Huma Shehwana
YOU?
Author Swipe
View article: An exploratory machine learning study on paediatric abdominal pain phenotyping and prediction
An exploratory machine learning study on paediatric abdominal pain phenotyping and prediction Open
Background The exact mechanisms underlying paediatric abdominal pain (AP) remain unclear due to patient heterogeneity. This preliminary study aimed to identify AP phenotypes and develop predictive models to explore associated factors, with…
View article: 118 Multi-omics profiling reveals shared molecular signatures in psoriasis target plaques across disease severities during guselkumab induction therapy
118 Multi-omics profiling reveals shared molecular signatures in psoriasis target plaques across disease severities during guselkumab induction therapy Open
View article: Clinical, pathological and molecular characteristics of patients with disease recurrence despite pathologic response to neoadjuvant ipilimumab plus nivolumab in stage III melanoma
Clinical, pathological and molecular characteristics of patients with disease recurrence despite pathologic response to neoadjuvant ipilimumab plus nivolumab in stage III melanoma Open
No genetic changes explaining tumor immune evasion are found. We propose that disease recurrence may potentially be explained by diminishing of the initial therapy-induced immune response, but not due to genetic changes in the tumor cells …
View article: Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas
Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas Open
Background Human gliomas are classified using isocitrate dehydrogenase (IDH) status as a prognosticator; however, the influence of genetic differences and treatment effects on ensuing immunity remains unclear. Methods In this study, we use…
View article: An exploratory machine learning study on paediatric abdominal pain phenotyping and prediction
An exploratory machine learning study on paediatric abdominal pain phenotyping and prediction Open
Background The exact mechanisms underlying paediatric abdominal pain (AP) remain unclear due to patient heterogeneity. This study aimed to identify AP phenotypes and develop predictive models to explore associated factors. Methods In 13,79…
View article: Supplementary Figures and Table from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells
Supplementary Figures and Table from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells Open
Supplementary Data file, Figure S1-S9, Table S1
View article: Supplementary Figures and Table from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells
Supplementary Figures and Table from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells Open
Supplementary Data file, Figure S1-S9, Table S1
View article: Data from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells
Data from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells Open
Cross-presentation of tumor antigens by dendritic cells (DC) is crucial to prime, stimulate and restimulate CD8+ T cells. This process is important in initiating and maintaining an antitumor response. Here, we show that the pres…
View article: Supplementary Figures and Table from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells
Supplementary Figures and Table from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells Open
Supplementary Data file, Figure S1-S9, Table S1
View article: Data from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells
Data from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells Open
Cross-presentation of tumor antigens by dendritic cells (DC) is crucial to prime, stimulate and restimulate CD8+ T cells. This process is important in initiating and maintaining an antitumor response. Here, we show that the pres…
View article: Data from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells
Data from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells Open
Cross-presentation of tumor antigens by dendritic cells (DC) is crucial to prime, stimulate and restimulate CD8+ T cells. This process is important in initiating and maintaining an antitumor response. Here, we show that the pres…
View article: Supplementary Figures and Table from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells
Supplementary Figures and Table from Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells Open
Supplementary Data file, Figure S1-S9, Table S1
View article: Immune landscape of isocitrate dehydrogenase stratified human gliomas
Immune landscape of isocitrate dehydrogenase stratified human gliomas Open
The brain tumor immune microenvironment (TIME) continuously evolves during glioma progression, but only a limited view of a highly complex glioma associated immune contexture across isocitrate dehydrogenase mutation (IDH) classified glioma…
View article: 1001 Immunophenotyping of brain tumors identifies interferon enriched phagocytes in human gliomas
1001 Immunophenotyping of brain tumors identifies interferon enriched phagocytes in human gliomas Open
Background Gliomas are recalcitrant brain tumors. Anti-glioma immunity and immunopathogenic responses are critical contributors for better survival of isocitrate dehydrogenase-mutant (IDHmut) over wild-type (IDHwt) gl…
View article: 979 Compound screen identifies inhibitor of apoptosis proteins (IAP) antagonist as an inducer of T cell proliferation after cross-presentation by dendritic cells
979 Compound screen identifies inhibitor of apoptosis proteins (IAP) antagonist as an inducer of T cell proliferation after cross-presentation by dendritic cells Open
Background Cross-presentation of tumor antigens by dendritic cells (DCs) is crucial to prime and (re-) stimulate CD8+ T cells. This process is important in initiating and maintaining an anti-tumor response. Previously, we found …
View article: RPPA SPACE: an R package for normalization and quantitation of Reverse-Phase Protein Array data
RPPA SPACE: an R package for normalization and quantitation of Reverse-Phase Protein Array data Open
Summary Reverse-Phase Protein Array (RPPA) is a robust high-throughput, cost-effective platform for quantitatively measuring proteins in biological specimens. However, converting raw RPPA data into normalized, analysis-ready data remains a…
View article: Transcriptome Analysis of Host Inflammatory Responses to the Ectoparasitic Mite Sarcoptes scabiei var. hominis
Transcriptome Analysis of Host Inflammatory Responses to the Ectoparasitic Mite Sarcoptes scabiei var. hominis Open
Scabies, a human skin infestation caused by the ectoparasitic mite Sarcoptes scabiei var. hominis , affects more than 200 million people globally. The prevailing knowledge of the disease process and host immune response mechanisms is limit…
View article: IMMU-43. IMMUNE CONTEXTURE OF ISOCITRATE DEHYDROGENASE STRATIFIED HUMAN GLIOMAS REVEALED BY SINGLE-CELL TRANSCRIPTOMICS AND ACCESSIBLE CHROMATIN
IMMU-43. IMMUNE CONTEXTURE OF ISOCITRATE DEHYDROGENASE STRATIFIED HUMAN GLIOMAS REVEALED BY SINGLE-CELL TRANSCRIPTOMICS AND ACCESSIBLE CHROMATIN Open
The immune cell composition of isocitrate dehydrogenase wild type (IDH-wt) glioma patients significantly differs compared to IDH-mutant (IDH-mut) yet a detailed and unbiased understanding of their transcriptomic and epigenetic landscapes r…
View article: Functional analysis of co-expression networks of zebrafish <i>ace2</i> reveals enrichment of pathways associated with development and disease
Functional analysis of co-expression networks of zebrafish <i>ace2</i> reveals enrichment of pathways associated with development and disease Open
Human Angiotensin I Converting Enzyme 2 (ACE2) plays an essential role in blood pressure regulation and SARS-CoV-2 entry. ACE2 has a highly conserved, one-to-one ortholog (ace2) in zebrafish, which is an important model for human diseases.…
View article: OTME-23. Single-cell transcriptomic and epigenomic immune landscape of isocitrate dehydrogenase stratified human gliomas
OTME-23. Single-cell transcriptomic and epigenomic immune landscape of isocitrate dehydrogenase stratified human gliomas Open
The brain tumor immune microenvironment (TIME) continuously evolves during glioma progression, but a comprehensive characterization of the glioma-centric immune cell repertoire beyond a priori cell states is uncharted. In this study, we pe…
View article: TISON: a next-generation multi-scale modeling theatre for<i>in silico</i>systems oncology
TISON: a next-generation multi-scale modeling theatre for<i>in silico</i>systems oncology Open
Multi-scale models integrating biomolecular data from genetic, transcriptional, and translational levels, coupled with extracellular microenvironments can assist in decoding the complex mechanisms underlying system-level diseases such as c…
View article: Transcriptome profiles associated with selenium-deficiency-dependent oxidative stress identify potential diagnostic and therapeutic targets in liver cancer cells
Transcriptome profiles associated with selenium-deficiency-dependent oxidative stress identify potential diagnostic and therapeutic targets in liver cancer cells Open
Hepatocellular carcinoma (HCC) is one of the most common cancer types with high mortality rates and displays increased resistance to various stress conditions such as oxidative stress. Conventional therapies have low efficacies due to resi…
View article: Prenatal Diagnosis of Birth Defects by Exome Sequencing
Prenatal Diagnosis of Birth Defects by Exome Sequencing Open
Prenatal screening and diagnosis are increasingly becoming a part of medical practice. Prenatal screening can reduce the incidence of birth defects which cause morbidity and mortality in newborns. With emerging technologies, now it is poss…
View article: <i>ace2</i>expression is higher in intestines and liver while being tightly regulated in development and disease in zebrafish
<i>ace2</i>expression is higher in intestines and liver while being tightly regulated in development and disease in zebrafish Open
Human Angiotensin I Converting Enzyme 2 ( ACE2 ) that acts as a receptor for SARS-CoV-2 entry is highly expressed in human type II pneumocytes and enterocytes and similarly in other mammals and zebrafish ( Danio rerio ). The zebrafish geno…
View article: 540 Transcriptionally defined immune landscape in human gliomas
540 Transcriptionally defined immune landscape in human gliomas Open
Background Brain immunity is largely myeloid cell dominated rather than lymphoid cells in healthy and diseased state including malignancies of glial origins called as gliomas. Despite this skewed myeloid centric immune contexture, immune c…
View article: IMMU-35. TRANSCRIPTIONALLY DEFINED IMMUNE CONTEXTURE IN HUMAN GLIOMAS AT SINGLE-CELL RESOLUTION
IMMU-35. TRANSCRIPTIONALLY DEFINED IMMUNE CONTEXTURE IN HUMAN GLIOMAS AT SINGLE-CELL RESOLUTION Open
The brain tumor immune microenvironment (TIME) continuously evolves during glioma progression and a comprehensive understanding of the glioma-centric immune cell repertoire beyond a priori cell types and/or states is uncharted. Consequentl…
View article: Transcription Factors STAT5A and SPI1 Reveals RHBDD2 as a Potential Biomarker in Sepsis and Septic Shock
Transcription Factors STAT5A and SPI1 Reveals RHBDD2 as a Potential Biomarker in Sepsis and Septic Shock Open
Sepsis is a serious health situation caused by uncontrolled infection and septic shock is a severe condition of sepsis. RHBDD2 is a member of the rhomboid superfamily which is overexpressed in different types of cancer and associated with …
View article: The Transcription Factor Elf3 Is Essential for a Successful Mesenchymal to Epithelial Transition
The Transcription Factor Elf3 Is Essential for a Successful Mesenchymal to Epithelial Transition Open
The epithelial to mesenchymal transition (EMT) and the mesenchymal to epithelial transition (MET) are two critical biological processes that are involved in both physiological events such as embryogenesis and development and also pathologi…
View article: Comparative Transcriptomics Between Zebrafish and Mammals: A Roadmap for Discovery of Conserved and Unique Signaling Pathways in Physiology and Disease
Comparative Transcriptomics Between Zebrafish and Mammals: A Roadmap for Discovery of Conserved and Unique Signaling Pathways in Physiology and Disease Open
OPINION article Front. Cell Dev. Biol., 01 February 2019Sec. Cell Growth and Division Volume 7 - 2019 | https://doi.org/10.3389/fcell.2019.00005
View article: Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi is associated with cell cycle inhibition, apoptosis, DNA damage response and drug sensitivity in breast cancer
Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi is associated with cell cycle inhibition, apoptosis, DNA damage response and drug sensitivity in breast cancer Open
Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is an important susceptibility locus for nicotine addiction and lung cancer. Depletion of CHRNA5 has been associated with reduced cell viability, increased apoptosis and alterations in cellul…