Hung‐Mo Lin
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View article: Effectiveness of the 2024–2025 KP.2 COVID-19 vaccines in the United States during long-term follow-up
Effectiveness of the 2024–2025 KP.2 COVID-19 vaccines in the United States during long-term follow-up Open
Up-to-date estimates of COVID-19 vaccine effectiveness (VE) are needed to inform COVID-19 vaccination strategies and recommendations. This target trial emulation study aimed to estimate the long-term vaccine effectiveness (VE) of the 2024-…
View article: Assessing the impact of distance from primary hemophilia treatment center on annualized bleeding rates in people with inheritable bleeding disorders
Assessing the impact of distance from primary hemophilia treatment center on annualized bleeding rates in people with inheritable bleeding disorders Open
Introduction: Access to federally-supported hemophilia treatment centers (HTC) is critically important in people with inheritable bleeding disorders (PwBD). Distance to an HTC has been reported as a barrier to access to acute care for blee…
View article: Single-cell transcriptomic analysis reveals the evolution of the immunosuppressive landscape from primary tumors to brain metastasis in LUAD
Single-cell transcriptomic analysis reveals the evolution of the immunosuppressive landscape from primary tumors to brain metastasis in LUAD Open
Brain metastasis (BM) is a major cause of mortality in lung adenocarcinoma, yet the cellular and molecular basis of its immune microenvironment remodeling remains unclear. Here, we systematically analyzed primary lung adenocarcinoma (LUAD)…
View article: Budget Impact of Adopting Nirmatrelvir-Ritonavir for Treating COVID-19 in a Large Integrated Healthcare System
Budget Impact of Adopting Nirmatrelvir-Ritonavir for Treating COVID-19 in a Large Integrated Healthcare System Open
Background Understanding the budget impact of prescribing nirmatrelvir-ritonavir (NR) for COVID-19 can inform procurement and allocation strategies in large healthcare systems. Methods We assessed the budget impact of providing NR in the V…
View article: Baseline values for Quantra® QPlus® in healthy pregnant women at term and comparison to standard laboratory coagulation values: a prospective observational study
Baseline values for Quantra® QPlus® in healthy pregnant women at term and comparison to standard laboratory coagulation values: a prospective observational study Open
Background Hypofibrinogenemia is associated with progression from moderate to severe postpartum hemorrhage (PPH). Early recognition and replacement of fibrinogen are emphasized during the management of PPH. The Quantra ® QPlus ® System, a …
View article: Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model
Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model Open
The outflow of 'dirty' brain fluids from the glymphatic system drains via the meningeal lymphatic vessels to the lymph nodes in the neck, primarily the deep cervical lymph nodes (dcLN). However, it is unclear whether dcLN drainage is essen…
View article: Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease
Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease Open
Objective To assess the relationship of subtle preclinical cognitive changes with white matter microstructure and cortical volume in middle‐aged adults at high AD risk due to a parental history. Methods Participants ( n = 278) were AD pati…
View article: The role of right ventricular systolic pressure and ARISCAT score in perioperative pulmonary risk assessment
The role of right ventricular systolic pressure and ARISCAT score in perioperative pulmonary risk assessment Open
RVSP demonstrated limited efficacy as a standalone predictor of 30-day PPC in patients with PH. Although integrating RVSP with ARISCAT scoring yielded marginal improvements in predictive accuracy, neither metric, independently or in combin…
View article: Rigosertib Reverses Hypertrophic Cardiomyopathy in<i>RAF1</i>-Associated Noonan Syndrome
Rigosertib Reverses Hypertrophic Cardiomyopathy in<i>RAF1</i>-Associated Noonan Syndrome Open
Background RASopathies constitute a group of rare genetic disorders caused by mutations in genes that reside along the canonical Ras/MAPK signaling pathway, affecting cell growth and differentiation. These syndromes, which include conditio…
View article: Seven-tesla magnetic resonance imaging of the nervus terminalis, olfactory tracts, and olfactory bulbs in COVID-19 patients with anosmia and hypogeusia
Seven-tesla magnetic resonance imaging of the nervus terminalis, olfactory tracts, and olfactory bulbs in COVID-19 patients with anosmia and hypogeusia Open
Introduction Linking olfactory epithelium to the central nervous system are cranial nerve 1, the olfactory nerve, and cranial nerve “0,” and the nervus terminalis (NT). Since there is minimal expression of angiotensin-converting enzyme-2 (…
View article: The Impact of Race/Ethnicity on Disparities in Utilization and Outcomes of Neuraxial Anesthesia for Hip and Femoral Shaft Fractures
The Impact of Race/Ethnicity on Disparities in Utilization and Outcomes of Neuraxial Anesthesia for Hip and Femoral Shaft Fractures Open
Background/Objectives: The use of neuraxial anesthesia versus general anesthesia for hip fracture surgery remains an active area of research, with recent studies demonstrating mixed findings supporting neuraxial over general anesthesia. Th…
View article: Speech markers of depression dimensions across cognitive status
Speech markers of depression dimensions across cognitive status Open
Introduction Depression and its components significantly impact dementia prediction and severity, necessitating reliable objective measures for quantification. Methods We investigated associations between emotion‐based speech measures (val…
View article: Poor self‐rated health is associated with faster cognitive decline and greater small vessel disease in older adults with type 2 diabetes
Poor self‐rated health is associated with faster cognitive decline and greater small vessel disease in older adults with type 2 diabetes Open
Background Self‐rated health (SRH) is a predictor for poor health outcomes and cognition. Older adults with type 2 diabetes (T2D) have multi‐morbidity and greater cognitive impairment. In this study we investigated the association of SRH w…
View article: Emotional Expression on Social Media Support Forums for Substance Cessation: Observational Study of Text-Based Reddit Posts
Emotional Expression on Social Media Support Forums for Substance Cessation: Observational Study of Text-Based Reddit Posts Open
Background Substance use disorder is characterized by distinct cognitive processes involved in emotion regulation as well as unique emotional experiences related to the relapsing cycle of drug use and recovery. Web-based communities and th…
View article: Behavioral and Brain Correlates of Emotional Distress in Older Adults During COVID-19 Quarantine
Behavioral and Brain Correlates of Emotional Distress in Older Adults During COVID-19 Quarantine Open
COVID-19 led to unprecedented lockdowns and changes in older adults’ lives, especially those with type 2 diabetes who have high risk of complications and mortality. We investigated the associations of cognitive and motor function and gray …
View article: Informative Censoring—A Cause of Bias in Estimating COVID-19 Mortality Using Hospital Data
Informative Censoring—A Cause of Bias in Estimating COVID-19 Mortality Using Hospital Data Open
(1) Background: Several retrospective observational analyzed treatment outcomes for COVID-19; (2) Methods: Inverse probability of censoring weighting (IPCW) was applied to correct for bias due to informative censoring in database of hospit…
View article: Optimal Dose of Spinal Bupivacaine on Maternal and Fetal Outcomes in Parturients Undergoing Combined Technique for Labor Analgesia: A Randomized Double Blinded Prospective Study
Optimal Dose of Spinal Bupivacaine on Maternal and Fetal Outcomes in Parturients Undergoing Combined Technique for Labor Analgesia: A Randomized Double Blinded Prospective Study Open
Study Objectives: Maternal hypotension and fetal bradycardia (FB) are recognized complications of combined spinal epidural. Our purpose was to ascertain which of 3 common doses of spinal bupivacaine results in optimal analgesia with minima…
View article: Emotional Expression on Social Media Support Forums for Substance Cessation: Observational Study of Text-Based Reddit Posts (Preprint)
Emotional Expression on Social Media Support Forums for Substance Cessation: Observational Study of Text-Based Reddit Posts (Preprint) Open
BACKGROUND Substance use disorder is characterized by distinct cognitive processes involved in emotion regulation as well as unique emotional experiences related to the relapsing cycle of drug use and recovery. Web-based communities and t…
View article: Real-time Machine Learning Alerts to Prevent Escalation of Care: A Pragmatic Clinical Trial
Real-time Machine Learning Alerts to Prevent Escalation of Care: A Pragmatic Clinical Trial Open
Importance Automated machine learning algorithms have been shown to outperform older methods in predicting clinical deterioration requiring escalation of care, but rigorous prospective data on their real-world efficacy are limited. Objecti…
View article: Alzheimer’s Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes
Alzheimer’s Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes Open
Objectives Multiple risk loci for late-onset Alzheimer’s disease (LOAD) have been identified. Type 2 diabetes (T2D) is a risk factor for cognitive decline, dementia and Alzheimer’s disease (AD). We investigated the association of polygenic…
View article: Nitric oxide versus epoprostenol for refractory hypoxemia in Covid-19
Nitric oxide versus epoprostenol for refractory hypoxemia in Covid-19 Open
Objective To compare the efficacy and outcomes with inhaled nitric oxide (iNO) and inhaled epoprostenol (iEPO) in patients with refractory hypoxemia due to COVID-19. Design Retrospective Cohort Study. Setting Single health system multicent…
View article: Hospitalized patients with HIV and COVID‑19 receiving convalescent plasma: A case series
Hospitalized patients with HIV and COVID‑19 receiving convalescent plasma: A case series Open
The use of convalescent plasma in coronavirus disease 2019 (COVID‑19) in the general population has not been shown to have a clear benefit. However, there are limited data available on its use in specific populations, such as in persons wi…