H.M. Pereira
YOU?
Author Swipe
View article: PERCEPÇÃO SOBRE CUIDADO DE SAÚDE E DE BELEZA EM PERÍODO DE ISOLAMENTO SOCIAL DURANTE A PANDEMIA DE COVID-19 NO BRASIL
PERCEPÇÃO SOBRE CUIDADO DE SAÚDE E DE BELEZA EM PERÍODO DE ISOLAMENTO SOCIAL DURANTE A PANDEMIA DE COVID-19 NO BRASIL Open
Este estudo visou analisar o impacto que as mudanças sociais decorrentes da adoção de medidas sanitárias de contenção da COVID-19 no Brasil tiveram sobre o comportamento e a percepção da população brasileira no que se refere à busca por se…
View article: Structural Insights into Ciona intestinalis Septins: Complexes Suggest a Mechanism for Nucleotide-dependent Interfacial Cross-talk
Structural Insights into Ciona intestinalis Septins: Complexes Suggest a Mechanism for Nucleotide-dependent Interfacial Cross-talk Open
View article: Structural and thermodynamic characterization of a highly amyloidogenic dimer of transthyretin involved in a severe cardiomyopathy
Structural and thermodynamic characterization of a highly amyloidogenic dimer of transthyretin involved in a severe cardiomyopathy Open
View article: Bacterial selenocysteine synthase structure revealed by single-particle cryoEM
Bacterial selenocysteine synthase structure revealed by single-particle cryoEM Open
The 21st amino acid, selenocysteine (Sec), is synthesized on its dedicated transfer RNA (tRNASec). In bacteria, Sec is synthesized from Ser-tRNA[Ser]Sec by Selenocysteine Synthase (SelA), which is a pivotal enzyme in …
View article: Phylogenetic Analysis and Structural Studies of Heteromeric Acetyl-Coa Carboxylase from the Oleaginous Amazonian Microalgae Ankistrodesmus Sp.: Insights into the Bc and Bccp Subunits
Phylogenetic Analysis and Structural Studies of Heteromeric Acetyl-Coa Carboxylase from the Oleaginous Amazonian Microalgae Ankistrodesmus Sp.: Insights into the Bc and Bccp Subunits Open
View article: X-ray structure of the metastable SEPT14–SEPT7 coiled coil reveals a hendecad region crucial for heterodimerization
X-ray structure of the metastable SEPT14–SEPT7 coiled coil reveals a hendecad region crucial for heterodimerization Open
Septins are membrane-associated, GTP-binding proteins that are present in most eukaryotes. They polymerize to play important roles as scaffolds and/or diffusion barriers as part of the cytoskeleton. α-Helical coiled-coil domains are believ…
View article: Engineering the catalytic activity of an Antarctic <scp>PET</scp>‐degrading enzyme by loop exchange
Engineering the catalytic activity of an Antarctic <span>PET</span>‐degrading enzyme by loop exchange Open
Several hydrolases have been described to degrade polyethylene terephthalate (PET) at moderate temperatures ranging from 25°C to 40°C. These mesophilic PET hydrolases (PETases) are less efficient in degrading this plastic polymer than thei…
View article: Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease
Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). The NSP15 endoribonuclease enzyme, known as NendoU, is highly conserved and plays a critical role in the ability of…
View article: A Key Piece of the Puzzle: The central tetramer of the<i>Saccharomyces cerevisiae</i>septin protofilament and Its Implications for Self-Assembly
A Key Piece of the Puzzle: The central tetramer of the<i>Saccharomyces cerevisiae</i>septin protofilament and Its Implications for Self-Assembly Open
Septins, often described as the fourth component of the cytoskeleton, are structural proteins found in a vast variety of living beings. They are related to small GTPases and thus, generally, present GTPase activity which may play an import…
View article: HGPRT and PNP: Recombinant Enzymes from Schistosoma mansoni and Their Role in Immunotherapy during Experimental Murine Schistosomiasis
HGPRT and PNP: Recombinant Enzymes from Schistosoma mansoni and Their Role in Immunotherapy during Experimental Murine Schistosomiasis Open
Schistosomiasis is a parasitic infection caused by trematode worms (also called blood flukes) of the genus Schistosoma sp., which affects over 230 million people worldwide, causing 200,000 deaths annually. There is no vaccine or new drugs …
View article: Effects of Immunization with Recombinant Schistosoma mansoni Enzymes AK and HGPRT: Murine Infection Control
Effects of Immunization with Recombinant Schistosoma mansoni Enzymes AK and HGPRT: Murine Infection Control Open
Schistosomiasis is one of the most important human helminthiases worldwide. Praziquantel is the current treatment, and no vaccine is available until the present. Thus, the presented study aimed to evaluate the immunization effects with rec…
View article: Structural Characterization of L-Galactose Dehydrogenase: An Essential Enzyme for Vitamin C Biosynthesis
Structural Characterization of L-Galactose Dehydrogenase: An Essential Enzyme for Vitamin C Biosynthesis Open
In plants, it is well-known that ascorbic acid (vitamin C) can be synthesized via multiple metabolic pathways but there is still much to be learned concerning their integration and control mechanisms. Furthermore, the structural biology of…
View article: Structural Characterization of L-Galactose Dehydrogenase: A Key Enzyme for Vitamin C Biosynthesis
Structural Characterization of L-Galactose Dehydrogenase: A Key Enzyme for Vitamin C Biosynthesis Open
In plants, it is well-known that ascorbic acid (vitamin C) can be synthesized via multiple metabolic pathways but there is still much to be learnt concerning their integration and control mechanisms. Furthermore, the structural biology of …
View article: Crystal structure of the Cys-NO modified YopH tyrosine phosphatase
Crystal structure of the Cys-NO modified YopH tyrosine phosphatase Open
View article: Ecological Carrying Capacity for Bivalve Aquaculture in the Sado Estuary (Portugal): How to Ensure Ecosystem Sustainability?
Ecological Carrying Capacity for Bivalve Aquaculture in the Sado Estuary (Portugal): How to Ensure Ecosystem Sustainability? Open
View article: The Structural Biology of Septins and Their Filaments: An Update
The Structural Biology of Septins and Their Filaments: An Update Open
In order to fully understand any complex biochemical system from a mechanistic point of view, it is necessary to have access to the three-dimensional structures of the molecular components involved. Septins and their oligomers, filaments a…
View article: Crystallographic approach to fragment-based hit discovery against <i>Schistosoma mansoni</i> purine nucleoside phosphorylase
Crystallographic approach to fragment-based hit discovery against <i>Schistosoma mansoni</i> purine nucleoside phosphorylase Open
Several Schistosoma species cause Schistosomiasis, an endemic disease in 78 countries that is ranked second amongst the parasitic diseases in terms of its socioeconomic impact and human health importance. The drug recommended for treatment…
View article: Structural and Evolutionary Analyses of PR-4 SUGARWINs Points to a Different Pattern of Protein Function
Structural and Evolutionary Analyses of PR-4 SUGARWINs Points to a Different Pattern of Protein Function Open
SUGARWINs are PR-4 proteins associated with sugarcane defense against phytopathogens. Their expression is induced in response to damage by Diatraea saccharalis larvae. These proteins play an important role in plant defense, in particular a…
View article: A crystallographic snapshot of SARS-CoV-2 main protease maturation process
A crystallographic snapshot of SARS-CoV-2 main protease maturation process Open
SARS-CoV-2 is the causative agent of COVID-19.The dimeric form of the viral Mpro is responsible for the cleavage of the viral polyprotein in 11 sites, including its own N and C -terminus.The lack of structural information for intermediary …
View article: A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process
A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process Open
View article: An atomic model for the human septin hexamer by cryo-EM
An atomic model for the human septin hexamer by cryo-EM Open
View article: Identification of potential inhibitors of<i>Schistosoma mansoni</i>purine nucleoside phosphorylase from neolignan compounds using molecular modelling approaches
Identification of potential inhibitors of<i>Schistosoma mansoni</i>purine nucleoside phosphorylase from neolignan compounds using molecular modelling approaches Open
Schistosomiasis is a parasitic disease that is part of the neglected tropical diseases (NTDs), which cause significant levels of morbidity and mortality in millions of people throughout the world. The enzyme purine nucleoside phosphorylase…
View article: Orientational Ambiguity in Septin Coiled Coils and its Structural Basis
Orientational Ambiguity in Septin Coiled Coils and its Structural Basis Open
View article: Trypanosomatid selenophosphate synthetase structure, function and interaction with selenocysteine lyase
Trypanosomatid selenophosphate synthetase structure, function and interaction with selenocysteine lyase Open
Eukaryotes from the Excavata superphylum have been used as models to study the evolution of cellular molecular processes. Strikingly, human parasites of the Trypanosomatidae family (T. brucei, T. cruzi and L. major) conserve the complex ma…
View article: Investigating Immunization With Nucleotide Enzymes of Schistosoma mansoni: Nucleoside Diphosphate Kinase and Adenylosuccinate Lyase as New Antigenic Targets Against Schistosomiasis
Investigating Immunization With Nucleotide Enzymes of Schistosoma mansoni: Nucleoside Diphosphate Kinase and Adenylosuccinate Lyase as New Antigenic Targets Against Schistosomiasis Open
Schistosomiasis, caused by Schistosoma mansoni trematode worm, affects more than 1.5 million people in Brazil. The current treatment consists in the administration of Praziquantel, the only medicine used for treatment for more than …
View article: Molecular Recognition at Septin Interfaces: The Switches Hold the Key
Molecular Recognition at Septin Interfaces: The Switches Hold the Key Open
View article: Molecular recognition at septin interfaces: the switches hold the key
Molecular recognition at septin interfaces: the switches hold the key Open
The assembly of a septin filament requires that homologous monomers must distinguish between one another in establishing appropriate interfaces with their neighbours. To understand this phenomenon at the molecular level, we present the fir…
View article: A complete compendium of crystal structures for the human SEPT3 subgroup reveals functional plasticity at a specific septin interface
A complete compendium of crystal structures for the human SEPT3 subgroup reveals functional plasticity at a specific septin interface Open
Human septins 3, 9 and 12 are the only members of a specific subgroup of septins that display several unusual features, including the absence of a C-terminal coiled coil. This particular subgroup (the SEPT3 septins) are present in rod-like…
View article: Correction: Structural characterization of a pathogenicity-related superoxide dismutase codified by a probably essential gene in Xanthomonas citri subsp. citri
Correction: Structural characterization of a pathogenicity-related superoxide dismutase codified by a probably essential gene in Xanthomonas citri subsp. citri Open
[This corrects the article DOI: 10.1371/journal.pone.0209988.].
View article: Trypanosomatid selenophosphate synthetase structure, function and interaction with selenocysteine lyase
Trypanosomatid selenophosphate synthetase structure, function and interaction with selenocysteine lyase Open
Early branching eukaryotes have been used as models to study the evolution of cellular molecular processes. Strikingly, human parasite of the Trypanosomatidae family ( T. brucei , T. cruzi and L. major ) conserve the complex machinery resp…