Humberto Alejandro Nati-Castillo
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View article: Immunodynamic Disruption in Sepsis: Mechanisms and Strategies for Personalized Immunomodulation
Immunodynamic Disruption in Sepsis: Mechanisms and Strategies for Personalized Immunomodulation Open
Sepsis is a life-threatening syndrome caused by a dysregulated host response to infection. It follows a dynamic course in which early hyperinflammation coexists and overlaps with progressive immune suppression, a process best described as …
View article: First successful use of ampicillin-sulbactam for rare Streptococcus agalactiae-associated peritonitis in peritoneal dialysis: a case report and literature review
First successful use of ampicillin-sulbactam for rare Streptococcus agalactiae-associated peritonitis in peritoneal dialysis: a case report and literature review Open
Introduction Peritonitis is a major complication of peritoneal dialysis, most often caused by gram-positive cocci. Streptococcus agalactiae (Group B Streptococcus) is an exceptionally rare pathogen in this context. Case presentation We des…
View article: Point-of-care ultrasound (POCUS) as a key tool in the diagnosis of pheochromocytoma: a case report in an elderly patient with extreme blood pressure variability
Point-of-care ultrasound (POCUS) as a key tool in the diagnosis of pheochromocytoma: a case report in an elderly patient with extreme blood pressure variability Open
Background Pheochromocytoma is a rare, life-threatening, neuroendocrine tumor originating from catecholamine-secreting chromaffin cells, with an incidence of up to 8 per million people globally each year. It manifests a broad spectrum of s…
View article: Inflammasomes and Signaling Pathways: Key Mechanisms in the Pathophysiology of Sepsis
Inflammasomes and Signaling Pathways: Key Mechanisms in the Pathophysiology of Sepsis Open
Sepsis is a life-threatening syndrome characterized by a dysregulated immune response to infection, frequently leading to multiorgan failure and high mortality. Inflammasomes—cytosolic multiprotein complexes of the innate immune system—ser…
View article: Correction: Molecular confirmation of Cryptosporidium and Cyclospora species in children with acute diarrhoea in Quindio region, Colombia
Correction: Molecular confirmation of Cryptosporidium and Cyclospora species in children with acute diarrhoea in Quindio region, Colombia Open
View article: Sepsis and post-sepsis syndrome: a multisystem challenge requiring comprehensive care and management—a review
Sepsis and post-sepsis syndrome: a multisystem challenge requiring comprehensive care and management—a review Open
Sepsis, a medical emergency with high mortality rates, demands comprehensive care spanning from early identification to patient rehabilitation. The sepsis survival chain encompasses early recognition, severity assessment, activation of eme…
View article: Microgravity and Cellular Biology: Insights into Cellular Responses and Implications for Human Health
Microgravity and Cellular Biology: Insights into Cellular Responses and Implications for Human Health Open
Microgravity, defined by minimal gravitational forces, represents a unique environment that profoundly influences biological systems, including human cells. This review examines the effects of microgravity on biological processes and their…
View article: Molecular confirmation of Cryptosporidium and Cyclospora species in children with acute diarrhoea in Quindio region, Colombia
Molecular confirmation of Cryptosporidium and Cyclospora species in children with acute diarrhoea in Quindio region, Colombia Open
View article: Impact of Mobile Phone Usage on Sleep Quality Among Medical Students Across Latin America: Multicenter Cross-Sectional Study
Impact of Mobile Phone Usage on Sleep Quality Among Medical Students Across Latin America: Multicenter Cross-Sectional Study Open
Background The ubiquitous use of mobile phones among medical students has been linked to potential health consequences, including poor sleep quality. Objective This study investigates the prevalence of mobile phone addiction and its associ…
View article: Pheochromocytoma: an updated scoping review from clinical presentation to management and treatment
Pheochromocytoma: an updated scoping review from clinical presentation to management and treatment Open
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from chromaffin cells, with 80–85% originating in the adrenal medulla and 15–20% from extra-adrenal chromaffin tissues (paragangliomas). Approximately 30–4…
View article: A decade of iron overload disorders and hemochromatosis: clinical and genetic findings from a specialized center in Colombia
A decade of iron overload disorders and hemochromatosis: clinical and genetic findings from a specialized center in Colombia Open
Background Iron overload disorders, including hereditary hemochromatosis (HH), are characterized by excessive iron accumulation, which can cause severe organ damage. HH is most associated with the C282Y mutation in Caucasian populations, b…
View article: Exploring smartphone use and its applicability in academic training of medical students in Latin America: a multicenter cross-sectional study
Exploring smartphone use and its applicability in academic training of medical students in Latin America: a multicenter cross-sectional study Open
Background Mobile phones are essential tools worldwide, including for the academic training of medical students. However, their role in Latin America (LATAM) remains underexplored. This study aimed to evaluate cell phone use and its applic…
View article: Fatal nephrobronchial fistula arising from xanthogranulomatous pyelonephritis: a case report
Fatal nephrobronchial fistula arising from xanthogranulomatous pyelonephritis: a case report Open
Introduction Nephrobronchial fistula is an exceptionally rare complication of renal infections, including the uncommon xanthogranulomatous pyelonephritis. Existing literature is limited to a few case reports, with antibiotic therapy and ne…
View article: Unusual adult-onset cardiac rhabdomyomas in tuberous sclerosis complex: a case report
Unusual adult-onset cardiac rhabdomyomas in tuberous sclerosis complex: a case report Open
Background Tuberous sclerosis complex is a genetic neurocutaneous autosomal dominant syndrome, characterized by the development of multiple benign tumors (hamartomas) affecting various systems. Heart-benign tumors that result from the comp…
View article: Takotsubo syndrome as an acute cardiac complication following combined chemotherapy
Takotsubo syndrome as an acute cardiac complication following combined chemotherapy Open
View article: Impact of Mobile Phone Usage on Sleep Quality Among Medical Students Across Latin America: A Multicenter Cross-Sectional Study (Preprint)
Impact of Mobile Phone Usage on Sleep Quality Among Medical Students Across Latin America: A Multicenter Cross-Sectional Study (Preprint) Open
BACKGROUND The ubiquitous use of mobile phones among medical students has been linked to potential health consequences, including poor sleep quality. OBJECTIVE This study investigates the prevalence of mobile phone addiction and its ass…
View article: Case Report: Expanding the phenotypic spectrum of PURA syndrome in South America with the first presentation of concurrent vitiligo
Case Report: Expanding the phenotypic spectrum of PURA syndrome in South America with the first presentation of concurrent vitiligo Open
Purine-rich element-binding protein A (PURα) regulates multiple cellular processes. Rare de novo mutations can lead to PURA syndrome, which manifests as a range of multisystem disturbances, including hypotonia, global developmental delay, …
View article: Characteristics of Inhaler Technique in COPD Patients in a Specialized Center in Armenia, Colombia: A Cross-Sectional Study
Characteristics of Inhaler Technique in COPD Patients in a Specialized Center in Armenia, Colombia: A Cross-Sectional Study Open
Nearly half of the patients who use inhalation devices make errors in the technique. Patient education and training of healthcare personnel represent a fundamental pillar in mitigating the incorrect use of these devices.
View article: Ansiedad y depresión en estudiantes de medicina de Latinoamérica durante la pandemia del COVID-19
Ansiedad y depresión en estudiantes de medicina de Latinoamérica durante la pandemia del COVID-19 Open
Objetivos: Determinar la frecuencia de depresión y ansiedad en estudiantes de la carrera de medicina de Latinoamérica durante el distanciamiento social en el perÃodo de brote del COVID-19.
View article: Prevalence of Intestinal Coccidia: First Description of Cyclosporidiosis Associated with Diarrhea in Children in Colombia
Prevalence of Intestinal Coccidia: First Description of Cyclosporidiosis Associated with Diarrhea in Children in Colombia Open
Background: In Colombia, the studies about the etiology of acute diarrhea disease (ADD) in children by using standard stool culture techniques methods and DNA detection tools for intestinal virus show that viral origin was the most frequen…
View article: Knowledge, Perceptions, and Practices on Risks and Disasters Among Medical Students. A Multicenter Cross-Sectional Study in 9 Latin American and Caribbean Countries
Knowledge, Perceptions, and Practices on Risks and Disasters Among Medical Students. A Multicenter Cross-Sectional Study in 9 Latin American and Caribbean Countries Open
Most of medical students from Latin America and Latin America and the Caribbean have high and medium level of knowledge in risks and disasters. However, the implementation of disaster training programs for medical students has the potentia…
View article: Toxoplasmosis-Associated Lymphadenopathy: Description of a Series of Cases in a Reference Center
Toxoplasmosis-Associated Lymphadenopathy: Description of a Series of Cases in a Reference Center Open
Background: Toxoplasmosis has a more severe manifestation in pregnant women and immunocompromised individuals. Up to 15% of immunocompetent individuals who have acquired the infection may be asymptomatic, however in others the symptoms may…
View article: How much do Latin American medical students know about radiology? Latin-American multicenter cross-sectional study
How much do Latin American medical students know about radiology? Latin-American multicenter cross-sectional study Open
The study was subject to selection bias determined by non-probability convenience sampling. The questionnaire assessed only theoretical knowledge and the evaluation system was designed by the investigators.
View article: Eficacia y tolerabilidad de Nitazoxanida para parasitismo intestinal en escolares atendidos en el Centro de Salud de la Universidad del Quindío
Eficacia y tolerabilidad de Nitazoxanida para parasitismo intestinal en escolares atendidos en el Centro de Salud de la Universidad del Quindío Open
Objetivo: Describir la efectividad del tratamiento antiparasitario intestinal brindado a niños de cuatro a nueve años atendidos en el centro de Salud de la Universidad del Quindío entre Julio de 2017 a marzo de 2018. Materiales y métodos: …
View article: Vasectomía: conocimientos, percepción y aceptación por parte de estudiantes de medicina en América Latina
Vasectomía: conocimientos, percepción y aceptación por parte de estudiantes de medicina en América Latina Open
Introducción. Los estudiantes de medicina desempeñan un rol importante en el logro de resultados en salud sexual y reproductiva, incluyendo una mayor participación de los hombres en la planificación familiar. Objetivo. Describir el nivel d…
View article: Congreso Estudiantil Colombiano de Investigación Médica: Una plataforma para el conocimiento científico y desarrollo integral
Congreso Estudiantil Colombiano de Investigación Médica: Una plataforma para el conocimiento científico y desarrollo integral Open
Los congresos científicos estudiantiles de investigación médica se han convertido en un espacio fundamental para intercambiar experiencias y brindar espacios de reflexión sobre la formación en investigación, permitiendo solventar la ausenc…
View article: Consentimiento informado en investigación: una perspectiva médica estudiantil de Latinoamérica
Consentimiento informado en investigación: una perspectiva médica estudiantil de Latinoamérica Open
Sr. Editor:La ética en la investigación es fundamental para salvaguardar el bienestar de los participantes. El uso del consentimiento informado (CI) definido como: “autorización voluntaria, por un sujeto de investigación, con plena compren…