Explanipedia

Dual Factors in Chemotherapy Dose Reductions: Bridging Causal Insights with Clinical Correlates Open

Hakan Bozcuk, Mustafa Yıldız, Mehmet Artaç, Hasan Mutlu, Hasan Şenol Çoşkun · 2025

Chemotherapy dose reductions are associated with adverse clinical outcomes in cancer patients, yet the underlying causal factors remain incompletely defined. We investigated causal determinants of chemotherapy dose reductions across three …

First-line immune-checkpoint inhibitor treatment in extensive-disease small-cell lung cancer: A classical and network meta-analysis Open

Hasan Mutlu, Hakan Bozcuk, Mehmet Artaç, İrfan Eser · 2022

Small-cell lung cancer (SCLC) has a poor prognosis. For the last 30 years, first-line systemic treatment has remained unaltered. After the integration of ımmunotherapy, a new first-line gold standard, atezolizumab in combination with carbo…

The optimal upfront therapy in metastatic hormone-sensitive prostate cancer: A network meta-analysis Open

Hasan Mutlu, Hakan Bozcuk · 2021

Background: Prostate cancer (PC) is one of the most common cancer types in men. In addition to androgen-deprivation therapy (ADT), new generation agents have provided survival advantages to patients with metastatic hormone-sensitive PC (mH…

Checkpoint inhibitors in advanced nonsmall-cell lung cancer; a Bayesian network meta-analysis Open

Hakan Bozcuk, Mustafa Yıldırım, Özlem Nuray Sever, Hasan Mutlu, Mehmet Artaç · 2020

Some degree of differences in terms of efficacy exists between different types, dosages, settings, and combinations of CPI. We quantify these differences to guide clinical practice.

Investigating CPAP Compliance in Patients with Obstructive Sleep Apnea Open

Övsen Önay, Hasan Mutlu, Ahmet Emre Süslü, Tevfik Metin Önerci · 2018

p { margin-bottom: 0.1in; direction: ltr; line-height: 120%; text-align: left; }a:link { color: rgb(0, 0, 0); }Objectives:Our aim in this study is to investigate, in patients who are advisedto use CPAP, the rate of usage, differences betwe…

The importance of stromal and intratumoral tumor lymphocyte infiltration for pathologic complete response in patients with locally advanced breast cancer Open

Melek Karakurt Eryılmaz, Hasan Mutlu, Betül Ünal, Derya Kıvrak Salim, Fatma Yalçın Müsri , et al. · 2018

There is significantly an association between pCR and increased number of intratumoral TILs (>4 cells/mm ² of tissue) in BC who received NACT.

Irreversible Heart Failure Related to Adjuvant Anastrozole in a Patient with Breast Cancer Open

Fatma Yalçın Müsri, Hasan Mutlu, Melek Karakurt Eryılmaz, Derya KIVRAK SALİM, Hasan Şenol Çoşkun · 2017

Multiple pelvic cysts in a patient with familial Mediterranean fever: Benign cystic mesothelioma Open

Melek Karakurt Eryılmaz, Hasan Mutlu, Gökhan Tazegül, Ramazan Eryılmaz, Fatma Yalçın Müsri , et al. · 2017

Benign cystic mesothelioma (BCM) is a rare tumor arising from endothelial cells of the pelvic visceral or parietal peritoneum. It is a clinically and histopathologically benign disease. Etiology and pathogenesis of BCM remain unclear. Fami…

More sunlight exposure may improve the overall survival in patients with pancreas cancer Open

Melek Karakurt Eryılmaz, Hasan Mutlu, Şeyda Gündüz, Mükremın Uysal, Fatma Yaçın Müsri , et al. · 2016

The protective effect of sun exposure on prognosis of cancer and cancer risk was previously reported in some studies except for melanoma and skin cancer. In presented study we aimed to compare the effect of sunlight exposure on prognosis o…

Mean Platelet Volume as an Independent Predictive Marker for Pathologic Complete Response after Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer Open

Hasan Mutlu, Melek Karakurt Eryılmaz, Fatma Yalçcn Musri, Şeyda Gündüz, Derya Kıvrak Salim , et al. · 2016

MPV has an independent predictive value for pCR after neoadjuvant chemotherapy in patients with LABC.

The Neutrophil to Lymphocyte Ratio is an Independent Prognostic Factor in Patients with Metastatic Gastric Cancer Open

Fatma Yalçın Müsri, Hasan Mutlu, Melek Karakurt Eryılmaz, Derya Kıvrak Salim, Şeyda Gündüz , et al. · 2016

Inflammation can play an important role in cancer progression and the prognostic importance of neutrophil to lymphocyte ratio (NLR), a marker of inflammation, in cancer is a current investigation topic. In the present study, we aimed to de…

Primary Tumor Resection and Survival in Patients with Stage IV Gastric Cancer Open

Fatma Yalçın Müsri, Hasan Mutlu, Mustafa Karaağaç, Melek Karakurt Eryılmaz, Şeyda Gündüz , et al. · 2016

Non-curative gastrectomy in patients with metastatic gastric cancer might increase their survival rate regardless of the occurrence of life-threatening tumor-related complications.

The role of blood groups in the development of diabetes mellitus after gestational diabetes mellitus Open

Abdülsamet Erden, Hatice Karagoz, Özerhan Özer, Kübra Esmeray, Ali Çetinkaya , et al. · 2015

In this study, we found a higher risk of GDM for the patients with blood group AB, which means that we have to be more careful on the follow-up of pregnant women with blood group AB. The patients with GDM of blood group O are under a highe…

Factors affecting disease-free survival in patients with human epidermal growth factor receptor 2-positive breast cancer who receive adjuvant trastuzumab Open

Şeyda Gündüz, Sema Sezgin Göksu, Deniz Arslan, Ali Murat Tatlı, Mükremın Uysal , et al. · 2015

Breast cancer is the most frequently diagnosed cancer in women worldwide and the second cause of cancer-related mortality. A total of 20-30% of patients with early-stage breast cancer develop recurrence within the first 5 years following d…

Neutrophil to lymphocyte ratio is an independent prognostic factor in patients with recurrent or metastatic head and neck squamous cell cancer Open

Derya Kıvrak Salim, Hasan Mutlu, MELEK KARAKURT ERYILMAZ, Ozan Salim, Fatma Yalçın Müsri , et al. · 2015

The neutrophil to lymphocyte ratio (NLR) has been widely investigated for its prognostic significance in cancer. In the present study, we aimed to determine whether NLR is a prognostic factor in patients with recurrent or metastatic head a…

Stewart-Treves Syndrome after Bilateral Mastectomy and Radiotherapy for Breast Carcinoma: Case Report Open

Arzu Taşdemi̇r, Hati̇ce Karaman, Dilek Ünal, Hasan Mutlu · 2015

Stewart-Treves syndrome is an angiosarcoma that occurs because of chronic lymphedema, which in most cases is a complication after mastectomy with axillary node dissection and postoperative radiation. Prognosis for this rare tumor is poor. …

High-Dose Steroid-Induced Protrusio Acetabuli: A Case Report Open

Ercan Madenci, Zeliha Eğilmez, Semra Alkal, Pınar Arslan, Hasan Mutlu · 2015

The aim of presenting this case was to demonstrate that using high doses of corticosteroids which are not directly involved in etiological factors can cause secondary protrusio acetabuli.Protrusio acetabuli is identified with an acetabular…

Mide ve kolon kanserlerinde metastaz göstergesi olarak serum folat ve vitamin B12 düzeylerininirdelenmesi Open

Veli ÇAKICI, Elif YORULMAZ, Hasan Mutlu, Celal Ulaşoğlu, Mehmet Çelik , et al. · 2015

Background and Aims:Vitamin B12 and folate are two important vitamins necessary for cell division, proliferation and DNA synthesis. In this study, we aimed to evaluate the levels of B12 and folate as indicators of liver metastases of stoma…

Gastrointestinal stromal tumor and isolated anterior tibial muscle metastasis as first recurrence Open

Hüseyin Balkarlı, Hasan Mutlu, FatmaYalçin Müsri, DeryaKıvrak Salim, MelekKarakurt Eryılmaz , et al. · 2015

In the presented case, we report gastrointestinal stromal tumor (GIST) in a patient using adjuvant imatinib in whom isolated metastasis to anterior tibial muscle as first recurrence was diagnosed. A 66-year-old woman was diagnosed with GIS…

Experience of bevacizumab in a patient with colorectal cancer after renal transplantation Open

FatmaYalçin Müsri, Hasan Mutlu, MelekKarakurt Eryılmaz, DeryaKıvrak Salim, HasanŞenol Coşkun · 2015

Bevacizumab is a drug that is widely used for the first-line treatment of metastatic colorectal cancer (mCRC). Bevacizumab neutralizes vascular endothelial growth factor and can lead to proteinuria and renal damage. In this case, experienc…

Metronomic oral chemotherapy with old agents in patients with heavily treated metastatic breast cancer Open

Hasan Mutlu, FatmaYalçin Müsri, Mehmet Artaç, Ayşegül Kargı, Mustafa Özdoğan , et al. · 2015

Metronomic treatment regimen with cyclophosphamide and etoposide is a novel and effective strategy in heavily pretreated MBC patients. This regimen can be used in early or late steps as independently from prognostic factors. Moreover, it h…

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