Hui Shao
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View article: RiskPO: Risk-based Policy Optimization via Verifiable Reward for LLM Post-Training
RiskPO: Risk-based Policy Optimization via Verifiable Reward for LLM Post-Training Open
Reinforcement learning with verifiable reward has recently emerged as a central paradigm for post-training large language models (LLMs); however, prevailing mean-based methods, such as Group Relative Policy Optimization (GRPO), suffer from…
View article: No-touch ablation for hepatocellular carcinoma: a narrative review
No-touch ablation for hepatocellular carcinoma: a narrative review Open
This technology has been used in hepatic tumor treatment for many years, and many global studies have reported its safety and reliable efficacy.
View article: Corneal biomechanical properties in myopic anisometropia measured by corneal visualization scheimpflug technology
Corneal biomechanical properties in myopic anisometropia measured by corneal visualization scheimpflug technology Open
CorVis ST provides a reliable method for measuring corneal biomechanical properties. In anisometropia, eyes with higher myopia show higher deformation amplitude, faster A2-velocity, shorter A2-time and HC-time, and reduced A2-length.
View article: Impact of myopic laser surgery and pregnancy-related hormonal fluctuations on corneal biomechanics
Impact of myopic laser surgery and pregnancy-related hormonal fluctuations on corneal biomechanics Open
Myopic laser surgery and hormonal fluctuations during pregnancy exert significant effects on corneal biomechanics, particularly on central corneal thickness and corneal curvature.
View article: Temporal Trends in Prevalence of Chronic Liver Disease among Women of Childbearing Age from 1992 to 2021
Temporal Trends in Prevalence of Chronic Liver Disease among Women of Childbearing Age from 1992 to 2021 Open
Background Chronic liver disease (CLD) is among the foremost contributors to global mortality. This investigation attempted to profoundly analyze temporal trends in CLD prevalence among women of childbearing age (WCBA) over a span of 30 ye…
View article: High expression of circulating exosomal PD-L1 contributes to immune escape of hepatocellular carcinoma and immune clearance of chronic hepatitis B
High expression of circulating exosomal PD-L1 contributes to immune escape of hepatocellular carcinoma and immune clearance of chronic hepatitis B Open
PD-L1 blockade in exosomes might promote the cytotoxic function of CD8+T cells and inhibit immune evasion during progression of HCC. Blocking PD-L1 in exosomes reduced the cytotoxic function of CD8+T cells in patients with CHB while enhanc…
View article: Effect of corneal diameter on preoperative screening results for corneal refractive surgery
Effect of corneal diameter on preoperative screening results for corneal refractive surgery Open
Corneal diameter significantly affects preoperative screening for corneal refractive surgery. Smaller corneal diameters exhibit a greater influence on the corneal topography BAD analysis system.
View article: Willingness of college students to receive COVID-19 heterologous vaccination in Taizhou, China
Willingness of college students to receive COVID-19 heterologous vaccination in Taizhou, China Open
This study aimed to determine the willingness of college students to choose COVID-19 heterologous vaccination and its associated influencing factors in Taizhou, China. A population-based, self-administered online questionnaire was conducte…
View article: Phase 2b, Randomized, 3-Month, Dose-Finding Study of Sepetaprost in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: The ANGEL Study
Phase 2b, Randomized, 3-Month, Dose-Finding Study of Sepetaprost in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: The ANGEL Study Open
Purpose: This phase 2b, randomized, observer-masked, placebo- and active-controlled, parallel-group, multinational (USA and Japan), multicenter study (NCT03216902) assessed the optimal dose of sepetaprost ophthalmic solution in patients wi…
View article: Changes and Clinical Significance of PIVKA-II in Hepatitis E Patients
Changes and Clinical Significance of PIVKA-II in Hepatitis E Patients Open
Increased protein induced by vitamin K absence or antagonist-II (PIVKA-II) levels had been widely reported in patients with hepatocellular carcinoma (HCC) and chronic hepatitis. However, the role of PIVKA-II in hepatitis E is unclear. The …
View article: LGK974 Potentiates the Lethality of TRAIL in Hepatocellular Carcinoma Cells by Inducing Apoptosis via Suppressing NF-κB Signaling Pathway
LGK974 Potentiates the Lethality of TRAIL in Hepatocellular Carcinoma Cells by Inducing Apoptosis via Suppressing NF-κB Signaling Pathway Open
LGK974 is a potent Wingless-related integration site inhibitor at Phase II of a clinical trial. However, little is known about its role and the underlying mechanisms in human hepatocellular carcinoma. 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphe…
View article: The Mechanism of miR-141 Regulating the Proliferation and Metastasis of Liver Cancer Cells by Targeting STAT4
The Mechanism of miR-141 Regulating the Proliferation and Metastasis of Liver Cancer Cells by Targeting STAT4 Open
Background. In recent years, it has been reported that miRNA can be used as one of the markers of tumor diagnosis, treatment, and prognosis (including liver cancer), and it plays an important role in tumorigenesis. However, there are still…
View article: Safety and efficacy of 25G anterior vitrectomy in glaucoma and cataract with extremely shallow anterior chamber
Safety and efficacy of 25G anterior vitrectomy in glaucoma and cataract with extremely shallow anterior chamber Open
AIM: To observe the safety and efficacy of the 25G anterior vitrectomy surgical technique via scleral flap in phacoemulsification combined with trabeculectomy for glaucoma and cataract with extremely shallow anterior chamber.METHODS: This …
View article: Effect of portal vein thrombosis on the prognosis of patients with cirrhosis without a liver transplant
Effect of portal vein thrombosis on the prognosis of patients with cirrhosis without a liver transplant Open
Background: Portal vein thrombosis (PVT) is a relatively common complication of cirrhosis. However, the effect of PVT on the prognosis might not be unequivocal. A systematic review and meta-analysis were performed to investigate the effect…
View article: Clinical study of pulmonary CT lesions and associated bronchiectasis in 115 convalescent patients with novel coronavirus pneumonia (COVID-19) in China
Clinical study of pulmonary CT lesions and associated bronchiectasis in 115 convalescent patients with novel coronavirus pneumonia (COVID-19) in China Open
A total of 115 convalescent inpatients with COVID-19 were enrolled. According to the results of scans of lung lesions via computed tomography (CT), the patients were divided into mild, moderate, and severe groups. The clinical data of the …
View article: Atezolizumab plus Bevacizumab versus Sorafenib in the Chinese Subpopulation with Unresectable Hepatocellular Carcinoma: Phase 3 Randomized, Open-Label IMbrave150 Study
Atezolizumab plus Bevacizumab versus Sorafenib in the Chinese Subpopulation with Unresectable Hepatocellular Carcinoma: Phase 3 Randomized, Open-Label IMbrave150 Study Open
Introduction: Atezolizumab plus bevacizumab significantly improved overall survival (OS) and progression-free survival (PFS) versus sorafenib in patients with unresectable hepatocellular carcinoma (HCC) in IMbrave150. Efficacy and safety d…
View article: Atezolizumab and Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma: Pharmacokinetic and Safety Assessments Based on Hepatic Impairment Status and Geographic Region
Atezolizumab and Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma: Pharmacokinetic and Safety Assessments Based on Hepatic Impairment Status and Geographic Region Open
Introduction: Phase 1b GO30140 and phase 3 IMbrave150 studies evaluated first-line atezolizumab + bevacizumab for unresectable hepatocellular carcinoma (HCC). Here, we evaluated pharmacokinetics (PK) and safety by hepatic impairment status…
View article: Supplementary Material for: Atezolizumab and Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma: Pharmacokinetic and Safety Assessments Based on Hepatic Impairment Status and Geographic Region
Supplementary Material for: Atezolizumab and Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma: Pharmacokinetic and Safety Assessments Based on Hepatic Impairment Status and Geographic Region Open
Introduction: Phase 1b GO30140 and phase 3 IMbrave150 studies evaluated first-line atezolizumab + bevacizumab for unresectable hepatocellular carcinoma (HCC). Here, we evaluated pharmacokinetics (PK) and safety by hepatic impairment status…
View article: Corneal biomechanical properties in myopic eyes evaluated via Scheimpflug imaging
Corneal biomechanical properties in myopic eyes evaluated via Scheimpflug imaging Open
Background: To investigate the biomechanical properties of the cornea in myopic eyes using corneal visualization scheimpflug technology (Corvis ST). The relationships between the biomechanical properties of the cornea and the degree of myo…
View article: CD127 Expression in Naive and Memory T Cells in HIV Patients Who Have Undergone Long-Term HAART
CD127 Expression in Naive and Memory T Cells in HIV Patients Who Have Undergone Long-Term HAART Open
CD127 expression in T cells is decreased in patients with HIV-1 and is related to recovery of CD4+T-cell counts and to naïve subsets.
View article: Nosocomial Co-Transmission of Avian Influenza A(H7N9) and A(H1N1)pdm09 Viruses between 2 Patients with Hematologic Disorders
Nosocomial Co-Transmission of Avian Influenza A(H7N9) and A(H1N1)pdm09 Viruses between 2 Patients with Hematologic Disorders Open
A nosocomial cluster induced by co-infections with avian influenza A(H7N9) and A(H1N1)pdm09 (pH1N1) viruses occurred in 2 patients at a hospital in Zhejiang Province, China, in January 2014. The index case-patient was a 57-year-old man wit…