects on the Functional Skin Microbiome Open
Background Acne vulgaris is a chronic inflammatory condition, which is estimated to affect greater than 85% of the population. Acne is a multifactorial condition, which can be influenced by diet, environment, and the microbiome. Aims The p…
View article: Emerging Therapies in Inflammatory Bowel Disease: A Comprehensive Review
Emerging Therapies in Inflammatory Bowel Disease: A Comprehensive Review Open
Inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), represents a significant challenge in gastroenterology due to its chronic nature, unpredictable course, and impact on patients’ quality of life.…
View article: Actinomyces in the Bloodstream: A Pathogen or Passenger?
Actinomyces in the Bloodstream: A Pathogen or Passenger? Open
Actinomyces bacteremia may often be clinically insignificant, as the majority of patients in this study did not receive treatment and showed varied outcomes. These findings suggest the need for a cautious approach in initiating prolonged a…
View article: The Mouth Tells the Tale: Kaposi Sarcoma as the First Clue to Undiagnosed AIDS
The Mouth Tells the Tale: Kaposi Sarcoma as the First Clue to Undiagnosed AIDS Open
Kaposi sarcoma (KS) is a vascular neoplasm associated with human herpesvirus-8 (HHV-8), most commonly seen in individuals with advanced human immunodeficiency virus (HIV)/AIDS. We report the case of a 52-year-old male patient with no known…
View article: Vancomycin-Induced Severe Neutropenia in a Patient With Osteomyelitis: A Case Report
Vancomycin-Induced Severe Neutropenia in a Patient With Osteomyelitis: A Case Report Open
Vancomycin is a glycopeptide antibiotic with activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). We present a 52-year-old Caucasian HIV-positive male patient who initially presented to an …
View article: Narrative Review of the Use of Hydrocolloids in Dermatology: Applications and Benefits
Narrative Review of the Use of Hydrocolloids in Dermatology: Applications and Benefits Open
Background/Objectives: Hydrocolloid dressings are commonly used in the treatment of chronic wounds by forming a gel-like protective layer upon the dispersion of water, absorbing exudate, and creating a moist environment that promotes heali…
View article: Endoscopic blind limb reduction with septotomy for the treatment of candy cane syndrome after Roux-en-Y gastric bypass: Pilot feasibility study
Endoscopic blind limb reduction with septotomy for the treatment of candy cane syndrome after Roux-en-Y gastric bypass: Pilot feasibility study Open
Candy cane syndrome (CCS) refers to patients with a long and symptomatic blind afferent roux limb (BARL) after Roux-en-Y gastric bypass (RYGB). Revisional surgery is efficacious but can be cost prohibitive. We describe endoscopic blind lim…
View article: Effects of Blood Flow Restriction Training in Rehabilitation of Athletes with Musculoskeletal Injuries
Effects of Blood Flow Restriction Training in Rehabilitation of Athletes with Musculoskeletal Injuries Open
Musculoskeletal injuries are prevalent among athletes and often lead to prolonged rehabilitation due to muscle atrophy, strength deficits, and joint dysfunction. Traditional high-load resistance training, while effective for muscle hypertr…
View article: Factors influencing survival in sphingosine phosphate lyase insufficiency syndrome: a retrospective cross-sectional natural history study of 76 patients
Factors influencing survival in sphingosine phosphate lyase insufficiency syndrome: a retrospective cross-sectional natural history study of 76 patients Open
Background Sphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) is a recently recognized inborn error of metabolism associated with steroid-resistant nephrotic syndrome as well as adrenal insufficiency and immunological, neurologic…
View article: Salivary CD44 and Total Protein Levels to Detect Risk for Oral and Oropharyngeal Cancer Recurrence
Salivary CD44 and Total Protein Levels to Detect Risk for Oral and Oropharyngeal Cancer Recurrence Open
Importance Oral and oropharyngeal cancer have low survival rates, and incidence continues to increase. Objective To determine whether soluble CD44 and total protein (TP) are useful for monitoring head and neck cancer recurrence, either use…
View article: Natural History of Sphingosine Phosphate Lyase Insufficiency Syndrome: A Retrospective Cross-Sectional Study of 76 Patients
Natural History of Sphingosine Phosphate Lyase Insufficiency Syndrome: A Retrospective Cross-Sectional Study of 76 Patients Open
Background Sphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) is a recently recognized metabolic disorder associated with kidney, endocrine, immunological, neurological, and skin manifestations. SPLIS is caused by inactivating mu…
View article: A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal
A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal Open
HPV-associated oropharynx carcinoma (HPVOPC) tumors have a relatively low mutational burden. Elucidating the relative contributions of other tumor alterations, such as DNA methylation alterations, alternative splicing events (ASE), and cop…
View article: Study protocol: randomised controlled trial of conditioned open-label placebo (COLP) for perioperative pain management in patients with head and neck cancer
Study protocol: randomised controlled trial of conditioned open-label placebo (COLP) for perioperative pain management in patients with head and neck cancer Open
Introduction Patients with head and neck cancer have a substantial risk of chronic opioid dependence following surgery due to pain and psychosocial consequences from both the disease process and its treatments. Conditioned open-label place…
View article: Supplemental Table 2 from A Novel Functional Splice Variant of <i>AKT3</i> Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers
Supplemental Table 2 from A Novel Functional Splice Variant of <i>AKT3</i> Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers Open
Summary of sample cohort clinical data in tumors and normal samples including age, gender, race, smoking history, TNM stage, recurrence, follow up time, survival and HPV status
View article: Data from Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks
Data from Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks Open
Chromatin alterations mediate mutations and gene expression changes in cancer. Chromatin immunoprecipitation followed by sequencing (ChIP-Seq) has been utilized to study genome-wide chromatin structure in human cancer cell lines, yet numer…
View article: Data from Detection of <i>TIMP3</i> Promoter Hypermethylation in Salivary Rinse as an Independent Predictor of Local Recurrence-Free Survival in Head and Neck Cancer
Data from Detection of <i>TIMP3</i> Promoter Hypermethylation in Salivary Rinse as an Independent Predictor of Local Recurrence-Free Survival in Head and Neck Cancer Open
Purpose: To validate a panel of methylation-based salivary rinse biomarkers (P16, CCNA1, DCC, TIMP3, MGMT, DAPK, and MINT31) previously shown to be independently associated with poor overall survival and local recurrence in a larger, separ…
View article: Data from Tadalafil Augments Tumor Specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma
Data from Tadalafil Augments Tumor Specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma Open
Purpose: To determine if phosphodiesterase 5 (PDE5) inhibitors can augment immune function in patients with head and neck cancer through inhibition of myeloid-derived suppressor cells (MDSC).Experimental Design: We performed a randomized, …
View article: Table S2 from Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant
Table S2 from Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant Open
Full list of 580 validated ASEs associated with HPV negative HNSCC
View article: Legends for supplemental figures and table from Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks
Legends for supplemental figures and table from Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks Open
Legends for supplemental figures S1-S15 and tables S1-S11
View article: Supplementary Figures from A Novel Functional Splice Variant of <i>AKT3</i> Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers
Supplementary Figures from A Novel Functional Splice Variant of <i>AKT3</i> Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers Open
SFigure 1. Distribution of ASEs present within each tumor. SFigure2. AKT3 splice variant expression by qRT-PCR in a panel of 20 cell lines. SFigure 3. Western blot analysis of canonical AKT1 pathway after transient knockdown of AKT3 splice…
View article: Table S6 from Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant
Table S6 from Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant Open
Correlations between the expression of DOCK5 variant and clinicopathological parameters in TCGA HPV negative HNSCC data
View article: Supplementary Table 3 from A Novel Functional Splice Variant of <i>AKT3</i> Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers
Supplementary Table 3 from A Novel Functional Splice Variant of <i>AKT3</i> Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers Open
List of 109 validated junctions associated with splice variants with location, gene symbol and category.
View article: Data from Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks
Data from Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks Open
Chromatin alterations mediate mutations and gene expression changes in cancer. Chromatin immunoprecipitation followed by sequencing (ChIP-Seq) has been utilized to study genome-wide chromatin structure in human cancer cell lines, yet numer…
View article: Table S4 from Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant
Table S4 from Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant Open
Correlations between number of ASEs and clinicopathological parameters in TCGA HPV negative HNSCC data
View article: Data from Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant
Data from Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant Open
Purpose: Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide, and alternative splicing is considered to play important roles in tumor progression. Our study is designed to identify alternative splicing…